Abstracts tagged "Osteoarthritis"

Abstract Number: 1491 • ACR Convergence 2020
Association of a Leaky Gut but Not Microbial Dysbiosis with Obesity-related OA: A Translational Study
Richard Loeser¹, Liubov Arbeeva¹, Kathryn Kelley², Anthony Fodor³, Shan Sun³, Veronica Ulici⁴, Lara Longobardi², Yang Cui², Susan Sumner², Andrea Azcarate-Peril², Balfour Sartor², Ian Carrol² and Amanda Nelson¹, ¹University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ²University of North Carolina, Chapel Hill, NC, ³University of North Carolina-Charlotte, Charlotte, NC, ⁴Brown University, Providence, RI
Background/Purpose: To test the hypothesis that an altered gut microbiota (dysbiosis) plays a causal role in the obese OA phenotype (obesity with both hand and…
Abstract Number: 1651 • ACR Convergence 2020
Efficacy and Safety of Multiple Intra-articular Corticosteroid Injections for Osteoarthritis – a Systematic Review and Meta-analysis of Randomised Controlled Trials and Observational Studies
Shazeen Ayub¹, Jaspreet Kaur¹, Michelle Hui², Michelle Hall¹, Michael Doherty³ and Weiya Zhang¹, ¹Academic Rheumatology, School of Medicine, University of Nottingham, UK, Nottingham, United Kingdom, ²Royal Derby Hospital, Derby, UK, Derby, United Kingdom, ³Academic Rheumatology, School of Medicine, University of Nottingham, UK, Nottingham, England, United Kingdom
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis worldwide and is becoming more prevalent with the increasing age of the population. As Intra-articular…
Abstract Number: 1971 • ACR Convergence 2020
Gut Microbiome Transplantation from MRL/MpJ Mice Prevents Post-Traumatic Osteoarthritis in C57BL6/J Mice
Matlock Jeffries¹, Jake Martin¹, Vladislav Izda¹, Cassandra Garman¹, Cassandra Velasco¹ and Christopher Dunn², ¹University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²University of Oklahoma HSC, Edmond, OK
Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. We have…
Abstract Number: 0063 • ACR Convergence 2020
Novel Repurposed Drugs Against Joint Inflammation Reveal Potential Use for Gout Treatment: An In Silico, In Vitro and Clinical Study
Eloi Franco-Trepat¹, Ana Alonso-Pérez¹, Maria Guillán-Fresco¹, Miriam López-Fagundez¹, Andrés Pazos-Pérez¹, Ana Lois Iglesias², Susana Belén Bravo³, Alberto Jorge-Mora¹, JJ Gómez-Reino⁴ and Rodolfo Gómez¹, ¹IDIS-CHUS - Musculoskeletal Pathology Group, Santiago de Compostela, Spain, ²IDIS-CHUS - Musculoskeletal Pathology Group, A Coruna, Spain, ³IDIS-CHUS - Proteomics Unit, Santiago de Compostela, Galicia, Spain, ⁴IDIS-CHUS - Rheumatology Group, Santiago de Compostela, Spain
Background/Purpose: Joint inflammation is a common feature across multiple rheumatic diseases. To deal with the induction of innate immune factors, targeting therapeutic targets such as…
Abstract Number: 0593 • ACR Convergence 2020
Patient Characteristics and Factors Affecting Decision-Making Regarding Total Knee Replacement by Different Types of Physicians Treating Patients with Knee OA
Angela Bedenbaugh¹, Vinson Lee¹, Gary Oderda², Sarah Kennedy¹, Jeyanesh Tambiah¹, Diana Brixner² and Timothy McAlindon³, ¹Samumed, LLC, San Diego, CA, ²University of Utah, Salt Lake City, UT, ³Tufts Medical Center, Boston, MA
Background/Purpose: Total knee replacement (TKR) is considered an effective knee OA treatment and is a commonly performed orthopedic procedure that relieves pain and improves function and…
Abstract Number: 0926 • ACR Convergence 2020
Risk Factors for Fractures and Osteoporosis Among Patients with Systemic Sclerosis in a United States Cohort
Sina Famenini¹, Jamie Perin², Kristin Wipfler³, Kaleb Michaud⁴ and Zsuzsanna McMahan⁵, ¹Johns Hopkins School of Medicine, Baltimore, MD, ²JHUSPH, Baltimore, ³FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵Johns Hopkins University, Baltimore
Background/Purpose:Systemic sclerosis (SSc) is associated with several risk factors for osteoporosis and fractures due to malabsorption or malnutrition, physical disability, chronic inflammation, and use of…
Abstract Number: 1110 • ACR Convergence 2020
Osteoarthritis-Related Knee Inflammation Measured by Ultrasound Is Associated with Performance-Based Measures of Function
Holly Philpott¹, Trevor Birmingham², Ryan Pinto², Dominique Arsenault², Codie Primeau², Edward Vasarhelyi³, Steven MacDonald³, Brent Lanting³ and Tom Appleton⁴, ¹Western University, London, ON, Canada, ²Western University, London, Canada, ³London Health Sciences Centre, London, Canada, ⁴The University of Western Ontario, LONDON, ON, Canada
Background/Purpose: Signs of inflammation in knee osteoarthritis (OA), including synovitis, are associated with worse clinical outcomes such as increased pain, risk of progression, and future…
Abstract Number: 1333 • ACR Convergence 2020
Ankylosing Spondylitis Patients at Risk of Developing Aortic Valve Regurgitation, Need for Mandatory Echocardiography?
