Abstracts tagged "Osteoarthritis"

Abstract Number: 1781 • ACR Convergence 2022
Knee Pain Is Highly Associated with Ankle/Foot Pain, Arch Height, and Arch Flexibility: The Johnston County Osteoarthritis Project
Yvonne Golightly¹, Marian Hannan², Howard Hillstrom³, Rajshree Hillstrom⁴, Mary Catherine Minnig⁵ and Amanda Nelson⁶, ¹University of Nebraska Medical Center, Omaha, NE, ²Marcus Institute for Aging Research, Hebrew SeniorLife, Milton, MA, ³Hospital for Special Surgery, New York, NY, ⁴Biomed Consulting, Inc., Manhattan, NY, ⁵University of North Carolina, Chapel Hill, NC, ⁶University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: In knee osteoarthritis (OA), the contribution of the ankle and foot up the kinetic chain to the knee is not well understood. Ankle and…
Abstract Number: 1900 • ACR Convergence 2022
CoLchicine for Treatment of OsteoArthritis of the Knee (CLOAK)-A Double-blind, Placebo-controlled Trial
Jonathan Samuels¹, Michael Pillinger², Michael Toprover³, Svetlana Krasnokutsky Samuels⁴, Apoorva Patil⁵, Fernando Bomfim⁶, Renata La Rocca Vieira⁶, David Wei⁵, Sydney Catron⁵, Maryfe coronel⁵, Annie Kim⁵ and Sarah Moussavi⁵, ¹NYU Langone, Rye Brook, NY, ²NYU Grossman School of Medicine, New York, NY, ³Division of Rheumatology, New York University Grossman School of Medicine and Rheumatology Section, New York Harbor Health Care System, New York Campus of the U.S. Department of Veterans Affairs, New York, NY, ⁴Westmed, Rye Brook, NY, ⁵NYU Langone Health, New York, NY, ⁶NYU Langone, New York, NY
Background/Purpose: Knee osteoarthritis (OA) is an inflammatory disease, with a probable role for IL-1b. Calcium and urate crystals may promote OA by activating the NLRP3…
Abstract Number: 1916 • ACR Convergence 2022
Defining Early-stage Knee Osteoarthritis: A Scoping Review
Jean Liew¹, Lauren King², Armaghan Mahmoudian³, Qiuke Wang⁴, Tuhina Neogi¹ and Gillian Hawker², ¹Boston University School of Medicine, Boston, MA, ²University of Toronto, Toronto, ON, Canada, ³Lund University, Lund, Sweden, ⁴Erasmus Medical Center, Rotterdam, Netherlands
Background/Purpose: Clinical trials of disease-modifying agents in knee osteoarthritis (OA) have largely failed to date. Identifying individuals with knee OA at an earlier stage in…
Abstract Number: 0033 • ACR Convergence 2022
Adenosine A2A Receptor Signaling Enhances Expression of an Endogenous p53 Mouse Variant in Bone Marrow Mesenchymal Stem Cells
Benjamin Friedman¹ and Bruce Cronstein², ¹NYU Langone, New York, NY, ²NYU School of Medicine, New York, NY
Background/Purpose: Our lab has demonstrated the ability of an intra-articular liposomal formulation of an adenosine A2A receptor (A2AR), CGS21680, to regenerate cartilage in multiple rodent…
Abstract Number: 0837 • ACR Convergence 2022
Providers’ Adoption of 2017 Guidelines on DMARD Use Perioperatively for Elective Total Hip and Knee Arthroplasty at a Single Academic Center
Chris Ching¹, Erica Mulcaire-Jones², Andrew Shaffer¹, Jeremy Gililland¹, Michael Battistone³ and Dorota Lebiedz-Odrobina¹, ¹University of Utah, Salt Lake City, UT, ²Intermountain Healthcare, Salt Lake City, UT, ³Salt Lake City VA, Salt Lake City, UT
Background/Purpose: Rate of prosthetic joint infection (PJI) after total joint arthroplasty (TJA) is higher in patients with rheumatic conditions than in patients with OA. Our…
Abstract Number: 1249 • ACR Convergence 2022
