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Abstracts tagged "pain"

  • Abstract Number: 2101 • ACR Convergence 2025

    LEVI-04, a Novel Neurotrophin-3 Inhibitor, Demonstrates Clinically Meaningful Improvements in Pain and Physical Function across a Range of OA Outcomes, Including the Staircase-Evoked Pain Procedure (StEPP)

    Philip Conaghan1, nathaniel katz2, Asger Bihlet3, Laus W Wullum4, Kerry af Forselles5, C Michael Perkins5, Bernadette Hughes6, Claire Herholdt7 and Iwona Bombelka8, 1University of Leeds, Leeds, United Kingdom, 2Rin Sof Innovation, Ltd, Boston, MA, 3NBCD A/S, Herlev, Denmark, 4Omicron A/S, Copenhagen, Denmark, 5Levicept, Sandwich, United Kingdom, 6Levicept, Ashtead, United Kingdom, 7Levicept Ltd, Ashtead, United Kingdom, 8Levicept, Sandwich, Kent, United Kingdom

    Background/Purpose: When evaluating new osteoarthritis (OA) therapies, we need to understand their clinical meaningfulness. LEVI-04, a first-in-class p75 neurotrophin receptor-Fc fusion protein that primarily inhibits…
  • Abstract Number: 1780 • ACR Convergence 2025

    Modeling Osteoarthritis Knee Joint in a Compartmentalized Microfluidic System using IPSC-derived Sensory Neurons and human Synovial Fibroblasts

    Abdelhak Belmadani1, Dongjun Ren1, Daniel Hoffman2, Nirupa Jayraj1, Paola Pacifico1, Vince Truong3, Patrick Walsh3, Daniela Menichella1, Anna Rapp4, Carla Scanzello5, Rachel Miller6, Richard Miller7 and Anne-Marie Malfait8, 1Northwestern University Chicago, Chicago, IL, 2Rush University, Chicago, IL, 3Anatomic Inc, Minneapolis, MN, 4University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 5University of Pennsylvania, Philadelphia, 6Rush University Medical Center, Chicago, IL, 7Northwestern University, Chicago, 8Rush University Medical Center, Chicago

    Background/Purpose: Joint pain is one of the most significant clinical hallmarks of knee osteoarthritis (OA). Knee OA is a chronic degenerative disease of the joints…
  • Abstract Number: 1257 • ACR Convergence 2025

    Integrated Behavioral Health Services for Patients with Rheumatic Diseases: Qualitative Analysis of a Pilot Study

    Shannon Teaw1, Jessica Link-Malcolm2, Michelle Ghebranious Farag3, Dorothy Patterson2, Jenny Foster4, Sofia Bereket2, Puneet Bajaj2, Urooj Wahid2, Elizabeth Solow2, Jennifer Barton5 and Una Makris6, 1UT Southwestern Medical School, Dallas, TX, 2UT Southwestern Medical Center, Dallas, TX, 3McGovern Medical School at UT Houston, Houston, TX, 4UT Southwestern Medical Center, Dallas, 5VA Portland Health Care System/OHSU, Portland, OR, 6UT Southwestern Medical Center and Dallas VA, Dallas, TX

    Background/Purpose: Rheumatic diseases (RD) often cause pain, fatigue and disability. Depression and anxiety are prevalent comorbidities in RD and ideally managed with behavioral health (BH)…
  • Abstract Number: 1230 • ACR Convergence 2025

    Chronic pain phenotypes in older adults: Identifying patterns of musculoskeletal pain and associated burden

    Gillian Fennell1, Sarah Tilley2, Sayali Dhamne3, Robert Edwards4, Mary Gheller3, Angelo Demalia3, Margaret Clancy3, Michael LaValley5, Emelia J Benjamin3 and Tuhina Neogi6, 1Boston University Medical, Boston, MA, 2Boston University School of Medicine, Somerville, MA, 3Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 4Brigham and Women's Hospital & Harvard Medical School, Boston, MA, 5Boston University School of Public Health, Arlington, MA, 6Boston University School of Medicine, Boston, MA

    Background/Purpose: Over a third of older Americans experience chronic pain, typically occupying multiple musculoskeletal body sites. While number of pain sites (NPS) is often touted…
  • Abstract Number: 0817 • ACR Convergence 2025

    More than 40% of Older Adults with Rheumatic Diseases Are Prescribed Opioid Medications

    Christine Anastasiou1, Eric Roberts2, gabriela Schmajuk3 and Jinoos Yazdany4, 1Stanford University, Pleasanton, CA, 2University of California, San Francisco, SF, CA, 3University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, CA, 4UCSF, San Francisco, CA

    Background/Purpose: Patients with rheumatic diseases commonly experience acute or chronic pain that may lead to both short- and long-term opioid use. Many patients do not…
  • Abstract Number: 0331 • ACR Convergence 2025

