Abstracts tagged "Osteoarthritis"

Abstract Number: 2135 • 2013 ACR/ARHP Annual Meeting
Musculoskeletal Pain Explains Differences In Function At Time Of Surgery In Black TKR and THR Patients
Anthony Porter¹, Wenjun Li², Leslie R. Harrold¹, Milagros Rosal³, Philip Noble⁴, David Ayers², Patricia D. Franklin² and Jeroan Allison⁵, ¹University of Massachusetts Medical School, Worcester, MA, ²Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ³Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA, ⁴Baylor College of Medicine, Houston, TX, ⁵Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: The existence of racial disparities in total knee (TKR) and total hip (THR) replacement outcomes is well established but not well understood. The burden…
Abstract Number: 771 • 2013 ACR/ARHP Annual Meeting
The S100A9 Inhibitor Paquinimod (ABR-215757) Reduces Synovial Activation, Osteophyte Formation and Cartilage Damage In Experimental Osteoarthritis
Rik Schelbergen¹, Arjen B. Blom¹, Tomas Leanderson², Helena Eriksson³, Wim B. van den Berg⁴ and Peter L.E.M. van Lent¹, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Immunology Group, Lund University, Lund, Sweden, ³BioScience, Active Biotech AB, Lund, Sweden, ⁴Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Synovial activation is present in a large subset of osteoarthritis (OA) patients and it is thought to play an important role in the development…
Abstract Number: 2136 • 2013 ACR/ARHP Annual Meeting
Does Functional Gain and Pain Relief After TKR and THR Differ By Patient Obese Status?
Wenjun Li¹, Leslie R. Harrold², Jeroan Allison³, Courtland Lewis⁴, Thomas Bowen⁵, Patricia D. Franklin¹ and David Ayers¹, ¹Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ²University of Massachusetts Medical School, Worcester, MA, ³Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, ⁴Hartford Hospital, Hartford, CT, ⁵Geisinger, Danville, PA
Background/Purpose: Obesity is an important predictor of functional status and pain after total knee (TKR) and total hip (THR) replacement. However, variations in pre-post TKR…
Abstract Number: 778 • 2013 ACR/ARHP Annual Meeting
Relationship of Meeting Physical Activity Guidelines and Quality Adjusted Life Years
Kai Sun¹, Jing Song², Larry Manheim³, C. Kent Kwoh⁴, Rowland W. Chang², Pamela A. Semanik⁵, Dorothy D. Dunlop² and Charles Eaton⁶, ¹Medicine, Northwestern University, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³Institute Healthcare Studies, Northwestern University, Chicago, IL, ⁴School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁵Northwestern University, Chicago, IL, ⁶Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI
Background/Purpose: Regular physical activity is associated with reduced chronic disease burden and mortality. Recognizing the importance of physical activity, there are US federal guidelines for…
Abstract Number: 2137 • 2013 ACR/ARHP Annual Meeting
Important Predictors Of Patient-Reported Outcomes After TKR and THR Are Not Included In Risk Models Based On Administrative Data
Patricia D. Franklin¹, Leslie R. Harrold², Wenjun Li¹, Jeroan Allison³, David Ayers¹ and Courtland Lewis⁴, ¹Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ²University of Massachusetts Medical School, Worcester, MA, ³Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, ⁴Hartford Hospital, Hartford, CT
Background/Purpose: Because total knee (TKR) and total hip (THR) replacement surgery is performed to relieve pain and improve physical function in patients with advanced arthritis,…
Abstract Number: 767 • 2013 ACR/ARHP Annual Meeting
Zinc Finger Protein ZCCHC6 Is Highly Expressed In Osteoarthritic Cartilage and Regulate The Expression Of Interleukin-6 In Human Chondrocytes
Nahid Akhtar, Ahmad Arida and Tariq M. Haqqi, Anatomy & Neurobiology, North East Ohio Medical University, Rootstown, OH
Background/Purpose: Interleukin-1β (IL-1β) is the major cytokine involved in cartilage catabolism in osteoarthritis(OA) and induces the expression of pro-inflammatory cytokine IL-6. Members of cytoplasmic RNA…
Abstract Number: 1129 • 2012 ACR/ARHP Annual Meeting
Prevalence of Symptomatic Basilar Thumb Joint Osteoarthritis in the General Population
Jennifer Moriatis Wolf¹, Aleksandra Turkiewicz², Isam Atroshi³ and Martin Englund², ¹Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, ²Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden, ³Department of Orthopedics Hässleholm-Kristianstad, Lund University, Hässleholm, Sweden
Prevalence of symptomatic basilar thumb joint osteoarthritis in the general population Background/Purpose: While the radiographic prevalence of basilar thumb osteoarthritis (OA) is well described, little…
Abstract Number: 799 • 2012 ACR/ARHP Annual Meeting
Does Unpredictable Intermittent Knee Pain Limit Functional Ability and Walking Frequency in Knee OA?
