Abstracts tagged "Osteoarthritis"

Abstract Number: 1123 • 2012 ACR/ARHP Annual Meeting
Comparison of Anatomic Knee Alignment On Physical Examination and Radiographs
Iman Hemmati¹, Eric C. Sayre², Ali Guermazi³, Savvakis Nicolaou⁴, Anona Thorne⁵, Joel Singer⁶ and Jolanda Cibere⁷, ¹Deparment of Medicine and Rheumatology, University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Centre of Canada, Vancouver, BC, Canada, ³Radiology, Boston University, Boston, MA, ⁴Department of Radiology, University of British Columbia, Vancouver, BC, Canada, ⁵School of Population and Public Health, University of British Columbia, Canadian Institutes of Health Research HIV Trials Network, Vancouver, BC, Canada, ⁶School of Population and Public Health, University of British Columbia, University of British Columbia, Vancouver, BC, Canada, ⁷Division of Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada
Background/Purpose: Severity of knee malalignment is a risk factor for osteoarthritis (OA) progression. Currently the hip-knee-angle (mechanical axis), assessed on a full-limb radiograph, is the…
Abstract Number: 795 • 2012 ACR/ARHP Annual Meeting
Racial Differences in Pain Coping Efficacy in Patients with Hip and Knee Osteoarthritis
Kelli D. Allen¹, Hayden B. Bosworth², Cynthia Coffman², Jennifer H. Lindquist³, Nina R. Sperber¹, Morris Weinberger⁴ and Eugene Z. Oddone¹, ¹Health Services Research, Duke and Durham VA Medical Center, Durham, NC, ²Health Services Research, Durham VA Medical Center and Duke University Medical Center, Durham, NC, ³Health Services Research, Durham VA Medical Center, Durham, NC, ⁴Health Services Research, University of North Carolina at Chapel Hill & Durham VA Medical Center, Durham, NC
Background/Purpose: Studies have shown that African Americans with osteoarthritis (OA) have greater pain than Caucasians. However, little is known about whether there are racial differences…
Abstract Number: 17 • 2012 ACR/ARHP Annual Meeting
Synovial Overexpression of Wnt and Wnt-1-Induced Secreted Protein 1 Induces Cartilage Damage by Skewing of TGF-Beta Signaling and Reduction of the Anti-Hypertrophy Factor Sox9
Martijn H. van den Bosch¹, Arjen B. Blom¹, Peter L. van Lent², Henk M. van Beuningen¹, Fons A. van de Loo³, Esmeralda N. Blaney Davidson¹, Peter M. van der Kraan¹ and Wim B. van den Berg⁴, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁴Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Although many osteoarthritis (OA) patients show significant synovial involvement, consequences are largely unknown. We found highly increased expression of canonical Wnts 2b and 16…
Abstract Number: 1129 • 2012 ACR/ARHP Annual Meeting
Prevalence of Symptomatic Basilar Thumb Joint Osteoarthritis in the General Population
Jennifer Moriatis Wolf¹, Aleksandra Turkiewicz², Isam Atroshi³ and Martin Englund², ¹Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, ²Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden, ³Department of Orthopedics Hässleholm-Kristianstad, Lund University, Hässleholm, Sweden
Prevalence of symptomatic basilar thumb joint osteoarthritis in the general population Background/Purpose: While the radiographic prevalence of basilar thumb osteoarthritis (OA) is well described, little…
Abstract Number: 799 • 2012 ACR/ARHP Annual Meeting
Does Unpredictable Intermittent Knee Pain Limit Functional Ability and Walking Frequency in Knee OA?
