ACR Meeting Abstracts

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Abstracts tagged "pain"

  • Abstract Number: L08 • ACR Convergence 2024

    A Phase 2b, Randomized, Double-blind, Placebo-controlled, Dose-ranging and Parallel-group Study to Evaluate the Safety and Efficacy of XG005 in Subjects with Painful Osteoarthritis of the Knee

    Limin Ren1, Wenjie Zheng2, Zhenpeng Guan3, Yang Zhang4, Zeyu Huang5, Tong Li6, Yuwei Peng7, Qiuli Wu8, Wei Gou9, Wei Zhao10, Pengyan Qiao11, Xiaoli Pan12 and Guang-Liang Jiang13, 1Peking University, People’s Hospital, Rheumatology and Immunology Department, Beijing, China, 2Yantai Yuhuangding Hospital of Qingdao University, Department of Orthopedics, Yantai, China, 3Peking University, Shougang Hospital, Department of Orthopedics, Beijing, China, 4Division of Orthopaedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China, 5West China Hospital of Sichuan University, Department of Orthopedics, Chengdu, China, 6Xiangya Hospital of Central South University, Rheumatology and Immunology Department, Changsha, China, 7PingXiang People’s Hospital, Rheumatology and Immunology Department, Pingxiang, China, 8Tianjin Medical University General Hospital, Department of Orthopedics, Tianjin, China, 9Hebei Petrochina Central Hospital, Rheumatology and Immunology Department, Langfang, China, 10Central Hospital Affiliated to Shenyang Medical College, Department of Orthopedics, Shenyang, China, 11Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Rheumatology and Immunology Department, Taiyuan, China, 12Affiliated Hospital of Zunyi Medical University, Rheumatology and Immunology Department, Zunyi, China, 13Xgene Pharmaceutical, Lexington, MA

    Background/Purpose: Osteoarthritis (OA) affects 595 million people globally; cases are projected to increase 49-95% for various joints by 2050 as populations age (GBD 2023). OA…
  • Abstract Number: L15 • ACR Convergence 2024

    LEVI-04, a Novel neurotrophin-3 Inhibitor, Substantially Improves Pain and Function Without Deleterious Effects on Joint Structure in People with Knee Osteoarthritis: A Randomized Controlled Phase II Trial

    Philip Conaghan1, Ali Guermazi2, Nathaniel Katz3, Asger Bihlet4, Dror Rom5, Michael Perkins6, Bernadette Hughes6, Claire Herholdt6, Iwona Bombelka6 and Simon Westbrook6, 1University of Leeds, Leeds, United Kingdom, 2Boston University, West Roxbury, MA, 3Rin Sof Innovation, Ltd, Boston, MA, 4NBCD A/S, Soeborg, Denmark, 5Prosoft Clinical, Chesterbrook, 6Levicept Ltd, Ramsgate, United Kingdom

    Background/Purpose: There is an urgent need for new therapies to treat OA. Excess neurotrophins (NT) are implicated in OA and other painful conditions. Previous OA…
  • Abstract Number: 0025 • ACR Convergence 2024

    Vagus Nerve Stimulation: A Promising Approach to Alleviate Pain and Systemic Inflammation in Slow and Rapid Models of Osteoarthritis

    Shivmurat Yadav1, Timothy Griffin2, Matlock Jeffries2, Stavros Stavrakis3 and Mary Beth Humphrey4, 1University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City, OK, 3University of Oklahoma, College of Mediicine, Oklahoma City, OK, 4University of Oklahoma College of Medicine, Oklahoma City, OK

    Background/Purpose: Osteoarthritis (OA) causes joint pain, stiffness, swelling, and functional impairment. Pain signals reach the brain, influencing inflammatory and immune responses through the parasympathetic efferent…
  • Abstract Number: 0601 • ACR Convergence 2024

    Early Improvement of Pain, Long-Term Disease Control, and Quality of Life Outcomes in Patients with Psoriatic Arthritis Treated with Upadacitinib

