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Abstracts tagged "outcomes and systemic lupus erythematosus (SLE)"

  • Abstract Number: 1670 • 2018 ACR/ARHP Annual Meeting

    Disease Course Patterns in Systemic Lupus Erythematosus: Impact on Long-Term Outcomes

    Konstantinos Tselios, Dafna D Gladman, Zahi Touma, Jiandong Su, Nicole Anderson and Murray Urowitz, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Previous studies have described three patterns of disease activity over time in systemic lupus erythematosus (SLE), namely long quiescence, relapsing remitting, and persistently active.…
  • Abstract Number: 2667 • 2018 ACR/ARHP Annual Meeting

    Sledai and Mex-Sledai Glucocorticoid Indices As Predictors of Damage and Mortality in Multinational Multiethnic Latin American Cohort

    Manuel Ugarte-Gil1,2, Ines Segami3,4, Guillermina Harvey5, Guillermo J. Pons-Estel6, Rosana Quintana7, Cristina Reategui-Sokolova8, Jorge Cieza4, Luis J. Catoggio9, Mercedes Garcia10, Verónica Saurit11, Francisco Caeiro12, Cristina Drenkard13, Guillermo Berbotto14, Emilia Sato15, Lilian Costallat16, Eloisa Bonfa17, Joao C. Tavares Brenol18, Nilzio A Da Silva19, Fernando Cavalcanti20, Antonio Iglesias-Gamarra21, Marlene Guibert-Toledano22, Gil A. Reyes22, Loreto Massardo23, Oscar J Neira24, Mario H Cardiel25, Leonor Barile26, Mary Carmen Amigo27, Luis H. Silveira28, Ignacio Garcia de la Torre29, Eduardo Acevedo-Vasquez2, Rosa Chacón-Díaz30, Maria H Esteva Spinetti31, Graciela S. Alarcón32,33 and Bernardo A Pons-Estel7, 1Rheumatology, Universidad Científica del Sur, Lima, Peru, 2Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, 3Universidad Nacional Mayor de San Marcos, Lima, Peru, 4Hospital Edgardo Rebagliati Martins. EsSalud, Lima, Peru, 5Escuela de Estadística, Universidad Nacional de Rosario, Rosario, Argentina, 6Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario. Argentina, Rosario, Argentina, 7Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Rosario, Argentina, 8Rheumatology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, 9Rheumatology Unit, Internal Medicine Service. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 10Rheumatology, HIGA General San Martin La Plata, La Plata, Argentina, 11Hospital Privado Centro Médico de Córdoba, Cordoba, Argentina, 12Rheumatology, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, 13Medicine/Rheumatology, Emory University, Atlanta, GA, 14Hospital Escuela Eva Perón, Granadero Baigorria, Argentina, Granadero Baigorria, Argentina, 15Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, 16Universidade Estadual da Campinas, Campinas, Brazil, 17Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, 18Hospital da Clinicas da Porto Alegre, Porto Alegre, Brazil, 19Faculdade de Medicina da Universidade Federal de Goiás, Goiania, Brazil, 20Universidade Federal da Pernambuco, Pernambuco, Brazil, 21Universidad Nacional de Colombia, Bogota, Colombia, 22Centro de Investigaciones Médico-Quirúrgicas (CIMEQ), Havana, Cuba, 23Centro de Biología Celular y Biomedicina (CEBICEM), Universidad San Sebastián, Santiago, Chile, 24Hospital del Salvador, Facultad de Medicina, Universidad de Chile, Santiago, Chile, 25Centro de Investigación Clínica de Morelia, Morelia, Mexico, 26Hospital Ángeles del Pedregal, Mexico, Mexico, 27Rheumatology, Centro Medico ABC, Mexico, Mexico, 28Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City DF, Mexico, 29Hospital General de Occidente, Guadalajara, Mexico, 30Servicio de Reumatología, Hospital Universitario de Caracas, Centro Nacional de Enfermedades Reumáticas, Caracas, Venezuela, 31Hospital Central de San Cristóbal, San Cristobal, Venezuela (Bolivarian Republic of), 32Universidad Peruana Cayetano Heredia, Lima, Peru, 33Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Disease activity is one of the major predictors of damage accrual and mortality in systemic lupus erythematosus (SLE). Glucocorticoid use, especially in high dose,…
  • Abstract Number: 715 • 2017 ACR/ARHP Annual Meeting

    Long-Term Outcome of Demyelnating Syndrome in Systemic Lupus Erythematosus: A Longitudinal Study

    Jamal A. Mikdashi1 and Ipolia Ramadan2, 1Div of Rheumatology, Univ of Maryland Schl of Med, Baltimore, MD, 2National Institue of Health, Rockville, MD

    Background/Purpose: Demyelinating syndromes (DS) in systemic lupus erythematosus (SLE) are characterized by inflammation, demyelination and neurodegeneration. Little is known, however, about the tenet of dissemination…
  • Abstract Number: 1839 • 2017 ACR/ARHP Annual Meeting

