Abstracts tagged "Osteoarthritis"

Abstract Number: 0439 • ACR Convergence 2025
Osteoarthritis and Other Degenerative Musculoskeletal Disorders Are Common and Often Associated with Active Inflammation in Difficult-to-Treat Rheumatoid Arthritis: A Cross-Sectional Cohort
Blanche QUERE¹, Grégoire CORMIER², LE GOFF Benoit³ and Adrien LE PLUART⁴, ¹CHU de Nantes, Nantes, Pays de la Loire, France, ²Centre Hospitalier département de Vendée, La Roche Sur Yon, France, ³CHU Nantes, Nantes, France, ⁴CHU Nantes, Nantes, Pays de la Loire, France
Background/Purpose: Despite advances in therapeutic strategies, a subset of patients with rheumatoid arthritis (RA) continues to experience persistent symptoms. In 2022, the EULAR proposed a…
Abstract Number: 0321 • ACR Convergence 2025
Per- and Polyfluoroalkyl Substances and Hand Osteoarthritis: Data from the Osteoarthritis Initiative
Jeffrey Driban¹, Lisa Rokoff², Bing Lu³, Timothy McAlington⁴, Charles Eaton⁵, Mary Roberts⁶, Diana Mathes⁷, Colleen Lestician⁷, Zhijin Carrie Xu⁷, Zhihua Tina Fan⁷, Shawn O'Leary⁷ and Abby Fleisch⁸, ¹University of Massachusetts Chan Medical School, Marlborough, NH, ²Center for Interdisciplinary and Population Health Research, MaineHealth Institute for Research, Westbrook, ME, ³UConn Health Center, Newton, MA, ⁴UMass Chan School of Medicine, Arlington, MA, ⁵Brown University, Pawtucket, RI, ⁶Center for Primary Care and Prevention, Kent Hospital, Pawtucket, RI, ⁷Environmental and Chemical Laboratory Services, Public Health & Environmental Laboratories, New Jersey Department of Health, Ewing, NJ, ⁸Maine Medical Center; ². Center for Interdisciplinary and Population Health Research, MaineHealth Institute for Research, Westbrook, ME
Background/Purpose: The prevalence of hand osteoarthritis (OA) has doubled in the United States over the past half century – a finding that cannot be solely…
Abstract Number: 2552 • ACR Convergence 2025
Effects of 360° Virtual Reality Embodiment Videos on Pain in Hand Osteoarthritis: A Within-Subject Pre-Post Study
David Vo¹, Robert Edwards² and Nancy Baker³, ¹Tufts University, Huntington Beach, CA, ²Brigham and Womens Hospital, Chestnut Hill, MA, ³Tufts University, Medford, MA
Background/Purpose: Osteoarthritis (OA) is associated with chronic pain in the joints, which affects many individuals’ daily function and quality of life. The sense of embodiment…
Abstract Number: 2089 • ACR Convergence 2025
Traction Therapy May Improve Hand Function in Those with Distal Interphalangeal Osteoarthritis
Grace Lo¹, Lauren Drillock², Kimberly Staines³, Michael Strayhorn⁴, Katherine Tse⁵, Gerald Virtanen⁶, Laura Welsh², Monica Seu², Eugene Gersh², Ida Kristin Haugen⁷, Andrew Grainger⁸ and Jonathan Samuels⁹, ¹Baylor College of Medicine / MEDVAMC, Houston, TX, ²NYU Langone Health, New York City, NY, ³MEDVAMC, Saltburn By The Sea, United Kingdom, ⁴Baylor College of Medicine, Houston, TX, ⁵NYU Langone Health, Brooklyn, NY, ⁶MEDVAMC, Houston, TX, ⁷Diakonhjemmet Hospital, Oslo, Norway, ⁸University of Cambridge, Cambridge, United Kingdom, ⁹NYU Langone, Rye Brook, NY
Background/Purpose: Hand osteoarthritis (OA) is the most common form of arthritis affecting the hand, but therapeutic options for OA at the distal interphalangeal (DIP) joint…
Abstract Number: 1909 • ACR Convergence 2025
Trends of venous thromboembolism after total joint replacement in the United Kingdom after the introduction of NICE guidelines.
