Abstracts tagged "Osteoarthritis"

Abstract Number: 2630 • 2012 ACR/ARHP Annual Meeting
Rheumatoid Arthritis and Osteoarthritis in the Population: How Different Is the Impact?
Christina H. Chan¹, Mayilee Canizares² and E.M. Badley³, ¹Division of Healthcare Outcomes and Research, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ²Division of Healthcare Outcomes and Research, Toronto Western Research Institute, Toronto, ON, Canada, ³Division of Health Care and Outcomes Research, Toronto Western Research Institute; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
Background/Purpose: It is a common perception that rheumatoid arthritis (RA) is a more severe and debilitating disease than osteoarthritis (OA); however, there have been many…
Abstract Number: 1099 • 2012 ACR/ARHP Annual Meeting
Whole Blood Lead Is Associated with Symptoms, but Not Radiographic Osteoarthritis, in Multiple Joint Sites: The Johnston County Osteoarthritis Project
Amanda E. Nelson¹, Xiaoyan A. Shi², Todd A. Schwartz³, Jordan B. Renner⁴, Kathleen L. Caldwell⁵, Charles G. Helmick⁶ and Joanne M. Jordan⁷, ¹University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, ²SAS Institute, Inc, Cary, NC, ³University of North Carolina Gillings School of Global Public Health, Dept of Biostatistics, Chapel Hill, NC, ⁴University of North Carolina School of Medicine, Dept of Radiology, Chapel Hill, NC, ⁵Centers for Disease Control and Prevention, Atlanta, GA, ⁶National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, ⁷Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: We have previously identified associations between whole blood lead (Pb) and knee osteoarthritis (OA) and with biomarkers of joint metabolism. We hypothesized that Pb…
Abstract Number: 272 • 2012 ACR/ARHP Annual Meeting
Interim Safety Analysis of a Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy Study of Apremilast (CC10004) in Subjects with Erosive Hand Osteoarthritis
Juergen Rech¹, Wolfgang Ochs², Wolfgang Spieler³, Herbert Kellner⁴, Ulf Müller-Ladner⁵, Mathias Grunke⁶, Matthias Schneider⁷ and Georg Schett⁸, ¹Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ²Rheumatologist in private practice, Bayreuth, Germany, ³Rheumatology Specialty Practice, Zerbst, Germany, ⁴Centre for Inflammatory Joint Diseases, Munich, Germany, ⁵Abt. f. Rheumatologie u. klinische Immunologie, Osteologie, Physikalische Therapie, Kerckhoff-Klinik GmbH, Bad Nauheim, Germany, ⁶Division of Rheumatology, Medizinische Klinik und Poliklinik IV, University of Munich, Munich, Germany, ⁷Department of Endocrinology, Diabetes and Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany, ⁸Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Apremilast is a small molecule,specific phospodiesterase4 inhibitor under investigation for a number of inflammatory conditions, including psoriasis and psoriatic arthritis. We report results of…
Abstract Number: 2517 • 2012 ACR/ARHP Annual Meeting
Inhibition of Notch Signaling Increases the Severity of Experimental Osteoarthritis
Neng-Yu Lin¹, Alfiya Distler¹, Christian Beyer², Clara Dees³, Jingang Huang³, Francesco Dell'Accio⁴, Oliver Distler⁵, Georg A. Schett⁶ and Joerg HW Distler¹, ¹Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Department of Internal Medicine 3, Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴William Harvey Research Institute, Barts and the London Queen Mary's School of Medicine and Dentistry, Centre for Experimental Medicine and Rheumatology, London, United Kingdom, ⁵Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁶Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: Notch signaling is triggered by binding of ligands such as Jagged-1 (Jag-1) to Notch receptors, which results in cleavage of Notch receptors by the…
Abstract Number: 1103 • 2012 ACR/ARHP Annual Meeting
Cumulative Occupational Physical Load As Risk Factor for Knee Osteoarthritis
