Abstracts tagged "Osteoarthritis"

Abstract Number: 1775 • ACR Convergence 2022
More Than Half of Patients with Osteoarthritis Have Positive Screening for Fibromyalgia And/or Depression, Feasibly Assessed in Routine Care on Indices Within a Single MDHAQ (multidimensional Health Assessment Questionnaire)
Theodore Pincus¹, Kathryn Gibson², Juan Schmukler¹, Tengfei Li³ and Joel Block¹, ¹Rush University Medical Center, Chicago, IL, ²Liverpool Hospital, Sydney, Australia, ³Georgetown University, Washington, DC
Background/Purpose: Osteoarthritis (OA) patients may have widely divergent scores for pain severity vs X-ray joint damage, indicating that elevated OA pain 0-10 visual numeric scale…
Abstract Number: 1899 • ACR Convergence 2022
A Phase 3, 28-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial (OA-10) to Evaluate the Efficacy and Safety of a Single Injection of Lorecivivint Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects
Yusuf Yazici¹, Christopher Swearingen², Heli Ghandehari³, Victor Lopez⁴, ismail simsek⁵, Mark Fineman⁶, Sarah Kennedy⁷, Jeyanesh Tambiah⁸ and Timothy McAlindon⁹, ¹New York University School of Medicine, La Jolla, CA, ²Samumed LLC, San Diego, CA, ³Biosplice Therapeutics, Inc., San Diego, CA, ⁴Biosplice Therapeutics, Santa Clarita, CA, ⁵Alpine Immunesciences, San Diego, CA, ⁶Biosplice Therapeutics, San Diego, CA, ⁷Biosplice Therapeutics, Inc, San Diego, CA, ⁸Biosplice Ther Inc., San Diego, CA, ⁹Tufts Medical Center, Arlington, MA
Background/Purpose: Knee osteoarthritis (OA) is a common joint disorder associated with pain, disability, and joint damage. There remains a large unmet need for treatments that…
Abstract Number: 1915 • ACR Convergence 2022
Development of an MRI-based Definition of Knee Osteoarthritis: Data from the Multicenter Osteoarthritis Study
Jean Liew¹, Gabriela Rabasa², Michael LaValley³, Jamie collins⁴, Joshua Stefanik⁵, Ali Guermazi², Cora E. Lewis⁶, Michael Nevitt⁷, James Torner⁸ and David Felson², ¹Boston University School of Medicine, Boston, MA, ²Boston University, Boston, MA, ³Boston University School of Public Health, Arlington, MA, ⁴Brigham and Women's Hospital, Boston, MA, ⁵Northeastern University, Boston, MA, ⁶University of Alabama at Birmingham, Birmingham, AL, ⁷University of California at San Francisco, Orinda, CA, ⁸University of Iowa, Iowa City, IA
Background/Purpose: MRI is becoming the OA imaging modality of choice. It allows quantification of cartilage damage, the signature pathologic feature of disease. Proposed MRI-based definitions…
Abstract Number: 0032 • ACR Convergence 2022
Defective Chaperone-mediated Autophagy Is a Hallmark of Joint Disease in Patients with Knee Osteoarthritis
Irene Lorenzo-Gomez¹, uxia Nogueira-recalde¹, Christian garcía-Domínguez¹, Natividad Oreiro², Martin Lotz³, JA Pinto-Tasende², FJ Blanco² and beatriz caranes¹, ¹Instituto de Investigación Biomédica de A Coruña (INIBIC), Unidad de Biología del Cartílago, A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ³Scripps Research, La Jolla
Background/Purpose: Defects in autophagy contribute to joint aging and Osteoarthritis (OA). Identifying specific autophagy types could be useful for developing novel treatments for OA.Methods: A…
Abstract Number: 0836 • ACR Convergence 2022
Bone Turnover and Physical Activity Before and After Anterior Cruciate Ligament Reconstruction
Elizabeth Wellsandt¹, David Werner¹, Mikayla McKee², Matthew Tao², Kaleb Michaud¹ and Yvonne Golightly¹, ¹University of Nebraska Medical Center, Omaha, NE, ²University of Nebraska Medical Center, Omaha