Subhashisa Swain¹, Nadja Leith², Sarah Brown², Cynthia Wright Drakesmith², Jonathan Rees³, Clare Bankhead⁴ and John Powell⁴, ¹Keele University, University of Oxford, Keele, United Kingdom, ²University of Oxford, Oxford, United Kingdom, ³NDORMS, University of Oxford, Oxford, United Kingdom, ⁴NDPCHS, University of Oxford, Oxford, United Kingdom
Background/Purpose: Joint replacement (JR) surgery is one of the preferred management for end-stage arthritis. Venous Thromboembolism (VTE) is one of the major post-surgical complications after…
Abstract Number: 1789 • ACR Convergence 2025
Spatial Analysis of Advanced Osteoarthritis Synovial Tissue
jacob Dickman¹, Stephanie Ruzicka¹, Holub Meaghan², Jutras Brandon³, Adam Edelstein³ and Robert Lochhead⁴, ¹Medical College of Wisconsin, Milwaukee, WI, ²Central Michigan University College of Medicine, Mount Pleasant, MI, ³Northwestern University, Chicago, IL, ⁴Medical College of Wisconsin, GERMANTOWN, WI
Background/Purpose: Osteoarthritis (OA) is a joint pathology involving joint cartilage destruction and synovial inflammation. Severe knee OA is often surgically treated with total knee arthroplasty…
Abstract Number: 1233 • ACR Convergence 2025
Synovial Joint Transcriptomic Differences in Individuals with Knee Osteoarthritis and Neuropathic Pain Symptomology
Joseph Lesnak¹, Michael Zuscik², Michael Dayton², Craig Hogan², Prabil Kaini², Andrew Clauw³, Jennifer Seifert⁴, Michael Clay⁵, Theodore Price¹ and Larry Moreland⁶, ¹University of Texas at Dallas, Dallas, ²University of Colorado School of Medicine, Aurora, ³Univ of Colorado, Aurora, CO, ⁴University of Colorado and Oklahoma Medical Research Foundation, Aurora, CO, ⁵University of Colorado, Aurora, CO, ⁶University of Colorado, Denver, CO
Background/Purpose: Osteoarthritis (OA) is a painful disease of the synovial joint and is the most common form of arthritis with a large global burden. A…
Abstract Number: 0354 • ACR Convergence 2025
Greater Neighborhood Walkability is Associated with Lower Incidence of Hip Fracture in Older, Community-dwelling Women in the United States: The Cardiovascular Health Study
Rachel Elam¹, Petra Buzkova², Howard Fink³, Joshua Barzilay⁴, Eric Roseen⁵, Jane Cauley⁶, John Robbins⁷, Laura Carbone¹, Gina Lovasi⁸ and Kenneth Mukamal⁹, ¹Augusta University, Augusta, GA, ²University of Washingon, Seattle, WA, ³University of Minnesota, Minneapolis, MN, ⁴Kaiser Permanente of Georgia, Atlanta, GA, ⁵Boston University, Boston, MA, ⁶University of Pittsburgh, Pittsburgh, PA, ⁷University of California Davis, Davis, CA, ⁸Drexel University, Philadelphia, PA, ⁹Beth Israel Deaconess Medical Center, Brookline, MA
Background/Purpose: Higher physical activity is linked to reduced fracture risk in older adults, especially for hip fractures. Emerging evidence demonstrates a potential role for the…
Abstract Number: 0320 • ACR Convergence 2025
Transcriptomic profiling of the skeletal muscle of knee OA patients uncovers elevated glucocorticoid and GABA signaling as mediators of skeletal muscle dysfunction in advanced disease
Gina Many¹, Tyler Mansfield², Tyler Sagendorf³, Daniel Evans², Sameneh Farsijani⁴, Bret Goodpaster⁵, Lauren Sparks⁵ and NANCY LANE⁶, ¹Pacific Northwest National Laboratory, Richland, WA, Richland, WA, ²California Pacific Medical Research Institute, San Francisco, CA, ³Pacific Northwest National Laboratory, Richland, WA, ⁴University of Pittsburgh, Pittsburgh, PA, ⁵Translational Research Institute, AventHealth, Orlando, FL, ⁶University of California at Davis, School of Medicine, Sacramento, CA
Background/Purpose: Age-related declines in muscle mass and function are leading causes for hospitalizations and mortality in elderly individuals. The risk of developing knee osteoarthritis also…
Abstract Number: 2105 • ACR Convergence 2025
Stratification for elevated urate identifies a pro-inflammatory synovial fluid proteome in knee osteoarthritis: a pilot study
Tuhina Neogi¹, Sayali Dhamne², Robert Terkeltaub³, Virginia Kraus⁴, Simon Dillon⁵ and Towia Libermann⁵, ¹Boston University School of Medicine, Boston, MA, ²Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ³Retired, San Diego, CA, ⁴Duke University, Durham, NC, ⁵Beth Israel Deaconess Medical Center, Boston, MA
