Abstracts tagged "osteoclastogenesis and rheumatoid arthritis (RA)"

Abstract Number: 840 • 2018 ACR/ARHP Annual Meeting
The CCL21/CCR7 Axis Drives Vascular, Inflammatory and Destructive Remodeling in Rheumatoid Arthritis
Katrien Van Raemdonck^1,2, Karol Palasiewicz^1,2, Sadiq Umar^1,2 and Shiva Shahrara², ¹Jesse Brown VA Medical Center, Chicago, IL, ²Medicine, Division of Rheumatology, University of Illinois at Chicago, Chicago, IL
Background/Purpose: The synovial tissue of rheumatoid arthritis (RA) patients exhibits abundant expression of CCL21, produced excessively by RA fibroblasts and macrophages. While CCR7 mediates CCL21-driven…
Abstract Number: 1099 • 2016 ACR/ARHP Annual Meeting
Synovial Exosomes Induce Osteoclast Differentiation in Rheumatoid arthritis
Ji Eun Song¹, Ji Hye Shin¹, Ki Won Moon², Se Hui Shon¹, Ji Soo Park³, Eun Bong Lee³, Yeong Wook Song^1,3 and Eun Young Lee³, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Republic of Korea, Seoul, Korea, The Republic of, ²Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Republic of Korea, Chuncheon, Korea, The Republic of, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Seoul, Korea, The Republic of
Background/Purpose: Exosomes are small membrane vesicles (40-150 nm) of endocytic origin secreted by many types of cells and engage in cell-to-cell communication by transferring proteins,…
Abstract Number: 1103 • 2016 ACR/ARHP Annual Meeting
Gingival Tissue-Derived MSC Cells (GMSC) Suppress Osteoclastogenesis and Bone Erosion in Collagen-Induced Arthritis Thought CD73 Signal Pathway
Yongjiang Zheng^1,2, Julie Wang³, Nancy J. Olsen⁴, Limin Rong¹ and Song Guo Zheng^4,5, ¹Center for Clinic Immunology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Guangzhou, China, ²Medicine, Penn State University Hershey Medical Center, Hershey, PA, ³Medicine, Penn State Hershey Medical Center, Hershey, PA, ⁴Medicine/Rheumatology, Penn State Hershey Medical Center, Hershey, PA, ⁵Medicine/Rheumatology, Penn State University Milton S. Hershey Medical Center, Hershey, PA
Background/Purpose: Rheumatoid arthritis (RA) is characterized by chronic inflammatory synovitis leading to joint destruction and systemic bone loss. Osteoclasts are responsible for bone destruction in…
Abstract Number: 2582 • 2016 ACR/ARHP Annual Meeting
N-Acetylcysteine Regulates Osteoclastogenesis and Th17 Cell Differentiation in Rheumatoid Arthritis
Kyung-Ann Lee¹, Hae-Rim Kim², Sang Heon Lee³, Bomi Kim⁴ and Kyoung-Woon Kim⁵, ¹Department of Nuclear medicine, Konkuk University Medical center, seoul, Korea, The Republic of, ²Division of Rheumatology, Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea, The Republic of, ³Department of Internal Medicine,Division of Rheumatology., Division of Rheumatology, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea, The Republic of, ⁴Convergent Research Consortium for Immunologic disease, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, The Republic of, ⁵Dept of Internal Medicine, Konkuk University Hospital, Seoul, South Korea
Background/Purpose: This study aimed to determine the regulatory role of N-Acetyl-L-cysteine (NAC), an antioxidant, in T cell and osteoclast differentiation in rheumatoid arthritis (RA). Methods:…
Abstract Number: 2716 • 2015 ACR/ARHP Annual Meeting
Dysregulated Osteoclastogenesis Is Related to Natural Killer T Cell Dysfunction in Rheumatoid Arthritis
Seung-Jung Kee¹, Hye Mi Jin², Jeong-Hwa Kang², Young-Nan Cho², Ki-Jeong Park², Hyun-Ju Jung² and Yong-Wook Park², ¹Laboratory Medicine, Chonnam National University Medical School and Hospital, Gwangju, South Korea, ²Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea
Background/Purpose: The aims of the present study were to investigate the role played by natural killer T (NKT) cells in osteoclastogenesis and their effects on…
Abstract Number: 1475 • 2014 ACR/ARHP Annual Meeting
Porphyromonas Gingivalis and Bone Turnover Biomarkers in Rheumatoid Arthritis
Manpreet Sethi¹, Anand Dusad¹, Harlan Sayles², Geoffrey Thiele³, Jeffrey Payne⁴, Michael J. Duryee⁵, Bart Hamilton⁶ and Ted R. Mikuls⁷, ¹Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ³Int Med/Sec of Rheum/Immun, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁴College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, ⁵Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁶University of Nebraska Medical Centre and Omaha VA Medical Center, Omaha, NE, ⁷Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Periodontitis (PD) associated with P. gingivalis has been implicated as a risk factor for rheumatoid arthritis (RA). We have previously demonstrated that RA patients…
Abstract Number: 1300 • 2013 ACR/ARHP Annual Meeting
The Role Of Celastrol On Osteoclastogenesis and Bone Erosion In Collagen-Induced Arthritis
Ke Gan^1,2, Wenfeng Tan³, Miaojia Zhang³, Xiaoke Feng⁴ and Lingxiao Xu³, ¹Rheumatology Department, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ²Nanjing University of Chinese Medicine, nanjing, China, ³Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA., Nanjing, China, ⁴Rheumatology, the First Affiliated Hospital of Nanjing Medical University, China, Nanjing, China
The Role of Celastrol on Osteoclastogenesis and Bone Erosion in Collagen-Induced ArthritisBackground/Purpose: Celastrus and its extract have been proven effective for treatment Rheumatoid arthritis (RA).…
Abstract Number: 2518 • 2012 ACR/ARHP Annual Meeting
The Sphingosine-1-Phosphate Pathway Is a Key Regulator of Bone Substrate-Mediated Osteoclast Differentiation in Inflammatory Arthritis
P. Edward Purdue¹, Jon Hill², Steven R. Goldring³, Nikolaus, B. Binder³, Jennifer L. Swantek⁴, Zhenxin Shen⁵, Tania N. Crotti⁵, Gerald H. Nabozny⁴ and Kevin P. McHugh⁵, ¹Research, Hospital for Special Surgery, New York, NY, ²Scientific Knowledge Discovery, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, ³Hospital for Special Surgery, New York, NY, ⁴Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁵Orthopedic Surgery, Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA
Background/Purpose: Multiple lines of evidence have established that osteoclasts are required for physiologic bone resorption and pathological bone loss in inflammatory disorders. Isolation of differentiated…
Abstract Number: 1804 • 2012 ACR/ARHP Annual Meeting
TNF-Like Protein 1A/Death Receptor 3 Pathway Regulates Osteoclastogenesis and Is Associated with Erosive Disease in Rheumatoid Arthritis
Fraser L. Collins¹, Michael D. Stone², Rhian Goodfellow³, Ernest Choy⁴, Edward C. Wang⁵ and Anwen S. Williams⁶, ¹Section of Rheumatology, Cardiff University, Institute of Infection and Immunity, Cardiff, United Kingdom, ²University Hospital Llandough, Cardiff & Vale University Health Board, Cardiff, United Kingdom, ³Section of Rheumatology, Cardiff University, Cardiff, ENGLAND, United Kingdom, ⁴Section of Rheumatology, Cardiff University School of Medicine, Cardiff, United Kingdom, ⁵Cardiff University, Institute of Infection and Immunity, Cardiff, United Kingdom, ⁶Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom
Background/Purpose: Bone erosion is a characteristic feature of inflammatory arthritides, such as rheumatoid arthritis (RA). Death Receptor 3 (DR3) and its only known ligand TNF-like…

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