Associations Between Autoantibodies and Clinical Manifestations in Systemic Lupus Erythematosus: Data from a Multiethnic Latin American Cohort

Manuel Ugarte-Gil^1,2, Daniel Wojdyla³, Ignacio Garcia-Valladares⁴, Rocio V. Gamboa-Cardenas¹, Yelitza Gonzalez-Bello^5,6, Guillermo J. Pons-Estel⁷, Cesar A. Pastor-Asurza^1,8, Ignacio Garcia-De La Torre^9,10, Graciela S. Alarcon¹¹, Bernado Pons-Estel¹² and GLADEL (Grupo Latinoamericano de Estudio de Lupus), ¹Rheumatology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ²Universidad Cientifica del Sur, Lima, Peru, ³Universidad Nacional de Rosario, Argentina, Rosario, Argentina, ⁴Centro de Estudios de Investigación Básica y Clínica, SC., Guadalajara, Jalisco, Mexico, ⁵Immunology and Rheumatology, Hospital General de Occidente, Secretaria de Salud Jalisco, Guadalajara, Jalisco, Mexico, ⁶Immunology and Rheumatlogy, Universidad de Guadalajara, Zapopan, Jalisco, Mexico, ⁷Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain, ⁸Universidad Nacional Mayor de San Marcos, Lima, Peru, ⁹Immunology and Rheumatology, Hospital General de Occidente, Secretaria de Salud Jalisco, Zapopan, Jalisco, Mexico, ¹⁰Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, ¹¹Medicine, University of Alabama at Birmingham, Birmingham, AL, ¹²Hospital Provincial de Rosario, Rosario, Argentina

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: outcomes and systemic lupus erythematosus (SLE)

Session Information

Date: Sunday, November 8, 2015

Title: Systemic Lupus Erythematosus - Clinical Aspects and Treatment Poster Session I

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Analyses of the association between autoantibodies and SLE clinical
manifestations using cluster analyses assume that centroid and within-cluster
residuals are similar inside the cluster and different between clusters. However,
these antibodies and their combinations within a cluster may have different clinical
impact; moreover, the residuals of two clusters may not be different enough
leading to incorrect conclusions. We have therefore evaluated these associations
individually and in combinations overcoming the problems noted above.

Methods: Patients with available data for anti-dsDNA, anti-histone, anti-Sm,
anti-RNP, anti-Ro and anti-La from a multinational SLE cohort were included.
Autoantibodies were evaluated individually and in pre-specified combinations (anti-dsDNA
+ anti-histone; anti-Sm + anti-RNP; anti-Ro + anti-La). About 100 clinical
manifestations were systematically recorded using a common protocol. Logistic
regressions were used to examine the association between autoantibodies and clinical
manifestations and components of the last SLICC/ACR Damage Index (SDI) and a
Poisson regression with the last total SDI.

Results: Three hundred and thirty-eight patients representative of the entire
cohort (n=1480) other than for their ethnic distribution (50.6% vs. 38.1%, Caucasians;
37.9% vs. 45.3%, Mestizo and 11.5% vs. 16.6%, others p=0.001) were studied.
Of them, 329 (97.3%) fulfilled ≥4ACR criteria. Mean age at diagnosis was 28.5
(SD: 11.5) years, 308 (91.1%) were female; follow-up was 4.6 (1.7) years. Baseline
SLEDAI was 10.5 (7.6) and baseline SDI was 1.0 (1.3). The associations between
clinical manifestations and autoantibodies are depicted in Tables 1 and 2. The
associations between autoantibodies and the last SDI and its components are
depicted in Table 3.

Conclusion: Autoantibodies profiles are associated with different manifestations
and damage among SLE patients. Anti-histone positivity, among anti-dsDNA
positive patients and anti-La positivity were associated with damage accrual,
but anti-Sm positivity among anti-RNP negative patients was negatively
associated with damage accrual. The interaction between autoantibodies should
be evaluated in larger populations in order to evaluate less frequent
manifestations.

Disclosure: M. Ugarte-Gil, None; D. Wojdyla, None; I. Garcia-Valladares, None; R. V. Gamboa-Cardenas, None; Y. Gonzalez-Bello, None; G. J. Pons-Estel, None; C. A. Pastor-Asurza, None; I. Garcia-De La Torre, None; G. S. Alarcon, None; B. Pons-Estel, None.

To cite this abstract in AMA style:

Ugarte-Gil M, Wojdyla D, Garcia-Valladares I, Gamboa-Cardenas RV, Gonzalez-Bello Y, Pons-Estel GJ, Pastor-Asurza CA, Garcia-De La Torre I, Alarcon GS, Pons-Estel B. Associations Between Autoantibodies and Clinical Manifestations in Systemic Lupus Erythematosus: Data from a Multiethnic Latin American Cohort [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/associations-between-autoantibodies-and-clinical-manifestations-in-systemic-lupus-erythematosus-data-from-a-multiethnic-latin-american-cohort/. Accessed .

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