Abstracts tagged "Osteoarthritis"

Abstract Number: 2205 • 2017 ACR/ARHP Annual Meeting
Trajectories of Knee Bone Shape Change Are Associated with Sex and Osteoarthritis
Barton L Wise¹, Jingbo Niu², Yuqing Zhang³, Felix Liu⁴, Joyce Pang⁵, John A. Lynch⁶ and Nancy E. Lane⁷, ¹Orthopaedics, Internal Medicine, University of California, Davis School of Medicine, Sacramento, CA, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³School Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁵University of Nevada, Reno, Reno, NV, ⁶Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁷Center for Musculoskeletal Health, University of California, Davis School of Medicine, Sacramento, CA
Background/Purpose: Knee osteoarthritis (OA) is more common in women than men; however, the biological mechanisms for sex difference in knee OA are not well understood.…
Abstract Number: 935 • 2017 ACR/ARHP Annual Meeting
Results from a 52 Week Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of a Novel, Intra-Articular, Wnt Pathway Inhibitor (SM04690) for the Treatment of Knee Osteoarthritis
Yusuf Yazici¹, Timothy E. McAlindon², Allan Gibofsky³, Nancy E. Lane⁴, Daniel J. Clauw⁵, Eddie Armas⁶, Nebojsa Skrepnik⁷, Christopher J. Swearingen¹, Anita DiFrancesco¹, Jeymi Tambiah¹ and Marc Hochberg⁸, ¹Samumed, LLC, San Diego, CA, ²Division of Rheumatology, Tufts Medical Center, Boston, MA, ³Rheumatology, Weill Cornell Medicine, and Hospital for Special Surgery, New York, NY, ⁴Center for Musculoskeletal Health, University of California at Davis, Hillsborough, CA, ⁵Chronic Pain & Fatigue Research Center, University of Michigan, Ann Arbor, MI, ⁶Well Pharma Medical Research, Miami, FL, ⁷Tuscon Orthopedics Institute, Tuscon, AZ, ⁸Head, Division of Rheumatology & Clinical Immunology; Vice Chair, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Knee osteoarthritis (OA) is characterized by pain, disability and joint deformity due to articular cartilage degradation and bone remodeling. Wnt signaling is involved in…
Abstract Number: 2208 • 2017 ACR/ARHP Annual Meeting
A Novel Omeract MRI Scoring System Providing Insights in the Association of MRI Synovitis and Bone Marrow Lesions with Pain in Thumb Base Osteoarthritis
F.P.B. Kroon¹, S. van Beest¹, W. Damman¹, R. Liu¹, J.L. Bloem², M. Reijnierse² and M. Kloppenburg^1,3, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Osteoarthritis (OA) in the thumb base joints (first carpometacarpal [CMC1] and scaphotrapeziotrapezoid [STT]) is highly prevalent and disabling, however much is still unknown about…
Abstract Number: 1186 • 2017 ACR/ARHP Annual Meeting
A Simple, Self-Assembled Hydrogel Depot for Localized Treatment of Post-Traumatic Osteoarthritis
Jing Yan¹, Nitin Joshi², Xueyin He², Sachin Bhagchandani², Kai Slaughter², Nicholas Sherman¹, Joerg Ermann¹ and Jeffrey Karp², ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA
Background/Purpose: Joint injuries, including sports- or combat-related ligamentous tears and fractures, can lead to post-traumatic osteoarthritis (PTOA), a chronic condition that causes pain, disability and…
Abstract Number: 2210 • 2017 ACR/ARHP Annual Meeting
Thumb Base Osteoarthritis: Associations between Pain and Synovitis on Ultrasound
F.P.B. Kroon¹, S. Ermurat², M. Kortekaas¹, M. Reijnierse³ and M. Kloppenburg^1,4, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Uludag University Medical Faculty, Bursa, Turkey, ³Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Osteoarthritis (OA) in the first carpometacarpal (CMC1) joint in the thumb base is frequent and has a large contribution in hand pain and disability.…
Abstract Number: 1188 • 2017 ACR/ARHP Annual Meeting
Initial Estimates of Efficacy of Intra-Articular 2.5% Polyacrylamide Hydrogel for the Treatment of Knee Osteoarthritis: An Observational Proof-of-Concept Study
