Abstracts tagged "pain"

Abstract Number: 2171 • 2019 ACR/ARP Annual Meeting
Functional Exercise for Adults with Chronic Nonspecific Low Back Pain
Emilia Moreira¹, Anamaria Jones ¹, Eider Lima ¹, Fabio Jennings ² and Jamil Natour ², ¹Federal University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil, ²Federal University of São Paulo, São Paulo, Brazil
Background/Purpose: To assess the effectiveness of a functional exercise program for pain, functional capacity, general health, kinesiophobia, medication consumption and patient satisfaction in adults with chronic…
Abstract Number: 2183 • 2019 ACR/ARP Annual Meeting
Relation of Intra-Articular Knee Mineralization on CT to Knee Pain in People with or at Risk of Knee Osteoarthritis
Tuhina Neogi¹, John Lynch ², Mohamed Jarraya ³, David Felson ⁴, Na Wang ¹, Michael Nevitt ², James Torner ⁵, Beth Lewis ⁶ and Ali Guermazi ¹, ¹Boston University School of Medicine, Boston, MA, ²University of California at San Francisco, San Francisco, CA, ³Mercy Catholic Medical Center, Darby, ⁴Boston University School of Medicine, Department of Rheumatology, Boston, ⁵University of Iowa at Iowa City, Iowa City, ⁶University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Intra-articular (i.a.) calcium crystal deposition is common in knee osteoarthritis (OA), particularly in end-stage disease. It is possible that low-grade inflammation related to crystals…
Abstract Number: 2594 • 2018 ACR/ARHP Annual Meeting
Median Time to Pain Improvement in Patients with Psoriatic Arthritis Treated with Tofacitinib
Kurt de Vlam¹, Alexis Ogdie², Andrew G Bushmakin³, Joseph C Cappelleri³, Roy Fleischmann⁴, Peter C. Taylor⁵, Valderilio F Azevedo⁶, Lara Fallon⁷, Anna Maniccia⁸, John Woolcott⁹ and Philip J. Mease¹⁰, ¹UZ Leuven, Leuven, Belgium, ²University of Pennsylvania, Philadelphia, PA, ³Pfizer Inc, Groton, CT, ⁴University of Texas Southwestern Medical Center, Dallas, TX, ⁵University of Oxford, Oxford, United Kingdom, ⁶Universidade Federal do Paraná, Curitiba, Brazil, ⁷Pfizer Canada, Montreal, QC, Canada, ⁸Pfizer Inc, New York, NY, ⁹Pfizer Inc, Collegeville, PA, ¹⁰Swedish Medical Center and University of Washington, Seattle, WA
Background/Purpose: Pain is a core domain of psoriatic arthritis (PsA).1 Rapid, sustained pain reduction is a priority for patients (pts) and physicians when choosing treatment.…
Abstract Number: 2652 • 2018 ACR/ARHP Annual Meeting
Engaging the Cholinergic Anti-Inflammatory Pathway By Stimulating the Vagus Nerve Reduces Pain and Fatigue in Patients with SLE
Cynthia Aranow¹, Martin Lesser², Meggan Mackay¹, Erik Anderson³, Theodoros P. Zanos², Timir Datta-Chaudhuri², Chad Bouton², Kevin J. Tracey⁴ and Betty Diamond¹, ¹The Feinstein Institute for Medical Research, Manhasset, NY, ²Feinstein Institute for Medical Research, Manhasset, NY, ³Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, Manhasset, NY, ⁴Laboratory of Biomedical Science, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Musculoskeletal (MS) pain is a common symptom of patients with Systemic Lupus Erythematosus (SLE) affecting up to 95% of patients and contributing to…
Abstract Number: 2868 • 2018 ACR/ARHP Annual Meeting
Tender Joint Count May Not Reflect Inflammatory Activity in Established Rheumatoid Arthritis Patients; Results from a Longitudinal Study of Tocilizumab
Hilde B Hammer¹, Inger Marie Jensen Hansen², Pentti Järvinen³, Marjatta Leirisalo-Repo⁴, Michael Ziegelasch⁵, Birte Agular⁶ and Lene Terslev⁷, ¹Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Rheumatology, Svendborg Hospital, Svendborg, Denmark, ³Rheumatology, Kiljava Medical Research, Kiljavan, Finland, ⁴Rheumatology, University of Helsinki, Helsinki, Finland, ⁵Rheumatology, University Hospital, Linköping, Linköping, Sweden, ⁶Roche, Copenhagen, Denmark, ⁷Rheumatology, Rigshospitalet Glostrup, Copenhagen, Denmark
