Abstracts tagged "pain"

Abstract Number: 1984 • ACR Convergence 2020
Causal Pathways to Health-Related Quality of Life in Children with Juvenile Idiopathic Arthritis: Results from the ReACCh-Out Cohort
Kiem Oen¹, Jiahao Tian², Thomas Loughin², Roberta Berard³, Mercedes Chan⁴, Ciaran Duffy⁵, Brian Feldman⁶, Adam Huber⁷, Deborah Levy⁸, Dax G. Rumsey⁹, Natalie Shiff¹⁰, Shirley Tse¹¹, Lori Tucker⁴, Karen Watanabe-Duffy⁵ and Jaime Guzman¹², ¹University of Manitoba, Toronto, ON, Canada, ²Simon Fraser University, Burnaby, BC, Canada, ³London Health Sciences Centre, London, ON, Canada, ⁴BC Children's Hospital, Vancouver, BC, Canada, ⁵Children's Hospital of Eastern Ontario, Ottawa, ON, Canada, ⁶The Hospital for Sick Children, Toronto, ON, Canada, ⁷Dalhousie University, Halifax, NS, Canada, ⁸Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁹University of Alberta, Edmonton, AB, Canada, ¹⁰Florida, Gainesville, FL, ¹¹SickKids, Toronto, ON, Canada, ¹²University of British Columbia and BC Children's Hospital, Vancouver, BC, Canada
Background/Purpose: The relative roles of disease activity and disability as determinants of health-related quality of life (HRQoL) in children with JIA have been controversial; sometimes…
Abstract Number: 0022 • ACR Convergence 2020
Association Between Changes in Pain Sensitization and Changes in Disease Activity After 12 Weeks of Disease Modifying Anti-Rheumatic Drug Therapy in Rheumatoid Arthritis
Andrew Heisler¹, Jing Song², Lutfiyya Muhammad³, Alyssa Wohlfahrt⁴, Wendy Marder⁵, Marcy Bolster⁶, Clifton Bingham III⁷, Daniel Clauw⁸, Dorothy Dunlop⁹, Tuhina Neogi¹⁰ and Yvonne Lee³, ¹Northwestern University Feinberg School of Medicine, Oak Park, IL, ²Northwestern University, Chicago, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Brigham and Womans Hospital, Boston, MA, ⁵University of Michigan, Ann Arbor, MI, ⁶Massachusetts General Hospital, Concord, MA, ⁷Johns Hopkins University, Baltimore, MD, ⁸Michigan Medicine, Ann Arbor, MI, ⁹Northwestern University, New Haven, CT, ¹⁰Boston University School of Medicine, Boston, MA
Background/Purpose: Patients with rheumatoid arthritis (RA) have abnormalities in central nervous system regulation of pain, leading to enhanced pain sensitivity at joint sites (peripheral sensitization)…
Abstract Number: 0542 • ACR Convergence 2020
Examining the Long-Term and Short-Term Day-To-Day Pain Variability in Inflammatory and Non-Inflammatory Rheumatic and Musculoskeletal Diseases Using Multilevel and Markov Transition Models: Cloudy with a Chance of Pain, a National U.K. Smartphone Study
Huai Leng Pisaniello¹, Mark Lunt², John McBeth³ and William Dixon², ¹University of Adelaide, Kidman Park, South Australia, Australia, ²Centre for Epidemiology Versus Arthritis, University of Manchester, Manchester, United Kingdom, ³University of Manchester, Manchester, United Kingdom
Background/Purpose: Chronic pain is common in rheumatic and musculoskeletal diseases (RMDs), yet the patterns and the extent of variability over time are poorly understood. Real-time…
Abstract Number: 0961 • ACR Convergence 2020
Development of a Pain Sensitivity Index to Examine the Transition from Intermittent to Constant Pain in Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Kosaku Aoyagi¹, Lisa Carlesso², S. Reza Jafarzadeh¹, Michael LaValley³, Na Wang¹, Laura Frey Law⁴, Beth Lewis⁵, Michael Nevitt⁶ and Tuhina Neogi¹, ¹Boston University School of Medicine, Boston, MA, ²McMaster University, Hamilton, ON, Canada, ³Boston University School of Public Health, Boston, MA, ⁴University of Iowa, Iowa City, IA, ⁵University of Alabama at Birmingham, Birmingham, ⁶University of California, San Francisco, San Francisco, CA
Background/Purpose: Alterations in nociceptive signaling, such as pain sensitization, which is an abnormal ascending pain facilitation, and/or inadequate descending pain modulation, are thought to be…