    Peter C. Taylor1, Lihi Eder2, Yael Klionsky3, Fabian Proft4, Thomas Iyile5, Erin Mancl6, Priscila Magalhaes Reis Nakasato7, Xiaolan Ye8, Limei Zhou6 and Philip Mease9, 1University of Oxford, Oxford, United Kingdom, 2University of Toronto, Women’s College Hospital and Department of Medicine, Toronto, ON, Canada, 3Division of Rheumatology, Department of Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 4Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 5AbbVie Inc., hyattsville, MD, 6AbbVie Inc., North Chicago, IL, 7AbbVie Inc., Randolph, NJ, 8AbbVie Inc., Mettawa, IL, 9Swedish Medical Center/Providence St. Joseph Health; University of Washington School of Medicine, Seattle, WA

    Background/Purpose: Severe musculoskeletal manifestations of PsA, particularly joint pain, can result in reduced physical function, decreased quality of life, and progressive and irreversible joint damage.1,2…
  • Abstract Number: 1191 • ACR Convergence 2024

    Discordant Associations Among Chronological and Biological Age with Multi-joint Osteoarthritis and Symptom Burden: The Johnston County Health Study

    Liubov Arbeeva1, Yvonne Golightly2, Cameron Kurz3, Matlock Jeffries4, Virginia Kraus5, Richard Loeser6, Duncan Lascelles7 and Amanda Nelson3, 1University of North Carolina, Chapel Hill, Carrboro, NC, 2University of Nebraska Medical Center, Omaha, NE, 3University of North Carolina at Chapel Hill, Chapel Hill, NC, 4Oklahoma Medical Research Foundation, Oklahoma City, OK, 5Duke University, Durham, NC, 6University of North Carolina, Chapel Hill, NC, 7North Carolina State University, Raleigh, NC

    Background/Purpose: Biological age (BA) may be superior to chronological age (CA) in predicting mortality and age-related conditions such as diabetes and cognitive/functional decline (PMID35715611), as…
  • Abstract Number: 1223 • ACR Convergence 2024

    Community Based Study of Prevalence and Social Factors for Chronic Pain and Fibromyalgia in Women from Western India

    Vidit Gupta1, Diksha Mishra1, Shikhar Singh1, Vaishnavi Chowhan1, Shraddha Thorat1, Kavita Krishna2 and Sandeep Kansurkar3, 1Bharati Vidyapeeth (Deemed to be University) Medical College, Pune), Pune, Maharashtra, India, 2Bharati Vidyapeeth University Medical College and Hospital, Pune, Maharashtra, India, 3Bharati Vidyapeeth University Medical College, Pune, India

    Background/Purpose: Fibromyalgia is a disorder of chronic widespread pain. There is huge burden of this entity in community but there is scarcity of quality studies…
  • Abstract Number: 1670 • ACR Convergence 2024

    Predictors of 6-Minute Walk Test Performance in Adults with Arthritis

    Kailyn Horn, Scott Jamieson, Katherine Devivo, Sara Wilcox, Yesil Kim, Chih-Hsiang Yang and Christine Pellegrini, University of South Carolina, Columbia, SC

    Background/Purpose: The 6-Minute Walk Test (6MWT) is a measure commonly used by clinicians to assess functional capacity and rehabilitation progress. While predictors of 6MWT performance…
  • Abstract Number: 2149 • ACR Convergence 2024

    Rheumatoid Arthritis: Patient’s Voice First! An Original Approach Based on Infodemiology Using Social Media Content – Results from the PRIMA Study

    Jérémie Sellam1, Luisa Attali2, Sonia Trope3, Paméla Voillot4 and Cécile Gaujoux-Viala5, 1Saint-Antoine Hospital - AP-HP, Paris, Ile-de-France, France, 2Centre de recherches en médecine, psychanalyse et société - Université Paris, Strasbourg, France, 3ANDAR, Paris, Ile-de-France, France, 4Kap code, Paris, France, 5CHU Nîmes, Nïmes, Languedoc-Roussillon, France