Background/Purpose: Individuals after anterior cruciate ligament reconstruction (ACLR) have 8 times higher odds of developing knee osteoarthritis (OA) within 10 years compared to those with…
Abstract Number: 1232 • ACR Convergence 2022
Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with Osteoarthritis
Greg Gilles¹, Arjun Vohra¹, Chelsea Caruso¹, Dagoberto Robles¹, Mihra Taljanovic¹, Jeffrey Duryea², Erin Ashbeck¹, Edward Bedrick³ and Kent Kwoh⁴, ¹University of Arizona Arthritis Center, Tucson, AZ, ²Brigham and Women's Hospital, Boston, MA, ³Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, ⁴University of Arizona, Tucson, AZ
Background/Purpose: Effusion-synovitis (ES) on knee MRI has been identified as an important biomarker of OA. Semi-automated software methods offer objective measurements of ES volume on…
Abstract Number: 1781 • ACR Convergence 2022
Knee Pain Is Highly Associated with Ankle/Foot Pain, Arch Height, and Arch Flexibility: The Johnston County Osteoarthritis Project
Yvonne Golightly¹, Marian Hannan², Howard Hillstrom³, Rajshree Hillstrom⁴, Mary Catherine Minnig⁵ and Amanda Nelson⁶, ¹University of Nebraska Medical Center, Omaha, NE, ²Marcus Institute for Aging Research, Hebrew SeniorLife, Milton, MA, ³Hospital for Special Surgery, New York, NY, ⁴Biomed Consulting, Inc., Manhattan, NY, ⁵University of North Carolina, Chapel Hill, NC, ⁶University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: In knee osteoarthritis (OA), the contribution of the ankle and foot up the kinetic chain to the knee is not well understood. Ankle and…
Abstract Number: 1900 • ACR Convergence 2022
CoLchicine for Treatment of OsteoArthritis of the Knee (CLOAK)-A Double-blind, Placebo-controlled Trial
Jonathan Samuels¹, Michael Pillinger², Michael Toprover³, Svetlana Krasnokutsky Samuels⁴, Apoorva Patil⁵, Fernando Bomfim⁶, Renata La Rocca Vieira⁶, David Wei⁵, Sydney Catron⁵, Maryfe coronel⁵, Annie Kim⁵ and Sarah Moussavi⁵, ¹NYU Langone, Rye Brook, NY, ²NYU Grossman School of Medicine, New York, NY, ³Division of Rheumatology, New York University Grossman School of Medicine and Rheumatology Section, New York Harbor Health Care System, New York Campus of the U.S. Department of Veterans Affairs, New York, NY, ⁴Westmed, Rye Brook, NY, ⁵NYU Langone Health, New York, NY, ⁶NYU Langone, New York, NY
Background/Purpose: Knee osteoarthritis (OA) is an inflammatory disease, with a probable role for IL-1b. Calcium and urate crystals may promote OA by activating the NLRP3…
Abstract Number: 1916 • ACR Convergence 2022
Defining Early-stage Knee Osteoarthritis: A Scoping Review
Jean Liew¹, Lauren King², Armaghan Mahmoudian³, Qiuke Wang⁴, Tuhina Neogi¹ and Gillian Hawker², ¹Boston University School of Medicine, Boston, MA, ²University of Toronto, Toronto, ON, Canada, ³Lund University, Lund, Sweden, ⁴Erasmus Medical Center, Rotterdam, Netherlands
Background/Purpose: Clinical trials of disease-modifying agents in knee osteoarthritis (OA) have largely failed to date. Identifying individuals with knee OA at an earlier stage in…
Abstract Number: 0033 • ACR Convergence 2022
Adenosine A2A Receptor Signaling Enhances Expression of an Endogenous p53 Mouse Variant in Bone Marrow Mesenchymal Stem Cells
Benjamin Friedman¹ and Bruce Cronstein², ¹NYU Langone, New York, NY, ²NYU School of Medicine, New York, NY
Background/Purpose: Our lab has demonstrated the ability of an intra-articular liposomal formulation of an adenosine A2A receptor (A2AR), CGS21680, to regenerate cartilage in multiple rodent…