Abstract Number: 1317 • ACR Convergence 2020
A Large Agreement Between the Pain Points of the ACR 1990 Fibromyalgia Criteria and the MASES Enthesitis Score Is Observed in Patients with Axial Spondylitis, Including in Patients Without Concomitant Fibromyalgia
Faten Hamitouche¹, Clementina Lopez-Medina², Laure Gossec³, Serge Perrot⁴, Maxime Dougados⁵ and Anna Molto⁶, ¹Rheumatology Department, Cochin Hospital, Paris, Ile-de-France, France, ²Rheumatology Department, Cochin Hospital, Paris, Paris, France, ³Sorbonne Université and Hôpital Universitaire Pitié Salpêtrière, Paris, France, ⁴Paris Descartes University, Paris, Ile-de-France, France, ⁵Université de Paris, Department of Rheumatology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France, ⁶Rheumatology Department, Cochin Hospital, APHP, Paris, France, Paris, France
Background/Purpose: Enthesitis is the hallmark lesion in Spondyloarthritis (SpA). The Maastricht Ankylosing Spondylitis Enthesitis score (MASES), which assesses 13 enthesitic sites, is the most widely…
Abstract Number: 1651 • ACR Convergence 2020
Efficacy and Safety of Multiple Intra-articular Corticosteroid Injections for Osteoarthritis – a Systematic Review and Meta-analysis of Randomised Controlled Trials and Observational Studies
Shazeen Ayub¹, Jaspreet Kaur¹, Michelle Hui², Michelle Hall¹, Michael Doherty³ and Weiya Zhang¹, ¹Academic Rheumatology, School of Medicine, University of Nottingham, UK, Nottingham, United Kingdom, ²Royal Derby Hospital, Derby, UK, Derby, United Kingdom, ³Academic Rheumatology, School of Medicine, University of Nottingham, UK, Nottingham, England, United Kingdom
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis worldwide and is becoming more prevalent with the increasing age of the population. As Intra-articular…
Abstract Number: 0027 • ACR Convergence 2020
CYP2D6 Genotype and Reduced Codeine Analgesic Effect in Real-World Clinical Practice
Daniel Carranza Leon¹, Alyson Dickson², Andrea Gaedigk³, C. Michael Stein² and Cecilia Chung², ¹Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt University Medical Center, Nashville, ³University of Missouri, Kansas City
Background/Purpose: Codeine, a widely prescribed analgesic, is an inactive pro-drug that is metabolized to morphine, the active drug, by cytochrome P450 2D6 (CYP2D6), a highly…
Abstract Number: 0551 • ACR Convergence 2020
Physical Performance as a Mediator of the Association Between Depression and Pain in Knee Osteoarthritis
Alan Rathbun¹, Elizabeth Stuart², Michelle Shardell¹, Trang Nguyen², Alice Ryan¹, Joseph Gallo², Michelle Yau³, Megan Schuler⁴ and Marc Hochberg¹, ¹University of Maryland School of Medicine, Baltimore, MD, ²Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ³Hinda and Arthur Marcus Institute for Aging Research, Boston, MA, ⁴RAND Corporation, Boston, MA
Background/Purpose: Depression is common in knee osteoarthritis (OA), and leads to reduced physical function, which may mediate the effect of depression on pain. However, research…
Abstract Number: 1030 • ACR Convergence 2020
Pain Medication Use Among Ankylosing Spondylitis and Psoriatic Arthritis Patients Before and After Initiation of Biologic Therapy
Theresa Hunter¹, Chi Nguyen², Julie Birt³, Joseph Smith², Mingyang Shan³, Hiangkiat Tan², Jeffrey Lisse³ and Keith Isenberg⁴, ¹Eli Lilly and Company, Indianapolis, ²Healthcore, Inc, Wilmington, DE, ³Eli Lilly and Company, Indianapolis, IN, ⁴Anthem, Inc, Indianapolis, IN
Background/Purpose: Pain is a common symptom among ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients and can be debilitating, making pain management an integral part…
Abstract Number: 1321 • ACR Convergence 2020
Central Sensitization, Disease Perception and Obesity Should Be Taken into Account When Interpreting Disease Activity in Patients with Axial Spondyloarthritis
