Abstracts tagged "outcomes and systemic lupus erythematosus (SLE)"

Abstract Number: 1670 • 2018 ACR/ARHP Annual Meeting
Disease Course Patterns in Systemic Lupus Erythematosus: Impact on Long-Term Outcomes
Konstantinos Tselios, Dafna D Gladman, Zahi Touma, Jiandong Su, Nicole Anderson and Murray Urowitz, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Previous studies have described three patterns of disease activity over time in systemic lupus erythematosus (SLE), namely long quiescence, relapsing remitting, and persistently active.…
Abstract Number: 2667 • 2018 ACR/ARHP Annual Meeting
Sledai and Mex-Sledai Glucocorticoid Indices As Predictors of Damage and Mortality in Multinational Multiethnic Latin American Cohort
Manuel Ugarte-Gil^1,2, Ines Segami^3,4, Guillermina Harvey⁵, Guillermo J. Pons-Estel⁶, Rosana Quintana⁷, Cristina Reategui-Sokolova⁸, Jorge Cieza⁴, Luis J. Catoggio⁹, Mercedes Garcia¹⁰, Verónica Saurit¹¹, Francisco Caeiro¹², Cristina Drenkard¹³, Guillermo Berbotto¹⁴, Emilia Sato¹⁵, Lilian Costallat¹⁶, Eloisa Bonfa¹⁷, Joao C. Tavares Brenol¹⁸, Nilzio A Da Silva¹⁹, Fernando Cavalcanti²⁰, Antonio Iglesias-Gamarra²¹, Marlene Guibert-Toledano²², Gil A. Reyes²², Loreto Massardo²³, Oscar J Neira²⁴, Mario H Cardiel²⁵, Leonor Barile²⁶, Mary Carmen Amigo²⁷, Luis H. Silveira²⁸, Ignacio Garcia de la Torre²⁹, Eduardo Acevedo-Vasquez², Rosa Chacón-Díaz³⁰, Maria H Esteva Spinetti³¹, Graciela S. Alarcón^32,33 and Bernardo A Pons-Estel⁷, ¹Rheumatology, Universidad Científica del Sur, Lima, Peru, ²Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ³Universidad Nacional Mayor de San Marcos, Lima, Peru, ⁴Hospital Edgardo Rebagliati Martins. EsSalud, Lima, Peru, ⁵Escuela de Estadística, Universidad Nacional de Rosario, Rosario, Argentina, ⁶Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario. Argentina, Rosario, Argentina, ⁷Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Rosario, Argentina, ⁸Rheumatology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ⁹Rheumatology Unit, Internal Medicine Service. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ¹⁰Rheumatology, HIGA General San Martin La Plata, La Plata, Argentina, ¹¹Hospital Privado Centro Médico de Córdoba, Cordoba, Argentina, ¹²Rheumatology, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, ¹³Medicine/Rheumatology, Emory University, Atlanta, GA, ¹⁴Hospital Escuela Eva Perón, Granadero Baigorria, Argentina, Granadero Baigorria, Argentina, ¹⁵Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ¹⁶Universidade Estadual da Campinas, Campinas, Brazil, ¹⁷Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ¹⁸Hospital da Clinicas da Porto Alegre, Porto Alegre, Brazil, ¹⁹Faculdade de Medicina da Universidade Federal de Goiás, Goiania, Brazil, ²⁰Universidade Federal da Pernambuco, Pernambuco, Brazil, ²¹Universidad Nacional de Colombia, Bogota, Colombia, ²²Centro de Investigaciones Médico-Quirúrgicas (CIMEQ), Havana, Cuba, ²³Centro de Biología Celular y Biomedicina (CEBICEM), Universidad San Sebastián, Santiago, Chile, ²⁴Hospital del Salvador, Facultad de Medicina, Universidad de Chile, Santiago, Chile, ²⁵Centro de Investigación Clínica de Morelia, Morelia, Mexico, ²⁶Hospital Ángeles del Pedregal, Mexico, Mexico, ²⁷Rheumatology, Centro Medico ABC, Mexico, Mexico, ²⁸Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City DF, Mexico, ²⁹Hospital General de Occidente, Guadalajara, Mexico, ³⁰Servicio de Reumatología, Hospital Universitario de Caracas, Centro Nacional de Enfermedades Reumáticas, Caracas, Venezuela, ³¹Hospital Central de San Cristóbal, San Cristobal, Venezuela (Bolivarian Republic of), ³²Universidad Peruana Cayetano Heredia, Lima, Peru, ³³Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Disease activity is one of the major predictors of damage accrual and mortality in systemic lupus erythematosus (SLE). Glucocorticoid use, especially in high dose,…