    Development and Validation of a Novel Evidence-Based Lupus Multivariable Outcome Score for Clinical Trials

    Michal Abrahamowicz1, John M. Esdaile2, Rosalind Ramsey-Goldman3, Lee S. Simon4, Vibeke Strand5 and Peter E. Lipsky6, 1Departmernt of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada, 2Arthritis Research Canada, Richmond, BC, Canada, 3FSM, Northwestern University, Chicago, IL, 4SDG LLC Consulting, West Newton, MA, 5Stanford University, Palo Alto, CA, 6AMPEL BioSolutions, LLC, Charlottesville, VA

    Background/Purpose: Randomized controlled trials (RCTs) of new SLE treatments are hampered by the lack of effective outcome measures that are responsive to change and clinically…
  • Abstract Number: 2623 • 2017 ACR/ARHP Annual Meeting

    Association between Smoking Status and the Clinical and Serological Characteristics at the Onset of Systemic Lupus Erythematosus. an Inception Cohort Analysis

    Jorge Sanchez-Guerrero1, Afra Al Dhaheri2, Stacey Morrison3, Jiandong Su4, Dafna D Gladman5 and Murray Urowitz6, 1Division of Rheumatology, Toronto Western Hospital, Toronto, AB, Canada, 2Tawam Hospital, Al Ain, United Arab Emirates, 3Rheumatology, Krembil Research Institute, Toronto, ON, Canada, 4University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 5Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 6Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Cigarette smoking regulates both innate and adaptive immunity and is associated with numerous diseases. In some inflammatory diseases smoking is associated with deleterious effects…
  • Abstract Number: 745 • 2016 ACR/ARHP Annual Meeting

    Clinical and Laboratory Correlates of Response in a Phase 3 Clinical Trial of Belimumab or Placebo Administered Subcutaneously Plus Standard Care to Patients with Systemic Lupus Erythematosus (SLE)

    Ronald F. van Vollenhoven1, William Stohl2, Richard Furie3, Norma Lynn Fox4, James Groark5, Damon Bass5, Milena Kurtinecz5, Bonnie Pobiner6, William Eastman6, Tania Gonzalez-Rivera5 and David Gordon5, 1Department of Clinical Immunology & Rheumatology, Amsterdam Rheumatology and Immunology Center ARC, Amsterdam, Netherlands, 2Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, 3Division of Rheumatology, Northwell Health, Great Neck, NY, 4GSK, Potomac, MD, 5GSK, Philadelphia, PA, 6GSK, Research Triangle Park, NC

    Background/Purpose: The SRI (SLE responder index) is a composite measure established as a primary endpoint in SLE clinical trials. However, it has been questioned whether…
  • Abstract Number: 1777 • 2016 ACR/ARHP Annual Meeting

    The Accumulation of Organ Damage, Public Insurance Enrollment and Youth Are Associated with Increased Hospitalizations in a Population-Based Cohort of Lupus Patient

    S. Sam Lim1, Gaobin Bao1, Hong J. Kan2, Bonnie Pobiner3, Julie Priest4, William Eastman3, Kirk Easley5 and Cristina Drenkard6, 1Medicine, Emory University School of Medicine, Atlanta, GA, 2John Hopkins University, Baltimore, MD, 3GSK, Research Triangle Park, NC, 4WW Epidemiology, GlaxoSmithKline, Durham, NC, 5Biostatistics, Emory University, Atlanta, GA, 6Emory University School of Medicine, Atlanta, GA

    Background/Purpose: Individuals with systemic lupus erythematosus (SLE) are frequently hospitalized. Determining factors associated with hospitalization rates may help to identify patients at highest risk for…
  • Abstract Number: 1968 • 2016 ACR/ARHP Annual Meeting

    Adverse Childhood Experiences and Outcomes of Systemic Lupus Erythematosus

    Laura Trupin1, Patricia P. Katz1, Cristina Lanata1, Edward H. Yelin1, Lindsey A. Criswell1, Charles G. Helmick2, Jinoos Yazdany1 and Maria Dall'Era1, 1Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 2National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA

    Background/Purpose: Adverse childhood experiences such as extreme deprivation, neglect, abuse, parental separation or incarceration, have been associated with adult health status, including onset of rheumatic…
  • Abstract Number: 2839 • 2016 ACR/ARHP Annual Meeting

    Circulating CD4+CD28null T-Cells Predict the Occurrence of New Lung Damage in  Systemic Lupus Erythematosus (SLE) Patients