Daniel K. White¹, Gillian A. Hawker², David T. Felson³, K. Douglas Gross⁴, Jingbo Niu⁵, Michael C. Nevitt⁶, C.E. Lewis⁷, James Torner⁸ and Tuhina Neogi⁹, ¹Department of Physical Therapy, University of Delaware, Newark, DE, ²Women's College Research Institute, University of Toronto, Toronto, ON, Canada, ³Boston University, Boston, MA, ⁴Physical Therapy, MGH Institute of Health Professions, Boston, MA, ⁵Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁶Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁷University of Alabama, Birmingham City, AL, ⁸Epidemiology, University of Iowa, Iowa City, Iowa City, IA, ⁹Boston University School of Medicine, Boston, MA
Background/Purpose: People with knee osteoarthritis (OA) reported that unpredictable pain restricts their ability to engage in physical activities in a qualitative study. Since walking is…
Abstract Number: 18 • 2012 ACR/ARHP Annual Meeting
Identification of 14-3-3å As a New Subchondral Bone Mediator Involved in Cartilage Degradation During Osteoarthritis
Sabrina Priam Jr.¹, Carole Bougault¹, Xavier Houard², Marjolaine Gosset³, Colette Salvat⁴, Francis Berenbaum⁵ and Claire Jacques¹, ¹Ur-4, Pierre et Marie Curie University Paris VI, Paris, France, ²Sorbonne Universités, UPMC Univ Paris 06, UMRS 938 and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris, France, ³EA 2496, Paris Descartes University, Montrouge, France, ⁴UR4, University Pierre and Marie Curie, Paris, France, ⁵Rheumatology, AP-HP, St Antoine Hospital, Paris, France
Background/Purpose: OA is a complex disease not limited to cartilage degeneration. Indeed, several experiments suggest that subchondral bone remodeling could initiate and/or contribute to cartilage…
Abstract Number: 1131 • 2012 ACR/ARHP Annual Meeting
Intraarticular Infliximab for Knee Osteoarthritis: High Baseline Levels of Synovial Cellularity and High MRI Cartilage Injury At the Lateral Tibial Plateau Predict Improvement in Total WOMAC Score
Jeremy R. Schue¹, Ossama Tawfik², Rebecca Bolce³, Donald D. Smith¹, Gary Hinson⁴, Jo A. Wick⁵ and Herbert B. Lindsley⁶, ¹Internal Medicine, Kansas University Med Ctr, Kansas City, KS, ²Pathology, Kansas University Med Ctr, Kansas City, KS, ³Crescendo Bioscience Inc., South San Francisco, CA, ⁴Radiology, Kansas University Med Ctr, Kansas City, KS, ⁵Biostatistics, Kansas University Med Ctr, Kansas City, KS, ⁶Medicine, Kansas University Med Ctr, Kansas City, KS
Background/Purpose: Synovial tissue from patients with OA often demonstrates inflammation. We hypothesized that a single intraarticular (IA) injection of an anti-TNF drug would decrease inflammatory…
Abstract Number: 733 • 2012 ACR/ARHP Annual Meeting
Intra-Articular Injection of Adipose-Derived Stem Cells Inhibits Activation of the Synovium and Protects Against Cartilage Damage and Enthesophyte Formation in Murine Experimental Osteoarthritis
