Abstracts tagged "Outcome measures"

Abstract Number: 1515 • ACR Convergence 2023
Performance of the Revised CRISS in a Phase 3 Trial of Early Systemic Sclerosis
Dinesh Khanna¹, Christopher Denton², Masataka Kuwana³, Daniel Furst⁴, Suiyuan Huang¹, Barbara White⁵ and Robert Spiera⁶, ¹University of Michigan, Ann Arbor, MI, ²University College London, London, United Kingdom, ³Nippon Medical School Graduate School of Medicine, Tokyo, Japan, ⁴University of California Los Angeles, Los Angeles, CA, ⁵SFJ Pharmaceuticals, Towson, MD, ⁶Hosptial for Special Surgery, New York, NY
Background/Purpose: Revised CRISS has been proposed an approvable outcome measure in early diffuse cutaneous SSc (dcSSc)1. The index is undergoing the FDA review as part…
Abstract Number: 1901 • ACR Convergence 2023
Which ASDAS-ESR Cut-offs for Disease Activity Correspond to ASDAS-CRP Cut-offs in Axial Spondyloarthritis? – Results from the EuroSpA Collaboration
Stylianos Georgiadis¹, Lykke Ørnbjerg¹, Brigitte Michelsen², Tore Kvien³, Daniela Di Giuseppe⁴, Johan Karlsson Wallman⁵, Jakub Zavada⁶, Sella Provan⁷, Ana Maria Rodrigues⁸, Maria Jose Santos⁹, Ziga Rotar¹⁰, Dan Nordstrom¹¹, Anna-Mari Hokkanen¹², Gary Macfarlane¹³, Gareth T. Jones¹³, Irene van der Horst-Bruinsma¹⁴, Pasoon Hellamand¹⁵, Mikkel Østergaard¹⁶ and Merete Hetland¹, ¹Copenhagen Center for Arthritis Research, Rigshospitalet, Copenhagen, Denmark, ²Rigshospitalet Glostrup; Diakonhjemmet Hospital; Sørlandet Hospital, Copenhagen, Denmark, ³Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, ⁴Karolinska Institutet, Stockholm, Sweden, ⁵Lund University and Skåne University Hospital, Lund, Sweden, ⁶Institute of Rheumatology; Charles University, Prague, Czech Republic, ⁷Diakonhjemmet Hospital, Oslo, Norway, ⁸Sociedade Portuguesa de Reumatologia; Nova Medical School; Hospital dos Lusíadas, Lisbon, Portugal, ⁹Hospital Garcia de Orta, Almada, Lisboa, Portugal, ¹⁰University Medical Centre Ljubljana, Ljubljana, Slovenia, ¹¹Helsinki University Hospital, Helsinki, Finland, ¹²Helsinki University and Helsinki University Hospital, Helsinki, Finland, ¹³Aberdeen Centre for Arthritis and Musculoskeletal Health (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, ¹⁴Radboud University Medical Centre, Department of Rheumatology, Nijmegen, Netherlands, ¹⁵Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands, ¹⁶Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet; University of Copenhagen, Copenhagen, Denmark
Background/Purpose: When assessing disease activity in patients with axial spondyloarthritis (axSpA), the Ankylosing Spondylitis Disease Activity Score with C-reactive protein (ASDAS-CRP) is recommended over ASDAS…
Abstract Number: 2262 • ACR Convergence 2023
Identifying Important Domains for Inclusion in a Novel Treatment Response Measure for Systemic Lupus Erythematosus (TRM-SLE): Results of a Modified Delphi Study
Kathryn Connelly¹, Rachel Koelmeyer¹, Darshini Ayton¹, Raychel Barrallon¹, Laura Eades², Vera Golder³, Kate gregory¹, John May¹, Rangi Kandane-Rathnayake³, Maisarah Mydin¹, Munni Akther¹, Afia Anzum¹, Jeanette Andersen⁴, Hermine Brunner⁵, Cynthia Aranow⁶, Laurent Arnaud⁷, Anca Askanase⁸, Catherine Barbey⁹, Joy Buie¹⁰, Laurie Burke¹¹, Alain Cornet¹², Karen Costenbader¹³, Maria Dall'Era¹⁴, Joan Merrill¹⁵, Khadija Dantata¹⁶, Alan Friedman¹⁷, Richard Furie¹⁸, Sandra Garces¹⁹, Maja Hojnik²⁰, Kenneth Kalunian²¹, Justine