Abstracts tagged "pain"

Abstract Number: LB03 • ACR Convergence 2025
Transcutaneous Electrical Nerve Stimulation Effectively Reduces Pain in Fibromyalgia: A Pragmatic Cluster-Randomized Trial Embedded in Physical Therapy Practice
Leslie Crofford¹, Dana Dailey², Barbara Van Gorp², Carol Vance², Andrew Post³, Ruth Chimenti², Ezgi Yarasir², Elizabeth Johnson¹, Kari Vance², Bridget Zimmerman², Fangfang Jiang², David-Erick Lafontant², Maxine Koepp², Dixie Ecklund², Emine Bayman² and Kathleen Sluka², ¹Vanderbilt University Medical Center, Nashville, Tennessee, ²University of Iowa, Iowa City, Iowa, ³Grand Valley State University, Grand Rapids, Michigan
Background/Purpose: Fibromyalgia (FM) is characterized by chronic widespread pain that is often exacerbated by movement. FM is associated with enhanced central pain transmission, while transcutaneous…
Abstract Number: LB12 • ACR Convergence 2025
Randomized, Double-Blind, Placebo-Controlled Phase IIa Trial of an Innovative Intra-Articular Apoptotic Cell Therapy in Knee Osteoarthritis (OA): 3-Month Positive Outcomes and Identification of Responder Population (NCT06233474)
Philip Conaghan¹, Bernt Husøy², Cecilie Rovsing³, Sidsel L Boll⁴, Liliana Groppa⁵, Amir Oron⁶, Asger Bihlet⁷, Ali Mobasheri⁸, Tobias Winkler⁹, Dror Mevorach¹⁰, Einat Galamidi¹¹, Lital Weinfeld-Bergman¹², Lior Binder¹² and Oren Hershkovitz¹¹, ¹University of Leeds, Leeds, United Kingdom, ²Sanos Clinic, Herlev, Denmark, ³Sanos Clinic, Gandrup, Denmark, ⁴Sanos Clinic, Vejle, Denmark, ⁵T. Mosneaga Republican Clinical Hospital, Chisinau, Moldova, ⁶Kaplan MC, Rehovot, Israel, ⁷NBCD A/S, Soeborg, Denmark, ⁸University of Oulu, Oulu, Finland, ⁹Charité - Universitätsmedizin Berlin, Berlin, Germany, ¹⁰Hadassah-University Hospital, Jerusalem, Israel, ¹¹Enlivex Therapeutics, Ness Ziona, Israel, ¹²Enlivex Therapeutics, Nes Ziona, Israel
Background/Purpose: OA is a prevalent disabling disease growing globally due to aging populations and rising obesity. In primary OA, the effects of joint tissue damage accumulate with age,…
Abstract Number: 2683 • ACR Convergence 2025
Association of Genetic Risk for Pain Intensity with Longitudinal Disease Activity in Rheumatoid Arthritis
Stevie Barry¹, Katie McMenamin², Austin Wheeler³, Bryant England³, Grant Cannon⁴, Brian Sauer⁵, Gary Kunkel⁶, Katherine Wysham⁷, Beth Wallace⁸, Andreas Reimold⁹, Gail Kerr¹⁰, Isaac Smith¹¹, John Richards¹², Iris Lee¹³, Rui Xiao¹, Sylvanus Toikumo¹⁴, Henry Kranzler¹⁴, Rachel Kember¹⁴, Scott Damrauer¹⁴, Michael Levin¹⁴, Michael George¹, Ted Mikuls³, Joshua Baker¹ and Thomas Riley¹, ¹University of Pennsylvania, Philadelphia, PA, ²Boston Medical Center, Boston, MA, ³University of Nebraska Medical Center, Omaha, NE, ⁴University of Utah and Salt Lake City VA, Salt Lake City, UT, ⁵Salt Lake City VA/University of Utah, Salt Lake City, UT, ⁶University of Utah and George E Wahlen VAMC, Salt Lake City, UT, ⁷VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, ⁸Michigan Medicine, VA Ann Arbor Healthcare System, Ann Arbor, MI, ⁹Dallas VA Medical Center, Dallas, TX, ¹⁰Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, ¹¹Duke University Hospital, Durham, NC, ¹²Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, ¹³Washington University in St Louis, Saint Louis, MO, ¹⁴University of Pennsylvania / Corporal Michael J. Crescenz VAMC, Philadelphia, PA
Background/Purpose: Guidelines recommend the use of composite scores to evaluate disease activity in RA and inform a treat-to-target approach. It is recognised that patient-reported components…
Abstract Number: 2090 • ACR Convergence 2025
Don’t Throw Out X-Rays! Radiographic Osteoarthritis Severity is Prognostic for Onset of Frequent Knee Pain
Grace Lo¹, Julieann Patarini², Timothy McAlington³, Charles Eaton⁴ and Jeffrey Driban⁵, ¹Baylor College of Medicine / MEDVAMC, Houston, TX, ²UMass Chan Medical School, Worcester, MA, ³UMass Chan School of Medicine, Arlington, MA, ⁴Brown University, Pawtucket, RI, ⁵University of Massachusetts Chan Medical School, Marlborough, NH
