Abstracts tagged "Osteoarthritis"

Abstract Number: 766 • 2013 ACR/ARHP Annual Meeting
Cholesterol Accumulation By Synovial Lining Macrophages Results In Ectopic Bone Formation During Experimental Osteoarthritis
Wouter de Munter¹, Arjen B. Blom¹, Monique M. Helsen¹, Birgitte Walgreen¹, Peter M. van Der Kraan¹, Leo A. Joosten², Wim B. van den Berg³ and Peter L. van Lent⁴, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ³Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands, ⁴Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Synovial macrophages have previously shown to play a significant role in the etiopathology of experimental collagenase-induced osteoarthritis (OA). In addition to production of pro-inflammatory…
Abstract Number: 161 • 2013 ACR/ARHP Annual Meeting
H3K9 Demethylation By LSD1 Contributes To IL-1-Induced mPGES-1 Expression In OA Chondrocytes
Fatima Ezzahra El Mansouri¹ and Hassan Fahmi², ¹Pharmacology, Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada, ²Pharmacology, Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada
Background/Purpose: Microsomal prostaglandin E synthase-1 catalyzes the terminal step in the biosynthesis of PGE2, which plays a critical role in the pathophysiology of osteoarthritis. To…
Abstract Number: 2121 • 2013 ACR/ARHP Annual Meeting
Total Hip Arthroplasty Outcomes In Patients With Psoriatic Arthritis, Osteoarthritis With Cutaneous Psoriasis, and Osteoarthritis
Lisa A. Mandl¹, Rebecca Zhu², Wei-Ti Huang³, Michael Alexiades⁴, Mark P. Figgie⁵ and Susan M. Goodman¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Clinical Research, Hospital for Special Surgery, New York, NY, ³Biostatistics, Hospital for Special Surgery, New York, NY, ⁴Orthopaedics, Hospital for Special Surgery, New York, NY, ⁵Orthopedics, Hospital for Special Surgery, New York, NY
Background/Purpose: Outcomes of total hip replacements (THR) in psoriatic arthritis (PsA) are poorly studied. Previous studies are conflicting, often not separating inflammatory PsA from osteoarthritis…
Abstract Number: 261 • 2013 ACR/ARHP Annual Meeting
Concordance Of Hip Pain With Radiographic Hip Osteoarthritis In An Urban US Community: The Framingham Osteoarthritis Study
Kyu Chan Kim¹, David T. Felson², Katherine D. Linsenmeyer³, Ali Guermazi⁴, Steven C. Vlad⁵, Mary M. Clancy⁶ and Jingbo Niu⁷, ¹Internal Medicine and Rheumatology, Boston Medical Center, Boston, MA, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Internal Medicine, Boston Medical Center, Boston, MA, ⁴Boston University, Boston, MA, ⁵Clinical Epidemiology, Boston University, Boston, MA, ⁶School of Medicine, Boston University, Boston, MA, ⁷Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: While it is well known that knee pain and radiographic knee osteoarthritis (OA) are often discordant, little is known of the concordance of hip…
Abstract Number: 150 • 2013 ACR/ARHP Annual Meeting
A Subset Of Osteoarthritis Individuals Has Elevated IL-6 Pathway Activation Associated With Worse Symptoms
Michael Kuziora¹, Zheng Liu², Brandon W. Higgs², Philip Brohawn², Kim Lehmann², Fernanda Pilataxi², Katie Streicher², Lydia Greenlees¹, Meina Liang³, Rozanne Lee⁴, Amy Schneider⁴, Raffaella Faggioni⁴, Yihong Yao² and Koustubh Ranade², ¹Translational Science, MedImmune, LLC, Gaithersburg, MD, ²Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ³Dmpk, MedImmune, LLC, Hayward, CA, ⁴DMPK, MedImmune, LLC, Hayward, CA
Background/Purpose: Elevated levels of the pro-inflammatory cytokine IL-6 have been found in the affected joint of patients with osteoarthritis (OA), although the prevalence of OA…
Abstract Number: 2103 • 2013 ACR/ARHP Annual Meeting
Relationships Between Self-Efficacy, Outcome Expectancy, and Outcomes In Older Adults With Osteoarthritis Of The Knee and Hypertension: Baseline Results
