Abstracts tagged "Osteoarthritis"

Abstract Number: 2668 • 2013 ACR/ARHP Annual Meeting
A Randomized, Double-Blind, Dose Ranging Study Comparing FX006, An Intra-Articular (IA) Sustained-Release Formulation Of Triamcinolone Acetonide (TCA), To An Approved Injectable Suspension Of TCA In Patients With Osteoarthritis (OA) Of The Knee
Neil Bodick¹, Joelle Lufkin¹, Christina Willwerth¹, Pierre Lachance², Gregory Jasey³, Anil Gupta⁴, Anthony Chris⁵, Marc Russo⁶, Michael O'Mahony⁷, Sam Henein⁸, Louise Murdoch⁹, Ferdinandus de Looze¹⁰, David Hunter¹¹ and Michael Clayman¹, ¹Flexion Therapeutics, Burlington, MA, ²Clinique St-Louis (Recherche) Inc, Quebec, QC, Canada, ³North Walkerville Orthopaedic Associates, Windsor, ON, Canada, ⁴Anil K. Gupta Medicine Professional Corporation, Toronto, ON, Canada, ⁵Aim Health Group, Waterloo, ON, Canada, ⁶Hunter Clinical Research, Broadmeadow, Australia, ⁷London Road Diagnostic Clinic and Medical Centre, Sarnia, ON, Canada, ⁸SKDS Research Inc., Newmarket, ON, Canada, ⁹Emeritus Research, Malvern East, Australia, ¹⁰AusTrials Pty Limited, Sherwood, Australia, ¹¹Royal North Shore Hospital, St. Leonards, Australia
Background/Purpose: FX006 is a novel sustained-release formulation of TCA in poly(lactic-co-glycolic) acid microspheres intended to maintain therapeutic concentrations in the joint up to 3 months…
Abstract Number: 1719 • 2013 ACR/ARHP Annual Meeting
High Reliability Was Found for Ultrasound Scoring of Osteophytes in Patients With Hand Osteoarthritis Using An Atlas As Reference; An Omeract Initiative
Hilde B. Hammer¹, Alexander Mathiessen¹, Annamaria Iagnocco², Emilio Filippucci³, Frédérique Gandjbakhch⁴, Marion C. Kortekaas⁵, Ingrid Möller⁶, Esperanza Naredo⁷, Richard J. Wakefield⁸, Philippe Aegerter⁹ and Maria-Antonietta d'Agostino¹⁰, ¹Dept of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Sapienza University of Rome, Rome, Italy, ³Clinica Reumatologica, Università Politecnica delle Marche, Ancona, Italy, ⁴Department of Rheumatology, APHP, Pitié Salpétrière Hospital, Universite Paris 6, Paris, France, ⁵Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁶Instituto Poal de Reumatologia, Barcelona, Spain, ⁷Rheumatology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ⁸NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds & Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁹Epidemiology, Versailles-Saint Quentin en Yvelines University- APHP, Ambroise-Paré Hospital,, Boulogne-Billancourt,, France, ¹⁰Rheumatology, Ambroise Paré Hospital, and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France
Background/Purpose: Ultrasound (US) is a sensitive method for detecting osteophytes (OP) in hand osteoarthritis (HOA). To improve the reliability of scoring OP, an US atlas…
Abstract Number: 86 • 2013 ACR/ARHP Annual Meeting
The Role Of Meniscal Cells In Osteoarthritis Calcification
Andrea Roberts¹, David Mauerhan² and Yubo Sun², ¹Orthopedic Biology Research, Carolinas Healthcare System, Charlotte, NC, ²Orthopaedic Surgery, Carolinas Medical Center, Charlotte, NC
Background/Purpose: Osteoarthritis (OA) is a disease that is characterized by the breakdown or loss of articular cartilage due to biomechanical and biochemical changes in the…
Abstract Number: 2315 • 2013 ACR/ARHP Annual Meeting
Reducing The Need For Total Knee Arthroplasty: The Experience Of a Multidisciplinary Osteoarthritis Clinic
Caroline Jones¹, Angelo Papachristos¹ and Laurence A. Rubin², ¹Physiotherapy, St Michael's Hospital, Toronto, ON, Canada, ²Rheumatology, St. Michael Hospital, Toronto, ON, Canada
Background/Purpose: St. Michael’s Hospital (SMH) is a tertiary care facility located in Toronto, serving a diverse social, economic and cultural urban population. In 2008, a…
Abstract Number: 1694 • 2013 ACR/ARHP Annual Meeting
A Randomised Trial Of A Brace For Patellofemoral Osteoarthritis Targeting Knee Pain and Bone Marrow Lesions
