Abstracts tagged "Osteoarthritis"

Abstract Number: 1198 • ACR Convergence 2023
Bicycling Is Not Associated with New Knee Pain or Disease Progression over 48 Months in Those with Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Colin McLaughlin¹, Grace Lo¹, Jeffrey Driban², Timothy McAlindon³, Andrea Kriska⁴, Bonnie Rockette-Wagner⁴, Marc Hochberg⁵, Michael Nevitt⁶, Kent Kwoh⁷ and Charles Eaton⁸, ¹Baylor College of Medicine, Houston, TX, ²Tufts Medical Center, Westborough, MA, ³Tufts Medical Center, Arlington, MA, ⁴University of Pittsburgh, Pittsburgh, PA, ⁵University of Maryland School of Medicine, Baltimore, MD, ⁶University of California San Francisco, Orinda, CA, ⁷University of Arizona, Tucson, AZ, ⁸Brown University, Pawtucket, RI
Background/Purpose: Bicycling is viewed as a non-weight bearing exercise and is often recommended as a preferred exercise for those with knee osteoarthritis (OA).However, there is…
Abstract Number: 1840 • ACR Convergence 2023
Value of Various Intra-Articular Injections for Knee Osteoarthritis Management
Hanna Mass¹, Jamie Collins¹, david Hunter², Catherine Yang¹, Morgan Jones¹, Stephen Messier³, Tuhina Neogi⁴, A. David Paltiel⁵, Jeffrey Katz¹ and Elena Losina⁶, ¹Brigham and Women's Hospital, Boston, MA, ²Sydney Musculoskeletal Health, University of Sydney, St. Leonards, Australia, ³Wake Forest University, Winston-Salem, NC, ⁴Boston University School of Medicine, Boston, MA, ⁵Yale School of Public health, New Haven, CT, ⁶Brigham and Women's Hospital, Boston, MA
Background/Purpose: Intra-articular injections (IAI) are commonly used to relieve pain and delay total knee replacement (TKR) in persons with knee OA. Despite higher costs and…
Abstract Number: 1985 • ACR Convergence 2023
Preliminary Results for the Total Knee Replacement Coaching Program for Patients Preparing to Undergo Total Knee Arthroplasty, a Pilot Randomized Trial
Noelia Hernandez¹, Yuliana Dominguez Paez², Assem Jabri², Mackenzie Brown², Geyanne Lui³, Wai-Kwong Hui⁴, Michael Parks⁴, Alejandro Gonzalez Della Valle⁴, Fred Cushner⁴, Peter Sculco⁴, Thomas Sculco⁴, Mathias Bostrom⁴, Alejandro Leali⁴, Jason Blevins⁴, Jose Rodriguez⁴, Gwo-Chin Lee⁴, Lisa Mandl⁵, Susan Goodman⁴, Samprit Banerjee², Monika Safford⁶ and Iris Navarro-Millán⁷, ¹Weill Cornell Medicine, The Bronx, NY, ²Weill Cornell Medicine, New York, NY, ³New York Institute of Technology, New York, NY, ⁴Hospital for Special Surgery, New York, NY, ⁵Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁶WCM Department of Medicine, New York, NY, ⁷Weill Cornell Medicine, Hospital for Special Surgery, New York, NY
Background/Purpose: Up to 30% of patients with primary knee osteoarthritis (KOA) who have undergone Total Knee Replacement (TKR) continue to experience knee pain after surgery.High…
Abstract Number: 2470 • ACR Convergence 2023
Low Serum Adiponectin Levels Were Associated with Radiographic Progression of Hand Osteoarthritis in a 6-year Follow-up of the Dong-gu Study
Sung-Eun Choi¹, Hyemin Jeong¹, Dong-Jin Park¹, Ji-Hyoun Kang², Min-Ho Shin³ and Shin-Seok Lee¹, ¹Chonnam National University Medical School & Hospital, Gwangju, South Korea, ²Chonnam National University Hospital, Gwangju, South Korea, ³Chonnam National University Medical School, Gwangju, South Korea
Background/Purpose: The association between serum adiponectin levels and hand osteoarthritis (OA) has been studied cross-sectionally, but longitudinal studies on the radiographic progression of hand OA…
Abstract Number: 0315 • ACR Convergence 2023
Identification of Calcium Crystals in End-Stage Osteoarthritis with Raman Spectroscopy
