Abstracts tagged "Osteoarthritis"

Abstract Number: 1190 • ACR Convergence 2023
Worsening of Pain as Perceived by Patients Is Not Reflected by an Annual Standardized Questionnaire
Coen van der Meulen¹, Lotte van de Stadt², Frits Rosendaal¹ and Margreet Kloppenburg¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²Reade, Amsterdam, Netherlands
Background/Purpose: The course of pain in hand osteoarthritis (OA) is often investigated with repeated validated pain questionnaires. However, it is unknown whether these questionnaires reliably…
Abstract Number: 1595 • ACR Convergence 2023
Pharmacological Modulation of Krüppel-like Factor 4 Reduces the Severity of Experimental Osteoarthritis via Tissue Protection and Regeneration
Manabu Kawata¹, Merissa Olmer², Kristen Johnson³ and Martin K Lotz², ¹Scripps Research Institute, San Diego, CA, ²Scripps Research Institute, La Jolla, CA, ³CALIBR, La Jolla, CA
Background/Purpose: Krüppel-like factors (KLFs) are members of the zinc finger family of transcription factors, which includes 17 members in mammals. We found that expression of…
Abstract Number: 1977 • ACR Convergence 2023
Combined Datasets for CNTX-4975 Osteoarthritis Knee Pain (OAKP) Phase 3 Trials (OAKP 301 and 304) to Assess Overall Efficacy and Safety of an Intra-articular Injection (IAI) of CNTX-4975-05 (CNTX) in Subjects with Chronic, Moderate-to-severe Osteoarthritis Knee Pain (MSOAKP)
James Connolly, James N Campbell, Randall Stevens and Colleen Newman, Centrexion Therapeutics Corporation, Boston, MA
Background/Purpose: 30+ million US adults have OAKP, (13% women / 10% men). After years of using NSAIDs, analgesics, surgery and IAI, many patients remain with…
Abstract Number: 1993 • ACR Convergence 2023
Impact of Metabolic Syndrome on Ultrasonographic Findings and Quality of Life in Patients with Early Osteoarthritis
Maria Fernanda Gonzalez-Hernandez¹, Rolando Espinosa-Morales², Carlos Pineda², Angelica Peña³, Araceli Bernal¹ and Alejandra Alabarda¹, ¹Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Mexico City, Mexico, ²Instituto Nacional de Rehabilitacion, Mexico City, Mexico, ³Instituto Mexicano del Seguro Social, Querétaro, Mexico
Background/Purpose: Osteoarthritis (OA) is a common disorder with increased incidence with age. Metabolic syndrome (MS) is frequently associated with OA, although other factors are considered…
Abstract Number: 0153 • ACR Convergence 2023
Diminished Vibration Perception and Greater Pressure Pain Sensitivity Are Associated with Worse Knee Osteoarthritis Outcomes Across Sex and Race
Chris Lane¹, Louise Thoma², Carolina Alvarez³, Deborah Givens⁴, Amanda Nelson⁴, Adam Goode⁵, Kharma Foucher⁶ and Yvonne Golightly⁷, ¹UNC Chapel Hill, Chapel Hill, NC, ²University of North Carolina, Chapel Hill, NC, ³University of North Carolina at Chapel Hill, Miami, FL, ⁴University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵Duke University, Durham, NC, ⁶University of Illinois at Chicago, Chicago, IL, ⁷University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Sex and race differences have been observed in clinical outcomes such as patient-reported pain and function in adults with knee OA. However, few studies…
Abstract Number: 0323 • ACR Convergence 2023
A Randomized, Double-blind, Placebo-controlled, Repeat Injection, 52-Week Study to Evaluate the Efficacy and Safety of an Intra-articular Injection (IAI) of CNTX-4975-05 (CNTX) in Subjects with Chronic, Moderate-to-severe Osteoarthritis Knee Pain (MSOAKP) – Study 304
James Connolly, James N Campbell, Randall Stevens and Colleen Newman, Centrexion Therapeutics Corporation, Boston, MA
Background/Purpose: 30+ million US adults have OAKP. After years of using NSAIDs, analgesics, surgery and IAI, many patients remain with MSOAKP. CNTX is a 1…
Abstract Number: 0864 • ACR Convergence 2023
Proteomic Analysis of Circulating Neutrophils from Osteoarthritis Patients Shows Metabolic Dysregulation That Is Associated with Decreased Physiologic Apoptosis
Jennifer Amsler¹, Morgane Le Gall², Camille Daste³, François Rannou³ and Véronique Witko-Sarsat², ¹Institut Cochin, Bern, Switzerland, ²Institut Cochin, Paris, France, ³Hôpital Cochin, Paris, France
Background/Purpose: Osteoarthritis (OA) has long been thought to be only of local mechanical origin. However, it has been shown recently that there is a phenotype…
Abstract Number: 0881 • ACR Convergence 2023
Deficiency of the Pattern-recognition Receptor CD14 Protects Against LPS-induced Inhibition of Osteoclastogenesis in Vitro
Lance Murphy¹, Kevin Burt², Baofeng Hu³, Vu Nguyen², Robert Mauck² and Carla Scanzello², ¹University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³University of Pennsylvania, Wynnewood, PA
Background/Purpose: Osteoarthritis is associated with bone changes such as subchondral sclerosis, bone marrow lesions, and osteophyte formation (Donel S, 2019). Prior work has demonstrated that…
Abstract Number: 1191 • ACR Convergence 2023