Abstract Number: 715 • 2017 ACR/ARHP Annual Meeting
Long-Term Outcome of Demyelnating Syndrome in Systemic Lupus Erythematosus: A Longitudinal Study
Jamal A. Mikdashi¹ and Ipolia Ramadan², ¹Div of Rheumatology, Univ of Maryland Schl of Med, Baltimore, MD, ²National Institue of Health, Rockville, MD
Background/Purpose: Demyelinating syndromes (DS) in systemic lupus erythematosus (SLE) are characterized by inflammation, demyelination and neurodegeneration. Little is known, however, about the tenet of dissemination…
Abstract Number: 1839 • 2017 ACR/ARHP Annual Meeting
Development and Validation of a Novel Evidence-Based Lupus Multivariable Outcome Score for Clinical Trials
Michal Abrahamowicz¹, John M. Esdaile², Rosalind Ramsey-Goldman³, Lee S. Simon⁴, Vibeke Strand⁵ and Peter E. Lipsky⁶, ¹Departmernt of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada, ²Arthritis Research Canada, Richmond, BC, Canada, ³FSM, Northwestern University, Chicago, IL, ⁴SDG LLC Consulting, West Newton, MA, ⁵Stanford University, Palo Alto, CA, ⁶AMPEL BioSolutions, LLC, Charlottesville, VA
Background/Purpose: Randomized controlled trials (RCTs) of new SLE treatments are hampered by the lack of effective outcome measures that are responsive to change and clinically…
Abstract Number: 2623 • 2017 ACR/ARHP Annual Meeting
Association between Smoking Status and the Clinical and Serological Characteristics at the Onset of Systemic Lupus Erythematosus. an Inception Cohort Analysis
Jorge Sanchez-Guerrero¹, Afra Al Dhaheri², Stacey Morrison³, Jiandong Su⁴, Dafna D Gladman⁵ and Murray Urowitz⁶, ¹Division of Rheumatology, Toronto Western Hospital, Toronto, AB, Canada, ²Tawam Hospital, Al Ain, United Arab Emirates, ³Rheumatology, Krembil Research Institute, Toronto, ON, Canada, ⁴University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁵Department of Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁶Centre for Prognosis Studies in the Rheumatic Diseases, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Cigarette smoking regulates both innate and adaptive immunity and is associated with numerous diseases. In some inflammatory diseases smoking is associated with deleterious effects…
Abstract Number: 2842 • 2016 ACR/ARHP Annual Meeting
Predictors of Good Long-Term Renal Outcomes in Lupus Nephritis
William Fung¹, Jiandong Su² and Zahi Touma³, ¹Medicine, University of Toronto, Toronto, ON, Canada, ²Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ³Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Lupus nephritis (LN) manifests with proteinuria and/or active urine sediment. Renal composite indices include proteinuria, urinary active sediment (RBCs, casts) and serum creatinine.…
Abstract Number: 745 • 2016 ACR/ARHP Annual Meeting
Clinical and Laboratory Correlates of Response in a Phase 3 Clinical Trial of Belimumab or Placebo Administered Subcutaneously Plus Standard Care to Patients with Systemic Lupus Erythematosus (SLE)