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, a condition associated with substantial disability. Radiographic severity of OA is associated with the presence…
Abstract Number: 1735 • ACR Convergence 2025
Endocrine Disruptors Exacerbates Osteoarthritis Pain And Inflammation
Elise Herardot¹, Nadine Soliman¹, Audrey Pigenet¹, Ilana Slotine¹, Anni Herranan², Samia Bahieddine¹, Jean-Baptiste Fini², Olivier Tabary¹, Adeline Cambon³, Xavier HOUARD⁴, Francis BERENBAUM⁵, SELLAM JEREMIE⁶ and Alice Courties⁷, ¹Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, F-⁷⁵⁰¹² Paris, France, Paris, France, ²UMR ⁷²²¹, Phyma, CNRS–Muséum National d’Histoire Naturelle, Sorbonne Université, ⁷⁵⁰⁰⁵ Paris, France, Paris, France, ³Department of Orthopedic, Trauma and Hand Surgery, Hôpital Saint-Antoine, Sorbonne University, ¹⁸⁴ Rue du Faubourg Saint-Antoine, ⁷⁵⁰¹², Paris, France, Paris, France, ⁴Centre de Recherche Saint-Antoine, UMR_S⁹³⁸ INSERM /Sorbonne Université, Paris, France, PARIS, France, ⁵Sorbonne University/Inserm/AP-HP/⁴Moving Biotech, Paris, France, ⁶Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, F-⁷⁵⁰¹² Paris, France, /Rheumatology Department, AP-HP Saint-Antoine Hospital, ¹⁸⁴, rue du Faubourg Saint-Antoine, ⁷⁵⁰¹², Paris, France., Paris, France, ⁷Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, F-⁷⁵⁰¹², Paris, France / Rheumatology Department, AP-HP Saint-Antoine Hospital, ¹⁸⁴, rue du Faubourg Saint-Antoine, ⁷⁵⁰¹², Paris, France, Paris, France
Background/Purpose: Osteoarthritis (OA) affects over 590 million individuals globally. Epidemiological data suggest that exposure to environmental pollutants, particularly endocrine-disrupting chemicals (EDCs) such as phthalates, PFAS,…
Abstract Number: 1246 • ACR Convergence 2025
Myo Vs. Myo-fascial Injection for Myofascial Trigger Points. Is There Really a Difference? A Randomized Controlled Trial
seda yildiz¹, bugra ince¹ and Halil ibrahim candal², ¹izmir sehir hastanesi, izmir, Turkey, ²ızmir sehir hastanesi, izmir
Background/Purpose: Experimental and clinical studies suggest that fascial structures play a critical role in the pathogenesis and pain mechanisms of myofascial pain syndrome (MTrP). It…
Abstract Number: 1227 • ACR Convergence 2025
The Composition of Circulating Immune Cells is Associated with Nociplastic Pain in Patients with Rheumatoid Arthritis
Tyler Therron¹, Meghan Mayer², Cecilia Stumpf³, Gelis Galarcé Lugo⁴, Morgan Langereis⁵, Kathleen Aren⁶, Mary Carns⁵, Cally Mills⁵, Cheol Min Lee⁷, Vanessa Manada De Lobos², Carla Marie Cuda⁵, Yvonne Lee⁵ and Deborah Rachelle Winter⁸, ¹Northwestern Feinberg School of Medicine, Chicago, IL, ²Northwestern University, Chicago, ³Northwestern University, Elmhurst, IL, ⁴Northwestern University Feinberg School of Medicine, Zionsville, IN, ⁵Northwestern University, Chicago, IL, ⁶Northwestern University Division of Rheumatology, Chicago, IL, ⁷Northwestern University Feinberg School of Medicine, Chicago, IL, ⁸Northwestern University, Skokie, IL
Background/Purpose: Over half of patients with RA report clinically meaningful pain, despite treatment with disease-modifying antirheumatic drugs (DMARDs). While joint inflammation is a known cause…
Abstract Number: 0814 • ACR Convergence 2025
Pain Patterns in a Multicenter Randomized Trial of Early RA – Link Between Initially Sustained Joint Inflammation and Subsequent Non-inflammatory Pain Outcomes
Annie Brink¹, Johan Karlsson Wallman², Jon T Einarsson¹, Meliha Kapetanovic¹, Elisabeth Mogard¹, Elisabet Lindqvist¹, Carmen Roseman¹, Kristina Lend³, Merete Hetland⁴, Mikkel Ostergaard⁵, Kim Horslev-Petersen⁶, Dan Nordstrom⁷, Tuulikki Sokka-isler⁸, Bjorn Gudbjornsson⁹, Gerður María Gröndal⁹, Marte Heiberg¹⁰, Espen Haavardsholm¹⁰, Michael Nurmohamed¹¹, Anna Rudin¹², Ronald van Vollenhoven¹³, Till Uhlig¹⁰, Jon Lampa¹⁴ and Tor Olofsson², ¹Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Rheumatology, Lund, Sweden, ²Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Rheumatology, Lund, Skane Lan, Sweden, ³Department of