Background/Purpose: Tender joints may be caused by non-inflammatory pathologies but are still included in composite scores like CDAI. The present objective was to explore the…
Abstract Number: 405 • 2018 ACR/ARHP Annual Meeting
Feasibility of Enabling Self-Management and Coping with Arthritic Pain Using Exercise (ESCAPE-Pain) Programme for Knee Osteoarthritis in Malaysia
Muhammad Kamil Che Hasan^1,2, Emma Stanmore² and Chris Todd², ¹Kulliyyah (Faculty) of Nursing, International Islamic University Malaysia (IIUM), Kuantan Pahang, Malaysia, ²Division of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, United Kingdom
Background/Purpose: In Malaysia around one in ten older people are diagnosed with osteoarthritis (OA), with the knee being one of the most commonly affected areas.…
Abstract Number: 447 • 2018 ACR/ARHP Annual Meeting
Discriminating between Central & Peripheral Pain Sensitization Using a Slowly Repeated Evoked Pain Protocol
Manuel Romero¹, Stephen Bruehl², Gustavo A Reyes del Paso³ and Pablo De la Coba³, ¹University Hospital of Jaén, Jaén, Spain, ²Department of Anesthesiology, Vanderbilt University, Nashville, TN, ³Department of Psychology, University of Jaén, Jaén, Spain
Background/Purpose: In a prior study, the response of pain sensitization by fibromyalgia (FM) patients to a protocol of Slowly Repeated Evoked Pain (SREP)* was strongly…
Abstract Number: 450 • 2018 ACR/ARHP Annual Meeting
Injection Site Reaction Associated with Subcutaneous Biologic Agents and Methotrexate. Analysis from the Rhumadata® Clinical Database and Registry
Denis Choquette¹, Louis Bessette², Jacques Brown², Boulos Haraoui¹, Frédéric Massicotte¹, Jean-Pierre Pelletier¹, Jean-Pierre Raynauld¹, Marie-Anaïs Rémillard¹, Diane Sauvageau¹, Angèle Turcotte², Édith Villeneuve¹ and Louis Coupal¹, ¹Rheumatology, Institut de Recherche en Rhumatologie de Montréal (IRRM), Montréal, QC, Canada, ²Rheumatology, Centre de l'Ostéoporose et de Rhumatologie de Québec (CORQ), Québec, QC, Canada
Background/Purpose: Injection Site Reaction (ISRs) are associated with the subcutaneous (SC) route of administration of all biologic agents, and 3% to 15% of patients reports…
Abstract Number: 933 • 2018 ACR/ARHP Annual Meeting
Inflammation in the Hippocampus Affects Insulin-like Growth Factor-1 Receptor Signaling and Contributes to Neurological Sequelae in Rheumatoid Arthritis
Karin Andersson¹, Caroline Wasén¹, Lina Juzokaite¹, Malin C Erlandsson^1,2, Anna Stokowska³, Lovisa Leifsdottir⁴, Marcela Pekna³, Milos Pekny³, Kjell Olmarker⁵, Rolf Heckemann^6,7,8, Marie Kalm⁹ and Maria I Bokarewa², ¹Department of rheumatology and inflammation research, University of Gothenburg, Gothenburg, Sweden, ²Rheumatology Clinic, Sahlgrenska University Hospital, Gothenburg, Sweden, ³Department of Clinical Neuroscience, University of Gothenburg, Gothenburg, Sweden, ⁴Rheumatology Clinics, Sahlgrenska University Hospital, Gothenburg, Sweden, ⁵Department of Medical Chemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden, ⁶Med Tech West at Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden, ⁷Department of Medical Radiation Science, University of Gothenburg, Gothenburg, Sweden, ⁸Faculty of Medicine, Imperial College London, London, United Kingdom, ⁹Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden
Background/Purpose: The central nervous system is not the primary target in rheumatoid arthritis (RA). However, neuropsychiatric symptoms including pain, depression and anxiety are common and…
Abstract Number: 1159 • 2018 ACR/ARHP Annual Meeting
Fat Mass Is Associated with Musculoskeletal Pain in Women : A Three-Year Longitudinal Study
