Abstract Number: 0876 • ACR Convergence 2023
Metabolomic Analysis Reveals Associations Between Calcium Crystals and Metabolites in Osteoarthritic Synovial Tissue
Background/Purpose: Emerging research suggests that synovial inflammation and metabolic alterations are involved in the progression of osteoarthritis (OA). Additionally, the presence of calcium-containing crystals (CC),…Abstract Number: 1186 • ACR Convergence 2023
Presence of Erosions Is Not a Risk Factor for the Development of Knee OA in a Hand OA Population: The Framingham OA Study
Background/Purpose: Osteoarthritis (OA) is a prevalent musculoskeletal disease and can affect multiple joint sites in one patient. Studies have shown an association between hand and…Abstract Number: 1591 • ACR Convergence 2023
Complement Factor D/Adipsin Knockout Mice Demonstrate Disparate Pain and Structural Damage Phenotypes in Obesity-induced Post Traumatic Osteoarthritis
Background/Purpose: Osteoarthritis (OA) is the leading cause of musculoskeletal pain, which is a primary driver of care-seeking behavior. There is lack of mechanistic information detailing…Abstract Number: 1883 • ACR Convergence 2023
Thalamocortical Mechanisms of a Remote Mind-body Intervention for Knee Osteoarthritis Pain
Background/Purpose: Studies found that individuals with pain exhibit altered thalamocortical rhythm, abnormal function, and structural connectivity within the network. Effective treatment may relieve pain by…Abstract Number: 1989 • ACR Convergence 2023
Shared Variation Among Cartilage Thickness Change Maps and Baseline Clinical Features at the Initiation of Structural Knee Osteoarthritis
Background/Purpose: To identify features of cartilage thickness change and baseline clinical indicators associated with the transition from normal to mildly reduced joint space as an…Abstract Number: 2499 • ACR Convergence 2023
Influence of Adiposity on Physical Function, Physical Activity, and Self-Reported Symptom Severity for Individuals with Arthritis Prior to Beginning a Physical Activity Promotion Intervention
Background/Purpose: Engagement in moderate-vigorous physical activity (MVPA) is recommended for individuals with obesity to promote weight loss and mitigate severity of chronic diseases associated with…Abstract Number: L05 • ACR Convergence 2022
Effect of Denosumab on Structure Modification in Erosive Hand Osteoarthritis: Results of a 48-Week, Monocentric, Randomized, Placebo-controlled, Double-blind Phase 2 Study and Open Label Extension Phase
Background/Purpose: Erosive hand osteoarthritis (OA) is a disabling disease with limited therapeutic options. Denosumab, a Receptor Activator of Nuclear Factor kappa-b Ligand inhibitor, affects bone…Abstract Number: 0026 • ACR Convergence 2022
Silencing of WISP-2 Induces Inflammatory Mediators and Catabolic Factors in Cartilage
Background/Purpose: Wnt-1 inducible signaling pathway protein 2 (WISP-2/CCN5) is an adipokine that has been described as an important mediator of canonical Wnt activation in adipogenic…Abstract Number: 0590 • ACR Convergence 2022
Molecular Profiling of Normal Human Synovium Reveals Striking Impact of Adipocytes and Homeostatic Cortisol Signaling
Background/Purpose: The synovium encapsulates joints and contains fibroblasts which proliferate, become invasive, and drive disease progression in rheumatoid arthritis (RA) and osteoarthritis (OA). There is…Abstract Number: 1143 • ACR Convergence 2022
Epigenome-wide Analysis of Osteoarthritis in the Multicenter Osteoarthritis Study
Background/Purpose: Epigenetic mechanisms like DNA methylation may play a role in OA. For example, expression of GDF5, a well-known OA gene, is modulated by demethylation…Abstract Number: 1754 • ACR Convergence 2022
Association of Cognitive Impairment and Symptomatic Lower Extremity Osteoarthritis by Level of Physical Activity: Preliminary Data from the Johnston County Health Study
Background/Purpose: While osteoarthritis (OA) is associated with an increased risk of dementia,1 the frequency of milder cognitive impairment is unknown. Mild to moderate cognitive impairment…Abstract Number: 1896 • ACR Convergence 2022
Alkylresorcinol, a Biomarker for Whole Grain Intake, and Its Association with Osteoarthritis: The MOST Study
Background/Purpose: Whole grains, particularly wheat, are an important source of dietary fiber in the US. By providing a fermentable source, whole grains can modify the…Abstract Number: 1912 • ACR Convergence 2022
Associations of Nociceptive Dysfunction with Physical Activity in Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Background/Purpose: Individuals with chronic pain due to knee osteoarthritis (OA) are insufficiently physically active and increasing physical activity is the first line recommendation for management…Abstract Number: 2263 • ACR Convergence 2022
Nanotherapeutic Approaches for the Treatment of Post-traumatic Osteoarthritis
Background/Purpose: Osteoarthritis (OA) represents the most common form of arthritis and is a major cause of morbidity in the aging population. Post-traumatic OA (PTOA) is…Abstract Number: 0027 • ACR Convergence 2022
Associations of Serum C3f with Selected Biomarkers and Radiographic and Clinical Features of Knee Osteoarthritis
Background/Purpose: C3 complement fragment (C3f) has been identified as a potential biomarker for evaluating osteoarthritis (OA). C3f is released during the catabolic degradation of C3b…
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