Abstracts tagged "Osteoarthritis"

Abstract Number: 222 • 2014 ACR/ARHP Annual Meeting
OA Phenotypes Rather Than Disease Stage Drive Structural Progression – Identification of Structural Progressors from 2 Phase III Randomized Clinical studies with Symptomatic Knee OA
Morten Asser Karsdal¹, Anne C. Bay-Jensen², Asger Bihlet³, Peter Alexandersen⁴, Inger Byrjalsen³, Bente J. Riis³ and Claus Christiansen³, ¹Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ²Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ³Nordic Bioscience, Herlev, Denmark, ⁴Center for Clinical and Basic Research, Vejle, Denmark
Background/Purpose: Osteoarthritis (OA) is a heterogeneous disorder, with several possible drivers of disease progression. Up to 50% of OA patients do not structurally progress, emphasizing…
Abstract Number: 2141 • 2014 ACR/ARHP Annual Meeting
Sensitivity to Change of Joint Space Width Measurements in Hand Osteoarthritis in a Two Year Follow-up Study
W. Damman¹, S.E. de Bruin¹, B.C. Stoel², R. van 't Klooster² and M. Kloppenburg¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Cartilage loss, represented by joint space width (JSW) on radiographs, is an important outcome measure in hand OA disease course. JSW can be assessed…
Abstract Number: 219 • 2014 ACR/ARHP Annual Meeting
DXA Body Composition, Sarcopenia and Knee and Hip Osteoarthritis: Results from the Khoala Cohort
Clémence Jeanmaire¹, Isabelle Chary-Valkenaere¹, Damien Loeuille², Lorraine Bernard³ and Anne-Christine Rat,⁴, ¹Rheumatology, CHU Nancy, Vandoeuvre Les Nancy, France, ²Rheumatology, CHU Brabois, Vandoeuvre les Nancy, France, ³CHU Nancy, Pôle S2R, Epidémiologie et Evaluation Cliniques, INSERM, CIC-EC, CIE6, Vandoeuvre Les Nancy, France, ⁴Université de Lorraine, Nancy, F-54000, France; Inserm, , CIC-EC, CIC 1433, Nancy, F-54000, France; CHU de Nancy, Clinical Epidemiology and Evaluation Department, Nancy, F-54000, France; CHU de Nancy, Rheumatology department, Nancy, France
Background/Purpose Obesity is a well known risk factor for the development and progression of knee osteoarthritis (OA), and to a lesser extent of hip OA.…
Abstract Number: 1969 • 2014 ACR/ARHP Annual Meeting
Neurotrophin Receptor p75 (CD271) Defines a Distinct Synovial Fibroblast Subset in Rheumatoid and Osteoarthritic Synovial Tissues with Enhanced Proinflammatory Potential
Manuel J. Del Rey¹, Regina Faré¹, Gabriel Criado², Alicia Usategui¹, Vanessa Miranda¹, Juan D. Cañete³ and Jose L. Pablos¹, ¹Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ²Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ³Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain
Background/Purpose Synovial mesenchynmal or stromal cells constitute a heterogeneous cell population difficult to characterize ex vivo due to a paucity of cell markers and are…
Abstract Number: 207 • 2014 ACR/ARHP Annual Meeting
Changes in Knee Compartment Distriubtion of Cartilage Loss and Bone Marrow Lesions over 7 Years: The MOST Study
Joshua Stefanik¹, Ali Guermazi², Jingbo Niu³, Frank Roemer⁴, C.E. Lewis⁵, Neil A. Segal⁶, Michael Nevitt⁷ and David T. Felson⁸, ¹Clinical Epidemiology, Boston University, Boston, MA, ²Radiology, Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University, Boston, MA, ⁴Klinikum Augsburg, Augsburg, Germany, ⁵University of Alabama at Birmingham, Birmingham City, AL, ⁶Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, ⁷Epidemiology and Biostatistics, UCSF, San Francisco, CA, ⁸Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Knee osteoarthritis (OA) occurs in both the patellofemoral joint (PFJ) and tibiofemoral joint (TFJ). Little is known about the natural history of OA and…
Abstract Number: 1820 • 2014 ACR/ARHP Annual Meeting
Discordance of Hip Pain with Radiographic Hip Osteoarthritis: The Osteoarthritis Initiative