Ronald F. van Vollenhoven¹, William Stohl², Richard Furie³, Norma Lynn Fox⁴, James Groark⁵, Damon Bass⁵, Milena Kurtinecz⁵, Bonnie Pobiner⁶, William Eastman⁶, Tania Gonzalez-Rivera⁵ and David Gordon⁵, ¹Department of Clinical Immunology & Rheumatology, Amsterdam Rheumatology and Immunology Center ARC, Amsterdam, Netherlands, ²Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, ³Division of Rheumatology, Northwell Health, Great Neck, NY, ⁴GSK, Potomac, MD, ⁵GSK, Philadelphia, PA, ⁶GSK, Research Triangle Park, NC
Background/Purpose: The SRI (SLE responder index) is a composite measure established as a primary endpoint in SLE clinical trials. However, it has been questioned whether…
Abstract Number: 1777 • 2016 ACR/ARHP Annual Meeting
The Accumulation of Organ Damage, Public Insurance Enrollment and Youth Are Associated with Increased Hospitalizations in a Population-Based Cohort of Lupus Patient
S. Sam Lim¹, Gaobin Bao¹, Hong J. Kan², Bonnie Pobiner³, Julie Priest⁴, William Eastman³, Kirk Easley⁵ and Cristina Drenkard⁶, ¹Medicine, Emory University School of Medicine, Atlanta, GA, ²John Hopkins University, Baltimore, MD, ³GSK, Research Triangle Park, NC, ⁴WW Epidemiology, GlaxoSmithKline, Durham, NC, ⁵Biostatistics, Emory University, Atlanta, GA, ⁶Emory University School of Medicine, Atlanta, GA
Background/Purpose: Individuals with systemic lupus erythematosus (SLE) are frequently hospitalized. Determining factors associated with hospitalization rates may help to identify patients at highest risk for…
Abstract Number: 1968 • 2016 ACR/ARHP Annual Meeting
Adverse Childhood Experiences and Outcomes of Systemic Lupus Erythematosus
Laura Trupin¹, Patricia P. Katz¹, Cristina Lanata¹, Edward H. Yelin¹, Lindsey A. Criswell¹, Charles G. Helmick², Jinoos Yazdany¹ and Maria Dall'Era¹, ¹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ²National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: Adverse childhood experiences such as extreme deprivation, neglect, abuse, parental separation or incarceration, have been associated with adult health status, including onset of rheumatic…
Abstract Number: 2839 • 2016 ACR/ARHP Annual Meeting
Circulating CD4+CD28null T-Cells Predict the Occurrence of New Lung Damage in Systemic Lupus Erythematosus (SLE) Patients
Manuel Ugarte-Gil^1,2, César Sánchez-Zúñiga³, Rocio V. Gamboa-Cardenas¹, Madeley Aliaga-Zamudio⁴, Francisco Zevallos¹, Ana Mosqueira-Riveros⁴, Mariela Medina¹, Giannina Tineo-Pozo⁴, Claudia Elera-Fitzcarrald¹, Victor Pimentel-Quiroz¹, Omar Sarmiento-Velasquez¹, Jorge M. Cucho-Venegas¹, Jose Alfaro-Lozano¹, Zoila Rodriguez-Bellido^1,5, Cesar A. Pastor-Asurza^1,5, Graciela S. Alarcón⁶ and Risto Perich-Campos^1,5, ¹Rheumatology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ²Universidad Cientifica del Sur, Lima, Peru, ³Diagnostic Support, Hospital Grau. EsSalud, Lima, Peru, ⁴Molecular Biology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ⁵Universidad Nacional Mayor de San Marcos, Lima, Peru, ⁶Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Peripheral CD4+CD28null T-cells constitute a subset of long-lived cytotoxic CD4+ T-cell with pro-inflammatory functions. This T-cell subpopulation has been reported to be associated with…
Abstract Number: 54 • 2015 ACR/ARHP Annual Meeting
Impact of Age at Disease Diagnosis on Clinical Manifestations, Disease Activity, and Outcomes in Patients with Systemic Lupus Erythematosus: Single-Center Prospective Cohort Study