Allison M. Ezzat¹, Jolanda Cibere², Mieke Koehoorn³, Eric C. Sayre⁴ and Linda C. Li⁵, ¹School of Rehabilitation Science, University of British Columbia, Vancouver, BC, Canada, ²Division of Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada, ³University of British Columbia, Vancouver, BC, Canada, ⁴Arthritis Research Centre of Canada, Vancouver, BC, Canada, ⁵Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Knee osteoarthritis (OA) results from the interaction of multiple risk factors, one of which may be physically demanding occupations. The purpose of this study…
Abstract Number: 248 • 2012 ACR/ARHP Annual Meeting
Synovial Fluid Leptin Level Is Associated with Residual Pain and Functional Disability One Year After Total Joint Arthroplasty
Anne Lübbeke¹, Gabor J. Puskas¹, Axel Finckh², Domizio Suva¹, Sylvette Bas³, Cem Gabay³, Daniel Fritschy¹ and Pierre Hoffmeyer¹, ¹Orthopaedic Surgery, Geneva University Hospitals, Geneva, Switzerland, ²Rheumatology, Geneva University Hospitals, Geneva 14, Switzerland, ³Rheumatology, Geneva University Hospitals, Geneva, Switzerland
Background/Purpose: A sizeable number of patients continue to suffer from pain, functional disability and reduced quality of life after total joint arthroplasty (TJA). The etiology…
Abstract Number: 2469 • 2012 ACR/ARHP Annual Meeting
A Virtual Knee Joint Replacement Clinical Endpoint Based On Longitudinal Trends and Thresholds in Koos Knee Pain and Function in Osteoarthritis Initiative Participants
Robert M. Boudreau¹, David J. Hunter², Zhijie Wang³, Frank Roemer⁴, Felix Eckstein⁵, Michael J. Hannon³, Ali Guermazi⁶ and C. Kent Kwoh⁷, ¹Epidemiology, University of Pittsburgh, Pittsburgh, PA, ²Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ³Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴Radiology, Boston University School of Medicine, Boston, MA, ⁵Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ⁶Boston University, Boston, MA, ⁷School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Knee joint replacement (KR) is a cost-effective procedure with good long-term outcomes, but has limitations as an endpoint in OA intervention trials. A definition…
Abstract Number: 1104 • 2012 ACR/ARHP Annual Meeting
The Association of Demographic, Modifiable, Structural and Biomechanical Risk Factors with Medial and Lateral Patellofemoral Joint Structural Damage On MRI: The Multicenter Osteoarthritis Study
Joshua J. Stefanik¹, Ke Wang², K. Douglas Gross³, Frank Roemer⁴, John A. Lynch⁵, Neil Segal⁶, Cora E. Lewis⁷, Michael C. Nevitt⁸, Ali Guermazi⁹ and David T. Felson¹⁰, ¹Clinical Epidemiology, Boston University, Boston, MA, ²Biostatistics, Boston University, Boston, MA, ³Physical Therapy, MGH Institute of Health Professions, Boston, MA, ⁴Klinikum Augsburg, Augsburg, Germany, ⁵Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, ⁶Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, ⁷Preventive Medicine, University of Alabama, Birmingham City, Birmingham, AL, ⁸Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁹Radiology, Boston University, Boston, MA, ¹⁰Boston University, Boston, MA
Background/Purpose: Past investigations into risk factors for patellofemoral joint (PFJ) osteoarthritis (OA) have been limited by the use of radiography, which is insensitive to identify…
Abstract Number: 251 • 2012 ACR/ARHP Annual Meeting
Smaller Baseline and Follow-up Quadriceps Muscle Cross-Sectional Area Increases the Odds of Knee Replacement in Knee Osteoarthritis
Serter Gumus¹, Michael J. Hannon², Diana Kaya¹, C. Kent Kwoh³ and Kyongtae Ty Bae¹, ¹Radiology, University of Pittsburgh, Pittsburgh, PA, ²Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ³School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Knee osteoarthritis (OA) is one of the major causes of disability among elderly. Knee replacement (KR) is the final effective treatment of OA after…
Abstract Number: 2471 • 2012 ACR/ARHP Annual Meeting
Oral Glucosamine Sulphate for the Prevention of Knee Osteoarthritis in Overweight Females; The First Ever Preventive Randomized Controlled Trial
Jos Runhaar¹, Marienke van Middelkoop¹, Max Reijman², Edwin Oei³, Dammis Vroegindeweij⁴, Gerjo van Osch², Bart Koes¹ and Sita Bierma-Zeinstra⁵, ¹General Practice, Erasmus MC, Rotterdam, Netherlands, ²Orthopaedics, Erasmus MC, Rotterdam, Netherlands, ³Radiology, Erasmus MC, Rotterdam, Netherlands, ⁴Radiology, Maasstad Hospital, Rotterdam, Netherlands, ⁵Orthopaedics and General Practice, Erasmus MC, Rotterdam, Netherlands
