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Abstracts tagged "Outcome measures"

  • Abstract Number: 2093 • ACR Convergence 2022

    Hazard Index Equations Using Data Collected at Baseline and After One Year Treatment Allow Early Prediction of Poor Outcome in an Incident Lupus Nephritis Population: Data from the Louvain Lupus Nephritis Cohort

    Farah Tamirou and Frédéric A. Houssiau, Cliniques Universitaires Saint-Luc, Brussels, Belgium

    Background/Purpose: While long-term follow-up (FU) is needed to unmask poor outcome in lupus nephritis (LN), most clinical trials evaluate outcome measures at short-term. Early endpoints…
  • Abstract Number: 0077 • ACR Convergence 2022

    Rheumatoid Arthritis – Are We Getting to Target?

    myint Thway1, Gurjit S. Kaeley2, Karishma Ramsubeik3, Laurie Ramrattan1, Lilian Otalora Rojas4 and Sukhraj Singh1, 1University of Florida-Jacksonville, Jacksonville, FL, 2UF COM-J, Ponte Vedra Beach, FL, 3University of Florida, Jacksonville, FL, 4University of Florida, Ponte Vedra Beach, FL

    Background/Purpose: Low disease activity (LDA) is a key goal in treating Rheumatoid arthritis, but implementing the treat to target approach in clinical practice has been…
  • Abstract Number: 0285 • ACR Convergence 2022

    Characteristics and Outcomes of Patients with Rheumatoid Arthritis Treated with Upadacitinib in a Global Real-World Setting

    Roberto Felice Caporali1, Jayeshkumar Patel2, Oliver Howell3, sander strengholt4, Hannah Jones3 and Peter Taylor5, 1University of Milan, Milano, Italy, 2AbbVie, Inc., North Chicago, IL, 3Adelphi Real World, Bollington, United Kingdom, 4AbbVie, Inc., Abcoude, Netherlands, 5University of Oxford, Oxford, United Kingdom

    Background/Purpose: Upadacitinib (UPA), a Janus kinase inhibitor, is a newly approved advanced therapy for patients (pts) with rheumatoid arthritis (RA), thus real-world evidence is lacking.…
  • Abstract Number: 0722 • ACR Convergence 2022

    Cardiovascular and Oncologic Outocomes of Anti-TNF Alfa and JAK Inhibitors in Patients with Rheumatoid and Psoriatic Arthritis. Real World Data and Insights of BIOBADASAR 3.0 Registry

    Alejandro Brigante1, Rosana Quintana2, Carolina Isnardi3, Karen Roberts4, Gimena Gomez5, Maria Haye Salinas6, Enrique Soriano7, Guillermo Pons-Estel8, Maria De la Vega8, Osvaldo kerzberg7, Julieta Gamba7, Anastasia Secco9, Gustavo Citera10, Cesar Graf7, Veronica Savio11, Maria de los Angeles Gallardo7, Nora Aste7, Mercedes A Garcia12, Gustavo Casado7, Carla Gobbi7, Graciela Gomez7, Joan Manuel Dapeña13, Guillermo Berbotto7, Malena Viola7, Jonathan Rebak7, Diana Dubinsky7, Veronica Saurit14, Ingrid Petkovic7, Ana Bertoli7, Erika Catay7, C Leoni7, Ida Elena Exeni7, Bernardo Pons-Estel15, Sergio Paira7, GH Bovea Castelblanco7, Mercedes De la Sota7, Dora Pereira7, Gustavo Medina7, Amelia Granel7, Maria s Larroude7, Analia Patricia Alvarez7, Santiago Agüero16, Cecilia Pisoni17, Monica Sacnun7 and Edson Velozo18, 1UNISAR, Lobos, Argentina, 2Centro Regional de Enfermedades Autoinmunes y Reumáticas. Grupo Oroño (GO CREAR) and Research Unit Argentine Society of Rheumatology, Buenos Aires, Argentina, 3SAR-COVID Coordinator, Research Unit Argentine Society of Rheumatology, Buenos Aires, Argentina, 4UNISAR, Rosario, Argentina, 5Sanatorio Guemes, Buenos Aires, Argentina, 6UNLAR, La Rioja, Argentina, 7On behalf of the BIOBADASAR 3.0 registry, Buenos Aires, Argentina, 8Argentine Society of Rheumatology, Buenos Aires, Argentina, 9Rivadavia Hospital, Buenos Aires, Argentina, 10Instituto de Rehabilitación Psicofísica (IREP), Buenos Aires, Argentina, 11Hospital Córdoba; Consultora Integral de Salud CMP, Cordoba, Argentina, 12HIGA San Martin, La Plata, Argentina, 13Hospital General de Agudos Dr. Enrique Tornu, Buenos Aires, Argentina, 14Hospital Privado Universitario, Cordoba, Argentina, 15Grupo Oroño - Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina, 16Centro de Rehabilitación Dr Mauricio Figueroa, Catamarca, Argentina, 17CEMIC- Centro de Educación Médica e Investigaciones Clínicas, Buenos Aires, Argentina, 18SAR COVID Investigator, Caba