Milad Baniaamam¹, Sjoerd C. Heslinga², Laura Boekel¹, M. Louis Handoko³, Thelma C. Konings³, Otto Kamp³, Vokko P. van Halm⁴, J. Christiaan van Denderen¹, Irene van der Horst-Bruinsma² and Mike Nurmohamed⁵, ¹Reade, Amsterdam, Netherlands, ²Department of Rheumatology, Amsterdam UMC, location VU University Medical Centre, Amsterdam, Netherlands, ³Department of Cardiology, Amsterdam UMC, location VU University Medical Centre, Amsterdam, Netherlands, ⁴Department of Cardiology, Amsterdam UMC, location VU University Medical Centre, Amsterdam, ⁵Amsterdam Rheumatology and immunology Center, location Reade and Amsterdam UMC, VU medical center, Amsterdam, Netherlands
Background/Purpose: The overall mortality rate in ankylosing spondylitis (AS) patients is increased by 60–90% compared with the general population. This higher mortality rate is predominately…
Abstract Number: 1541 • ACR Convergence 2020
Ultrasound in Knee Osteoarthritis: Reader Performance, Sonographic Features, and Correlation with Radiographic Findings
Ogonna Nwawka¹, Susan Lee¹, Bin Lin², Said Ibrahim³, Collin Brantner⁴, Peter Sculco⁵, Michael Parks¹, Mark Figgie⁶, Laura Donlin¹, Dana Orange⁷, Serene Mirza², Michael Cross¹, Jose Rodriguez¹, Thomas Sculco¹, Miguel Otero², William Robinson⁸, Susan Goodman⁶ and Bella Mehta⁵, ¹Hospital for Special Surgery, Weill Cornell Medicine, New York, ²Hospital for Special Surgery, New York, ³Weill Cornell Medicine, Cleveland, OH, ⁴Hospital for Special Surgery, New York, NY, ⁵Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁶Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁷Rockefeller University, New York, ⁸Stanford University, Palo Alto, CA
Background/Purpose: Radiography is the most widespread imaging technique used in the evaluation of knee osteoarthritis (KOA), and MRI is known to be specific in characterization…
Abstract Number: 1652 • ACR Convergence 2020
Progression of Knee OA with Use of Intra-articular Corticosteroids (CS) vs Hyaluronic Acid (HA)
Justin Bucci¹, Xiaoyang Chen¹, James Torner², Michael Nevitt³, Cora Lewis⁴ and David Felson⁵, ¹Boston University, Boston, MA, ²University of Iowa, Iowa City, IA, ³University of California, San Francisco, Orinda, CA, ⁴University of Alabama Birmingham, Birmingham, AL, ⁵Boston University School of Medicine, Boston, MA
Background/Purpose: Recent studies have questioned whether CS injections (CSI), a popular treatment recommended by guidelines, hasten progression of knee OA. A recent cohort study suggested…
Abstract Number: 1972 • ACR Convergence 2020
NGF-Responsive Neurons Are Sensitized in Experimental Osteoarthritis
Rachel Miller¹, Shingo Ishihara¹, Alia Obeidat¹ and Anne-Marie Malfait¹, ¹Rush University, Chicago, IL
Background/Purpose: Nerve growth factor (NGF) is under investigation as a promising target for osteoarthritis (OA) pain. NGF exerts its potent pro-algesic effects through sensitization of…
Abstract Number: 0081 • ACR Convergence 2020
Prevalence of Systemic Autoimmune Diseases in Polycystic Ovary Syndrome
Saika Sharmeen¹, Hafsa Nomani², Erin Taub³ and Qingping Yao³, ¹Stony Brook University Renaissance School of Medicine, Dix Hills, NY, ²Stony Brook University Renaissance School of Medicine, West Babylon, NY, ³Stony Brook University Renaissance School of Medicine, Stony Brook, NY
Background/Purpose: Polycystic ovary syndrome (PCOS) is characterized by hormonal abnormality, chronic anovulation, hyperandrogenism, and obesity. Due to the hormonal imbalance, we hypothesize that patients with…
Abstract Number: 0609 • ACR Convergence 2020
Impact of Depressive Symptoms, Anti-depression Treatment on Direct Medical Costs Among Medicare Beneficiaries with Knee Osteoarthritis (KOA)
Shuang Song¹, Jeffrey Katz² and Elena Losina², ¹Brigham and Women's Hospital, Brighton, MA, ²Harvard Medical School / The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Boston, MA
Background/Purpose: Depressive symptoms are prevalent among knee OA (KOA) patients and likely lead to additional medical costs. We sought to quantify the prevalence of depressive…
Abstract Number: 0934 • ACR Convergence 2020
Warfarin Use and Risk of Knee and Hip Replacements
Priyanka Ballal¹, Christine Peloquin¹, Cindy Boer² and Tuhina Neogi¹, ¹Boston University School of Medicine, Boston, MA, ²Erasmus Medical Center, Rotterdam, Netherlands
Background/Purpose: Vitamin K is an essential co-factor in the post-translational gamma-carboxylation of glutamic acid to form gamma-carboxy-glutamic acid (Gla) residues. This confers functionality to vitamin…
Abstract Number: 1111 • ACR Convergence 2020
Intra-Articular Mineralization on Knee CT Increases Risk of Knee Pain: The Multicenter Osteoarthritis Study
Tuhina Neogi¹, John Lynch², Mohamed Jarraya³, David Felson¹, Na Wang¹, James Torner⁴, Cora Lewis⁵, Michael Nevitt⁶ and Ali Guermazi¹, ¹Boston University School of Medicine, Boston, MA, ²UCSF, San Francisco, CA, ³Boston University School of Medicine, Boston, ⁴University of Iowa, Iowa City, IA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶University of California, San Francisco, San Francisco, CA
Background/Purpose: Intra-articular (i.a.) calcium crystal deposition is common in knee osteoarthritis (OA). Low-grade inflammation related to crystals may contribute to knee pain, including pain fluctuation.…

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