Maller²², Patrick Marquis²³, Marta Mosca²⁴, Erika Noss²⁵, Guillermo Pons-Estel²⁶, Lee Simon²⁷, Eve Smith²⁸, Alessandro Sorrentino²⁹, Anna Stevens³⁰, George Stojan³¹, Ying Sun³², Yoshiya Tanaka³³, Ed Vital³⁴, Ronald van Vollenhoven³⁵, Victoria P. Werth³⁶ and Eric Morand³⁷, ¹Monash University, Clayton, Australia, ²Monash Health and Monash University, Clayton, Australia, ³Monash University, Department of Medicine, Sub-faculty of Clinical and Molecular Medicine, Clayton, Australia, ⁴Lupus Europe, Knebel, Denmark, ⁵Cincinnati Children's Hospital Medical Center, Division of Rheumatology, Cincinnati, OH, ⁶Feinstein Institutes for Medical Research, Manhasset, NY, ⁷University Hospitals of Strasbourg, Strasbourg, France, ⁸Columbia University Medical Center, New York, NY, ⁹Biogen, Baar, Switzerland, ¹⁰Lupus Foundation of America, York, SC, ¹¹LORA Group, Normal, IL, ¹²Lupus Europe, Brussels, Belgium, ¹³Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹⁴University of California San Francisco, San Francisco, CA, ¹⁵Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁶Lupus Foundation of America, Richmond Hill, GA, ¹⁷AbbVie, Inc., North Chicago, IL, ¹⁸Northwell Health, Manhasset, NY, ¹⁹Amgen, Inc., Thousand Oaks, CA, ²⁰Eli Lilly and Company, Indianapolis, IN, ²¹University of California San Diego, La Jolla, CA, ²²Genentech, Inc., Half Moon Bay, CA, ²³Modus Outcomes, Newton, MA, ²⁴Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, ²⁵Janssen Research and Development, Dresher, PA, ²⁶CREAR, Rosario, Argentina, ²⁷SDG LLC, West Newton, MA, ²⁸University of Liverpool, Liverpool, United Kingdom, ²⁹Medical Affairs, AstraZeneca, Cambridge, United Kingdom, ³⁰Bristol Myers Squibb, Groton, CT, ³¹UCB, Baltimore, MD, ³²the healthcare business of Merck KGaA, Darmstadt, Germany, ³³University of Occupational and Environmental Health, Kitakyushu, Japan, ³⁴University of Leeds, Leeds, United Kingdom, ³⁵Amsterdam University Medical Centers, Amsterdam, Netherlands, ³⁶University of Pennsylvania, Wynnewood, PA, ³⁷Monash University, Centre for Inflammatory Diseases, Melbourne, Australia
Background/Purpose: The Treatment Response Measure for Systemic Lupus Erythematosus (TRM-SLE) is a novel clinical outcome assessment (COA) for SLE randomized controlled trials (RCTs), being developed…
Abstract Number: 2522 • ACR Convergence 2023
Diabetes Mellitus Impacts Primary Total Hip Arthroplasty Outcomes: A National Cohort Study
Sumanth Chandrupatla¹, Kranti Rumalla² and Jasvinder Singh¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²Northwestern School of Medicine, Chicago, IL
Background/Purpose: Primary total hip arthroplasty (THA) patients often have concomitant medical comorbidities. This study aims to identify the impact of diabetes mellitus (DM) on inpatient…
Abstract Number: 0176 • ACR Convergence 2023
Impact of Social Determinants of Health Factors on Medication Adherence in Members with Rheumatoid Arthritis, Psoriatic Arthritis, and Systemic Lupus Erythematosus
Jean Park, W. Cliff Rutter, Elisea Avalos-Reyes, Chen Liu, Will Cavers, Dorothea Verbrugge and Kjel Johnson, CVS Health, Woonsocket, RI
Background/Purpose: Social determinants of health (SDOH) have a significant impact on the health outcomes of many chronic conditions, including rheumatoid arthritis (RA), psoriatic arthritis (PsA)…
Abstract Number: 0482 • ACR Convergence 2023
