Abstracts tagged "pain"

Abstract Number: 2588 • 2018 ACR/ARHP Annual Meeting
Baseline Pain Severity As a Predictor of Pain Improvement Following Treatment with Tofacitinib in Psoriatic Arthritis
Alexis Ogdie¹, Kurt de Vlam², Andrew G Bushmakin³, Joseph C Cappelleri³, Philip J. Mease⁴, Roy Fleischmann⁵, Peter C. Taylor⁶, Valderilio F Azevedo⁷, Lara Fallon⁸, Anna Maniccia⁹ and John Woolcott¹⁰, ¹University of Pennsylvania, Philadelphia, PA, ²UZ Leuven, Leuven, Belgium, ³Pfizer Inc, Groton, CT, ⁴Swedish Medical Center and University of Washington, Seattle, WA, ⁵University of Texas Southwestern Medical Center, Dallas, TX, ⁶University of Oxford, Oxford, United Kingdom, ⁷Universidade Federal do Paraná, Curitiba, Brazil, ⁸Pfizer Canada, Montreal, QC, Canada, ⁹Pfizer Inc, New York, NY, ¹⁰Pfizer Inc, Collegeville, PA
Background/Purpose: Pain is a core domain of psoriatic arthritis (PsA), and it is recommended that all randomized controlled trials (RCTs) in patients (pts) with PsA…
Abstract Number: 2594 • 2018 ACR/ARHP Annual Meeting
Median Time to Pain Improvement in Patients with Psoriatic Arthritis Treated with Tofacitinib
Kurt de Vlam¹, Alexis Ogdie², Andrew G Bushmakin³, Joseph C Cappelleri³, Roy Fleischmann⁴, Peter C. Taylor⁵, Valderilio F Azevedo⁶, Lara Fallon⁷, Anna Maniccia⁸, John Woolcott⁹ and Philip J. Mease¹⁰, ¹UZ Leuven, Leuven, Belgium, ²University of Pennsylvania, Philadelphia, PA, ³Pfizer Inc, Groton, CT, ⁴University of Texas Southwestern Medical Center, Dallas, TX, ⁵University of Oxford, Oxford, United Kingdom, ⁶Universidade Federal do Paraná, Curitiba, Brazil, ⁷Pfizer Canada, Montreal, QC, Canada, ⁸Pfizer Inc, New York, NY, ⁹Pfizer Inc, Collegeville, PA, ¹⁰Swedish Medical Center and University of Washington, Seattle, WA
Background/Purpose: Pain is a core domain of psoriatic arthritis (PsA).1 Rapid, sustained pain reduction is a priority for patients (pts) and physicians when choosing treatment.…
Abstract Number: 2652 • 2018 ACR/ARHP Annual Meeting
Engaging the Cholinergic Anti-Inflammatory Pathway By Stimulating the Vagus Nerve Reduces Pain and Fatigue in Patients with SLE
Cynthia Aranow¹, Martin Lesser², Meggan Mackay¹, Erik Anderson³, Theodoros P. Zanos², Timir Datta-Chaudhuri², Chad Bouton², Kevin J. Tracey⁴ and Betty Diamond¹, ¹The Feinstein Institute for Medical Research, Manhasset, NY, ²Feinstein Institute for Medical Research, Manhasset, NY, ³Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, Manhasset, NY, ⁴Laboratory of Biomedical Science, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Musculoskeletal (MS) pain is a common symptom of patients with Systemic Lupus Erythematosus (SLE) affecting up to 95% of patients and contributing to…
Abstract Number: 2868 • 2018 ACR/ARHP Annual Meeting
Tender Joint Count May Not Reflect Inflammatory Activity in Established Rheumatoid Arthritis Patients; Results from a Longitudinal Study of Tocilizumab
Hilde B Hammer¹, Inger Marie Jensen Hansen², Pentti Järvinen³, Marjatta Leirisalo-Repo⁴, Michael Ziegelasch⁵, Birte Agular⁶ and Lene Terslev⁷, ¹Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Rheumatology, Svendborg Hospital, Svendborg, Denmark, ³Rheumatology, Kiljava Medical Research, Kiljavan, Finland, ⁴Rheumatology, University of Helsinki, Helsinki, Finland, ⁵Rheumatology, University Hospital, Linköping, Linköping, Sweden, ⁶Roche, Copenhagen, Denmark, ⁷Rheumatology, Rigshospitalet Glostrup, Copenhagen, Denmark
Background/Purpose: Tender joints may be caused by non-inflammatory pathologies but are still included in composite scores like CDAI. The present objective was to explore the…
Abstract Number: 405 • 2018 ACR/ARHP Annual Meeting
Feasibility of Enabling Self-Management and Coping with Arthritic Pain Using Exercise (ESCAPE-Pain) Programme for Knee Osteoarthritis in Malaysia