    Background/Purpose: Social media and online forums are popular for understanding patients' feelings and concerns, which are hard to assess with traditional methods. Infodemiology collects and…
  • Abstract Number: 0028 • ACR Convergence 2024

    Human Meniscus Histopathological and Transcriptomic Changes at Early and Advanced Stages of Knee Osteoarthritis

    Takuya Sakamoto1, Hannah Swahn1, Merissa Olmer1, Rachel Miller2, Anne-Marie Malfait3 and Martin Lotz1, 1Scripps Research Institute, La Jolla, CA, 2Rush University Medical Center, Chicago, IL, 3Rush University Medical Center, Division of Rheumatology, Chicago, IL

    Background/Purpose: The knee menisci are essential elements in joint biomechanics and meniscus damage is a driver of cartilage destruction and knee osteoarthritis. Meniscus damage and…
  • Abstract Number: 0702 • ACR Convergence 2024

    AISA 021, a Novel Calcium Channel Antagonist in Development for Raynaud’s & Systemic Sclerosis, Has Antagonistic Activity at Sodium Channel Targets for Pain Relief and Treats Scleroderma Pain Better Than Current Calcium Channel Blockers in a Phase 2A Study

    Andrew Sternlicht1 and Meredith Todd2, 1Tufts University Medical Center and Aisa Pharma, Inc., Boston, MA, 2Aisa Pharma Pty Ltd., East Lindfield, New South Wales, Australia

    Background/Purpose: Improved treatments for Raynaud's phenomenon in Systemic Sclerosis (SSc) are needed.  A novel oral calcium channel blocker (cilnidipine), with N-type channel antagonism is being…
  • Abstract Number: 1193 • ACR Convergence 2024

    Ultrasound-Guided Corticosteroid Injection versus Iontophoresis in Rhizarthrosis: A Prospective Comparative Multicentric Study

    Olga Rusinovich1, Andrea Liso Andrino2, Maria Concepcion Sanchez3, Pilar Navarro Alonso4, Miguel Cantalejo Moreira5, ALBERTO DIAZ OCA4, Pablo Navarro Palomo6, Maria Machattou7, Maria Alonso de Francisco3, Carlota Navarro Joven8, Alejandro Martinez Rodado3, laura Ramos Ortiz de Zarate9, hildegarda Godoy Tundidor10, Maria Carmen Barbadillo Mateos7, Blanca Garcia-Magallon7, Jose Campos7, Mónica Fernández Castro11, JESUS SANZ SANZ6 and Jose Luis Andreu6, 1Hospital Universitario Puerta de Hierro Majadahonda., Boadilla del Monte, Spain, 2Servicio de Reumatología, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA , Madrid, Majadahonda, Madrid, Spain, 3Puerta de Hierro Majadahonda University Hospital, Majadahonda, Spain, 4Fuenlabrada University Hospital, Fuenlabrada, Spain, 5Hospital Universitario de Fuenlabrada, Fuenlabrada. Madrid, Spain, 6Hospital Universitario Puerta de Hierro Majadahonda., Majadahonda, Spain, 7Hospital Universitario Puerta de Hierro Majadahonda., Madrid, Spain, 8Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Spain, 9Puerta de Hierro Majadahonda University Hospital, Majahonda, Spain, 10Servicio de Reumatología, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA , Madrid, Madrid, Spain, 11Hospital Universitario Puerta de Hierro Majadahonda., Madrid, Madrid, Spain

    Background/Purpose: Trapeziometacarpal osteoarthritis is a common degenerative disease that causes pain and thumb dysfunction. It affects 16-25% of the population, mainly middle-aged women.  Treatment modalities…
  • Abstract Number: 1224 • ACR Convergence 2024

    Occupational Stress and Fibromyalgia Among Healthcare Professionals in Abu Dhabi Region, United Arab Emirates: A Cross-sectional Study

