Abstracts tagged "Osteoarthritis"

Abstract Number: 1198 • 2012 ACR/ARHP Annual Meeting
Cardiovascular Risk Factors and Events Are More Frequent Prior to the Onset of Rheumatoid Arthritis Than in the General Population
Helen Pahau Sr.¹, Vibeke Videm², Sanjoy Paul³ and Ranjeny Thomas⁴, ¹Diamantina Institute, University of Queensland Diamantina Institute, Brisbane, Australia, ²Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, and Department of Immunology and Transfusion Medicine, Trondheim University Hospital,, Trondheim, Norway, ³University of Queensland School of Population Health, Brisbane, Australia, ⁴University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose: Patients with the inflammatory autoimmune disease Rheumatoid Arthritis (RA) have a higher mortality and morbidity than the general population, predominantly related to cardiovascular disease…
Abstract Number: 919 • 2012 ACR/ARHP Annual Meeting
Sedentary Time, Physical Activity, and Concurrent Blood Pressure in Osteoarthritis Initiative Participants
Min-Woong Sohn¹, Rowland W. Chang², Grace Ahn³, Linda S. Ehrlich-Jones⁴, Marc C. Hochberg⁵, Jungwha Lee⁶, Michael C. Nevitt⁷, Pamela A. Semanik⁸, Jing Song⁶, Kai Sun⁹ and Dorothy D. Dunlop², ¹Institute for Public Health and Medicine, Northwestern University, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³Rheumatology, Northwestern University, Chicago, IL, ⁴Research CROR, Rehabilitation Institute Chicago, Chicago, IL, ⁵Department of Medicine, University of Maryland, Baltimore, MD, ⁶Northwestern University, Chicago, IL, ⁷Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁸Northwestern University, IL, ⁹Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL
Background/Purpose: The inactivity physiology hypothesis suggests that sedentarism is a cardiovascular risk factor independent of time spent in moderate-vigorous activity (MV). Previous research suggests that…
Abstract Number: 105 • 2012 ACR/ARHP Annual Meeting
Combined Synovial and Structural Ultrasound Score for the Diagnosis of RA
Gary A. Kunkel¹, Grant W. Cannon² and Daniel O. Clegg³, ¹Div of Rheumatology, George Wahlen Veterans Affairs Medical Center, Salt Lake City, UT, ²Division of Rheumatology, George E. Wahlen VA Medical Center, Salt Lake City, UT, ³Division of Rheumatology, George E. Wahlen Veteran Affairs Medical Center, Salt Lake City, UT
Background/Purpose: Current ultrasonographic scoring systems used to assess the degree of finger joint synovitis in rheumatoid arthritis (RA) are not designed for distinguishing healthy or…
Abstract Number: 1136 • 2012 ACR/ARHP Annual Meeting
Aesthetic Dissatisfaction in Hand Osteoarthritis Patients, Its Impact and Risk Factors
R. Liu, L.J.J. Beaart-van de Voorde, T.W.J. Huizinga and M. Kloppenburg, Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Hand osteoarthritis (HOA) leads to aesthetic damage and is rarely studied. We aim to investigate in HOA patients the prevalence of dissatisfaction with the…
Abstract Number: 895 • 2012 ACR/ARHP Annual Meeting
Transcriptomics of Synovial Tissue of Early Human (CHECK) and Experimental OA Identify Pathways Associated with Cartilage Damage
Arjen B. Blom¹, Peter L.E.M. van Lent², Martijn H. van den Bosch¹, Hans Cats³, Peter M. van der Kraan¹ and Wim B. van den Berg⁴, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology, Rheumatology Centre Sint Maartenskliniek, Nijmegen, Netherlands, ⁴Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Many osteoarthritis (OA) patients show synovial inflammation, even relatively early during the disease. Mechanisms through which synovial activation contributes to the joint pathology that…
Abstract Number: 46 • 2012 ACR/ARHP Annual Meeting
Synovitis in Secondary Osteoarthritis Due to Rheumatoid Arthritis: A Proof-of-Concept Study
