Abstract Number: 0702 • ACR Convergence 2020
Distinct Murine Cartilage Microbial DNA Signatures Are Seen in High Fat Diet-Induced Obesity and Aging
Background/Purpose: The strongest nongenetic risk factors for primary knee OA are advanced age and obesity. We have previously shown a human cartilage microbial DNA signature…Abstract Number: 1102 • ACR Convergence 2020
Neuropathic Pain in Inflammatory Hand Osteoarthritis(OA) Lowers Quality of Life and May Require Another Approach Than Anti-inflammatory Treatment
Background/Purpose: To investigate whether neuropathic pain is present in patients with inflammatory hand OA, to investigate characteristics of those patients and the impact of neuropathic…Abstract Number: 1118 • ACR Convergence 2020
Bone Marrow Lesion Scores in Patients with Knee Osteoarthritis Undergoing Tibial Osteotomy: Reliability and Concurrent Validity of the Knee Inflammation MRI Scoring System (KIMRISS)
Background/Purpose: Bone marrow lesions (BMLs) commonly occur in knee osteoarthritis (OA) and are associated with increased risk of cartilage damage and pain. The Knee Inflammation…Abstract Number: 1484 • ACR Convergence 2020
Efficacy of Tocilizumab in Patients with Hand Osteoarthritis: Double Blind, Randomized, Placebo Controlled, Multicenter Trial
Background/Purpose: To evaluate the efficacy of tocilizumab, an antibody against interleukin-6 receptor (IL-6R), in patients with hand osteoarthritis.Methods: This was a multicenter, 12-week, randomized, double-blind,…Abstract Number: 1644 • ACR Convergence 2020
Radiographic Exclusionary Findings During Screening for Three Phase III Trials of Subcutaneous Tanezumab in Patients with Moderate to Severe Hip or Knee Osteoarthritis
Background/Purpose: Tanezumab is a nerve growth factor monoclonal antibody in development for osteoarthritis (OA). Following a clinical hold due to concerns around adverse joint events,…Abstract Number: 1660 • ACR Convergence 2020
Sleep Disturbance and Pain Severity and Multi-site Pain: A Prospective 10.7-year Follow-up Study
Background/Purpose: Sleep disturbance is often comorbid with chronic pain disorders, with emerging evidence suggesting a stronger effect of sleep disturbance on pain than vice versa;…Abstract Number: 0537 • ACR Convergence 2020
Hip Abductor Strength and Its Association with New or Worsening Knee Pain: The MOST Study
Background/Purpose: Hip abductors are important for controlling pelvic orientation and rotation of the femur during gait, both of which affect knee mechanics. Thus hip abductor…Abstract Number: 0703 • ACR Convergence 2020
Liraglutide as a Potential Intra-Articular Treatment for Cartilage Regeneration in Osteoarthritis: In Vitro and In Vivo Studies Supporting a Pro-Chondrogenic Effect
Background/Purpose: Osteoarthritis (OA) is an age-related joint disease affecting millions of individuals worldwide and associated with an extremely high burden largely attributable to disability. To…Abstract Number: 1103 • ACR Convergence 2020
Metacarpo-phalangeal Osteoarthritis Is Not Rare and Is Associated with Mechanical Rather Than Systemic Factors in Hand Osteoarthritis: An Observational Study from a Large Hospital-based Cohort
Background/Purpose: Proximal and distal inter-phalangeal (PIP, DIP) and thumb base joints are the most common sites affected in hand osteoarthritis (HOA), while involvement of metacarpo-phalangeal…Abstract Number: 1119 • ACR Convergence 2020
Association of Primary Insurance Status on Bilateral Knee Arthroplasty Utilization and Complications: A United States Nationwide Analysis
Background/Purpose: In patients with end-stage bilateral knee osteoarthritis, treatment options include either a staged total knee arthroplasty (TKA) procedure, often with a few months in…Abstract Number: 1485 • ACR Convergence 2020
LNA043, a Novel Cartilage Regenerative Treatment for Osteoarthritis: Results from a First-In-Human Trial in Patients with Knee Osteoarthritis
Background/Purpose:LNA043 is a modified human angiopoietin-like 3 (ANGPTL3) protein identified in a phenotypic screen for inducers of chondrogenesis and cartilage repair. The primary objective of…Abstract Number: 1645 • ACR Convergence 2020
Placebo Group Responses in Clinical Trials of Patients with Osteoarthritis: Data from the Tanezumab Development Program
Background/Purpose: The level of placebo group response in clinical trials for chronic pain conditions is a concern for the development of novel analgesics1. Here, we…Abstract Number: 1661 • ACR Convergence 2020
Systematic Review and Meta-Analysis of the Prevalence of Neuropathic-Like Pain and Pain Sensitisation in People with Knee and Hip Osteoarthritis
Background/Purpose: Pain in osteoarthritis (OA) may be nociceptive or neuropathic-like in nature. In knee OA, pain severity is known to be poorly correlated with joint…Abstract Number: 0539 • ACR Convergence 2020
Sports with a Bat or Racket Are Not Associated with Thumb-base Osteoarthritis: Data from the Osteoarthritis Initiative
Background/Purpose: Sports that require the use of a racket or bat to propel a ball (e.g., baseball, softball, tennis) expose the thumb-base to repetitive high-velocity…Abstract Number: 0704 • ACR Convergence 2020
The Murine Ear Wound Cartilage Superhealer Trait, Mediated by the Gut Microbiome, Is Transgenerationally Heritable Following Cecal Transplantation
Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. We have…
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