Chan Kim¹, Michael C. Nevitt², Pia M. Jungmann³, Irina Tolstykh⁴, Nancy E. Lane⁵, Thomas M. Link⁶ and David T. Felson⁷, ¹Rheumatology, Boston University, Boston, MA, ²Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ³Radiology, Technische Universitaet Muenchen, Munich, Germany, ⁴Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁵Internal Medicine, Center for Musculoskeletal Health, UC Davis School of Medicine, Sacramento, CA, ⁶Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, ⁷Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom
Background/Purpose It is assumed that persons with hip pain from osteoarthritis (OA) are likely to have radiographic OA, making it possible to readily diagnose disease,…
Abstract Number: 200 • 2014 ACR/ARHP Annual Meeting
Leg Length Inequality and Hip Osteoarthritis
Chan Kim¹, Jingbo Niu², Mary Clancy³, Ali Guermazi⁴, Michael C. Nevitt⁵, Neil A. Segal⁶, William F. Harvey⁷, Cora E Lewis⁸ and David T. Felson⁹, ¹Rheumatology, Boston University, Boston, MA, ²Clinical Epidemiology Research and Training Unit, Boston University, Boston, MA, ³Clinical Epidemiology, Boston University Sch Med, Boston, MA, ⁴Radiology, Boston University School of Medicine, Boston, MA, ⁵Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁶Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, ⁷Rheumatology, Tufts Medical Center, Boston, MA, ⁸Division of Preventive Medicine, University of Alabama Birmingham School of Medicine, Birmingham, AL, ⁹Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom
Background/Purpose Leg length inequality (LLI), a side-to-side difference in lower limb lengths, is common. In the Multicenter Osteoarthritis Study (MOST), in persons with LLI, the…
Abstract Number: 1800 • 2014 ACR/ARHP Annual Meeting
Objectively Measured Sedentary Behavior Is a Distinct Risk Factor from Low Moderate-to-Vigorous Activity in Predicting Subsequent Frailty: Evidence from Osteoarthritis Initiative
Jing Song¹, Lee A. Lindquist¹, Rowland W. Chang¹, Pamela A. Semanik², Linda S. Ehrlich-Jones³, Jungwha Lee⁴, Min-Woong Sohn¹ and Dorothy D. Dunlop¹, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Rush University Medical Center, Chicago, IL, ³Rehabilitation Institute of Chicago, Chicago, IL, ⁴Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Physical frailty represents a state of high vulnerability for adverse health outcomes including disability and mortality. Physical activity interventions to improve health have largely…
Abstract Number: 197 • 2014 ACR/ARHP Annual Meeting
Differences in Total Hip Replacement Outcomes Based on Age
Leslie Harrold¹, David Ayers², Wenjun Li², Courtland Lewis³, Philip Noble⁴, Regis O'Keefe⁵, Jeroan Allison⁶ and Patricia D. Franklin², ¹Department of Orthopedics and Medicine, University of Massachusetts Medical School, Worcester, MA, ²Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ³Hartford Hospital, Hartford, CT, ⁴Baylor College of Medicine, Houston, TX, ⁵University of Rochester Medical Center, Rochester, NY, ⁶Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: The fastest growing segment of patients who undergo total hip replacement (THR) are younger than 130 surgeons across 22 states in the US. The…
Abstract Number: 1420 • 2014 ACR/ARHP Annual Meeting
Non-Use of Glucocorticoid and Osteoarthritis Absence As Predictors of Clinical Remission in AR
Salvador Loredo-Alanís¹, David Vega-Morales², Mario Garza-Elizondo¹, Mario Garcia-Pompermayer³, Roberto Negrete-López¹, Daniel Treviño-Montes¹ and Diana Flores-Alvarado², ¹Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Servicio de Reumatología, Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, Mexico, ²Rheumatology, Hospital Universitario UANL, Monterrey, Mexico, ³Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Servicio de Reumatología, Departamento de Medicina Interna del Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterey, Mexico
Background/Purpose The clinical evaluation of Rheumatoid arthritis (RA) is accomplished with compound indexes allowing better clinical decision. Clinical remission nowadays is an attainable target in…
Abstract Number: 187 • 2014 ACR/ARHP Annual Meeting
Revision Arthroplasty in Rheumatoid and Osteoarthritis: Does Methotrexate Decrease Radiographic Lucency in RA Patients?