    Background/Purpose: Major adverse cardiovascular events (MACE) and neoplasms are a concern in autoimmune diseases. RA and PsA are diseases where inflammation plays a key role…
  • Abstract Number: 1084 • ACR Convergence 2022

    Rituximab versus Cyclophosphamide for Induction Therapy in Granulomatosis with Polyangiitis: A Target Trial Emulation Study

    Xavier Puéchal1, Michele Iudici2, Elodie Perrodeau3, bernard bonnotte4, Francois Lifermann5, Thomas Le Gallou6, Alexandre Karras7, Claire Blanchard-Delaunay8, Thomas Quéméneur9, Achille Aouba10, Olivier Aumaître11, Vincent Cottin12, Mohamed Hamidou13, Marc Ruivard11, Pascal Cohen1, Luc Mouthon1, Loïc Guillevin1, Philippe Ravaud3, Raphaël Porcher3 and Benjamin Terrier1, 1National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, 2Division of Rheumatology, Geneva University Hospitals, Geneva, Switzerland, 3Université Paris Cité, Hôtel-Dieu, Paris, France, 4Centre Hospitalo-Universitaire de Dijon, Dijon, France, 5Dax Hospital, Dax, France, 6Rennes Sud University Hospital, Rennes, France, 7HEGP, Paris, France, 8Niort Hospital, Niort, France, 9Valenciennes Hospital, Valenciennes, France, 10Department of Internal Medicine, UR4650 PSIR, Normandie Univ, UNICAEN, CHU de Caen Normandie, Caen, France, 11Clermont Ferrand University Hospital, Clermont-Ferrand, France, 12Coordinating Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, University of Lyon, INRAE, Lyon, France, 13Nantes University Hospital, Nantes, France

    Background/Purpose: Randomized controlled trials showed rituximab (RTX)'s non-inferiority to cyclophosphamide (CYC) for induction therapy of ANCA-associated vasculitis and neither treatment was favoured in granulomatosis with…
  • Abstract Number: 1388 • ACR Convergence 2022

    Updating and Validating the Rheumatic Disease Comorbidity Index to Incorporate ICD-10 Diagnostic Codes

    Anthony Dolomisiewicz1, Hanifah Ali2, Punyasha Roul3, Yangyuna Yang1, Grant Cannon4, Joshua Baker5, Ted Mikuls6, Kaleb Michaud1 and Bryant England1, 1University of Nebraska Medical Center, Omaha, NE, 2UNMC, Omaha, 3UNMC, Omaha, NE, 4Salt Lake City VA, Salt Lake city, 5University of Pennsylvania and Corporal Michael J. Crescenz VA Medical Center, Philadelphia, 6Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The Rheumatic Disease Comorbidity Index (RDCI) was designed to quantify comorbidity burden for risk stratification of health outcomes in patients with rheumatic disease. Developed…
  • Abstract Number: 1847 • ACR Convergence 2022

    Differences in Key Patient-reported Outcome Domains Identified by the Patient Acceptable Symptom State in the Adult SAPHO and Chronic Nonbacterial Osteomyelitis Observational Study (The SAPHO-CNO Study)