Elizabeth A. Schlenk¹, Deborah Crowley-Lisowski¹, Sarah Twerski¹, Alice Fallon¹, Alyssa Sartore¹, Susan Sereika¹, Joan Rogers², G. Kelley Fitzgerald³ and C. Kent Kwoh⁴, ¹School of Nursing, University of Pittsburgh, Pittsburgh, PA, ²School of Health and Rehabilitation Sciences, Occupational Therapy, University of Pittsburgh, Pittsburgh, PA, ³School of Health and Rehabilitation Sciences, Physical Therapy, University of Pittsburgh, Pittsburgh, PA, ⁴School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Staying Active with Arthritis (STAR), an intervention guided by Bandura’s Self-Efficacy Theory, is being investigated in an ongoing clinical trial of an individually delivered,…
Abstract Number: 263 • 2013 ACR/ARHP Annual Meeting
“Generalized Osteoarthritis”: A Systematic Review
Amanda E. Nelson¹, Michael W. Smith² and Yvonne M. Golightly³, ¹University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, ²Rheumatology, Saint Luke's Hospitals, Kansas City, MO, ³Gillings School of Global Public Health, Dept of Epidemiology, Thurston Arthritis Research Center, Injury Prevention Research Center, University of North Carolina Dept of Epidemiology, Chapel Hill, NC
Background/Purpose: To perform a systematic review of definitions, risk factors, and outcomes in "generalized osteoarthritis" (GOA). Methods: We performed a systematic review of Medline literature…
Abstract Number: 2108 • 2013 ACR/ARHP Annual Meeting
Pre- and Postoperative Physical Therapy In Total Hip and Knee Replacement Surgery: A Multi Center Study
Wilfred FH Peter^1,2, Claire Tilbury³, Rutger Tordoir⁴, Suzan Verdegaal⁵, Ron Onstenk⁶, Menno Benard⁷, Stephan Vehmeijer⁸, Enrike van der Linden-van der Zwaag¹, Eric Vermeulen¹, Rob Nelissen¹ and Thea VlietVlieland⁹, ¹Department of Orthopaedics, Leiden University Medical Center, Leiden, Netherlands, ²Reade, center for rehabilitation and rheumatology, Amsterdam, Nicaragua, ³Departement of Orthopedics, Leiden University Medical Center, Leiden, Netherlands, ⁴Departement of orthopedics, Rijnland Hospital, Leiderdorp, Netherlands, ⁵Departement of Orthopedics, Rijnland Hospital, Leiderdorp, Netherlands, ⁶Department of Orthopedics, Het Groene Hart Hospital, Gouda, Netherlands, ⁷Departement of Orthopedics, Reinier de Graaf Hospital, Delft, Netherlands, ⁸Department of Orthopedics, Reinier de Graaf Hospital, Delft, Netherlands, ⁹Department of Orthopaedics, Leids University Medical Center, Leiden, Netherlands
Background/Purpose: Physical therapy shown to be effective after Total Hip and Knee Arthroplasty. Less evidence is available for preoperative physical therapy in Total Hip and…
Abstract Number: 264 • 2013 ACR/ARHP Annual Meeting
The Proportion Of Knee Osteoarthritis Patients In Southern Sweden That Seek Medical Car
Aleksandra Turkiewicz¹, Maria Gerhardsson de Verdier², Gunnar Engström³, Stefan Lohmander¹ and Martin Englund¹, ¹Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden, ²Astra Zeneca R&D Molndal, Molndal, Sweden, Molndal, Sweden, ³Dept of Cardiovascular epidemiology, Clinical Sciences, Lund University, Lund, Sweden
Background/Purpose: To provide estimates of the proportion of subjects with knee osteoarthritis (OA) that seek healthcare for knee OA or joint pain within an 8-year…
Abstract Number: 1099 • 2012 ACR/ARHP Annual Meeting
Whole Blood Lead Is Associated with Symptoms, but Not Radiographic Osteoarthritis, in Multiple Joint Sites: The Johnston County Osteoarthritis Project
Amanda E. Nelson¹, Xiaoyan A. Shi², Todd A. Schwartz³, Jordan B. Renner⁴, Kathleen L. Caldwell⁵, Charles G. Helmick⁶ and Joanne M. Jordan⁷, ¹University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, ²SAS Institute, Inc, Cary, NC, ³University of North Carolina Gillings School of Global Public Health, Dept of Biostatistics, Chapel Hill, NC, ⁴University of North Carolina School of Medicine, Dept of Radiology, Chapel Hill, NC, ⁵Centers for Disease Control and Prevention, Atlanta, GA, ⁶National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, ⁷Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: We have previously identified associations between whole blood lead (Pb) and knee osteoarthritis (OA) and with biomarkers of joint metabolism. We hypothesized that Pb…
Abstract Number: 272 • 2012 ACR/ARHP Annual Meeting
Interim Safety Analysis of a Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy Study of Apremilast (CC10004) in Subjects with Erosive Hand Osteoarthritis