David T. Felson^1,2, Matthew J. Parkes¹, Andrew D. Gait³, Elizabeth J. Marjanovic³, Mark Lunt⁴, Charles E. Hutchinson⁵, Laura Forsythe⁶, Timothy F. Cootes³ and Michael Callaghan¹, ¹Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Imaging Sciences, School of Cancer & Enabling Sciences, University of Manchester, Manchester, United Kingdom, ⁴Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, United Kingdom, ⁵Warwick Medical School, University of Warwick, Coventry, United Kingdom, ⁶Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom
Background/Purpose: Patellofemoral (PF) braces have been shown to increase contract area in this joint, decreasing focal stress and may also correct patellar malalignment. Bone marrow…
Abstract Number: 84 • 2013 ACR/ARHP Annual Meeting
New Formulation With Potential To Prevent and Treat Osteoporosis and Osteoarthritis
A. Torrent¹, E. Montell², J. Vergés¹, P. Dalmau³, R. Ruhí³, M.C. Carceller⁴, A. Blanco⁴, M.C. Terencio⁴, M.L. Ferrándiz⁴ and M.J. Alcaraz⁵, ¹Pre-Clinical R&D Area, Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain, ²Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain, ³Technological Extraction Dept, BIOIBERICA S.A., Palafolls, Spain, ⁴Department of Pharmacology and IDM, University of Valencia, Burjassot, Spain, ⁵University of Valencia, Burjasot, Valencia, Spain
Background/Purpose: Osteoarthritis (OA) is a multidimensional disease that affects all anatomical joint structures, particularly cartilage, synovium and subchondral bone. In turn, osteoporosis (OP) is a…
Abstract Number: 2479 • 2012 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Does Not Increase Risk of Short Term Total Knee Replacement (TKR) Adverse Events (AE)
Zachary J. LoVerde¹, Lisa A. Mandl², Beverly K. Johnson², Mark P. Figgie³, Friedrich Boettner⁴ and Susan M. Goodman², ¹New York Medical College, Valhalla, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Orthopedics, Hospital for Special Surgery, New York, NY, ⁴Orthopaedics, Hospital for Special Surgery, New York, NY
Background/Purpose: TKR is commonly performed for rheumatoid arthritis (RA) and osteoarthritis (OA). Historically, RA patients were at higher risk of post-operative AEs. The purpose of…
Abstract Number: 1109 • 2012 ACR/ARHP Annual Meeting
Effects of Strontium Ranelate On Hand Osteoarthritis – Analysis of Data From the Sekoia Trial
E. Maheu¹, C. Cadet² and F. Berenbaum³, ¹AP-HP, Saint-Antoine Hospital, Rheumatology Department and DHU i2B, Paris, France, ²Rheumatology, Paris, France, ³Rheumatology, AP-HP St Antoine Hospital, Paris, France
Background/Purpose: Strontium ranelate (SrRan) has shown the ability to reduce radiological progression of knee osteoarthritis (OA) over 3 years. Patients with knee OA are also…
Abstract Number: 260 • 2012 ACR/ARHP Annual Meeting
Adjudication of Reported Serious Adverse Joint Events in the Tanezumab Clinical Development Program
Marc C. Hochberg¹, Steven B. Abramson², David S. Hungerford³, Edward McCarthy⁴, Eric P. Vignon⁵, Michael D. Smith⁶, Leslie Tive⁷, Kenneth M. Verburg⁶ and Christine R. West⁸, ¹Department of Medicine, University of Maryland, Baltimore, MD, ²Dept of Rheumatology/Medicine, NYU Langone Medical Center, New York, NY, ³Department of Ortho Surgery, Johns Hopkins University, Baltimore, MD, ⁴Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Rheumatology 2B, Centre Hospitalier, Pierre Benite, France, ⁶Pfizer, Inc., Groton, CT, ⁷Arthritis, Pfizer Inc, New York, NY, ⁸Clinical Sciences, Pfizer, Williamston, MI
Background/Purpose: Tanezumab (TNZ) has been shown to be efficacious for pain and function in patients with hip and knee osteoarthritis (OA). Unexpected reports of adverse…
Abstract Number: 2441 • 2012 ACR/ARHP Annual Meeting
Readability and Suitability Assessment of Patient Education Materials in Rheumatic Diseases