Short-term Variations in Subchondral Tibial Bone Texture of Conventional X-Rays Predicts Knee Osteoarthritis Progression
Ahmad Almhdie-Imjabbar¹, Hechmi TOUMI², Zineb ZERZOUF³ and Eric LESPESSAILLES⁴, ¹University of Orleans / CHR Orleans, France, Orleans, Centre, France, ²Regional hospital centre of Orleans, France, Orleans, France, ³University of Tours, Tours, France, ⁴Regional hospital centre of Orleans, France, ORLEANS, Centre, France
Background/Purpose: Early detection and assessment of Knee Osteoarthritis (KOA) prognostic factors are crucial for developing management and treatments that aim at prevention of irreversible damage…
Abstract Number: 1783 • ACR Convergence 2022
Exploring How and Why Organizations Identify, Adopt, Disseminate, and Sustain Evidence-based Programs for Latinos with Arthritis
Marvin Albert Meza Jarquín¹, Leigh Callahan², Serena Weisner³, Kirsten Ambrose³ and Sandra Soto⁴, ¹School of Medicine, University of North Carolina (UNC), Chapel Hill, NC, ²University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, ³Thurston Arthritis Research Center, Chapel Hill, NC, ⁴Thurston Arthritis Research Center, UNC Division of Rheumatology, Allergy and Immunology, Chapel Hill, NC
Background/Purpose: Physical activity (PA) is effective in the self-management of arthritis. As such, several evidence-based programs aimed at supporting safe and meaningful PA have been…
Abstract Number: 1901 • ACR Convergence 2022
What Does Radiographic Minimum JSW Actually Measure? Comparison of Radiographic and MRI Measures Using Data from the OAI
Alan Brett¹, Michael Bowes² and Philip G Conaghan³, ¹Stryker, Austin, TX, ²Stryker, Manchester, United Kingdom, ³University of Leeds, Leeds, United Kingdom
Background/Purpose: Change in radiographic joint space width (JSW) is used as a surrogate for cartilage loss and recognized by regulatory bodies as a measure of…
Abstract Number: 1917 • ACR Convergence 2022
A Remote Behaviorally-Designed Intervention to Promote Physical Activity in Patients with Knee Osteoarthritis: Results of a Pilot Randomized Clinical Trial
William Leach¹, Marianna Olave¹, Caleigh Doherty², Rachel Gillcrist¹, Daniel White³, Keith Robinson¹, Alexis Ogdie⁴, Tuhina Neogi⁵, Carla Scanzello⁶ and Joshua Baker⁶, ¹Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, ²Corporal Michael J. Crescenz VAMC, Philadelphia, PA, ³University of Delaware, Newark, DE, ⁴Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ⁵Boston University School of Medicine, Boston, MA, ⁶University of Pennsylvania, Philadelphia, PA
Background/Purpose: In this pilot and feasibility study, we evaluated whether a behaviorally-designed intervention utilizing gamification and social support could improve both physical activity and reduce…
Abstract Number: 0072 • ACR Convergence 2022
Geographical Patterns of Healthcare Utilization Among RA and OA Patients
Sofia Pedro¹, Luke Desilet², Patricia Katz³ and Kaleb Michaud², ¹Forward, The National Databank for Rheumatic Diseases, Wichita, KS, ²University of Nebraska Medical Center, Omaha, NE, ³UCSF, San Rafael, CA
Background/Purpose: Rural residence has been associated with disparities in healthcare-related outcomes in both rheumatic diseases and other chronic conditions. A primary causal pathway for this…
Abstract Number: 0838 • ACR Convergence 2022
Is SARS-CoV-2 Associated with Worse Outcomes After Total Knee Arthroplasty?
