Abstracts tagged "Osteoarthritis"

Abstract Number: 1044 • ACR Convergence 2024
Analysis of Rheumatic Patients’ Self – Reported Symptoms in Free Written Text Using Natural Language Processing
Inés Pérez - Sancristóbal¹, Nils Steinz², Ling Qin², Tjardo Maarseveen³, Floor Zegers⁴ and Rachel Knevel², ¹Department of Rheumatology, Hospital Clinico San Carlos,, Madrid, Madrid, Spain, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Wormerveer, Netherlands, ⁴Deparment of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Patient-reported symptoms are crucial for medical anamnesis. Digital symptom checkers often use fixed questions, thereby potentially overlooking relevant symptoms. However, the reliability of self-reported…
Abstract Number: 1192 • ACR Convergence 2024
Relationship Between Measures of Fat Mass and Knee Osteoarthritis Incidence: The Multicenter Osteoarthritis (MOST) Study
Kristine Godziuk¹, Sarah Tilley², mike LaValley³, Douglas Kiel⁴, Michael Nevitt⁵, C.E. Lewis⁶, James Torner⁷ and Tuhina Neogi², ¹University of Alberta, Edmonton, AB, Canada, ²Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ³Boston University School of Public Health, Arlington, MA, ⁴Hebrew SeniorLife and Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, ⁵UCSF, Orinda, CA, ⁶University of Alabama at Birmingham, Birmingham, AL, ⁷University of Iowa, Iowa City
Background/Purpose: Obesity [defined by body mass index (BMI) ≥30 kg/m2] is an established risk factor for incident radiographic knee OA (ROA). However, the relative contributions…
Abstract Number: 1208 • ACR Convergence 2024
Statin Use and Risk of Total Joint Replacement of Knee and Hip in Osteoarthritis Patients: Study Based on the French National Health Insurance Cohort
christian roux¹, stephanie ferrero², Julie Bulsai² and eric fontas², ¹rheumatology department, university Cote d'Azur, nice, France, ²university cote d'azur, CHU de Nice, nice, France
Background/Purpose: Potential beneficial effect of statin use on osteoarthritis progression is discussed. some studies have suggested that statins may have a protective effect on structural…
Abstract Number: 1658 • ACR Convergence 2024
IGF1 Drives Wnt-induced Joint Damage and Is a Therapeutic Target for Osteoarthritis
Ana Escribano-Nunez¹, Frederique Cornelis², Astrid Deroover¹, An Sermon¹, Frederic Cailotto³, Rik Lories² and Silvia Monteagudo⁴, ¹KU Leuven, Leuven, Vlaams-Brabant, Belgium, ²Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium, Leuven, Belgium, ³Université Lorraine, Nancy, Lorraine, France, ⁴KU Leuven, Leuven, Belgium
Background/Purpose: Osteoarthritis is the most common joint disease and a global leading cause of pain and disability. Its multifactorial etiology includes excessive activation of Wnt…
Abstract Number: 2088 • ACR Convergence 2024
Personalized Prediction of Pain and Function for Knee Osteoarthritis Patients 1 Year After Total Knee Arthroplasty Using Machine Learning
Carly Wanglin¹, Michael Dayton², Craig Hogan², Ryan Koonce², Larry Moreland³ and Michael David², ¹University of California - San Francisco, San Francisco, CA, ²University of Colorado Anschutz Medical Campus, Aurora, CO, ³University of Colorado, Denver, CO
Background/Purpose: Accurate preoperative (pre-op) prediction of postoperative (post-op) patient-specific improvement and satisfaction in pain and function after total knee arthroplasty (TKA) for osteoarthritis (OA) is…
Abstract Number: 2104 • ACR Convergence 2024
The Relationship of Soluble Biomarkers to OA Pain: A Systematic Literature Review
Sylvain Mathieu¹, Liisa Kuhi², Philip G Conaghan³, Niels Eijkelkamp⁴, Yves Henrotin⁵, Eva Kosek⁶, Hans-George Schaible⁷, Ali Mobasheri⁸, Kalle Kisand⁹ and Jérémie Sellam¹⁰, and GO-PAIN working group, ¹CHU Gabriel Montpied, Clermont-Ferrand, France, ²East Tallinn Central Hospital, Tallinn, Estonia, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁴University Medical Center, Umtrecht, Netherlands, ⁵MusculoSkeletal Innovative research Lab (mSKIL), Liege, Belgium, ⁶Karolinska Institute, Stockholm, Sweden, ⁷Institute of Physiology, Jena, Germany, ⁸Research Unit of Medical Imaging, Physics and Technology, Ouli, Finland, ⁹University of Tartu, Tartu, Estonia, ¹⁰Saint-Antoine Hospital - AP-HP, Paris, Ile-de-France, France