Background/Purpose: Previous studies showed the largest effects of glucosamine on osteoarthritis (OA) symptoms of the knee joint and when used in an early phase of…
Abstract Number: 1108 • 2012 ACR/ARHP Annual Meeting
A Randomized Controlled Trial of Hylan G-F 20 for the Treatment of Carpometacarpal Osteoarthritis
Lisa A. Mandl¹, Scott Wolfe², Aaron Daluiski², Robert N. Hotchkiss³, Stephen L. Lyman⁴ and Jeffrey N. Katz⁵, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Department of Orthopedics, Hospital For Special Surgery, New York, NY, ³Department of Orthopedics, Hospital for Special Surgery, New York, NY, ⁴Research, Hospital Special Surgery, New York, NY, ⁵Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Painful carpometacarpal osteoarthritis (CMC OA) is associated with substantial impairment, and is often unresponsive to medical treatment. Hylan G-F 20 has been shown…
Abstract Number: 255 • 2012 ACR/ARHP Annual Meeting
Clinically Meaningful Effect of Strontium Ranelate On Knee Osteoarthritis Symptoms
O. Bruyere¹, N. Bellamy², J. Brown³, P. Richette⁴, L. Punzi⁵, X. Chevalier⁶, Cyrus Cooper⁷ and Jean-Yves Reginster¹, ¹Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, Belgium, ²CONROD. The University of Queensland, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia, ³Rheumatology Centre,, Quebec City, QC, Canada, ⁴Centre Viggo Petersen / Service de Rhumatologie, Hôpital Lariboisière, Paris, France, ⁵Cattedra e Divisione di Reumatologia, Azienda Ospedaliera di Padova, Padova, Italy, ⁶Service de Rhumatologie, Hôpital Henri-Mondor, Creteil, France, ⁷NDORMS; MRC Lifecourse Epidemiology Unit, University of Oxford; Southampton General Hospital, Southampton, United Kingdom
Background/Purpose: In the SEKOIA study, strontium ranelate 2g/day has been demonstrated to reduce total WOMAC score, pain subscore and global knee pain assessed using a…
Abstract Number: 2479 • 2012 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Does Not Increase Risk of Short Term Total Knee Replacement (TKR) Adverse Events (AE)
Zachary J. LoVerde¹, Lisa A. Mandl², Beverly K. Johnson², Mark P. Figgie³, Friedrich Boettner⁴ and Susan M. Goodman², ¹New York Medical College, Valhalla, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Orthopedics, Hospital for Special Surgery, New York, NY, ⁴Orthopaedics, Hospital for Special Surgery, New York, NY
Background/Purpose: TKR is commonly performed for rheumatoid arthritis (RA) and osteoarthritis (OA). Historically, RA patients were at higher risk of post-operative AEs. The purpose of…
Abstract Number: 1109 • 2012 ACR/ARHP Annual Meeting
Effects of Strontium Ranelate On Hand Osteoarthritis – Analysis of Data From the Sekoia Trial
E. Maheu¹, C. Cadet² and F. Berenbaum³, ¹AP-HP, Saint-Antoine Hospital, Rheumatology Department and DHU i2B, Paris, France, ²Rheumatology, Paris, France, ³Rheumatology, AP-HP St Antoine Hospital, Paris, France
Background/Purpose: Strontium ranelate (SrRan) has shown the ability to reduce radiological progression of knee osteoarthritis (OA) over 3 years. Patients with knee OA are also…
Abstract Number: 260 • 2012 ACR/ARHP Annual Meeting
Adjudication of Reported Serious Adverse Joint Events in the Tanezumab Clinical Development Program
Marc C. Hochberg¹, Steven B. Abramson², David S. Hungerford³, Edward McCarthy⁴, Eric P. Vignon⁵, Michael D. Smith⁶, Leslie Tive⁷, Kenneth M. Verburg⁶ and Christine R. West⁸, ¹Department of Medicine, University of Maryland, Baltimore, MD, ²Dept of Rheumatology/Medicine, NYU Langone Medical Center, New York, NY, ³Department of Ortho Surgery, Johns Hopkins University, Baltimore, MD, ⁴Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Rheumatology 2B, Centre Hospitalier, Pierre Benite, France, ⁶Pfizer, Inc., Groton, CT, ⁷Arthritis, Pfizer Inc, New York, NY, ⁸Clinical Sciences, Pfizer, Williamston, MI
Background/Purpose: Tanezumab (TNZ) has been shown to be efficacious for pain and function in patients with hip and knee osteoarthritis (OA). Unexpected reports of adverse…

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