Muhammad Kamil Che Hasan^1,2, Emma Stanmore² and Chris Todd², ¹Kulliyyah (Faculty) of Nursing, International Islamic University Malaysia (IIUM), Kuantan Pahang, Malaysia, ²Division of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, United Kingdom
Background/Purpose: In Malaysia around one in ten older people are diagnosed with osteoarthritis (OA), with the knee being one of the most commonly affected areas.…
Abstract Number: 447 • 2018 ACR/ARHP Annual Meeting
Discriminating between Central & Peripheral Pain Sensitization Using a Slowly Repeated Evoked Pain Protocol
Manuel Romero¹, Stephen Bruehl², Gustavo A Reyes del Paso³ and Pablo De la Coba³, ¹University Hospital of Jaén, Jaén, Spain, ²Department of Anesthesiology, Vanderbilt University, Nashville, TN, ³Department of Psychology, University of Jaén, Jaén, Spain
Background/Purpose: In a prior study, the response of pain sensitization by fibromyalgia (FM) patients to a protocol of Slowly Repeated Evoked Pain (SREP)* was strongly…
Abstract Number: 450 • 2018 ACR/ARHP Annual Meeting
Injection Site Reaction Associated with Subcutaneous Biologic Agents and Methotrexate. Analysis from the Rhumadata® Clinical Database and Registry
Denis Choquette¹, Louis Bessette², Jacques Brown², Boulos Haraoui¹, Frédéric Massicotte¹, Jean-Pierre Pelletier¹, Jean-Pierre Raynauld¹, Marie-Anaïs Rémillard¹, Diane Sauvageau¹, Angèle Turcotte², Édith Villeneuve¹ and Louis Coupal¹, ¹Rheumatology, Institut de Recherche en Rhumatologie de Montréal (IRRM), Montréal, QC, Canada, ²Rheumatology, Centre de l'Ostéoporose et de Rhumatologie de Québec (CORQ), Québec, QC, Canada
Background/Purpose: Injection Site Reaction (ISRs) are associated with the subcutaneous (SC) route of administration of all biologic agents, and 3% to 15% of patients reports…
Abstract Number: 933 • 2018 ACR/ARHP Annual Meeting
Inflammation in the Hippocampus Affects Insulin-like Growth Factor-1 Receptor Signaling and Contributes to Neurological Sequelae in Rheumatoid Arthritis
Karin Andersson¹, Caroline Wasén¹, Lina Juzokaite¹, Malin C Erlandsson^1,2, Anna Stokowska³, Lovisa Leifsdottir⁴, Marcela Pekna³, Milos Pekny³, Kjell Olmarker⁵, Rolf Heckemann^6,7,8, Marie Kalm⁹ and Maria I Bokarewa², ¹Department of rheumatology and inflammation research, University of Gothenburg, Gothenburg, Sweden, ²Rheumatology Clinic, Sahlgrenska University Hospital, Gothenburg, Sweden, ³Department of Clinical Neuroscience, University of Gothenburg, Gothenburg, Sweden, ⁴Rheumatology Clinics, Sahlgrenska University Hospital, Gothenburg, Sweden, ⁵Department of Medical Chemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden, ⁶Med Tech West at Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden, ⁷Department of Medical Radiation Science, University of Gothenburg, Gothenburg, Sweden, ⁸Faculty of Medicine, Imperial College London, London, United Kingdom, ⁹Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden
Background/Purpose: The central nervous system is not the primary target in rheumatoid arthritis (RA). However, neuropsychiatric symptoms including pain, depression and anxiety are common and…
Abstract Number: 1159 • 2018 ACR/ARHP Annual Meeting
Fat Mass Is Associated with Musculoskeletal Pain in Women : A Three-Year Longitudinal Study
Hyun Ah Kim and Jeong-Im Hong, Hallym University Sacred Heart Hospital, Kyunggi-do, Korea, Republic of (South)
Background/Purpose: Increase in fat mass is correlated with musculoskeletal pain. The aim of this study was to examine the relationship between fat mass and the…
Abstract Number: 614 • 2017 ACR/ARHP Annual Meeting
Effect of Tofacitinib on Reducing Pain in Patients with Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis
Alexis Ogdie¹, Kurt de Vlam², Iain B. McInnes³, Philip J Mease⁴, Philip Baer⁵, Tatjana Lukic⁶, Kenneth Kwok⁶, Cunshan Wang⁷, Ming-Ann Hsu⁷ and Anna Maniccia⁶, ¹Division of Rheumatology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ²UZ Leuven, Leuven, Belgium, ³Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, United Kingdom, ⁴Swedish Medical Center and University of Washington, Seattle, WA, ⁵Baer Weinberg MPC, Scarborough, ON, Canada, ⁶Pfizer Inc, New York, NY, ⁷Pfizer Inc, Groton, CT
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA), which has also been evaluated in other inflammatory rheumatic diseases…
Abstract Number: 860 • 2017 ACR/ARHP Annual Meeting
Effective Treatment of Persistent Arthritis Pain Requires Co-Modulation of TNF and Type I Interferon
Sarah Woller¹, Tony Yaksh² and Maripat Corr³, ¹Anesthesiology, UCSD, La Jolla, CA, ²Anesthesiology 0818, UCSD, La Jolla, CA, ³Division of Rheumatology, Allergy, and Immunology, UCSD, La Jolla, CA
Background/Purpose: Pain persisting beyond the resolution or control of clinical signs of rheumatoid arthritis (RA) decreases quality of life for millions of people. Unfortunately, this…
Abstract Number: 1261 • 2017 ACR/ARHP Annual Meeting
The Effects of Disease Burden, Helplessness, and Pain on Depressive Symptoms in Rheumatoid Arthritis and Systemic Lupus Erythematosus
Sera Ramadan¹, Perry M. Nicassio², George Karpouzas³ and Sarah Ormseth⁴, ¹Internal Medicine, Dignity Health St. Mary Medical Center, Long Beach, CA, ²Cousins Center for PNI, UCLA, LA, CA, ³Division of Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, ⁴Rheumatology, Harbor-UCLA Medical Center, Torrance, CA
Background/Purpose: This research tested an integrated framework examining patient global assessment of disease activity (PtGA), maladaptive illness beliefs and pain as determinants of mood disturbance…
Abstract Number: 1345 • 2017 ACR/ARHP Annual Meeting
Tender Joints Have Low Associations with Patient’s Evaluation of Joint Pain and Ultrasound Findings Explored at Joint Level in Patients with Rheumatoid Arthritis
Hilde B Hammer¹, Joseph Sexton¹, Sella A. Provan², Brigitte Michelsen^3,4 and Tore Kvien⁵, ¹Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Rheumatology, Hospital of Southern Norway trust, Kristiansand, Norway, ⁴Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁵Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: In patients with rheumatoid arthritis (RA) the pain experience in joints with different degrees of joint inflammation is highly individual and dependent upon the…
Abstract Number: 1602 • 2017 ACR/ARHP Annual Meeting
Fatigue in Systemic Lupus: The Role of Disease Activity and Its Mediators
Desiree R Azizoddin¹, Meenakshi Jolly², Joel A. Block³ and Perry M. Nicassio⁴, ¹Department of Medicine and Behavioral Sciences, Rush University, Chicago, IL, ²Rush, Chicago, IL, ³Division of Rheumatology, Rush University Medical Center, Chicago, IL, ⁴Cousins Center for PNI, UCLA, LA, CA
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that leads to a variety of negative health outcomes. Though treatment continues to advance, fatigue…
Abstract Number: 2210 • 2017 ACR/ARHP Annual Meeting
Thumb Base Osteoarthritis: Associations between Pain and Synovitis on Ultrasound
F.P.B. Kroon¹, S. Ermurat², M. Kortekaas¹, M. Reijnierse³ and M. Kloppenburg^1,4, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Uludag University Medical Faculty, Bursa, Turkey, ³Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Osteoarthritis (OA) in the first carpometacarpal (CMC1) joint in the thumb base is frequent and has a large contribution in hand pain and disability.…

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