Rheumatology and Amsterdam Rheumatology Center, Amsterdam University Medical Centers, Amsterdam; Department of Medicine, Rheumatology Unit, Center for Molecular Medicine (CMM), Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ⁴Copenhagen Center for Arthritis Research (COPECARE) and DANBIO, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup; Department of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, ⁵Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, and Copenhagen Center for Arthritis Research, Center for Rheumatology, Rigshospitalet, Glostrup, Denmark, ⁶Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sønderborg; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark, ⁷Division of Rheumatology, Helsinki University Hospital, Helsinki, Finland, ⁸Department of Medicine and University of Eastern Finland, Jyväskylä Central Hospital, Juväskylä, Finland, ⁹Landspitali University Hospital; Faculty of Medicine, University of Iceland, Reykjavik, Iceland, ¹⁰Center for treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, ¹¹Amsterdam Rheumatology and Immunology Center, Reade; Department of Rheumatology and Amsterdam Rheumatology Center, Amsterdam University Medical Centers, Amsterdam, Netherlands, ¹²Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy of University of Gothenburg, Gothenburg, Sweden, ¹³Department of Rheumatology, Amsterdam University Medical Centre, Amsterdam, Netherlands, ¹⁴Department of Medicine, Rheumatology Unit, Center for Molecular Medicine (CMM), Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Emerging data indicate an uncoupling between pain and inflammation during the RA disease course, and comorbid fibromyalgia – thought to stem from central pain…
Abstract Number: 0317 • ACR Convergence 2025
“No matter how great my doctor is, he hasn’t had a knee replacement, he doesn’t understand all that pain” Program Evaluation of the Moving Well Peer Coach Intervention for Total Knee Replacement
Cara Murphy¹, Sarah Young², Vanessa Madrigal³, Noelia Hernandez⁴, Daniel Garcia⁵, Yuliana Dominguez Paez⁶, Monika Safford³, Iris Navarro-Millan⁷ and Mackenzie Brown⁸, ¹HSS, New York, NY, ²Weill Cornell Medicine, Johnson City, NY, ³Weill Cornell Medicine, New York, ⁴Weill Cornell Medicine, New York, NY, ⁵Weill Cornell, Brooklyn, NY, ⁶Albert Einstein College of Medicine, The Bronx, NY, ⁷Weill Cornell Medicine, Hospital for Special Surgery, Poughkeepsie, NY, ⁸Weill Cornell Medicine, Brooklyn, NY
Background/Purpose: Moving Well was a pre-habilitation peer coach intervention aimed at reducing levels of anxiety, depression, and pain among individuals undergoing total knee replacement (TKR)1.…
Abstract Number: 2623 • ACR Convergence 2025
Disease Activity is a Novel Imaging Biomarker Associated with Knee Pain: Data from the Osteoarthritis Initiative
Jeffrey Driban¹, Jonggyu Baek², Julieann Patarini², Emily Kirillov³, Nhung Vo³, Michael Richard³, Ming Zhang⁴, Matthew Harkey⁵, Grace Lo⁶, Kate Lapane², Shao-Hsien Liu², Charles Eaton⁷, James Mackay⁸, Joshua Harvey² and Timothy McAlington⁹, ¹University of Massachusetts Chan Medical School, Marlborough, NH, ²UMass Chan Medical School, Worcester, MA, ³Tufts Medical Center, Boston, MA, ⁴Boston University, Westford, MA, ⁵Michigan State University, East Lansing, MI, ⁶Baylor College of Medicine / MEDVAMC, Houston, TX, ⁷Brown University, Pawtucket, RI, ⁸University of Cambridge; Norwich Medical School, San Diego, CA, ⁹UMass Chan School of Medicine, Arlington, MA
Background/Purpose: Barriers to developing effective osteoarthritis (OA) therapies include the lack of standardized definitions for disease progression and structural endpoints that reliably predict changes in…
Abstract Number: 2085 • ACR Convergence 2025
Estimating the Association between Effusion-synovitis and Knee Pain in a Subset of Participants with Radiographic Knee Osteoarthritis: Data from the Osteoarthritis Initiative (OAI)