Abstract Number: 0837 • ACR Convergence 2022
Providers’ Adoption of 2017 Guidelines on DMARD Use Perioperatively for Elective Total Hip and Knee Arthroplasty at a Single Academic Center
Chris Ching¹, Erica Mulcaire-Jones², Andrew Shaffer¹, Jeremy Gililland¹, Michael Battistone³ and Dorota Lebiedz-Odrobina¹, ¹University of Utah, Salt Lake City, UT, ²Intermountain Healthcare, Salt Lake City, UT, ³Salt Lake City VA, Salt Lake City, UT
Background/Purpose: Rate of prosthetic joint infection (PJI) after total joint arthroplasty (TJA) is higher in patients with rheumatic conditions than in patients with OA. Our…
Abstract Number: 1249 • ACR Convergence 2022
Short-term Variations in Subchondral Tibial Bone Texture of Conventional X-Rays Predicts Knee Osteoarthritis Progression
Ahmad Almhdie-Imjabbar¹, Hechmi TOUMI², Zineb ZERZOUF³ and Eric LESPESSAILLES⁴, ¹University of Orleans / CHR Orleans, France, Orleans, Centre, France, ²Regional hospital centre of Orleans, France, Orleans, France, ³University of Tours, Tours, France, ⁴Regional hospital centre of Orleans, France, ORLEANS, Centre, France
Background/Purpose: Early detection and assessment of Knee Osteoarthritis (KOA) prognostic factors are crucial for developing management and treatments that aim at prevention of irreversible damage…
Abstract Number: 1783 • ACR Convergence 2022
Exploring How and Why Organizations Identify, Adopt, Disseminate, and Sustain Evidence-based Programs for Latinos with Arthritis
Marvin Albert Meza Jarquín¹, Leigh Callahan², Serena Weisner³, Kirsten Ambrose³ and Sandra Soto⁴, ¹School of Medicine, University of North Carolina (UNC), Chapel Hill, NC, ²University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, ³Thurston Arthritis Research Center, Chapel Hill, NC, ⁴Thurston Arthritis Research Center, UNC Division of Rheumatology, Allergy and Immunology, Chapel Hill, NC
Background/Purpose: Physical activity (PA) is effective in the self-management of arthritis. As such, several evidence-based programs aimed at supporting safe and meaningful PA have been…
Abstract Number: 1901 • ACR Convergence 2022
What Does Radiographic Minimum JSW Actually Measure? Comparison of Radiographic and MRI Measures Using Data from the OAI
Alan Brett¹, Michael Bowes² and Philip G Conaghan³, ¹Stryker, Austin, TX, ²Stryker, Manchester, United Kingdom, ³University of Leeds, Leeds, United Kingdom
Background/Purpose: Change in radiographic joint space width (JSW) is used as a surrogate for cartilage loss and recognized by regulatory bodies as a measure of…
Abstract Number: 1917 • ACR Convergence 2022
A Remote Behaviorally-Designed Intervention to Promote Physical Activity in Patients with Knee Osteoarthritis: Results of a Pilot Randomized Clinical Trial
William Leach¹, Marianna Olave¹, Caleigh Doherty², Rachel Gillcrist¹, Daniel White³, Keith Robinson¹, Alexis Ogdie⁴, Tuhina Neogi⁵, Carla Scanzello⁶ and Joshua Baker⁶, ¹Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, ²Corporal Michael J. Crescenz VAMC, Philadelphia, PA, ³University of Delaware, Newark, DE, ⁴Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ⁵Boston University School of Medicine, Boston, MA, ⁶University of Pennsylvania, Philadelphia, PA
Background/Purpose: In this pilot and feasibility study, we evaluated whether a behaviorally-designed intervention utilizing gamification and social support could improve both physical activity and reduce…

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