Stefan Vordenbäumen¹, Tim Lögters², Philipp Sewerin¹, Thomas Pauly³, Ellen Bleck⁴, Paulina Philippski¹, Matthias Schneider¹, Michael Schädel-Höpfner² and Benedikt Ostendorf¹, ¹Endocrinology, Diabetology and Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany, ²Trauma and Hand Surgery, Heinrich-Heine-University, Düsseldorf, Germany, ³Orthopaedics, Rheinisches Rheumazentrum St. Elisabeth-Hospital, Meerbusch, Germany, ⁴Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany
Background/Purpose: Rheumatoid arthritis (RA) is characterized by considerable synovial inflammation which may result in secondary osteoarthritis (sOA). Primary OA (pOA) occurs in patients without predisposing…
Abstract Number: 1138 • 2012 ACR/ARHP Annual Meeting
Nonpharmacologic and Pharmacologic Therapy Utilization by Primary Care Providers for Hand Osteoarthritis-Comparative Review by Electronic Health Record Data Mining and in-Home Visit Verification
Gale A. McCarty, President, Rheum.Ed Consulting, Harborside, ME
Background/Purpose: To compare current utilization of usual nonpharmacologic (NP) and pharmacologic (P) therapies for hand osteoarthritis (OA) by primary care providers (PCPs) and patients (Pts)…
Abstract Number: 908 • 2012 ACR/ARHP Annual Meeting
Race, Gender and Total Knee Replacement Consideration: The Role of Social Support
Ernest R. Vina¹, Yona Cloonan², Said Ibrahim³, Michael J. Hannon⁴, Robert M. Boudreau⁵ and C. Kent Kwoh⁶, ¹Division of Rheumatology and Clinical Immunology, University of Pittsburgh and VA Healthcare System, Pittsburgh, PA, ²Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, ³Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ⁴Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁵Epidemiology, University of Pittsburgh, Pittsburgh, PA, ⁶School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: There is marked variation in patient preference (i.e. willingness) regarding total knee replacement (TKR), an effective treatment option for end-stage osteoarthritis (OA). Studies have…
Abstract Number: 17 • 2012 ACR/ARHP Annual Meeting
Synovial Overexpression of Wnt and Wnt-1-Induced Secreted Protein 1 Induces Cartilage Damage by Skewing of TGF-Beta Signaling and Reduction of the Anti-Hypertrophy Factor Sox9
Martijn H. van den Bosch¹, Arjen B. Blom¹, Peter L. van Lent², Henk M. van Beuningen¹, Fons A. van de Loo³, Esmeralda N. Blaney Davidson¹, Peter M. van der Kraan¹ and Wim B. van den Berg⁴, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁴Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Although many osteoarthritis (OA) patients show significant synovial involvement, consequences are largely unknown. We found highly increased expression of canonical Wnts 2b and 16…
Abstract Number: 1123 • 2012 ACR/ARHP Annual Meeting
Comparison of Anatomic Knee Alignment On Physical Examination and Radiographs
Iman Hemmati¹, Eric C. Sayre², Ali Guermazi³, Savvakis Nicolaou⁴, Anona Thorne⁵, Joel Singer⁶ and Jolanda Cibere⁷, ¹Deparment of Medicine and Rheumatology, University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Centre of Canada, Vancouver, BC, Canada, ³Radiology, Boston University, Boston, MA, ⁴Department of Radiology, University of British Columbia, Vancouver, BC, Canada, ⁵School of Population and Public Health, University of British Columbia, Canadian Institutes of Health Research HIV Trials Network, Vancouver, BC, Canada, ⁶School of Population and Public Health, University of British Columbia, University of British Columbia, Vancouver, BC, Canada, ⁷Division of Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada
Background/Purpose: Severity of knee malalignment is a risk factor for osteoarthritis (OA) progression. Currently the hip-knee-angle (mechanical axis), assessed on a full-limb radiograph, is the…
Abstract Number: 795 • 2012 ACR/ARHP Annual Meeting
Racial Differences in Pain Coping Efficacy in Patients with Hip and Knee Osteoarthritis