Daniel K. White¹, Gillian A. Hawker², David T. Felson³, K. Douglas Gross⁴, Jingbo Niu⁵, Michael C. Nevitt⁶, C.E. Lewis⁷, James Torner⁸ and Tuhina Neogi⁹, ¹Department of Physical Therapy, University of Delaware, Newark, DE, ²Women's College Research Institute, University of Toronto, Toronto, ON, Canada, ³Boston University, Boston, MA, ⁴Physical Therapy, MGH Institute of Health Professions, Boston, MA, ⁵Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁶Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁷University of Alabama, Birmingham City, AL, ⁸Epidemiology, University of Iowa, Iowa City, Iowa City, IA, ⁹Boston University School of Medicine, Boston, MA
Background/Purpose: People with knee osteoarthritis (OA) reported that unpredictable pain restricts their ability to engage in physical activities in a qualitative study. Since walking is…
Abstract Number: 18 • 2012 ACR/ARHP Annual Meeting
Identification of 14-3-3å As a New Subchondral Bone Mediator Involved in Cartilage Degradation During Osteoarthritis
Sabrina Priam Jr.¹, Carole Bougault¹, Xavier Houard², Marjolaine Gosset³, Colette Salvat⁴, Francis Berenbaum⁵ and Claire Jacques¹, ¹Ur-4, Pierre et Marie Curie University Paris VI, Paris, France, ²Sorbonne Universités, UPMC Univ Paris 06, UMRS 938 and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris, France, ³EA 2496, Paris Descartes University, Montrouge, France, ⁴UR4, University Pierre and Marie Curie, Paris, France, ⁵Rheumatology, AP-HP, St Antoine Hospital, Paris, France
Background/Purpose: OA is a complex disease not limited to cartilage degeneration. Indeed, several experiments suggest that subchondral bone remodeling could initiate and/or contribute to cartilage…
Abstract Number: 1131 • 2012 ACR/ARHP Annual Meeting
Intraarticular Infliximab for Knee Osteoarthritis: High Baseline Levels of Synovial Cellularity and High MRI Cartilage Injury At the Lateral Tibial Plateau Predict Improvement in Total WOMAC Score
Jeremy R. Schue¹, Ossama Tawfik², Rebecca Bolce³, Donald D. Smith¹, Gary Hinson⁴, Jo A. Wick⁵ and Herbert B. Lindsley⁶, ¹Internal Medicine, Kansas University Med Ctr, Kansas City, KS, ²Pathology, Kansas University Med Ctr, Kansas City, KS, ³Crescendo Bioscience Inc., South San Francisco, CA, ⁴Radiology, Kansas University Med Ctr, Kansas City, KS, ⁵Biostatistics, Kansas University Med Ctr, Kansas City, KS, ⁶Medicine, Kansas University Med Ctr, Kansas City, KS
Background/Purpose: Synovial tissue from patients with OA often demonstrates inflammation. We hypothesized that a single intraarticular (IA) injection of an anti-TNF drug would decrease inflammatory…
Abstract Number: 733 • 2012 ACR/ARHP Annual Meeting
Intra-Articular Injection of Adipose-Derived Stem Cells Inhibits Activation of the Synovium and Protects Against Cartilage Damage and Enthesophyte Formation in Murine Experimental Osteoarthritis
Peter L.E.M. van Lent¹, Menno C. ter Huurne², Arjen B. Blom³, Rik Schelbergen³, Louis Casteilla⁴, Thomas Vogl⁵, Johannes Roth⁵, Roxane Blattes⁴, Christian Jorgensen⁶ and Wim B. van den Berg⁷, ¹Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁴STROMALab UPS/CNRS UMR5273, INSERM U1031, Toulouse, France, ⁵Institute of Immunology, University of Muenster, Munster, Germany, ⁶Department of therapy & Immuno-Rhumatology, Hospital Lapeyronie, Montpellier, France, ⁷Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: OA lesions are treated with mesenchymal stem cells aiming to enhance tissue repair by transformation to eg. chondrocytes. Recently it has been shown that…
Abstract Number: 1132 • 2012 ACR/ARHP Annual Meeting
Prevalence of Knee Pain in Ultramarathon Runners
Victoria M. Kelly¹, Martin Hoffman², Bharathi Lingala³, Mihoko Bennett⁴ and Eswar Krishnan⁵, ¹Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Palo Alto, CA, ²Physical Medicine and Rehabilitation, Department of Veteran's Affairs, Northern California Health Care System and University of California Davis Medical Center, Sacramento, CA, ³Stanford University, Palo Alto, CA, ⁴Pediatrics, Stanford University, Palo Alto, CA, ⁵Division of Rheumatology, Stanford University, Palo Alto, CA
Prevalence of Knee Pain in Ultramarathon Runners Background/Purpose: Approximately one in four Americans suffer from frequent knee pain. While some studies have linked long-distance running…
Abstract Number: 744 • 2012 ACR/ARHP Annual Meeting
Racial Differences in Reported Knee Pain Severity Persist Even After Adjustment for Knee Examination and Radiographic Findings: Data From the Osteoarthritis Initiative
Paige Luneburg¹, Laura Yerges-Armstrong², Braxton D. Mitchell² and Marc C. Hochberg¹, ¹Department of Medicine, University of Maryland, Baltimore, MD, ²Departments of Medicine and Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: African Americans have a higher prevalence of both radiographic and symptomatic radiographic knee osteoarthritis (OA) than Caucasians. In addition, African Americans with knee OA…
Abstract Number: 1134 • 2012 ACR/ARHP Annual Meeting
What Are the Levels of Physical Activities and Their Associations with Quality of Life in Patients with Symptomatic Hip and/or Knee Osteoarthritis?