Background/Purpose: Chronic joint pain is a major factor driving poor quality of life in people with osteoarthritis (OA). A better understanding of the complex mechanisms…
Abstract Number: 0022 • ACR Convergence 2024
Transcriptomic Characterization of Knee Capsule Fibroblasts and Mesenchymal Stromal Cells Reveals an Association Between Flexion Contracture and Alterations in Immune Pathways in People with End-stage OA
Odette Laneuville¹, Daniel Stratis¹, Robert Feibel², Guy Trudel³ and T Mark Campbell⁴, ¹University of Ottawa, Ottawa, ON, Canada, ²The Ottawa Hospital, Ottawa, ON, Canada, ³Ottawa Hospital Research Institute, Ottawa, ON, Canada, ⁴Bruyère Research Institute, Ottawa, ON, Canada
Background/Purpose: Over 10% of adults have symptomatic knee OA but no disease-modifying interventions exist. A flexion contracture (loss of extension; FC) presents in 1/3 of…
Abstract Number: 0789 • ACR Convergence 2024
An Online Trial to Assess the Efficacy and Safety of a Supplement Combination in People with Hand Osteoarthritis
Xiaoqian Liu¹, Sarah Robbins¹, Jillian Eyles¹, Leticia Deveza¹, Andrew McLachlan¹ and David Hunter², ¹The University of Sydney, Sydney, New South Wales, Australia, ²Sydney Musculoskeletal Health, University of Sydney, St Leonards, New South Wales, Australia
Background/Purpose: Hand osteoarthritis is a debilitating and highly prevalent disease with limited treatment options. The aim of this study was to investigate the efficacy and…
Abstract Number: 1050 • ACR Convergence 2024
The Cost-effectiveness of Glucagon-Like Peptide-1 Receptor Agonists (GLP1RAs) for Patients with Knee Osteoarthritis and Obesity
Daniel Betensky¹, Jeffrey Katz¹, Catherine Yang², David Hunter³, Jamie Collins¹, Candace Feldman¹, Karen Smith¹, Stephen Messier⁴, Jason Kim⁵, Faith Selzer⁶ and Elena Losina¹, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Brookline, MA, ³Sydney Musculoskeletal Health, University of Sydney, St Leonards, New South Wales, Australia, ⁴Wake Forest University, Winston Salem, NC, ⁵Arthritis Foundation, Atlanta, GA, ⁶Brigham and Women's Hospital, Amesbury, MA
Background/Purpose: Weight-loss has been shown to alleviate knee osteoarthritis (OA) symptoms in persons with OA and obesity. Utilization of GLP1RA medications has increased rapidly. These…
Abstract Number: 1193 • ACR Convergence 2024
Ultrasound-Guided Corticosteroid Injection versus Iontophoresis in Rhizarthrosis: A Prospective Comparative Multicentric Study
Olga Rusinovich¹, Andrea Liso Andrino², Maria Concepcion Sanchez³, Pilar Navarro Alonso⁴, Miguel Cantalejo Moreira⁵, ALBERTO DIAZ OCA⁴, Pablo Navarro Palomo⁶, Maria Machattou⁷, Maria Alonso de Francisco³, Carlota Navarro Joven⁸, Alejandro Martinez Rodado³, laura Ramos Ortiz de Zarate⁹, hildegarda Godoy Tundidor¹⁰, Maria Carmen Barbadillo Mateos⁷, Blanca Garcia-Magallon⁷, Jose Campos⁷, Mónica Fernández Castro¹¹, JESUS SANZ SANZ⁶ and Jose Luis Andreu⁶, ¹Hospital Universitario Puerta de Hierro Majadahonda., Boadilla del Monte, Spain, ²Servicio de Reumatología, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA , Madrid, Majadahonda, Madrid, Spain, ³Puerta de Hierro Majadahonda University Hospital, Majadahonda, Spain, ⁴Fuenlabrada University Hospital, Fuenlabrada, Spain, ⁵Hospital Universitario de Fuenlabrada, Fuenlabrada. Madrid, Spain, ⁶Hospital Universitario Puerta de Hierro Majadahonda., Majadahonda, Spain, ⁷Hospital Universitario Puerta de Hierro Majadahonda., Madrid, Spain, ⁸Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Spain, ⁹Puerta de Hierro Majadahonda University Hospital, Majahonda, Spain, ¹⁰Servicio de Reumatología, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA , Madrid, Madrid, Spain, ¹¹Hospital Universitario Puerta de Hierro Majadahonda., Madrid, Madrid, Spain
Background/Purpose: Trapeziometacarpal osteoarthritis is a common degenerative disease that causes pain and thumb dysfunction. It affects 16-25% of the population, mainly middle-aged women. Treatment modalities…
Abstract Number: 1209 • ACR Convergence 2024