    Aleksander Lenert1, Robyn Domsic2, Karmela Kim Chan3, Melissa Oliver4, Jisna Paul5, Courtney Kremer6, Emma Leisinger1, Svjetlana Dolovcak7, Sandy D. Hong8, Aruni Jayatilleke9, Petar Lenert7, T. Shawn Sato1, Samir Shah10, Shima Yasin11, Yongdong (Dan) Zhao12, Daniel Solomon13, Jonathan Templin1 and Polly Ferguson11, 1University of Iowa, Iowa City, IA, 2University of Pittsburgh, Pittsburgh, PA, 3Hospital for Special Surgery, New York, NY, 4Indiana University School of Medicine, Indianapolis, IN, 5Ohio State University Hospital, Dublin, OH, 6University of Iowa Stead Family Children's Hospital, Solna, IA, 7University of Iowa Hospitals and Clinics, Iowa City, IA, 8University of Iowa Stead Family Children's Hospital, Iowa City, IA, 9Temple University, PHILADELPHIA, PA, 10Tufts Medical Center, Boston, MA, 11University of Iowa Carver College of Medicine, Iowa City, IA, 12University of Washington, Redmond, WA, 13Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Incorporating patient perspectives of their disease state is needed for disease activity assessment in adults with SAPHO syndrome and chronic nonbacterial osteomyelitis (CNO). The…
  • Abstract Number: 2105 • ACR Convergence 2022

    Comparison of the Systemic Lupus International Collaborating Clinics Frailty Index (SLICC-FI) and the FRAIL Scale for Identifying Frailty Among Individuals with Systemic Lupus Erythematosus

    Alexandra Legge1, Sarah Lieber2 and John Hanly3, 1Arthritis Research Canada, Dalhousie University, Halifax, NS, Canada, 2Hospital for Special Surgery, New York, NY, 3Division of Rheumatology, Queen Elizabeth II Health Sciences Center (Nova Scotia Rehabilitation Site) and Dalhousie University, Halifax, NS, Canada

    Background/Purpose: Frailty is associated with increased risk of adverse health outcomes in SLE. Multiple definitions for frailty exist, and how best to measure frailty in…
  • Abstract Number: 0092 • ACR Convergence 2022

    Characterizing Levels of Specialist Care Received by Patients with Systemic Lupus Erythematosus: Clinical Characteristics, Emergency Care, Hospitalization, and Costs Among Commercially-insured Adults in the United States

    Sandra Sze-jung Wu1, Allison Perry2, Helen Varker3, Christine Dube1 and Gary Bryant4, 1AstraZeneca, Wilmington, DE, 2IBM Watson Health, Cambridge, MA, 3Merative, Cambridge, MA, 4AstraZeneca, New Castle, DE

    Background/Purpose: Heterogeneous SLE manifestations can delay referral and diagnosis by a rheumatologist (rheum) in as many as 75% of patients (pts) with SLE.1 After diagnosis,…
  • Abstract Number: 0319 • ACR Convergence 2022

    Factors Associated with Worsening Interstitial Fibrosis/Tubular Atrophy in Lupus Nephritis Patients Undergoing Repeat Kidney Biopsy

    Daming Shao1, Alejandra Londoño Jimenez2, Maria Auxiliadora Salgado Guerrero3, Anna Broder4 and Shudan Wang5, 1Albert Einstein College of Medicine/Jacobi Medical Center, Bronx, NY, 2McFarland Clinic, Ames, IA, 3University of Alabama at Birmingham, Birmingham, AL, 4Hackensack University Medical Center, Hackensack, NJ, 5Montefiore Medical Center / Albert Einstein College of Medicine, New York, NY

    Background/Purpose: Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE). Approximately 10 to 30% of patients with LN progress…
  • Abstract Number: 0729 • ACR Convergence 2022

    Understanding the Practice and Process of Patient Reported Outcome Measures Collection in North American Pediatric Rheumatology Clinics: A Survey of the Pediatric Rheumatology-Care and Outcomes Improvement Network

    Y. Ingrid Goh1, Esi Morgan2, Meghan Ryan3, Beth Gottlieb4 and Nancy Pan5, 1Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute, Toronto, ON, Canada, 2Seattle Children's Hospital, Seattle, WA, 3University of Minnesota, Vadnais Heights, MN, 4Cohen Children's Medical Center, Lake Success, NY, 5Hospital for Special Surgery, New York, NY

    Background/Purpose: Patients/proxies (Pts) complete patient reported outcome measures (PROMs) to inform their healthcare team about their health status. PROMs completed by Pts prior to their…
  • Abstract Number: 1214 • ACR Convergence 2022

