Abstracts tagged "Osteoarthritis"

Abstract Number: 1113 • ACR Convergence 2020
Intrameniscal Signal Alterations Strongly Predict Destabilizing Meniscal Tears and Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Jeffrey Driban¹, James MacKay², Timothy McAlindon¹, Matthew Harkey³, Bing Lu⁴, Charles Eaton⁵, Grace Lo⁶, Mary Barbe⁷ and Robert Ward¹, ¹Tufts Medical Center, Boston, MA, ²University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital; Norwich Medical School, University of East Anglia, Cambridge, United Kingdom, ³University of Massachusetts, Worcester, MA, ⁴Brigham and Women's Hospital and Harvard Medical School, Newton, MA, ⁵Brown University, Pawtucket, RI, ⁶Michael E. Debakey VA Medical Center, Baylor College of Medicine, Houston, TX, ⁷Temple University School of Medicine, Philadelphia, PA
Background/Purpose: It is unknown whether early changes in the menisci (e.g., intrameniscal signal alterations) have long-term consequences. We conducted a study to assess the prognostic…
Abstract Number: 1466 • ACR Convergence 2020
Multimorbidity in Rheumatoid Arthritis, Psoriatic Arthritis, Gout, and Osteoarthritis Within the Rheumatology Informatics System for Effectiveness (RISE) Registry
Bryant England¹, Huifeng Yun², Lang Chen³, Kaleb Michaud¹, Ted Mikuls¹ and Jeffrey R Curtis², ¹University of Nebraska Medical Center, Omaha, NE, ²Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Rheumatic and musculoskeletal diseases (RMDs) often predispose the development of other chronic conditions, resulting in multimorbidity. While multimorbidity is increasingly being recognized and examined…
Abstract Number: 1635 • ACR Convergence 2020
Profile of Topical Diclofenac Sodium Gel 1% (Voltaren®) Users in a United States Longitudinal Electronic Health Records Database
Amy Kenneally¹, Frédérique Bariguian², Richard Petruschke¹, Arlene Tave³, Jess Edison⁴, Nicholas M. Sicignano⁵ and Francis Barbone¹, ¹GSK Consumer Healthcare, Warren, NJ, ²GSK Consumer Healthcare S.A., Nyon, Switzerland, ³PharmaLex US Corporation, Fairfax, VA, ⁴Walter Reed National Military Medical Center, Bethesda, ⁵Health ResearchTx LLC., Prevose, PA
Background/Purpose: Diclofenac sodium gel 1% (DSG), a topical non-steroidal anti-inflammatory drug (NSAID), is effective for the relief of osteoarthritis (OA) pain in the elbows, wrists,…
Abstract Number: 1655 • ACR Convergence 2020
Pain Reduction Post Total Knee Replacement in Opioid Users and Non-users
Lindsey MacFarlane¹, Yinzhu Jin¹, Yvonne Lee², Joyce Lii³, Jeffrey Katz⁴, Patricia Franklin⁵ and Seoyoung Kim¹, ¹Brigham and Women's Hospital, Boston, MA, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³Brigham and Women's Hospital, Boston, ⁴Harvard Medical School / The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Boston, MA, ⁵Northwestern University, Chicago
Background/Purpose: End-stage knee osteoarthritis (OA) is often managed with opioids and total knee replacement (TKR). Studies ascertaining opioid use via record review are conflicting as…
Abstract Number: 0130 • ACR Convergence 2020
The Prevalence of Osteoporosis in Individuals with Osteoarthritis: A Systematic Review
Timothy Varghese¹, Ali Ahmadi Pirshahid², Dongkeun Kim² and Yueyang Li², ¹Schulich School of Medicine & Dentistry, Richmond Hill, ON, Canada, ²Schulich School of Medicine & Dentistry, London, ON, Canada
Background/Purpose: There is controversy regarding the relationship between osteoarthritis (OA) and osteoporosis (OP). While OA may be associated with increased bone mineral density (BMD) due…
Abstract Number: 0694 • ACR Convergence 2020
Relationships Among Adherence and Patient Outcomes in a Cognitive Behavioral Plus Physical Activity Intervention for Older Adults with Osteoarthritis and Hypertension
Xiaojun Shi¹, Elizabeth Schlenk² and Susan Sereika¹, ¹University of Pittsburgh School of Nursing, Pittsburgh, ²University of Pittsburgh School of Nursing, Pittsburgh, PA
Background/Purpose: Osteoarthritis of the knee (OAK) affects nearly 14 million older adults and more than half are diagnosed with hypertension (HTN). Cognitive behavior therapy (CBT)…
Abstract Number: 0963 • ACR Convergence 2020