    Manuel Ugarte-Gil1,2, César Sánchez-Zúñiga3, Rocio V. Gamboa-Cardenas1, Madeley Aliaga-Zamudio4, Francisco Zevallos1, Ana Mosqueira-Riveros4, Mariela Medina1, Giannina Tineo-Pozo4, Claudia Elera-Fitzcarrald1, Victor Pimentel-Quiroz1, Omar Sarmiento-Velasquez1, Jorge M. Cucho-Venegas1, Jose Alfaro-Lozano1, Zoila Rodriguez-Bellido1,5, Cesar A. Pastor-Asurza1,5, Graciela S. Alarcón6 and Risto Perich-Campos1,5, 1Rheumatology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, 2Universidad Cientifica del Sur, Lima, Peru, 3Diagnostic Support, Hospital Grau. EsSalud, Lima, Peru, 4Molecular Biology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, 5Universidad Nacional Mayor de San Marcos, Lima, Peru, 6Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose:  Peripheral CD4+CD28null T-cells constitute a subset of long-lived cytotoxic CD4+ T-cell with pro-inflammatory functions. This T-cell subpopulation has been reported to be associated with…
  • Abstract Number: 2842 • 2016 ACR/ARHP Annual Meeting

    Predictors of Good Long-Term Renal Outcomes in Lupus Nephritis

    William Fung1, Jiandong Su2 and Zahi Touma3, 1Medicine, University of Toronto, Toronto, ON, Canada, 2Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, 3Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose:   Lupus nephritis (LN) manifests with proteinuria and/or active urine sediment. Renal composite indices include proteinuria, urinary active sediment (RBCs, casts) and serum creatinine.…
  • Abstract Number: 54 • 2015 ACR/ARHP Annual Meeting

    Impact of Age at Disease Diagnosis on Clinical Manifestations, Disease Activity, and Outcomes in Patients with Systemic Lupus Erythematosus: Single-Center Prospective Cohort Study

    Il Woong Sohn1, Young Bin Joo1, Soyoung Won2, Seung Taek Song1, Seung Lee3, Hye-Jin Jeong3 and Sang-Cheol Bae1, 1Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 2Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, 3Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease that affects frequently in their 20s and 30s. However, SLE could develop in other age group…
  • Abstract Number: 404 • 2015 ACR/ARHP Annual Meeting

    Long-Term Outcomes of Macrophage Activation Syndrome in Childhood-Onset Systemic Lupus Erythematosus

    Roberto Ezequiel Borgia1, Maya Gerstein1, Deborah M. Levy2, Earl Silverman2 and Linda T Hiraki2, 1Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 2The Hospital for Sick Children, Toronto, ON, Canada

    Background/Purpose: Macrophage activation syndrome (MAS) is a life-threatening inflammatory complication of childhood-onset systemic lupus erythematosus (cSLE). There are few reports of long-term outcomes of MAS complicating cSLE.…
  • Abstract Number: 778 • 2015 ACR/ARHP Annual Meeting

    Associations Between Autoantibodies and Clinical Manifestations in Systemic Lupus Erythematosus: Data from a Multiethnic Latin American Cohort

    Manuel Ugarte-Gil1,2, Daniel Wojdyla3, Ignacio Garcia-Valladares4, Rocio V. Gamboa-Cardenas1, Yelitza Gonzalez-Bello5,6, Guillermo J. Pons-Estel7, Cesar A. Pastor-Asurza1,8, Ignacio Garcia-De La Torre9,10, Graciela S. Alarcon11, Bernado Pons-Estel12 and GLADEL (Grupo Latinoamericano de Estudio de Lupus), 1Rheumatology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, 2Universidad Cientifica del Sur, Lima, Peru, 3Universidad Nacional de Rosario, Argentina, Rosario, Argentina, 4Centro de Estudios de Investigación Básica y Clínica, SC., Guadalajara, Jalisco, Mexico, 5Immunology and Rheumatology, Hospital General de Occidente, Secretaria de Salud Jalisco, Guadalajara, Jalisco, Mexico, 6Immunology and Rheumatlogy, Universidad de Guadalajara, Zapopan, Jalisco, Mexico, 7Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain, 8Universidad Nacional Mayor de San Marcos, Lima, Peru, 9Immunology and Rheumatology, Hospital General de Occidente, Secretaria de Salud Jalisco, Zapopan, Jalisco, Mexico, 10Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, 11Medicine, University of Alabama at Birmingham, Birmingham, AL, 12Hospital Provincial de Rosario, Rosario, Argentina

    Background/Purpose: Analyses of the association between autoantibodies and SLE clinical manifestations using cluster analyses assume that centroid and within-cluster residuals are similar inside the cluster…
  • Abstract Number: 2651 • 2014 ACR/ARHP Annual Meeting

    Predictors of Therapeutic Outcomes in Patients with Neuropsychiatric Systemic Lupus Erythematosus

    Kunihiro Ichinose1, Kazuhiko Arima2, Masataka Umeda1, Shoichi Fukui3, Ayako Nishino1, Yoshikazu Nakashima1, Takahisa Suzuki1, Yoshiro Horai4, Tomohiro Koga4, Shin-ya Kawashiri2, Naoki Iwamoto1, Mami Tamai1, Hideki Nakamura1, Tomoki Origuchi5 and Atsushi Kawakami1, 1Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 2Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 3Departments of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, Nagasaki, Japan, 4Departments of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 5Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

    Background/Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious organ disorder with a variety of symptoms. Despite advances in the understanding of the immunopathogenic and…
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