    In-hospital Outcomes of Autoimmune Diseases Complicated by Interstitial Lung Disease: A National Inpatient Sample Analysis

    Sandhya shri Kannayiram1 and Shilpa Arora2, 1John H. Stroger, Jr. Hospital of Cook County, Chicago, IL, 2Rush University Medical Center, Chicago, IL

    Background/Purpose: Several autoimmune diseases (AD) may be associated with interstitial lung disease (ILD), contributing to increased morbidity and mortality in these patients. We aimed to…
  • Abstract Number: 1414 • ACR Convergence 2022

    2022 Revision of the ACR/EULAR Remission Criteria for Rheumatoid Arthritis

    Paul Studenic1, Daniel Aletaha2, Maarten de Wit3, Tanja Stamm4, Farideh Alasti5, Diane Lacaille6, Josef Smolen1 and David Felson7, 1Medical University of Vienna, Vienna, Austria, 2Medical University Vienna, Wien, Austria, 3Patient research partner, Amsterdam, Netherlands, 4Medical University of Vienna, CeMSIIS - Center for Medical Statistics, Informatics, and Intelligent Systems, Section for Outcomes Research, Wien, Austria, 5Medical University of Vienna, Department of Internal Medicine 3, Division of Rheumatology, Vienna, Austria, 6Arthritis Research Canada, University of British Columbia, Vancouver, BC, Canada, 7Boston University, Boston, MA

    Background/Purpose: More than 10 years ago ACR and EULAR endorsed provisional criteria to define remission in RA, both Boolean and index-based. However, the agreement between…
  • Abstract Number: 1871 • ACR Convergence 2022

    Hospitalization Outcomes for Acute Myocardial Infraction and Acute Heart Failure in Patients with Idiopathic Inflammatory Myopathies (IIM) from 2016-2019 National Inpatient Sample (NIS)

    Zi Ying Li1, Siyi Huang2, Kevin Xi3, Deepan Dalal4 and Anthony Reginato5, 1Roger Williams Medical Center, Providence, RI, 2UCSF Fresno, Fresno, CA, 3Brown University, Providence, 4Brown University School of Medicine, Providence, RI, 5Brown University, Providence, RI

    Background/Purpose: Cardiovascular disease was encountered in 15% of hospital admission from 2016-2017 for patients with idiopathic inflammatory myopathies (IIM) based on the National Inpatient Sample…
  • Abstract Number: 2109 • ACR Convergence 2022

    Domains Contributing to Minimal Disease Activity Non-Achievement in Patients with Psoriatic Arthritis Receiving Golimumab: Post Hoc Analysis of a Phase 3, Randomized, Double-blind, Placebo-controlled Study

    Arthur Kavanaugh1, Gordon Lam2, Lai-shan Tam3, Natalie Shiff4, Youngja Lee5, Ana-Maria Bravo Perdomo6, May Shawi7, Elizabeth Hsia8, Emmanouil Rampakakis9 and Carlos Enrique Toro Gutiérrez10, 1University of California San Diego, La Jolla, CA, 2Arthritis and Osteoporosis Consultants of the Carolinas; Clinical Affiliate, Atrium Health and the Wake Forest School of Medicine, Cornelius, NC, 3The Chinese University of Hong Kong, Hong Kong, China, 4Janssen Scientific Affairs, LLC, Horsham, PA, USA/ Department of Community Health and Epidemiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada, Philadelphia, PA, 5Immunology Medical Affairs, Janssen Asia Pacific, Yongsan-gu, Seoul, Republic of Korea, 6Immunology Medical Affairs, Janssen Latin America, Columbia, Colombia, 7Immunology Global Medical Affairs, Janssen Pharmaceutical Companies of Johnson & Johnson, Horsham, PA, 8Janssen Research and Development, LLC; University of Pennsylvania School of Medicine, Kennett Square, PA, 9McGill University, Department of Pediatrics and JSS Medical Research, Montréal, QC, Canada, 10Internal Medicine and Rheumatology, Reference Center for Osteoporosis, Rheumatology & Dermatology. Pontificia Javeriana University, Calí, Colombia

    Background/Purpose: Sustained minimal disease activity (MDA) is only achieved by a small portion of PsA patients (pts). Levels of disease activity consistent with MDA may…
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