Marius Henriksen^1,2, Anders Overgaard¹ and Henning Bliddal³, ¹The Parker Institute, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark, ²Department of physical therapy, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark, ³The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark
Background/Purpose: There is a draught of available effective treatments of knee osteoarthritis (OA) and tests of new therapies are needed. Polyacrylamide hydrogel (PAAG) is a…
Abstract Number: 2211 • 2017 ACR/ARHP Annual Meeting
Investigation of Self-Reported Painful Joint Count As an Outcome Measure in Hand Osteoarthritis
F.P.B. Kroon¹, J.L. van der Plas¹, S. van Beest¹, W. Damman¹ and M. Kloppenburg^1,2, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Hand osteoarthritis (OA) research is in need of disease-specific validated instruments to measure patient-reported outcomes. Self-reported painful joint count (PJC) could be useful to…
Abstract Number: 299 • 2016 ACR/ARHP Annual Meeting
Minimally Important Differences for Four Patient-Reported Outcomes Measurement Information System (PROMIS) Short Forms: Physical Function, Pain Interference, Depression, and Anxiety Among Adults with Knee Osteoarthritis
Augustine Lee¹, Lori Lyn Price², Jeffrey Driban³, William F. Harvey¹, Timothy E. McAlindon⁴, Angie Mae Rodday⁵ and Chenchen Wang¹, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Clinical Care Research, Tufts Medical Center, Boston, MA, ³Tufts Medical Center, Boston, MA, ⁴Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁵Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA
Background/Purpose: Patient-Reported Outcomes Measurement Information System (PROMIS) provides reliable, valid measures of health status to resolve many challenges with comparability and interpretability in OA.…
Abstract Number: 2346 • 2016 ACR/ARHP Annual Meeting
The Improving Motivation for Physical Activity in Arthritis Clinical Trial for Adults with Knee Osteoarthritis and Rheumatoid Arthritis
Abigail Gilbert¹, Julia (Jungwha) Lee², Pamela Semanik³, Jing Song⁴, Christine Pellegrini⁵, Daniel Pinto⁶, Dorothy D. Dunlop⁴, Rowland W. Chang⁷ and Linda S. Ehrlich-Jones⁸, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Preventive Medicine/Biostatistics, Northwestern University Feinberg School of Medicine, Chicago, IL, ³College of Nursing, Rush University, Chicago, IL, ⁴Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Department of Physical Therapy & Human Movement Sciences, Northwestern University, Chicago, IL, ⁷Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁸Research CROR, Rehabilitation Institute Chicago, Chicago, IL
Abstract: Background/Purpose: Insufficiently active adults experience reduced quality of life. Because half of adults with arthritis are physically inactive, we evaluated the additional effect of…
Abstract Number: 303 • 2016 ACR/ARHP Annual Meeting
Knee Physical Exam Findings and Self-Reported Symptoms Are Associated with MRI-Detected Effusion-Synovitis Among Participants with or at Risk for Knee Osteoarthritis: Data from the Osteoarthritis Initiative (OAI)
Adam Berlinberg¹, Jordan Westra², Erin L. Ashbeck², Jaren Trost¹, Frank Roemer^3,4, Ali Guermazi⁵ and C. Kent Kwoh⁶, ¹Department of Medicine, University of Arizona, Tucson, AZ, ²The University of Arizona Arthritis Center, Tucson, AZ, ³Department of Radiology, Boston University School of Medicine, Boston, MA, ⁴Radiology, University of Erlangen, Erlangen, Germany, ⁵Boston University School of Medicine, Boston, MA, ⁶1501 N. Campbell Avenue, Room 8303, The University of Arizona Arthritis Center, Tucson, AZ
Background/Purpose: Inflammation has been implicated in the pathogenesis of KOA, but the relevance of physical exam findings and patient-reported symptoms of inflammation is unknown. Our…
Abstract Number: 2362 • 2016 ACR/ARHP Annual Meeting
Progression of Pain and Ultrasound Detected Synovitis in Patients with Erosive Hand Osteoarthritis over One Year