Rennie L. Rhee¹, Joan Marie Von Feldt², H. Ralph Schumacher³ and Peter A. Merkel⁴, ¹Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Rheumatology, Univ of Pennsylvania/Philadelphia VAMC, Philadelphia, PA, ³Department of Medicine, University of Pennsylvania and VA Medical Center, Philadelphia, PA, ⁴University of Pennsylvania, Philadelphia, PA
Background/Purpose: Comprehension of health resources may be challenging for patients particularly those with limited health literacy. The objective of this study was to examine the…
Abstract Number: 1112 • 2012 ACR/ARHP Annual Meeting
Patients with Erosive Osteoarthritis Have Less Extensive Synovitis Than Patients with Rheumatoid Arthritis On Histopathology
Allen P. Anandarajah¹, Stephen Kates², Kate Burns³ and Ellen Giampoli⁴, ¹Dept of Rheumatology, Univ of Rochester Medical Ctr, Rochester, NY, ²Orthopedic Surgery, University of Rochester Medical Center, Rochester, NY, ³Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁴Pathology, University of Rochester Medical Ctr, Rochester, NY
Background/Purpose: Patients with erosive osteoarthritis (EOA) often develop disfiguring deformities and associated decline in hand function. We have previously demonstrated that synovitis was a common…
Abstract Number: 240 • 2012 ACR/ARHP Annual Meeting
Degenerative Changes in Patients with Knee Pain: A Comparative Study Between Ultrasound and Conventional Radiology
Santiago Ruta¹, Erika Catay², Javier Rosa², David A. Navarta³, Ricardo Garcia-Monaco⁴ and Enrique R. Soriano⁵, ¹Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ²Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ³Internal Medicine, Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁴Radiology and Imagenology Department, Hospital italiano de Buenos Aires, Buenos Aires, Argentina, ⁵Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina
Background/Purpose: Knee osteoarthritis (OA) is one of the most common rheumatologic joint diseases and causes an important disability in the elderly population. To date the…
Abstract Number: 2400 • 2012 ACR/ARHP Annual Meeting
Hospital for Special Surgery Osteoarthritis Wellness Initiative: the Impact of a Hospital-Based Exercise Program On Osteoarthritis
Sandra Goldsmith¹, Dana Friedman¹, Linda Roberts¹, Dana Sperber¹ and Laura Robbins², ¹Public and Patient Education, Hospital for Special Surgery, New York, NY, ²Education & Academic Affairs, Hospital for Special Surgery, New York, NY
Background/Purpose: The Centers for Disease Control and Prevention (CDC) reports that about 27 million adults were affected by osteoarthritis (OA) in 2005. OA is characterized…
Abstract Number: 1114 • 2012 ACR/ARHP Annual Meeting
Prevalence of Radiographic and Symptomatic Hip Osteoarthritis in an Urban US Population: The Framingham Osteoarthritis Study
Katherine D. Linsenmeyer¹, Ali Guermazi², Kyu-Chan Kim¹, David T. Felson³, Mary M. Clancy⁴ and Steven C. Vlad⁵, ¹Internal Medicine, Boston Medical Center, Boston, MA, ²Radiology, Boston University, Boston, MA, ³Boston University, Boston, MA, ⁴School of Medicine, Boston University, Boston, MA, ⁵Clinical Epidemiology, Boston University, Boston, MA
Background/Purpose: There are few studies of hip osteoarthritis (OA) in the United States and none in the last 35 years that have addressed the prevalence…
Abstract Number: 241 • 2012 ACR/ARHP Annual Meeting
Excess Body Weight and 4-Year Function Outcomes: Comparison of African-Americans and Caucasians in the Osteoarthritis Initiative
Carmelita J. Colbert¹, Orit Almagor², Joan S. Chmiel², Jing Song³, Dorothy D. Dunlop³, Karen W. Hayes⁴ and Leena Sharma², ¹Department of Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, ²Northwestern University, Chicago, IL, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL
Background/Purpose: Given the heterogeneity of knee OA impact, it is important to identify persons at risk for poor outcome. A better understanding of differences…

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