Irawati Lemonnier¹, Anne Vuillemin² and Anne-Christine Rat³, ¹Lorraine Université Paris Descartes University, EA 4360 Apemac, Nancy, France, Nancy, France, ²Universite de Lorraine, Paris Descartes University, EA 4360 Apemac, Nancy, France, Nancy, France, ³CHU Nancy, Clinical Epidemiology and Evaluation, Université de Lorraine, Paris Descartes University, APEMAC, EA 4360, Nancy, France
Background/Purpose: Physical activities (PA) practice is recommended by numerous public health organizations. According to international recommendations, patients with hip and knee osteoarthritis (OA) should be…
Abstract Number: 745 • 2012 ACR/ARHP Annual Meeting
Soft Drink Intake and Progression of Radiographic Knee Osteoarthritis: Data From the Osteoarthritis Initiative
Bing Lu¹, Jeffrey Driban², Tim McAlindon³ and Charles Eaton⁴, ¹Rheumatology, Brigham and Women's Hospital, Boston, MA, ²Tufts Medical Center, MA, ³Tufts Medical Center, Boston, MA, ⁴Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI
Soft Drink Intake and Progression of Radiographic Knee Osteoarthritis: Data from the Osteoarthritis InitiativeBackground/Purpose : Soft drink consumption has been associated with weight gain and…
Abstract Number: 2630 • 2012 ACR/ARHP Annual Meeting
Rheumatoid Arthritis and Osteoarthritis in the Population: How Different Is the Impact?
Christina H. Chan¹, Mayilee Canizares² and E.M. Badley³, ¹Division of Healthcare Outcomes and Research, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ²Division of Healthcare Outcomes and Research, Toronto Western Research Institute, Toronto, ON, Canada, ³Division of Health Care and Outcomes Research, Toronto Western Research Institute; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
Background/Purpose: It is a common perception that rheumatoid arthritis (RA) is a more severe and debilitating disease than osteoarthritis (OA); however, there have been many…
Abstract Number: 1099 • 2012 ACR/ARHP Annual Meeting
Whole Blood Lead Is Associated with Symptoms, but Not Radiographic Osteoarthritis, in Multiple Joint Sites: The Johnston County Osteoarthritis Project
Amanda E. Nelson¹, Xiaoyan A. Shi², Todd A. Schwartz³, Jordan B. Renner⁴, Kathleen L. Caldwell⁵, Charles G. Helmick⁶ and Joanne M. Jordan⁷, ¹University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, ²SAS Institute, Inc, Cary, NC, ³University of North Carolina Gillings School of Global Public Health, Dept of Biostatistics, Chapel Hill, NC, ⁴University of North Carolina School of Medicine, Dept of Radiology, Chapel Hill, NC, ⁵Centers for Disease Control and Prevention, Atlanta, GA, ⁶National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, ⁷Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: We have previously identified associations between whole blood lead (Pb) and knee osteoarthritis (OA) and with biomarkers of joint metabolism. We hypothesized that Pb…
Abstract Number: 272 • 2012 ACR/ARHP Annual Meeting
Interim Safety Analysis of a Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy Study of Apremilast (CC10004) in Subjects with Erosive Hand Osteoarthritis
Juergen Rech¹, Wolfgang Ochs², Wolfgang Spieler³, Herbert Kellner⁴, Ulf Müller-Ladner⁵, Mathias Grunke⁶, Matthias Schneider⁷ and Georg Schett⁸, ¹Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ²Rheumatologist in private practice, Bayreuth, Germany, ³Rheumatology Specialty Practice, Zerbst, Germany, ⁴Centre for Inflammatory Joint Diseases, Munich, Germany, ⁵Abt. f. Rheumatologie u. klinische Immunologie, Osteologie, Physikalische Therapie, Kerckhoff-Klinik GmbH, Bad Nauheim, Germany, ⁶Division of Rheumatology, Medizinische Klinik und Poliklinik IV, University of Munich, Munich, Germany, ⁷Department of Endocrinology, Diabetes and Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany, ⁸Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Apremilast is a small molecule,specific phospodiesterase4 inhibitor under investigation for a number of inflammatory conditions, including psoriasis and psoriatic arthritis. We report results of…

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