Olga Sleglova¹, Olga Ruzickova¹, Karel Pavelka¹ and Ladislav Senolt^1,2, ¹Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ²Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
Background/Purpose: Hand osteoarthritis (HOA) is a common and frequent cause of pain. HOA is a heterogeneous group of disorders with two main subsets including non-erosive…
Abstract Number: 316 • 2016 ACR/ARHP Annual Meeting
Postural Stability Is Associated with Lower Pain, Lower Stiffness, and Higher Muscle Power Among Adults with Symptomatic Knee Osteoarthritis
Wei Liu¹, Augustine C. Lee², William F. Harvey², Lori Lyn Price³, Jeffrey B. Driban² and Chenchen Wang², ¹Osteopathic Rehabilitation and Biomechanics, 1Edward Via College of Osteopathic Medicine, Auburn, AL, USA, Auburn, AL, ²Rheumatology, Tufts Medical Center, Boston, MA, ³Clinical Care Research, Tufts Medical Center, Boston, MA
Background/Purpose: Postural stability is an indicator of static standing balance and a critical component of physical function and fall prevention among those with knee OA.…
Abstract Number: 2363 • 2016 ACR/ARHP Annual Meeting
Synovial Changes Detected By Ultrasound and Its Association with Knee Pain: A Population-Based Case Control Study
Aliya Sarmanova^1,2, Michelle Hall³, Gwen Fernandes^2,4,5, Archan Bhattacharya^1,6, Ana Valdes^1,2,5, David Walsh^2,5,7, Michael Doherty^2,4,5 and Weiya Zhang^2,4,5, ¹Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, the UK, Nottingham, United Kingdom, ²Arthritis Research UK Pain Centre, Nottingham, United Kingdom, ³School of Health Sciences, University of Nottingham, the UK, Nottingham, United Kingdom, ⁴Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ⁵Arthritis Research UK Centre for Sports, Exercise and Osteoarthritis, Nottingham, United Kingdom, ⁶Arthritis Research UK Centre for Sports, Exercise and Osteoarthritis, Nottignham, United Kingdom, ⁷Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, the UK, Nottignham, United Kingdom
Background/Purpose: To examine whether synovial changes on ultrasound (US) associate with knee pain (KP) and/or underlying structural radiographic changes of osteoarthritis (OA).Methods: In this case-control…
Abstract Number: 320 • 2016 ACR/ARHP Annual Meeting
The Value of Adjusting for Physical Activity When Measuring Osteoarthritis-Related Pain
Kelli Allen¹, Katherine Hall², Jennifer H. Lindquist³, Shannon Taylor⁴ and Cynthia Coffman⁵, ¹University of North Carolina at Chapel Hill and Durham VA Medical Center, Chapel Hill, NC, ²Durham VA Medical Center and Duke University Medical Center, Durham, NC, ³Health Services Research, Durham VA Medical Center, Durham, NC, ⁴Durham VA Medical Center, Durham, NC, ⁵Health Services Research, Durham VA Medical Center and Duke University Medical Center, Durham, NC
Background/Purpose: Measures of chronic pain typically do not account for individuals’ physical activity (PA) levels. Although PA is essential for managing conditions like osteoarthritis (OA),…
Abstract Number: 2370 • 2016 ACR/ARHP Annual Meeting
Factors Affecting Interval Changes in Perceived Fatigue over Five Years in Patients with Rheumatoid Arthritis Compared with Osteoarthritis
Simon Stebbings^1,2, Gareth Treharne³, J. Haxby Abbott⁴ and Andrew Gray⁵, ¹Dunedin Hospital, Department of Rheumatology, Dunedin, New Zealand, ²Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand, ³Psychology, University of Otago, Dunedin, New Zealand, ⁴Centre for Musculoskeletal Outcomes Research, Department of Surgical Sciences, University of Otago, Dunedin, New Zealand, ⁵Department of Preventive and Social Medicine, University of Otago, Dunedin, New Zealand
Background/Purpose: In a previous cross-sectional study we noted higher fatigue levels in patients with advanced lower limb OA compared with RA, and identified differences in…

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