A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Multiple-Dosing, Ascending-Dose Study Evaluating the Safety, Tolerability and Pharmacokinetics of XG004 Applied Topically in Participants with Osteoarthritis of the Knee
Guang-Liang Jiang¹ and Feng Xu², ¹Xgene Pharmaceutical Inc., Lexington, MA, ²Xgene Pharmaceutical Inc., Altos Hills, CA
Background/Purpose: Globally osteoarthritis affects about 302 million patients, knee osteoarthritis accounts for 263 million and ranks the highest in disability and pain compared to OA…
Abstract Number: 1596 • ACR Convergence 2023
A Cell and Transcriptomic Atlas of the Infrapatellar Fat Pad from Patients with Knee Osteoarthritis: Identification of an Obesity-Associated Transcriptomic Signature
Hayley Peters¹, Pratibha Potla¹, Jason Rockel¹, Keemo Delos Santos¹, Shabana Vohra¹, starlee lively², Kim Perry³, Anthony Perruccio¹, Nizar Mahomed⁴, Raja Rampersaud¹, Rajiv Gandhi⁵ and Mohit Kapoor⁶, ¹Schroeder Arthritis Institute, Toronto, ON, Canada, ²University Health Network, Toronto, ON, Canada, ³Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada, ⁴Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, Krembil Research Institute, and Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ⁵Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and Division of Orthopaedics, Department of Surgery, University of Toronto, Toronto, ON, Canada, ⁶Schroeder Arthritis Institute, University Health Network and Department of Surgery, University of Toronto, Toronto, ON, Canada
Background/Purpose: Knee osteoarthritis (KOA) is the most common form of arthritis that affects multiple knee joint tissues. The infrapatellar fat pad is the largest fat…
Abstract Number: 1978 • ACR Convergence 2023
Infrapatellar Fat Pad Size and Subcutaneous Fat in Knee Osteoarthritis Radiographic Progression: Data from the Osteoarthritis Initiative
Kwanghoon Lee¹, Marina Banuls-Mirete², Alecio Lombardi³, Alexander Posis³, Eric Chang³, Nancy Lane⁴ and Monica Guma⁵, ¹Dongguk University ilsan Hospital, San Diego, CA, ²Department of Medicine, University of California San Diego, San Diego, CA, ³University of California San Diego, San Diego, CA, ⁴University of California, Hillsborough, CA, ⁵University of California San Diego, La Jolla, CA
Background/Purpose: Adipose tissue is associated with knee osteoarthritis (KOA) progression. This study aimed to determine the association of infrapatellar fat pad (IPFP) size and subcutaneous…
Abstract Number: 1994 • ACR Convergence 2023
How Is Paracetamol Prescribed in Low Back Pain and Osteoarthritis in France? Paracetamol Prescription Patterns in the Real-World General Practice
Jasque Cittée¹, Pierre Lemire², Anna Annenkova³, Jean-Yves Milon³ and Serge Perrot⁴, ¹University Paris-Est Créteil Val de Marne Department of General Medicine, Paris, France, ²IQVIA, Paris, France, ³UPSA, Rueil-Malmaison, France, ⁴Cochin Hospital, Université Paris Cité, INSERM U987, Paris, France
Background/Purpose: Lower back pain (LBP) and osteoarthritis (OA) are the most frequent musculoskeletal disorders in the general population significantly impacting patients' quality of life. An…
Abstract Number: 0308 • ACR Convergence 2023
Burden of Osteoarthritis Attributable to High BMI in 38 OECD Countries: A Benchmarking Analysis
Dhruvkumar Gadhiya¹, Utsav Patel², Hiren Chhayani³, Krushi Shah³, Sneh Patel³, Victor Adedara⁴, Divya Patel³ and Hardik Desai⁵, ¹St.Luke's University Health, Anderson Campus, Easton, PA, ²Tulane University, New Orleans, LA, ³G.M.E.R.S. Medical College, Gandhinagar, Gandhinagar, India, ⁴St George’s University SOM, True Blue Greneda, True Blue, Grenada, ⁵Gujarat Adani Institute of Medical Sciences, Bhuj, India., Bhuj, India
Background/Purpose: The burden of osteoarthritis related to high body mass index (BMI) in OECD countries is a significant public health concern. Osteoarthritis is strongly associated…
Abstract Number: 0324 • ACR Convergence 2023
A Randomized, Double-blind, Placebo-controlled, Single Injection, 52-Week Study to Evaluate the Efficacy and Safety of an Intra-articular Injection (IAI) of CNTX-4975-05 (CNTX) in Subjects with Chronic, Moderate-to-severe Osteoarthritis Knee Pain (OAKP) – Study 301
Randall Stevens, James N Campbell, Colleen Newman and James Connolly, Centrexion Therapeutics Corporation, Boston, MA
Background/Purpose: 30+ million US adults have OAKP. After years of using NSAIDs and other conservative measures many patients remain with OAKP. CNTX is a 1…
Abstract Number: 0865 • ACR Convergence 2023
Reactive Oxygen Species-scavenging Nanoparticles Target Macrophage Polarization for Osteoarthritis Therapy
Caifeng Deng¹, Yongbing Xiao², Xuan Zhao¹, Hui Li², Yuxiao Chen¹, Chao Zeng² and Guanghua Lei², ¹Xiangya Hospital, Changsha, China, ²Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China
Background/Purpose: Unbalanced M1/M2 polarization of synovial macrophages plays vital roles in the symptomatic and structural progression of osteoarthritis (OA). The accumulation of intracellular reactive oxygen…

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