    Safety and Efficacy of Colchicine in Osteoarthritis: A Systematic Review and Meta-Analysis of 6,965 Patients

    Mohamed Abdelsalam1, Bassant Elaraby Elsayed Badwy2, Menat Alla Ayman Ali Mahdy2, Maryam Lasheen3, Hadeer Hafez4, Omar Sameh Nabil El Sedafy1 and Mohamed Reda Awad5, 1Misr University For Science and Technology, 6 october, Al Jizah, Egypt, 2Misr University For Science and Technology, Nasr City, Al Qahirah, Egypt, 3Misr University For Science and Technology, Helwan, Al Qahirah, Egypt, 46th October University, 6 october, Al Jizah, Egypt, 5Al Azhar University, Cairo, Egypt, Giza, Al Jizah, Egypt

    Background/Purpose: Osteoarthritis (OA) is the most common joint disease, that leads to significant pain and affects quality of life, particularly in older adults. Current treatments…
  • Abstract Number: 2098 • ACR Convergence 2025

    Responder Phenotype Analysis for Intra-Articular Injections: Secondary Analysis from a Large Multi-Site Crossover Clinical Trial

    Natalie Keller1, Bryant England2, Katherine Wysham3, Mercedes Quinones4, Marianna Olave5, Sarah Wetzel6, Hannah Brubeck7, Rachel Gillcrist6, Criswell Lavery8, Bibiana Ateh9, Bridget Kramer2, Kimberly Hayes6, Rui Xiao8, Kaitian Jin8, Alexis Ogdie8, Daniel K. White10, Tuhina Neogi11, Carla Scanzello12 and Joshua Baker8, 1University of Oklahoma, Philadelphia, PA, 2University of Nebraska Medical Center, Omaha, NE, 3VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, 4Howard University Hospital and Washington DC Veterans Affairs Medical Center, Washington, District of Columbia, 5Brown University, Philadelphia, PA, 6Corporal Michael J. Crescenz VA Medical Center, Philadelphia, 7VA Puget Sound Health Care System, Seattle, WA, 8University of Pennsylvania, Philadelphia, PA, 9Washington VA Medical Center, Washington, District of Columbia, 10University of Delaware, Newark, DE, 11Boston University School of Medicine, Boston, MA, 12University of Pennsylvania, Philadelphia

    Background/Purpose: Intra-articular (IA) corticosteroid injections are commonly utilized for pain management in knee osteoarthritis (KOA). However, clinical characteristics associated with a greater benefit from corticosteroid…
  • Abstract Number: 1739 • ACR Convergence 2025

    Acute Transcriptomic Response of Synovium and Dorsal Root Ganglia to Joint Injury

    Michael Newton1, Lai Wang2, Anne-Marie Malfait3, Rachel Miller2 and Tristan Maerz4, 1University of Michigan, South Lyon, MI, 2Rush University Medical Center, Chicago, IL, 3Rush University, Oak Park, IL, 4University of Michigan, Ann Arbor, MI

    Background/Purpose: In arthritic synovium, emerging clinical evidence suggests crosstalk between synovial cells and dorsal root ganglion (DRG) neurons drives nerve sprouting and pain sensitization [Bai+…
  • Abstract Number: 1256 • ACR Convergence 2025

    Quantitative Analysis of a Pilot Study: Integrating Behavioral Health Services for Patients with Rheumatic Diseases

    Shannon Teaw1, Jessica Link-Malcolm2, Michelle Ghebranious Farag3, Dorothy Patterson2, Jenny Foster4, Sofia Bereket2, Urooj Wahid2, Puneet Bajaj2, Elizabeth Solow2, Jennifer Barton5 and Una Makris6, 1UT Southwestern Medical School, Dallas, TX, 2UT Southwestern Medical Center, Dallas, TX, 3McGovern Medical School at UT Houston, Houston, TX, 4UT Southwestern Medical Center, Dallas, 5VA Portland Health Care System/OHSU, Portland, OR, 6UT Southwestern Medical Center and Dallas VA, Dallas, TX

    Background/Purpose: Patients with rheumatic diseases (RD) often experience chronic pain, along with comorbid depression and anxiety, which can be addressed using behavioral health (BH) interventions…
  • Abstract Number: 1231 • ACR Convergence 2025

    TNX-102 SL, Cyclobenzaprine HCl Sublingual Tablets, Demonstrates Pain Reduction and Favorable Tolerability in Patients with Fibromyalgia

    Gregory Sullivan1, Errol Gould2, Mary Kelley1, Jean Engels1 and Seth Lederman3, 1Tonix Pharmaceuticals, Inc., Chatham, NJ, 2Tonix Pharmaceutical, Inc., Henderson, NV, 3Tonix Pharmaceuticals, Inc., Austin, TX