Mike Wei¹, Douglas N. Mintz², Lisa A. Mandl³, Arielle Fein⁴, Jayme C. Burket⁵, Yuo-Yu Lee⁴, Wei-Ti Huang⁶, Vivian P. Bykerk⁴, Mark P. Figgie⁷, Edward F. DiCarlo⁸, Bruce N. Cronstein⁹ and Susan M. Goodman³, ¹Weill Cornell Medical College, New York, NY, ²Radiology, Hospital for Special Surgery, New York, NY, ³Rheumatology, Hospital for Special Surgery, New York, NY, ⁴Hospital for Special Surgery, New York, NY, ⁵Healthcare Research Institute, Hospital for Special Surgery, New York, NY, ⁶Biostatistics, Hospital for Special Surgery, New York, NY, ⁷Orthopedics, Hospital for Special Surgery, New York, NY, ⁸Pathology, Hospital for Special Surgery, New York, NY, ⁹NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose Rheumatoid arthritis (RA) patients have excellent total hip arthroplasty (THA) survival, and methotrexate (MTX), an anti-inflammatory disease modifying drug which may affect bone reabsorption,…
Abstract Number: 1291 • 2014 ACR/ARHP Annual Meeting
Relationships Between Inflammation, Disease Severity and Synovial Fluid Calcium Crystals Detected By Scanning Electronic Microscopy in Early Osteoarthritis
Paola Frallonardo¹, Francesca Oliviero¹, Luca Peruzzo², Leonardo Tauro³, Anna Scanu¹, Mariagrazia Lorenzin¹, Augusta Ortolan¹, Leonardo Punzi⁴ and Roberta Ramonda¹, ¹Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, ²Institute for Geosciences and Earth Resources IGG-CNR, Padova, Italy, ³Department of Geosciences, University of Padova, Padova, Italy, ⁴Department of Medicine - DIMED, University of Padova, Padova, Italy
Background/Purpose The presence of calcium crystals (CC) in synovial fluid (SF) of osteoarthritis (OA) is a well known and frequent feature (1). However, their role…
Abstract Number: 108 • 2014 ACR/ARHP Annual Meeting
Patient Reported Outcomes Following Total Knee Arthroplasty in Rheumatoid Arthritis and Osteoarthritis
Anand Dusad¹, Sofia Pedro², Kevin Garvin³, Curtis Hartman⁴, James O'Dell⁵, Ted R. Mikuls⁵ and Kaleb Michaud⁶, ¹Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²National Data Bank for Rheumatic Diseases, Wichita, KS, ³Orthopaedic Surgery, University of Nebraska Medical Center, Omaha, NE, ⁴Orthopaedic Surgery and Rehabilitation, University of Nebraska Medical Center, Omaha, NE, ⁵University of Nebraska Medical Center, Omaha, NE, ⁶University of Nebraska Medical Center and National Data Bank, Omaha, NE
Background/Purpose: Due to the progressive and debilitating nature of knee arthritis, total knee arthroplasty (TKA) is the ultimate outcome. TKA is an effective surgical intervention…
Abstract Number: 1284 • 2014 ACR/ARHP Annual Meeting
Sensitivity to Change of Patient Preference Outcome Measures for Pain in Trials of Patients with Knee Osteoarthritis
Matthew J. Parkes¹, Michael J. Callaghan¹, Terence W. O'Neill¹ and David T. Felson^1,2, ¹Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA
Background/Purpose A variety of pain and function instruments are often measured in osteoarthritis (OA) clinical trials. Instruments with maximal sensitivity to change are preferred as the…
Abstract Number: 76 • 2014 ACR/ARHP Annual Meeting
Identification of Synovial Genes and Pathways Associated with Disease Progression in a Cohort of Early Symptomatic Osteoarthritis Patients Using a Transcriptomic Approach
Arjen B. Blom¹, Peter L. van Lent¹, Martijn H. van den Bosch², Hans Cats³, Frank H.J. van den Hoogen⁴, Floris P.J.G. Lafeber⁵, Wim B. van den Berg¹ and Peter M. van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands, ³Hengstdal 3, Sint Maartenskliniek, Ubbergen, Netherlands, ⁴Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, ⁵Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: If and how the synovial activation that is observed in over 50% of osteoarthritis (OA) patients contributes to irreversible joint pathology, is not known.…

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