Time to Knee Replacement by Kellgren-Lawrence Grade and Presence of Frequent Knee Pain in Two Large and Diverse Longitudinal Cohorts: Data from MOST and OAI
Kent Kwoh¹, Rongrong Tang², Edward Bedrick³, Jeffery Duryea⁴, Zong-Ming Li², Jean Liew⁵, Xiaoxiao Sun⁶ and Tuhina Neogi⁵, ¹University of Arizona, Tucson, AZ, ²University of Arizona Arthritis Center, University of Arizona College of Medicine - Tucson, Tucson, AZ, ³Department of Epidemiology andBiostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, ⁴Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ⁵Boston University Chobanian & Avedisian School of Medicine, Boston, MA, ⁶Department of Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ
Background/Purpose: Receipt of knee replacement has been proposed by the FDA as a structural and symptom outcome for clinical trials of Disease Modifying Osteoarthritis Drugs…
Abstract Number: 1665 • ACR Convergence 2024
Multicenter Randomized Controlled Trial of Physical Therapy (PT) or Sham PT in Persons with Knee Pain, Meniscal Tear, and Osteoarthritic Imaging Changes
Jeffrey Katz¹, Jamie Collins², Leslie Bisson³, Faith Selzer⁴, Morgan Jones², Heidi Yang², James Irrgang⁵, Clare Safran-Norton², Kurt Spindler⁶ and Elena Losina², ¹Brigham and Women's Hospital, Brookline, MA, ²Brigham and Women's Hospital, Boston, MA, ³University at Buffalo, Buffalo, NY, ⁴Brigham and Women's Hospital, Amesbury, MA, ⁵University of Pittsburgh, Pittsburgh, PA, ⁶Cleveland Clinic, Clev, OH
Background/Purpose: The syndrome of knee pain and meniscal tear (MT) is prevalent and disabling. The TeMPO trial (Treatment of Meniscal Problems in Osteoarthritis (OA)) compares…
Abstract Number: 2089 • ACR Convergence 2024
Diagnostic Performance of ACR and NICE Criteria for Hip Osteoarthritis
Jos Runhaar¹, Dieuwke Schiphof¹, Qiuke Wang¹, Margreet Kloppenburg², Maarten Boers³, Hans Bijlsma⁴ and Sebastia Bierma-Zeinstra¹, and the CREDO expert group, ¹Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Amsterdam UMC, Vrije Universiteit, Amersfoort, Netherlands, ⁴UMCU, Utrecht, Utrecht, Netherlands
Background/Purpose: Available criteria for diagnosis or classification of hip osteoarthritis (OA) have been poorly validated. The few validation studies available all used radiographic features of…
Abstract Number: 2105 • ACR Convergence 2024
The Identity, Impact, and Management of OA and OA Pain from the Perspective of People with OA: A Systematic Literature Review of Qualitative Studies
Sylvain Mathieu¹, Alice Courties², Céline Mathy³, Serge Perrot⁴, Françoise Alliot Launois⁵, Stan Moumbe⁶, Nathan Foulquier⁷, Jérémie Sellam⁸ and Rinie Geenen⁹, and GO-PAIN Working group, ¹CHU Gabriel Montpied, Clermont-Ferrand, France, ²AP-HP, Paris, France, ³University of Liège, Liège, Belgium, ⁴Paris Dauphine University, Paris, France, ⁵AFLAR, Paris, France, ⁶Patient, Paris, France, ⁷LBAI. UMR 1227, University of Brest, Brest, France, ⁸Saint-Antoine Hospital - AP-HP, Paris, Ile-de-France, France, ⁹Department of Psychology, Utrecht, Netherlands
Background/Purpose: Knowledge of beliefs, needs, and priorities of people with osteoarthritis (OA) is of utmost important to be able to offer person-centered care. Concepts that…
Abstract Number: L04 • ACR Convergence 2023
EP-104IAR (Extended-Release Fluticasone Propionate for Injectable Suspension): Topline and Key Secondary Results from a Phase 2 Randomized, Double-blind, Vehicle-Controlled Trial in Subjects with Knee Osteoarthritis
James Helliwell¹, Amanda Malone¹, Mark Kowalski², Asger Reinstrup Bihlet³, Claire Miller⁴, Alejandro Castillo Mondragon⁵, Yanqi Li⁶, Christine Dobek⁷, Vik Peck¹, Mike Wilmink⁸ and Lee Simon⁹, ¹Eupraxia Pharmaceuticals, Victoria, BC, Canada, ²Eupraxia Pharmaceuticals, Winchester, VA, ³NBCD A/S, Soeborg, Denmark, ⁴NBCD A/S, Copenhagen, Denmark, ⁵NBCD, Copenhagen, Denmark, ⁶NBCD A/S, Soborg, Denmark, ⁷Eupraxia Pharmaceuticals, Edmonton, AB, Canada, ⁸OrthoArizona, Phoenix, AZ, ⁹SDG LLC, Cambridge, MA
Background/Purpose: EP-104IAR is being developed to treat OA symptoms. Previous results from non-clinical studies evaluating local joint safety in beagle dogs, in contrast to other…

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