Stan Kieskamp¹, Davy Paap², Marllies Carbo¹, Freke Wink³, Reinhard Bos⁴, Hendrika Bootsma¹, Suzanne Arends⁵ and Anneke Spoorenberg⁵, ¹University Medical Centre Groningen, Groningen, Netherlands, ², Department of Rehabilitation Medicine, University of Medical Centre Groningen, Groningen, Netherlands, ³Medical Centre Leeuwarden, Leeuwarden, Netherlands, ⁴Medical Centre Leeuwarden, Leeuwarden, ⁵University Medical Centre Groningen and Medical centre Leeuwarden, Groningen, Netherlands
Background/Purpose: Up to 40% of ankylosing spondylitis patients report persistently high pain scores of >4 (scale of 0-10) even after responding to long-term TNF-α blocking…
Abstract Number: 1655 • ACR Convergence 2020
Pain Reduction Post Total Knee Replacement in Opioid Users and Non-users
Lindsey MacFarlane¹, Yinzhu Jin¹, Yvonne Lee², Joyce Lii³, Jeffrey Katz⁴, Patricia Franklin⁵ and Seoyoung Kim¹, ¹Brigham and Women's Hospital, Boston, MA, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³Brigham and Women's Hospital, Boston, ⁴Harvard Medical School / The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Boston, MA, ⁵Northwestern University, Chicago
Background/Purpose: End-stage knee osteoarthritis (OA) is often managed with opioids and total knee replacement (TKR). Studies ascertaining opioid use via record review are conflicting as…
Abstract Number: 0028 • ACR Convergence 2020
Pain in the Time of Corona: Impact of COVID 19 Outbreak on Fibromyalgia Patients
Valerie Aloush¹, Avital Gurfinkel², Noam Shachar³, Jacob Ablin¹ and Odelia Elkana⁴, ¹Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ²Academic College TelAviv- Jaffa, Tel Aviv, Israel, ³Acamedic College Tel Aviv- Jaffa, Tel Aviv, Israel, ⁴Academic College Tel Aviv Jaffa, Tel Aviv, Israel
Background/Purpose: Fibromyalgia is a chronic pain disorder, characterized by abnormal pain processing in the central nervous system. Acute or chronic stress may trigger or aggravate…
Abstract Number: 0563 • ACR Convergence 2020
Relation of Pain Sensitization to Isokinetic Knee Extension Torque: The MOST Study
Patrick Corrigan¹, Tuhina Neogi², Laura Frey Law³, Neil Segal⁴, Michael Nevitt⁵, Beth Lewis⁶ and Joshua Stefanik¹, ¹Northeastern University, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³University of Iowa, Iowa City, IA, ⁴University of Kansas Medical Center, Iowa City, IA, ⁵Department of Epidemiology and Biostatistics, University of California San Francisco, Orinda, CA, ⁶University of Alabama at Birmingham, Birmingham
Background/Purpose: Central and local alterations in nociception are related to heightened pain severity and can be present in people who have knee osteoarthritis (OA). Yet,…
Abstract Number: 1085 • ACR Convergence 2020
Pain in Myositis Is Associated with the Disease Activity
Anjana Chandrasekhara Pillai¹, Chester Oddis², Siamak Moghadam-Kia³, Dana Ascherman⁴, Nicole Neiman⁵, Diane Koontz⁵, Ren Dianxu⁵ and Rohit Aggarwal⁴, ¹UPMC Mckeesport, Pittsburgh, PA, ²Department of Medicine, Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ³University of Pittsburgh Medical Center, Pittsburgh, PA, ⁴University of Pittsburgh, Pittsburgh, PA, ⁵UPMC, Pittsburgh, PA
Background/Purpose: Pain in myositis is poorly studied and multifactorial relating to muscle weakness, arthritis, myofasciitis, fibromyalgia or other co-morbidities. We sought to prospectively evaluate patient-reported…
Abstract Number: 1459 • ACR Convergence 2020
The Association of Frequent Knee Bending with Trajectories of Pain and Physical Function over 8 Years in Knee Osteoarthritis
Jason Jakiela¹, Dana Voinier¹, Thomas Bye¹, Maria Tukis¹, Kiely Konyak¹, Dylan Orloff¹ and Daniel White¹, ¹University of Delaware, Newark, DE
Background/Purpose: Frequent bending increases loading at the knee and is a risk factor for worsening knee pain associated with knee osteoarthritis (OA). Knee bending is…

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