Preference and Relative Sensitivity of Indicators Reporting Response Rate in Pharmaceutical Trials of Psoriasis and Psoriatic Arthritis
Jingru Tian¹, Shuntong Kang², Dingyao Zhang³ and Qianjin Lu⁴, ¹Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China, ²Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Nanjing, China, ³Graduate Program in Biological and Biomedical Sciences, Yale University, New Haven, CT, ⁴Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Changsha, China
Background/Purpose: Numerous indicators have been proposed to evaluate the efficacy for randomized clinical trials (RCTs) of psoriasis (Pso) and psoriatic arthritis (PsA), but the comparability…
Abstract Number: 1020 • ACR Convergence 2023
An Increase in Safety Outcome Trials and the Issue of Informed Consent
Ayse Ozdede¹, Sinem Nihal Esatoglu² and Hasan Yazici³, ¹Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Department of Internal Medicine, Division of Rheumatology, İstanbul, Turkey, ²Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ³Academic Hospital, Istanbul, Turkey
Background/Purpose: The randomized controlled trial (RCT remains a most important research tool and a necessary document for drug licensing. Informed consent is an integral component…
Abstract Number: 1286 • ACR Convergence 2023
Impact of Body Mass Index (BMI) on Upper versus Lower Extremity Joints Assessed Using Clinical and Musculoskeletal Ultrasound Measures in Rheumatoid Arthritis Patients
Nicolette Morris¹, Elena Saab², Lucia Chen¹, Jenny Brook¹, Gurjit S Kaeley³, David Elashoff¹ and Veena Ranganath¹, ¹David Geffen School of Medicine, UCLA, Los Angeles, CA, ²Wake Forest University School of Medicine, Los Angeles, CA, ³University of Florida College of Medicine – Jacksonville, Ponte Vedra Beach, FL
Background/Purpose: Tender and swollen joints counts may be differentially affected in rheumatoid arthritis (RA) patients with obesity. A prior study demonstrated an association between increased…
Abstract Number: 1552 • ACR Convergence 2023
Epidemiology and Outcome of Eosinophilic Granulomatosis with Polyangiitis in France
Benjamin Terrier¹, Camille Taillé², Alice Brouquet³, Solenne Tauty³, Francoise Bugnard³, Loic Guillevin⁴, Xavier Puéchal⁵ and Vincent Cottin⁶, ¹Department of Internal Medicine, Hôpital Cochin, AP-HP, Paris, France, ²AP-HP, Bichat Hospital, Reference Center for Rare Pulmonary Diseases and University of Paris Cité, Inserm 1152, Paris, France, ³Steve Consultant, Lyon, France, ⁴University Paris Descartes, Paris, France, ⁵National Referral Center for Rare Systemic Autoimmune Diseases, Paris, France, ⁶Coordinating Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, University of Lyon, INRAE, Lyon, France
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA, formerly Churg-Strauss) belongs to the group of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV). There are no recent data on…
Abstract Number: 1902 • ACR Convergence 2023
Improving the Sharing of Information from Reviews of Measurement Properties: The OMERACT Summary of Measurement Properties (SOMP) Table
shawna grosskleg¹, lara maxwell², Dorcas Beaton³, B Shea¹ and Peter Tugwell¹, ¹OMERACT, Ottawa, ON, Canada, ²University of Ottawa, Ottawa, ON, Canada, ³Institute for Work & Health, Toronto, ON, Canada
Background/Purpose: Systematic reviews of measurement properties of an outcome measurement instrument are fast becoming the evidence base for making decisions about the suitability of the…