Dagoberto Robles¹, Greg Gilles², Nathaniel H. Christiansen³, Luke Grawer⁴, Karim Jayyusi⁴, Ali Shaikh⁴, Rongrong Tang⁵, Mihra S. Taljanovic⁴, Jeffrey Duryea⁶, Edward J. Bedrick⁵ and C. Kent Kwoh⁷, ¹University of Arizona, Tucson, AZ, ²University of Arizona Arthritis Center, The University of Arizona College of Medicine, Tucson, AZ, ³University of Arizona, Stockton, NJ, ⁴University of Arizona, Tucson, ⁵The University of Arizona Arthritis Center, University of Arizona, Tucson, ⁶Brigham and Women’s Hospital, Boston, MA, ⁷The University of Arizona Arthritis Center, University of Arizona, Tucson, AZ
Background/Purpose: Even though knee pain is ubiquitous in knee osteoarthritis (KOA) patients, currently there are limited treatment options which are only minimally or moderately efficacious…
Abstract Number: 1647 • ACR Convergence 2025
Clinical Phenotypes of Participants with Radiographic Osteoarthritis Attaining Patient Acceptable Symptom State in the Multicenter Osteoarthritis Study
Sarah Tilley¹, Michael LaValley², Brooke McGinley³, Cora Lewis⁴, James Torner⁵, David Felson³ and Tuhina Neogi⁶, ¹Boston University School of Medicine, Somerville, MA, ²Boston University School of Public Health, Arlington, MA, ³Boston University, Boston, MA, ⁴The University of Alabama at Birmingham, Birmingham, AL, ⁵University of Iowa, Iowa City, IA, ⁶Boston University School of Medicine, Boston, MA
Background/Purpose: Osteoarthritis (OA) is a leading cause of pain and disability in older adults marked by progressive joint degeneration. Symptom trajectories vary: some experience persistent…
Abstract Number: 1247 • ACR Convergence 2025
Relation of Measures of Pain Sensitization to Widespread Pain
ZHIQIANG WANG¹, Sarah Tilley², Laura Frey Law³, Cora Lewis⁴, Michael Nevitt⁵, Kosaku Aoyagi⁶, Chunyi Wen⁷, Changhai Ding¹ and Tuhina Neogi⁸, ¹Zhujiang Hospital, Southern Medical University, Guangzhou, China (People's Republic), ²Boston University School of Medicine, Somerville, MA, ³Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, IA, ⁴The University of Alabama at Birmingham, Birmingham, AL, ⁵University of California, San Francisco, San Francisco, CA, ⁶University of Texas at El Paso, El Paso, TX, ⁷The Hong Kong Polytechnic University, Hong Kong, China (People's Republic), ⁸Boston University School of Medicine, Boston, MA
Background/Purpose: Widespread pain (WSP) is thought to be related to alterations in nociceptive signaling such as pain sensitization. Whether pain sensitization predisposes to an increase…
Abstract Number: 1226 • ACR Convergence 2025
Preliminary Findings in the Validation of the Modified Pain and Symptom Assessment Tool in Juvenile Fibromyalgia Syndrome
Daniella Schocken¹, Mark Connelly², Sabrina Gmuca³, Andrea Ramirez⁴, Mary Ellen Riordan⁵, Tracy Ting⁶, Susmita Kashikar-Zuck⁷ and Jennifer Weiss⁸, ¹Children's Mercy Kansas City, Tampa, FL, ²Children’s Mercy Kansas City/University of Missouri-Kansas City School of Medicine, Kansas City, MO, ³Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Baylor College of Medicine, Houston, TX, ⁵Hackensack University Medical Center, Hackensack, NJ, ⁶Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷University of Cincinnati College of Medicine; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁸Joseph M. Sanzari Children's Hospital and Hackensack Meridian School of Medicine, Hackensack, NJ
Background/Purpose: Diagnosing juvenile fibromyalgia (JFM) in youth with chronic musculoskeletal (MSK) pain is challenging in the absence of a validated diagnostic tool. The Pain and…
Abstract Number: 0783 • ACR Convergence 2025
Pain reduction and functional improvements following a non-invasive biomechanical intervention for gait rehabilitation may explain a reduction in healthcare claims. An observational study
Eric Freeman and William Vanderveer, Redefine Healthcare. Orthopedic Pain & Spine Center,, New Jersey
Background/Purpose: Musculoskeletal (MSK) conditions significantly impact public health in the United States, affecting approximately 128 million adults and resulting in over $600 billion in annual…

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