Il Woong Sohn¹, Young Bin Joo¹, Soyoung Won², Seung Taek Song¹, Seung Lee³, Hye-Jin Jeong³ and Sang-Cheol Bae¹, ¹Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ³Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease that affects frequently in their 20s and 30s. However, SLE could develop in other age group…
Abstract Number: 404 • 2015 ACR/ARHP Annual Meeting
Long-Term Outcomes of Macrophage Activation Syndrome in Childhood-Onset Systemic Lupus Erythematosus
Roberto Ezequiel Borgia¹, Maya Gerstein¹, Deborah M. Levy², Earl Silverman² and Linda T Hiraki², ¹Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ²The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Macrophage activation syndrome (MAS) is a life-threatening inflammatory complication of childhood-onset systemic lupus erythematosus (cSLE). There are few reports of long-term outcomes of MAS complicating cSLE.…
Abstract Number: 778 • 2015 ACR/ARHP Annual Meeting
Associations Between Autoantibodies and Clinical Manifestations in Systemic Lupus Erythematosus: Data from a Multiethnic Latin American Cohort
Manuel Ugarte-Gil^1,2, Daniel Wojdyla³, Ignacio Garcia-Valladares⁴, Rocio V. Gamboa-Cardenas¹, Yelitza Gonzalez-Bello^5,6, Guillermo J. Pons-Estel⁷, Cesar A. Pastor-Asurza^1,8, Ignacio Garcia-De La Torre^9,10, Graciela S. Alarcon¹¹, Bernado Pons-Estel¹² and GLADEL (Grupo Latinoamericano de Estudio de Lupus), ¹Rheumatology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ²Universidad Cientifica del Sur, Lima, Peru, ³Universidad Nacional de Rosario, Argentina, Rosario, Argentina, ⁴Centro de Estudios de Investigación Básica y Clínica, SC., Guadalajara, Jalisco, Mexico, ⁵Immunology and Rheumatology, Hospital General de Occidente, Secretaria de Salud Jalisco, Guadalajara, Jalisco, Mexico, ⁶Immunology and Rheumatlogy, Universidad de Guadalajara, Zapopan, Jalisco, Mexico, ⁷Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain, ⁸Universidad Nacional Mayor de San Marcos, Lima, Peru, ⁹Immunology and Rheumatology, Hospital General de Occidente, Secretaria de Salud Jalisco, Zapopan, Jalisco, Mexico, ¹⁰Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, ¹¹Medicine, University of Alabama at Birmingham, Birmingham, AL, ¹²Hospital Provincial de Rosario, Rosario, Argentina
Background/Purpose: Analyses of the association between autoantibodies and SLE clinical manifestations using cluster analyses assume that centroid and within-cluster residuals are similar inside the cluster…
Abstract Number: 2651 • 2014 ACR/ARHP Annual Meeting
Predictors of Therapeutic Outcomes in Patients with Neuropsychiatric Systemic Lupus Erythematosus
Kunihiro Ichinose¹, Kazuhiko Arima², Masataka Umeda¹, Shoichi Fukui³, Ayako Nishino¹, Yoshikazu Nakashima¹, Takahisa Suzuki¹, Yoshiro Horai⁴, Tomohiro Koga⁴, Shin-ya Kawashiri², Naoki Iwamoto¹, Mami Tamai¹, Hideki Nakamura¹, Tomoki Origuchi⁵ and Atsushi Kawakami¹, ¹Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Departments of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, Nagasaki, Japan, ⁴Departments of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁵Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Background/Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious organ disorder with a variety of symptoms. Despite advances in the understanding of the immunopathogenic and…

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