Abstract Number: 2265 • ACR Convergence 2023
Lupus Damage Index Revision – Item Generation and Reduction Phase
Burak Kundakci¹, Megan Barber², Ann Clarke², Sindhu Johnson³, Ian Bruce⁴ and On behalf of the revised SLE organ damage index (SDI) collaborators⁴, ¹Centre for Epidemiology Versus Arthritis, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom, ²University of Calgary, Division of Rheumatology, Cumming School of Medicine, Calgary, AB, Canada, ³Division of Rheumatology, Department of Medicine, Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western and Mount Sinai Hospitals; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada, ⁴University of Manchester, Manchester, United Kingdom
Background/Purpose: The SDI is a robust instrument, but is limited by incomplete items, restricted applicability in paediatric patients, and outdated item definitions1. The SLICC, ACR…
Abstract Number: 2523 • ACR Convergence 2023
Region, Race, and Hospital Factors Impact Length of Stay and Hospital Charges Post-primary Total Knee Arthroplasty
Kranti Rumalla¹, Sumanth Chandrupatla² and Jasvinder Singh², ¹Northwestern School of Medicine, Chicago, IL, ²University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Osteoarthritis (OA) affects nearly 33 million adults in the US and total knee arthroplasty (TKA) is an effective treatment. Outcomes can vary by regional…
Abstract Number: 0179 • ACR Convergence 2023
Social Disparities and Pathology Markers at Lupus Nephritis Diagnosis Predict Worse Kidney Outcomes
Shivani Garg¹, Brad Astor², Amish Raval², S. Sam Lim³, Weixiong Zhong², Sarah Panzer², Brad Rovin⁴ and Christie M. Bartels², ¹Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, ²University of Wisconsin, School of Medicine and Public Health, Madison, WI, ³Emory University, Atlanta, GA, ⁴Ohio State University, Columbus, OH
Background/Purpose: At diagnosis, a typical 30-year-old with lupus nephritis (LN) already has 10-fold higher chronic kidney disease (CKD) risk than peers and LN is a…
Abstract Number: 0505 • ACR Convergence 2023
Factors Associated with Minimal Disease Activity in Psoriatic Arthritis: Insights from a Registry-Based Study
Shashank Cheemalavagu¹, Yuxuan Jin² and M. Elaine Husni³, ¹Cleveland Clinic Foundation, Cleveland, OH, ²Cleveland Clinic, Cleveland, OH, ³Cleveland Clinic / Department of Rheumatic and Immunologic Diseases, Cleveland, OH
Background/Purpose: Achieving minimal disease activity (MDA) is an important treatment goal in psoriatic arthritis (PsA), as it leads to improved clinical outcomes and quality of…
Abstract Number: 1038 • ACR Convergence 2023
Improved Assessment of Structural Damage in the Spine in Patients with Axial Spondyloarthritis by MRI-based Synthetic CT: A Comparison with Low-dose CT and X-ray
Simone Tromborg Willesen¹, Nora Vladimirova¹, Jakob Moeller², Anna Enevold Fløistrup Hadsbjerg¹, Bimal Mayur Kumar Vora³, Sengul Seven¹, Susanne Juhl Pedersen¹ and Mikkel Østergaard¹, ¹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet; University of Copenhagen, Copenhagen, Denmark, ²Herlev-Gentofte Hospital, Herlev, Denmark, ³Singapore General Hospital, Singapore, Singapore
Background/Purpose: Whether a therapy has bone structure-modifying effects in the spine is crucial to determine since this is a prerequisite for a therapy to reduce…

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