    Shamma Al Nokhatha1, Asma Alneyadi2, Noor Alnuaimi3, Hajar Almansoori3, Sara Alhosani3, Shammah Almemari4 and Muhammad Hashim3, 1Tawam hospital/ College of Medicine and Health Sciences, Al Ain, Abu Dhabi, United Arab Emirates, 2Tawam hospital, Al Ain, Abu Dhabi, United Arab Emirates, 3College of Medicine and Health Sciences, Al Ain, Abu Dhabi, United Arab Emirates, 4Ambulatory Health Services, Al Ain, Abu Dhabi, United Arab Emirates

    Background/Purpose: The stress level of healthcare workers may impact the quality of care provided to patients. The prevalence of occupational stress among healthcare workers can…
  • Abstract Number: 1868 • ACR Convergence 2024

    Opioid Prescription Rates in Patients with Radiographic Axial Spondyloarthritis in the US Between 2008-2021: A Joinpoint Regression Analysis

    Berk Degirmenci1, Christine Peloquin2, Sara Lodi1, Pedro M Machado3, S. Reza Jafarzadeh2, Tuhina Neogi2, Lianne S Gensler4, Maureen Dubreuil5 and Jean Liew2, 1Boston University, Boston, MA, 2Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 3Department of Neuromuscular Diseases and Centre for Rheumatology, University College London, London, United Kingdom, 4Department of Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 5Section of Rheumatology, Boston University School of Medicine, Boston, MA

    Background/Purpose: Current axial spondyloarthritis (axSpA) guidelines do not provide recommendations for opioids in pain management. Opioid use is common in axSpA, despite widespread uptake of…
  • Abstract Number: 2152 • ACR Convergence 2024

    Factors Associated with Health-related Quality of Life in Adults with SAPHO and Chronic Nonbacterial Osteomyelitis – a Cross Sectional Analysis from the SAPHO-CNO Study

    Aleksander Lenert1, Helena Abodeely1, Karmela Kim Chan2, Sandy Hong3, Arundathi Jayatilleke4, Courtney Kremer5, Emma Leisinger1, Petar Lenert6, Melissa Oliver7, T. Shawn Sato8, Melanie Smith2, Thomason Jenna9, Yongdong (Dan) Zhao10, Jonathan Templin1, Robyn Domsic11, Mary Vaughan-Sarrazin1, Daniel Solomon12 and Polly Ferguson13, 1University of Iowa, Iowa City, IA, 2Hospital For Special Surgery, New York, NY, 3University of Iowa Stead Family Children's Hospital, Iowa City, IA, 4Temple University, Philadelphia, PA, 5University of Iowa Stead Family Children's Hospital, Solon, Iowa, IA, 6University of Iowa Hospitals and Clinics, Iowa City, IA, 7Indiana University, Indianapolis, IN, 8University of Iowa, Iowa City, 9University of Washington, Division of Rheumatology, Seattle, WA, 10University of Washington, Redmond, WA, 11Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 12Brigham and Women's Hospital, Newton, MA, 13University of Iowa Carver College of Medicine, Iowa City, IA

    Background/Purpose: Health-related quality of life (HRQOL) is decreased in individuals with chronic rheumatic diseases (CRD) yet remains undefined in adults with SAPHO syndrome and chronic…
  • Abstract Number: 0031 • ACR Convergence 2024

    Beyond Pain and Inflammation: Intra-articular Liraglutide’s Comprehensive Benefits on Synovial Health and Cartilage in Osteoarthritis Compared to Dexamethasone

    Coralie Meurot1, Celine Martin1, Margot Vieubled1, Jerome Breton1, Indira Toillon2, Revital Rattenbach3 and Francis Berenbaum2, 14Moving Biotech, lille, France, 2Sorbonne University, Paris, France, 34Moving Biotech, Paris, France

    Background/Purpose: Osteoarthritis (OA) is an age-related joint disease that causes chronic pain and limited mobility. Patients mainly have access to therapies aimed at reducing inflammation…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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