Hyun Ah Kim and Jeong-Im Hong, Hallym University Sacred Heart Hospital, Kyunggi-do, Korea, Republic of (South)
Background/Purpose: Increase in fat mass is correlated with musculoskeletal pain. The aim of this study was to examine the relationship between fat mass and the…
Abstract Number: 1392 • 2018 ACR/ARHP Annual Meeting
Decreased Injection Site Pain Associated with New Etanercept Formulation in Patients with Rheumatoid Arthritis or Psoriatic Arthritis
Stanley Cohen¹, Ahmed Samad², Elaine Karis², Bradley S. Stolshek², Mona Trivedi², Hao Zhang², Girish A. Aras², Greg Kricorian² and James Chung², ¹Metroplex Clinical Research Center, Dallas, TX, ²Amgen Inc., Thousand Oaks, CA
Background/Purpose: Injection site pain (ISP) is a component of the patient experience with injectable drugs. A new formulation of etanercept was developed to reduce ISP.…
Abstract Number: 1558 • 2018 ACR/ARHP Annual Meeting
Intravenous Immunoglobulin Efficacy for Primary Sjögren’s Syndrome Associated Small Fiber Neuropathy
Antoine Gaillet¹, Karine Champion¹, Jean-Pascal Lefaucheur², Herve Trout³, Jean-François Bergmann¹ and Damien Sène⁴, ¹Internal Medicine Department, Lariboisière Hospital, Paris, France, ²Clinical Neurophysiology Unit,, Henri-Mondor Hospital, Créteil, France, ³Pharmacy Department, Lariboisière Hospital, Paris, France, ⁴Lariboisière Hospital, Paris Diderot University, Paris, France
Background/Purpose: To analyze the efficacy and tolerance of intravenous immunoglobulin (IVIG) therapy in 11 patients with primary Sjögren's syndrome (pSS)-associated small-fiber neuropathy (SFN).Methods: Retrospective, single-center…
Abstract Number: 1644 • 2018 ACR/ARHP Annual Meeting
Improvement in Morning Stiffness in Subjects with Psa Is Associated with Improvements in Pain, Physical Function, and Patient Global Response to Treatment
Ana-Maria Orbai¹, Jessica Walsh², Peter Nash³, Lichen Teng⁴, Benoit Guerette⁴ and Rieke Alten⁵, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²University of Utah School of Medicine, Salt Lake City, UT, USA, Salt Lake City, UT, ³University of Queensland, Brisbane, Australia, ⁴Celgene Corporation, Summit, NJ, ⁵Schlosspark-Klinik University Medicine, Berlin, Germany
Background/Purpose: Stiffness is an important component of inflammatory arthritis and plays a role in PsA flare. Patients with inflammatory arthritis report difficulty with activities, “slowing…
Abstract Number: 1918 • 2018 ACR/ARHP Annual Meeting
Defining Pain That Does Not Interfere with Activities Among Rheumatoid Arthritis (RA) Patients
Yvonne C. Lee¹, Patricia Katz^2,3, Amanda Quebe⁴, Luna Sun⁴, Himanshu Patel⁴, Carol L. Gaich⁴, Natalie Boytsov⁴ and Kaleb Michaud^5,6, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Forward/National Data Bank for Rheumatic Diseases, Wichita, KS, ³University of California San Francisco, San Francisco, CA, ⁴Eli Lilly and Company, Indianapolis, IN, ⁵Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁶FORWARD, The National Databank for Rheumatic Diseases, Wichita, KS
Background/Purpose: RA patients differ in the degree to which pain interferes with function. To improve function, an understanding of this diversity is needed. Our objectives…
Abstract Number: 1922 • 2018 ACR/ARHP Annual Meeting
Characterization of the Pharmacology and Pharmacokinetics of Cntx-4975, a High-Purity, Synthetic Trans-Capsaicin in Clinical Development for the Treatment of Moderate to Severe OA Knee Pain
James Campbell, Randall Stevens and Peter Hanson, Centrexion Therapeutics, Boston, MA
Background/Purpose: CNTX-4975, a highly purified, synthetic trans-capsaicin and long-acting, non-opioid analgesic in phase 3 trials for moderate to severe OA knee pain, has demonstrated safety…