Background/Purpose: The causes of inflammation, pain fluctuations, and disease progression in osteoarthritis (OA) are not well understood. Soluble urate is a “danger signal”, and synovial…
Abstract Number: 2088 • ACR Convergence 2025
Aging Unevenly: National Trends and Inequities in Osteoarthritis Mortality, 1999–2020
Ghassan Makhoul¹, Aziz-ur-Rahman Khalid², Hasan Munshi¹, Islam Rajab¹, MD Walid Akram Hussain¹, Reshma John¹, Elvira Assaf¹, Amer Al Badawy¹, Barbare Khatiashvili¹, Rouba Isshak¹, Nargis Mateen³ and Robert Lahita⁴, ¹St. Josephs University Medical Center, Paterson, ²St. Joseph's University Medical Center, wayne, ³St. Josephs University Medical Center, Paterson, NJ, ⁴St. Josephs University Medical Center, Wayne, NJ
Background/Purpose: Osteoarthritis (OA) is a leading cause of disability and pain in older adults. While not traditionally viewed as fatal, OA contributes significantly to morbidity…
Abstract Number: 1808 • ACR Convergence 2025
Lightsheet imaging with 3D analysis for wholistic assessment of synovial lymphatic vasculature within joints of murine models of arthritis
Xi Lin¹, Edward Schwarz² and Lianping Xing³, ¹University of Rochester, Rochester, NY, ²University of Rochester, Rochester, NY, USA, Rochester, NY, ³University of Rochester, Webster, NY
Background/Purpose: The synovial lymphatic system (SLS) maintains joint homeostasis. Post-traumatic osteoarthritis (PTOA) has increased lymphatic vessels (LVs), but decreased SLS drainage. LVs are routinely studied…
Abstract Number: 1788 • ACR Convergence 2025
Manganese-associated Single-nucleotide Polymorphisms are Associated with Radiographic Knee Osteoarthritis: The Johnston County Osteoarthritis Project
Griffin Sonaty¹, Carolina Alvarez², Liubov Arbeeva³, Joanne Jordan¹, Brian Diekman⁴, Doug Phanstiel¹, Richard Loeser⁵ and Amanda Nelson¹, ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Miami, FL, ³University of North Carolina, Chapel Hill, Carrboro, NC, ⁴Univesity of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵University of North Carolina, Chapel Hill, NC
Background/Purpose: Trace elements may be differentially associated with osteoarthritis (OA) risk. Single-nucleotide polymorphisms (SNPs) have been found to correlate to cumulative exposure level, free of…
Abstract Number: 1222 • ACR Convergence 2025
Efficacy of Fasinumab, An Anti-Nerve Growth Factor Monoclonal Antibody, in Managing Chronic Musculoskeletal Pain: A Systematic Review and Meta-Analysis
Ahmed Abouelella¹, Mohammad Alhasan², Ahmed Hamoudah³, Ayman Ibrahim⁴, Ola O.A. Abuzied⁵, Mansoor Al-Tamimi⁶ and Muhammed Elhadi⁷, ¹Faculty of Medicine, Benha University, Benha, Al Qalyubiyah, Egypt, ²Health Education England Internal Medicine Training ( Cambridge), Cambridge, United Kingdom, ³Libyan International University, Sarasota, FL, ⁴University of Gezira, Medina, Saudi Arabia, ⁵University of Khartoum, Khartoum, Sudan, ⁶Faculty of Medicine, Cairo University, Cairo, Egypt, ⁷University of Tripoli, Huston, TX
Background/Purpose: Chronic musculoskeletal pain can be a significant source of disability and poor quality of life in adults. Many patients do not achieve adequate relief…
Abstract Number: 0335 • ACR Convergence 2025
Discontinuation and Non-Publication of Osteoarthritis Clinical Studies: A Cross-Sectional Analysis of 10,686,413 Patients
Mohamed Abdelsalam¹, Hadeer Hafez², Maryam Lasheen³, Bassant Elaraby Elsayed Badwy⁴, Omar Sameh Nabil El Sedafy¹, Abdelrahman M Hafez⁵, Omnia Samy El-Sayed⁴, Menat Alla Ayman Ali Mahdy⁴, Ali Tarek Hassanin³, Mohamed Reda Awad⁶ and Mohammed Safwat Kamal Hamza⁷, ¹Misr University For Science and Technology, ⁶ october, Al Jizah, Egypt, ²⁶th October University, ⁶ october, Al Jizah, Egypt, ³Misr University For Science and Technology, Helwan, Al Qahirah, Egypt, ⁴Misr University For Science and Technology, Nasr City, Al Qahirah, Egypt, ⁵Faculty of medecine, Damietta university, Mansoura, Ad Daqahliyah, Egypt, ⁶Al Azhar University, Cairo, Egypt, Giza, Al Jizah, Egypt, ⁷Faculty of Medicine, Misr University for Science and Technology, ⁶ october, Al Jizah, Egypt
Background/Purpose: Osteoarthritis (OA) is rising at an alarming rate, affecting millions worldwide and threatening mobility, independence, and quality of life. High-quality evidence is essential to…

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