Lisa Mandl¹, Benjamin Swett¹, Robyn Lipschultz¹, Myriam Lin¹, Alison Zhao², Carola Hanreich¹, Dongmei Sun¹, Kethy Jules-elysee¹ and Friedrich Boettner¹, ¹Hospital for Special Surgery, New York, NY, ²Cleveland Clinic Lerner College of Medicine, Cleveland, OH
Background/Purpose: Over 520 million people have been infected by SARS-CoV-2. In 10-40%, disabling symptoms such as fatigue and dyspnea can persist. Risk factors for poor…
Abstract Number: 1307 • ACR Convergence 2022
Effect of Romosozumab in Postmenopausal Women with Knee Osteoarthritis: Results from the FRAME Clinical Trial
Nancy Lane¹, Donald Betah², Cynthia Deignan², Mary Oates², Zhenxun Wang², Jen Timoshenko³, Aliya Khan⁴ and Neil Binkley⁵, ¹University of California Davis, Hillsborough, CA, ²Amgen, Inc., Thousand Oaks, CA, ³UCB Pharma, Slough, United Kingdom, ⁴McMaster University, Oakville, ON, Canada, ⁵University of Wisconsin, Madison, WI
Background/Purpose: Osteoarthritis (OA) and osteoporosis (OP) often occur concomitantly in the elderly. The relationship between OA and OP is complex, with increased fracture risk reported…
Abstract Number: 1784 • ACR Convergence 2022
Gait Alterations Associated with Worsening Physical Function over 2 Years: A Machine-learning Approach in the Multicenter Osteoarthritis (MOST) Study
Kathryn Bacon¹, David Felson¹, S. Reza Jafarzadeh², Vijaya Kolachalama², Jeffrey Hausdorff³, Eran Gazit⁴, Joshua Stefanik⁵, Patrick Corrigan⁶, Neil Segal⁷, Cora E. Lewis⁸, Michael Nevitt⁹ and Deepak Kumar¹, ¹Boston University, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³Tel Aviv University, Tel Aviv, Israel, ⁴Tel Aviv Suarasky Medical Center, Tel Aviv, Israel, ⁵Northeastern University, Boston, MA, ⁶Saint Louis University, St. Louis, MO, ⁷University of Kansas, Kansas City, KS, ⁸University of Alabama at Birmingham, Birmingham, AL, ⁹University of California at San Francisco, Orinda, CA
Background/Purpose: Altered gait is related to pathogenesis of knee osteoarthritis (OA). For people with knee OA, in addition to pain, declines in physical function are…
Abstract Number: 1902 • ACR Convergence 2022
Structural Severity in Knee Osteoarthritis Impacts Treatment Response: A Post Hoc Pooled Analysis of Lorecivivint Clinical Trials
Yusuf Yazici¹, Christopher Swearingen², Heli Ghandehari³, ismail simsek⁴, Sarah Kennedy⁵, Jeyanesh Tambiah⁶ and Timothy McAlindon⁷, ¹New York University School of Medicine, La Jolla, CA, ²Samumed LLC, San Diego, CA, ³Biosplice Therapeutics, Inc., San Diego, CA, ⁴Alpine Immunesciences, San Diego, CA, ⁵Biosplice Therapeutics, Inc, San Diego, CA, ⁶Biosplice Ther Inc., San Diego, CA, ⁷Tufts Medical Center, Arlington, MA
Background/Purpose: Osteoarthritis (OA) is a leading cause of disability globally, and its disease burden is expected to increase as risk factors such as aging and…
Abstract Number: 1918 • ACR Convergence 2022
Neurobiological Mechanisms of a Remote-Delivered Mind-body Intervention for Knee Osteoarthritis
Jian Kong¹ and Chenchen Wang², ¹Massachusetts General Hospital, Boston, MA, ²Tufts Medical Center, Boston, MA
Background/Purpose: As a recommended intervention for knee Osteoarthritis (OA) according to current guidelines, Tai Chi, a multi-dimensional exercise has exhibited clinically significant improvements in knee…

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