Kelli D. Allen¹, Hayden B. Bosworth², Cynthia Coffman², Jennifer H. Lindquist³, Nina R. Sperber¹, Morris Weinberger⁴ and Eugene Z. Oddone¹, ¹Health Services Research, Duke and Durham VA Medical Center, Durham, NC, ²Health Services Research, Durham VA Medical Center and Duke University Medical Center, Durham, NC, ³Health Services Research, Durham VA Medical Center, Durham, NC, ⁴Health Services Research, University of North Carolina at Chapel Hill & Durham VA Medical Center, Durham, NC
Background/Purpose: Studies have shown that African Americans with osteoarthritis (OA) have greater pain than Caucasians. However, little is known about whether there are racial differences…
Abstract Number: 18 • 2012 ACR/ARHP Annual Meeting
Identification of 14-3-3å As a New Subchondral Bone Mediator Involved in Cartilage Degradation During Osteoarthritis
Sabrina Priam Jr.¹, Carole Bougault¹, Xavier Houard², Marjolaine Gosset³, Colette Salvat⁴, Francis Berenbaum⁵ and Claire Jacques¹, ¹Ur-4, Pierre et Marie Curie University Paris VI, Paris, France, ²Sorbonne Universités, UPMC Univ Paris 06, UMRS 938 and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris, France, ³EA 2496, Paris Descartes University, Montrouge, France, ⁴UR4, University Pierre and Marie Curie, Paris, France, ⁵Rheumatology, AP-HP, St Antoine Hospital, Paris, France
Background/Purpose: OA is a complex disease not limited to cartilage degeneration. Indeed, several experiments suggest that subchondral bone remodeling could initiate and/or contribute to cartilage…
Abstract Number: 1129 • 2012 ACR/ARHP Annual Meeting
Prevalence of Symptomatic Basilar Thumb Joint Osteoarthritis in the General Population
Jennifer Moriatis Wolf¹, Aleksandra Turkiewicz², Isam Atroshi³ and Martin Englund², ¹Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, ²Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden, ³Department of Orthopedics Hässleholm-Kristianstad, Lund University, Hässleholm, Sweden
Prevalence of symptomatic basilar thumb joint osteoarthritis in the general population Background/Purpose: While the radiographic prevalence of basilar thumb osteoarthritis (OA) is well described, little…
Abstract Number: 799 • 2012 ACR/ARHP Annual Meeting
Does Unpredictable Intermittent Knee Pain Limit Functional Ability and Walking Frequency in Knee OA?
Daniel K. White¹, Gillian A. Hawker², David T. Felson³, K. Douglas Gross⁴, Jingbo Niu⁵, Michael C. Nevitt⁶, C.E. Lewis⁷, James Torner⁸ and Tuhina Neogi⁹, ¹Department of Physical Therapy, University of Delaware, Newark, DE, ²Women's College Research Institute, University of Toronto, Toronto, ON, Canada, ³Boston University, Boston, MA, ⁴Physical Therapy, MGH Institute of Health Professions, Boston, MA, ⁵Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁶Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁷University of Alabama, Birmingham City, AL, ⁸Epidemiology, University of Iowa, Iowa City, Iowa City, IA, ⁹Boston University School of Medicine, Boston, MA
Background/Purpose: People with knee osteoarthritis (OA) reported that unpredictable pain restricts their ability to engage in physical activities in a qualitative study. Since walking is…
Abstract Number: 1131 • 2012 ACR/ARHP Annual Meeting
Intraarticular Infliximab for Knee Osteoarthritis: High Baseline Levels of Synovial Cellularity and High MRI Cartilage Injury At the Lateral Tibial Plateau Predict Improvement in Total WOMAC Score
Jeremy R. Schue¹, Ossama Tawfik², Rebecca Bolce³, Donald D. Smith¹, Gary Hinson⁴, Jo A. Wick⁵ and Herbert B. Lindsley⁶, ¹Internal Medicine, Kansas University Med Ctr, Kansas City, KS, ²Pathology, Kansas University Med Ctr, Kansas City, KS, ³Crescendo Bioscience Inc., South San Francisco, CA, ⁴Radiology, Kansas University Med Ctr, Kansas City, KS, ⁵Biostatistics, Kansas University Med Ctr, Kansas City, KS, ⁶Medicine, Kansas University Med Ctr, Kansas City, KS
Background/Purpose: Synovial tissue from patients with OA often demonstrates inflammation. We hypothesized that a single intraarticular (IA) injection of an anti-TNF drug would decrease inflammatory…

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