Juergen Rech¹, Wolfgang Ochs², Wolfgang Spieler³, Herbert Kellner⁴, Ulf Müller-Ladner⁵, Mathias Grunke⁶, Matthias Schneider⁷ and Georg Schett⁸, ¹Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ²Rheumatologist in private practice, Bayreuth, Germany, ³Rheumatology Specialty Practice, Zerbst, Germany, ⁴Centre for Inflammatory Joint Diseases, Munich, Germany, ⁵Abt. f. Rheumatologie u. klinische Immunologie, Osteologie, Physikalische Therapie, Kerckhoff-Klinik GmbH, Bad Nauheim, Germany, ⁶Division of Rheumatology, Medizinische Klinik und Poliklinik IV, University of Munich, Munich, Germany, ⁷Department of Endocrinology, Diabetes and Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany, ⁸Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Apremilast is a small molecule,specific phospodiesterase4 inhibitor under investigation for a number of inflammatory conditions, including psoriasis and psoriatic arthritis. We report results of…
Abstract Number: 2517 • 2012 ACR/ARHP Annual Meeting
Inhibition of Notch Signaling Increases the Severity of Experimental Osteoarthritis
Neng-Yu Lin¹, Alfiya Distler¹, Christian Beyer², Clara Dees³, Jingang Huang³, Francesco Dell'Accio⁴, Oliver Distler⁵, Georg A. Schett⁶ and Joerg HW Distler¹, ¹Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴William Harvey Research Institute, Barts and the London Queen Mary's School of Medicine and Dentistry, Centre for Experimental Medicine and Rheumatology, London, United Kingdom, ⁵Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁶Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Notch signaling is triggered by binding of ligands such as Jagged-1 (Jag-1) to Notch receptors, which results in cleavage of Notch receptors by the…
Abstract Number: 1103 • 2012 ACR/ARHP Annual Meeting
Cumulative Occupational Physical Load As Risk Factor for Knee Osteoarthritis
Allison M. Ezzat¹, Jolanda Cibere², Mieke Koehoorn³, Eric C. Sayre⁴ and Linda C. Li⁵, ¹School of Rehabilitation Science, University of British Columbia, Vancouver, BC, Canada, ²Division of Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada, ³University of British Columbia, Vancouver, BC, Canada, ⁴Arthritis Research Centre of Canada, Vancouver, BC, Canada, ⁵Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Knee osteoarthritis (OA) results from the interaction of multiple risk factors, one of which may be physically demanding occupations. The purpose of this study…
Abstract Number: 248 • 2012 ACR/ARHP Annual Meeting
Synovial Fluid Leptin Level Is Associated with Residual Pain and Functional Disability One Year After Total Joint Arthroplasty
Anne Lübbeke¹, Gabor J. Puskas¹, Axel Finckh², Domizio Suva¹, Sylvette Bas³, Cem Gabay³, Daniel Fritschy¹ and Pierre Hoffmeyer¹, ¹Orthopaedic Surgery, Geneva University Hospitals, Geneva, Switzerland, ²Rheumatology, Geneva University Hospitals, Geneva 14, Switzerland, ³Rheumatology, Geneva University Hospitals, Geneva, Switzerland
Background/Purpose: A sizeable number of patients continue to suffer from pain, functional disability and reduced quality of life after total joint arthroplasty (TJA). The etiology…
Abstract Number: 2469 • 2012 ACR/ARHP Annual Meeting
A Virtual Knee Joint Replacement Clinical Endpoint Based On Longitudinal Trends and Thresholds in Koos Knee Pain and Function in Osteoarthritis Initiative Participants
Robert M. Boudreau¹, David J. Hunter², Zhijie Wang³, Frank Roemer⁴, Felix Eckstein⁵, Michael J. Hannon³, Ali Guermazi⁶ and C. Kent Kwoh⁷, ¹Epidemiology, University of Pittsburgh, Pittsburgh, PA, ²Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ³Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴Radiology, Boston University School of Medicine, Boston, MA, ⁵Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ⁶Boston University, Boston, MA, ⁷School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Knee joint replacement (KR) is a cost-effective procedure with good long-term outcomes, but has limitations as an endpoint in OA intervention trials. A definition…

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