Peter L.E.M. van Lent¹, Menno C. ter Huurne², Arjen B. Blom³, Rik Schelbergen³, Louis Casteilla⁴, Thomas Vogl⁵, Johannes Roth⁵, Roxane Blattes⁴, Christian Jorgensen⁶ and Wim B. van den Berg⁷, ¹Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁴STROMALab UPS/CNRS UMR5273, INSERM U1031, Toulouse, France, ⁵Institute of Immunology, University of Muenster, Munster, Germany, ⁶Department of therapy & Immuno-Rhumatology, Hospital Lapeyronie, Montpellier, France, ⁷Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: OA lesions are treated with mesenchymal stem cells aiming to enhance tissue repair by transformation to eg. chondrocytes. Recently it has been shown that…
Abstract Number: 1132 • 2012 ACR/ARHP Annual Meeting
Prevalence of Knee Pain in Ultramarathon Runners
Victoria M. Kelly¹, Martin Hoffman², Bharathi Lingala³, Mihoko Bennett⁴ and Eswar Krishnan⁵, ¹Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Palo Alto, CA, ²Physical Medicine and Rehabilitation, Department of Veteran's Affairs, Northern California Health Care System and University of California Davis Medical Center, Sacramento, CA, ³Stanford University, Palo Alto, CA, ⁴Pediatrics, Stanford University, Palo Alto, CA, ⁵Division of Rheumatology, Stanford University, Palo Alto, CA
Prevalence of Knee Pain in Ultramarathon Runners Background/Purpose: Approximately one in four Americans suffer from frequent knee pain. While some studies have linked long-distance running…
Abstract Number: 744 • 2012 ACR/ARHP Annual Meeting
Racial Differences in Reported Knee Pain Severity Persist Even After Adjustment for Knee Examination and Radiographic Findings: Data From the Osteoarthritis Initiative
Paige Luneburg¹, Laura Yerges-Armstrong², Braxton D. Mitchell² and Marc C. Hochberg¹, ¹Department of Medicine, University of Maryland, Baltimore, MD, ²Departments of Medicine and Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: African Americans have a higher prevalence of both radiographic and symptomatic radiographic knee osteoarthritis (OA) than Caucasians. In addition, African Americans with knee OA…
Abstract Number: 1134 • 2012 ACR/ARHP Annual Meeting
What Are the Levels of Physical Activities and Their Associations with Quality of Life in Patients with Symptomatic Hip and/or Knee Osteoarthritis?
Irawati Lemonnier¹, Anne Vuillemin² and Anne-Christine Rat³, ¹Lorraine Université Paris Descartes University, EA 4360 Apemac, Nancy, France, Nancy, France, ²Universite de Lorraine, Paris Descartes University, EA 4360 Apemac, Nancy, France, Nancy, France, ³CHU Nancy, Clinical Epidemiology and Evaluation, Université de Lorraine, Paris Descartes University, APEMAC, EA 4360, Nancy, France
Background/Purpose: Physical activities (PA) practice is recommended by numerous public health organizations. According to international recommendations, patients with hip and knee osteoarthritis (OA) should be…
Abstract Number: 745 • 2012 ACR/ARHP Annual Meeting
Soft Drink Intake and Progression of Radiographic Knee Osteoarthritis: Data From the Osteoarthritis Initiative
Bing Lu¹, Jeffrey Driban², Tim McAlindon³ and Charles Eaton⁴, ¹Rheumatology, Brigham and Women's Hospital, Boston, MA, ²Tufts Medical Center, MA, ³Tufts Medical Center, Boston, MA, ⁴Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI
Soft Drink Intake and Progression of Radiographic Knee Osteoarthritis: Data from the Osteoarthritis InitiativeBackground/Purpose : Soft drink consumption has been associated with weight gain and…

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