    Background/Purpose: FDA-approved treatments for fibromyalgia (FM) have historically been limited by intolerable side effects that often lead to poor adherence. TNX-102 SL, a sublingual formulation…
  • Abstract Number: 0815 • ACR Convergence 2025

    Neuropathic-like Pain Characteristics Predict Worse Pain Outcomes in Early Rheumatoid Arthritis: a Prospective Cohort Study with Embedded Neuroimaging Evaluation

    Eoin Kelleher1, Amanda Wall1, Isabelle Brennan2, Robert Murphy1, Antonella Delmis1, John Davis3, Vishvarani Wanigasekera4, Irene Tracey1 and Anushka Irani5, 1University of Oxford, Oxford, United Kingdom, 2University of Cambridge, Cambridge, United Kingdom, 3Mayo Clinic, Rochester, MN, 4University of Oxford, Oxford, 5Mayo Clinic, Jacksonville, FL

    Background/Purpose: Despite effective control of inflammation in rheumatoid arthritis (RA), persistent and severe pain remains a clinical challenge. Dysregulated pain processing in the central nervous…
  • Abstract Number: 0326 • ACR Convergence 2025

    Gender Disparities in Clinical Outcomes Among Older Adults with Knee Osteoarthritis: A Retrospective Cohort Study

    Kinga Grzybowski1, Ahmer Khan2, Samuel Bonomo3 and Arthur Lau4, 1Jefferson Einstein Montgomery Hospital, Maspeth, NY, 2Jefferson Einstein Philadelphia Hospital, Philadelphia, 3Jefferson Einstein Montgomery Hospital, East Norriton, PA, 4Jefferson Einstein Hospital, Maple Glen, PA

    Background/Purpose: Osteoarthritis (OA) is the most common type of arthritis which classically affects multiple joints, mainly the knees. About 595 million people worldwide suffer from…
  • Abstract Number: 2096 • ACR Convergence 2025

    Gamification and Social Incentivization to Promote Physical Activity in Adults with Knee Osteoarthritis: Results from a Multi-Site Randomized Trial

    Kimberly Hayes1, Bryant England2, Katherine Wysham3, Mercedes Quinones4, Marianna Olave5, Sarah Wetzel6, Hannah Brubeck7, Rachel Gillcrist8, Criswell Lavery9, Natalie Keller10, Bibiana Ateh11, Bridget Kramer2, Rui Xiao9, Kaitian Jin9, Alexis Ogdie12, Daniel K. White13, Tuhina Neogi14, Carla Scanzello9 and Joshua Baker9, 1Teachers College, Columbia University, Philadelphia, PA, 2University of Nebraska Medical Center, Omaha, NE, 3VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, 4Washington DC VA Medical Center, Bethesda, MD, 5Brown University, Philadelphia, PA, 6Drexel University, Pittsburgh, PA, 7VA Puget Sound Health Care System, Seattle, WA, 8Dartmouth College, Lebanon, NH, 9University of Pennsylvania, Philadelphia, PA, 10University of Oklahoma, Philadelphia, PA, 11Washington VA Medical Center, Washington, District of Columbia, 12Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Wilmington, DE, 13University of Delaware, Newark, DE, 14Boston University School of Medicine, Boston, MA

    Background/Purpose: Promotion of physical activity is important in the management of knee osteoarthritis (KOA), though effective strategies for behavioral change to promote exercise are lacking.…
  • Abstract Number: 1737 • ACR Convergence 2025

    CR10049, the first intra-articular Src family kinase inhibitor as a long-acting symptom- and disease-modifying drug for the inflammatory OA phenotype

    Luigino Giancotti, Tiziana Piepoli, Roberto Artusi, Matteo Ghirri, Michela Visintin, Gianfranco Caselli and Lucio Rovati, Rottapharm Biotech, Monza, Italy

    Background/Purpose: The inflammatory osteoarthritis (OA) phenotype is characterized by the presence of synovial membrane inflammation, pain and pathological changes in joint structure leading to rapid…
  • Abstract Number: 1253 • ACR Convergence 2025

    Patient Reported Outcome Measures: Assessing Resident Physician Acceptance of the Routine Assessment of Patient Index Data 3 Survey and its Impact on Physician-Patient Relationship

    Nisha Sapkota1, Chana Birnbaum2, Henna Levitansky2, Yevheniia Andriushchenko2, Saadia Malik2, Melissa Andrade2, Sarang Choi2 and Sima Terebelo2, 1Interfaith Medical Center, One Broolyn Health, Brooklyn, NY, 2Brookdale Hospital Medical Center, One Brooklyn Health, Brooklyn

    Background/Purpose: When treating patients with rheumatological conditions, building a strong physician-patient relationship plays an important role in determining disease outcomes. The Routine Assessment of Patient…
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Embargo Policy

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

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