Chronic Obstructive Pulmonary Disease Associated with Prolonged Opiate Use, Increased Short-Term Complications and the Need for Revision Surgery Following Total Knee Arthroplasty
Jillian Glasser¹, Nicholas Lemme², Daniel Yang², Edward Testa², Alan Daniels³ and Valentin Antoci³, ¹University Orthopedics Inc, East Providence, RI, ²Warren Alpert School of Medicine, Providence, RI, ³Warren Alpert School of Medicine, East Providence, RI
Background/Purpose: Chronic obstructive pulmonary disease (COPD) is a condition which causes a substantial burden to patients, physicians, and the healthcare system at large. Medical comorbidities…
Abstract Number: 1114 • ACR Convergence 2020
Longitudinally Assessed Structural Abnormalities on MRI and Relative Contributions to Risk of Incident Radiographic Knee Osteoarthritis over 10 Years of Follow-up
C. Kent Kwoh¹, Ali Guermazi², Erin Ashbeck³, Chengcheng Hu³, Edward Bedrick³, Leena Sharma⁴, Charles Eaton⁵, Marc Hochberg⁶, Rebecca Jackson⁷, Timothy McAlindon⁸, Michael Nevitt⁹, Jane Cauley¹⁰ and Frank Roemer¹¹, ¹University of Arizona of Arizona Arthritis Center and Division of Rheumatology, College of Medicine, University of Arizona, Tucson, AZ, ²Boston University School of Medicine, Boston, MA, ³University of Arizona, Tucson, AZ, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Department of Family Medicine and Epidemiology, Warren Alpert Medical School of Brown University,Department of Epidemiology, School of Public Health of Brown University, Providence, RI, ⁶University of Maryland School of Medicine, Baltimore, MD, ⁷Ohio State University, Columbus, OH, ⁸Tufts Medical Center, Boston, MA, ⁹University of California, San Francisco, San Francisco, CA, ¹⁰University of Pittsburgh, Pittsburgh, PA, ¹¹Boston University School of Medicine, Boston, MA, and Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany
Background/Purpose: MRI has identified joint tissues affected during knee OA development, though the relative importance of structures in the pathogenic process is unknown. Our objective…
Abstract Number: 1468 • ACR Convergence 2020
The Association of Walking Speed from Short- and Standard-Distance Tests with Mortality Risk Among Adults with Radiographic Knee Osteoarthritis: Data from Johnston County Osteoarthritis Project, Osteoarthritis Initiative and Multicenter Osteoarthritis Study
Hiral Master¹, Tuhina Neogi², Leigh Callahan³, Amanda Nelson⁴, Michael LaValley⁵, Rebecca Cleveland⁶, Yvonne Golightly⁷, Louise Thoma⁸, Yuqing Zhang⁹, Dana Voinier¹⁰, Meredith Christiansen¹¹, Jason Jakiela¹⁰, Michael Nevitt¹², Cora Lewis¹³, Laura Frey Law¹⁴ and Daniel White¹⁰, ¹Vanderbilt University Medical Center, Nashville, TN, ²Boston University School of Medicine, Boston, MA, ³University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, ⁴University of North Carolina Chapel Hill, Chapel Hill, ⁵Boston University School of Public Health, Boston, MA, ⁶University of North Carolina, Chapel Hill, NC, ⁷University of North Carolina at Chapel Hill Dept of Epidemiology, Chapel Hill, NC, ⁸University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁹Massachusetts General Hospital, Harvard Medical School, Boston, ¹⁰University of Delaware, Newark, DE, ¹¹University of Delaware, New York, NY, ¹²University of California, San Francisco, San Francisco, CA, ¹³University of Alabama Birmingham, Birmingham, AL, ¹⁴University of Iowa, Iowa City, IA
Background/Purpose: Patients with radiographic knee OA (rKOA) are at increased risk of mortality and walking difficulty may mediate this relation. Walking speed may be used…
Abstract Number: 1640 • ACR Convergence 2020
Clinically Important Improvement in Osteoarthritis Pain at Week 16 After Subcutaneous Administration of Tanezumab: Pooled Analysis from International Studies
Thomas Schnitzer¹, Francis Berenbaum², Philip G Conaghan³, Robert Dworkin⁴, Takaharu Yamabe⁵, Isabelle Davignon⁵, Stefan Wilhelm⁶, Erika Dragon⁷ and Lars Viktrup⁶, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Centre de Recherche Saint-Antoine, INSERM UMR_S 938,Sorbonne Université, Paris, 75012, France, Paris, France, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research Leeds Biomedical Research Centre, Leeds, United Kingdom, ⁴University of Rochester School of Medicine and Dentistry, Rochester, NY, ⁵Pfizer Inc, Groton, CT, ⁶Eli Lilly and Company, Indianapolis, IN, ⁷Pfizer Ltd, Budapest, Hungary
Background/Purpose: Tanezumab is under investigation for the treatment of moderate to severe OA pain. As part of the phase 3 OA program, two randomized, placebo-controlled…
Abstract Number: 1656 • ACR Convergence 2020
Knee OA Outcomes in Patients with Severe Obesity Following Bariatric Surgery or Total Knee Arthroplasty
Jonathan Samuels¹, Stephen Zak², Ran Schwarzkopf², Christine Ren-Fielding³, Manish Parikh⁴, Alex McLawhorn⁵, James Browne⁶, Peter Hallowell⁷, Brian Irving⁸, Craig Wood⁹, Christopher Still⁹ and Peter Benotti⁹, ¹NYU Langone, Rye Brook, NY, ²NYU Langone Health, New York, NY, ³NYU Langone Health, New YOrk, ⁴Bellevue Hospital, New York, NY, ⁵Hospital for Special Surgeyr, New York, ⁶University of Virginia, Charlottesville, VA, ⁷University of Virginia, Charlottesville, ⁸Louisiana State University, Baton Rouge,, LA, ⁹Obesity institute at Geisinger, Danville
Background/Purpose: High body mass index (BMI, kg/m2) is a modifiable risk factor that has been associated with the development and progression of osteoarthritis (OA) and…
Abstract Number: 0140 • ACR Convergence 2020
Meaningful Within-Patient Change in WOMAC Domains in Patients with Moderate-To- Severe Osteoarthritis
Philip G Conaghan¹, Robert Dworkin², Thomas Schnitzer³, Francis Berenbaum⁴, Andrew Bushmakin⁵, Joseph Cappelleri⁵, Lars Viktrup⁶ and Lucy Abraham⁷, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and National Institute for Health Research Leeds Biomedical Research Centre, Leeds, United Kingdom, ²University of Rochester School of Medicine and Dentistry, Rochester, NY, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Sorbonne Universite�, Paris, France, ⁵Pfizer Inc, Groton, CT, ⁶Eli Lilly and Company, Indianapolis, IN, ⁷Pfizer Inc, Tadworth, United Kingdom
Background/Purpose: The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is a disease-specific measure of osteoarthritis (OA) symptoms (pain and stiffness) and functional impairment regularly…
Abstract Number: 0699 • ACR Convergence 2020
Lumbar Spine Stenosis Treatment : Is Surgery Better Than Medical Treatment in Afro-Descendant Populations ?
Fabienne Louis-sidney¹, Serge Arfi¹, Moustapha Drame¹, Christophe Deligny¹, Philippe Cabre¹ and Michel de Bandt¹, ¹University Hospital Martinique, Fort de France, Martinique
Background/Purpose: Lumbar spinal stenosis (LSS) is a disabling condition, mostly prevalent in the aging population and associated with significant healthcare cost. Clinical presentation involving neurogenic…
Abstract Number: 0964 • ACR Convergence 2020
Is Meniscal Status in the Anterior Cruciate Ligament Injured Knee Associated with Change in Bone Surface Area? An Exploratory Analysis of Data from the KANON Trial
Barbara Snoeker¹, Aleksandra Turkiewicz¹, Mike Bowes², Frank Roemer³, Stefan Lohmander¹, Richard Frobell¹ and Martin Englund¹, ¹Lund University, Lund, Sweden, ²Imorphics Ltd, Manchester, United Kingdom, ³Boston University School of Medicine, Boston, MA, and Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany
Background/Purpose: Bone shape changes, which may be an important feature of osteoarthritis (OA) development, have been observed to occur early in the knee after anterior…
Abstract Number: 1115 • ACR Convergence 2020
The Relation of MRI-Based Cartilage Lesions to Knee Replacement and Knee Pain Severity in Osteoarthritis: The Multicenter Osteoarthritis Study
Tuhina Neogi¹, David Felson¹, Kathy Bacon², James Torner³, Cora Lewis⁴, Michael Nevitt⁵ and S. Reza Jafarzadeh¹, ¹Boston University School of Medicine, Boston, MA, ²Boston University School of Medicine, Boston, ³University of Iowa, Iowa City, IA, ⁴University of Alabama Birmingham, Birmingham, AL, ⁵University of California, San Francisco, San Francisco, CA
Background/Purpose: Recently, the FDA has indicated that data supporting imaging biomarkers of relevance to clinically important outcomes, such as knee replacement (KR) may be considered…

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