Tom Niessink¹, Tim Welting², Matthijs Janssen³, Cees Otto⁴ and Tim Jansen⁵, ¹University of Twente, Utrecht, Netherlands, ²MUMC+, Maastricht, Netherlands, ³Viecuri MC / Venlo, Wijgmaal, Belgium, ⁴University of Twente, Enschede, Netherlands, ⁵VieCuri MC, Venlo, Netherlands
Background/Purpose: Calcium containing crystals in osteoarthritis (OA) are of interest as they potentially stimulate the NRLP-3 inflammasome and may become treatable with novel therapeutics. Previous…
Abstract Number: 0820 • ACR Convergence 2023
Radiographic and Pain Outcomes from a Phase 3 Extension Study Evaluating the Safety and Efficacy of Lorecivivint in Subjects with Severe Osteoarthritis of the Knee (OA-07): 36 Month Single Blind and Placebo Crossover Phase Results
Yusuf Yazici¹, Christopher Swearingen², Victor Lopez³, Jon Britt⁴, Sarah Kennedy⁵, Jeyanesh Tambiah² and Timothy McAlindon⁶, ¹NYU Grossman School of Medicine, La Jolla, CA, ²Biosplice Therapeutics, Inc., San Diego, CA, ³Biosplice Therapeutics, Inc., Santa Clarita, CA, ⁴Biosplice Therapeutics, Inc., Los Angeles, CA, ⁵Biosplice Therapeutics, Inc., Superior, CO, ⁶Tufts Medical Center, Arlington, MA
Background/Purpose: Knee osteoarthritis (OA) has unmet need for safe, efficacious symptom and disease-modifying treatments. Lorecivivint (LOR), an intra-articular (IA) CLK/DYRK inhibitor thought to modulate Wnt…
Abstract Number: 0873 • ACR Convergence 2023
FOXO Activators as Drugs for Osteoarthritis
Ichiro Kurakazu, Merissa Olmer, Kevin Myers and Martin K Lotz, Scripps Research Institute, La Jolla, CA
Background/Purpose: Forkhead box O (FOXO) proteins are a family of transcription factors involved in lifespan, aging, and autophagy. FOXO are essential for maintaining cartilage homeostasis…
Abstract Number: 1183 • ACR Convergence 2023
CoLchicine for Treatment of OsteoArthritis of the Knee—Updated Data from a Double-blind, Placebo-controlled Trial
Katherine Tse¹, Roni Meidan², Michael Toprover³, David Wei², Nicole Leung⁴, Maryfe Coronel², Julia Cai², Aryan Jain², maria lessa², Renata La Rocca Vieira², Svetlana Krasnokutsky Samuels², Michael Pillinger⁵ and Jonathan Samuels⁶, ¹NYU Langone, New York, NY, ²NYU Langone Helath, New York, NY, ³New York University Langone Health, New York, NY, ⁴New York University Langone Hospital, New York, NY, ⁵New York University Grossman School of Medicine, New York, NY, ⁶NYU Langone, Rye Brook, NY
Background/Purpose: Knee osteoarthritis (OA) has a probable inflammatory role for IL-1b. The presence of calcium and urate crystals may contribute to OA by activating the…
Abstract Number: 1199 • ACR Convergence 2023
Association of Dipeptidyl Peptidase-4 Inhibitor Use for Type 2 Diabetes and Incidence of OA in Taiwan
Hsiang-Yen Lee¹, Ching-Kuei Chang¹, Tzu-Min Lin¹, Tzu-Tung Ku², Jin-Hua Chen², Yu-Hsiu Chen³, Shu-Chuan Chen⁴ and Chi-Ching Chang², ¹Taipei Medical University Hospital, Taipei, Taiwan, ²Taipei Medical University, Taipei, Taiwan, ³Tri-Service General Hospital, Taipei, Taiwan, ⁴Idaho State University, Idaho State Pocatello, ID
Background/Purpose: Cellular senescence is involved in osteoarthritis (OA) development. Dipeptidyl Peptidase-4 (DPP4) is associated with senescence in OA chondrocytes. It is uncertain whether DPP4 inhibitor…
Abstract Number: 1843 • ACR Convergence 2023
Detection of Clinically Relevant Subgroups in Patients Undergoing Knee Replacement Using Machine Learning
Brooke McGinley¹, Gabriela Rabasa¹, Jean Liew¹, Tuhina Neogi², David Felson¹ and Michael LaValley³, ¹Boston University, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³Boston University School of Public Health, Arlington, MA
Background/Purpose: In the US the lifetime risk for Knee Replacement surgery (KR) is 7% for men and 9.5% for women, and this accounts for substantial…
Abstract Number: 1986 • ACR Convergence 2023
Deep Immunophenotyping of Osteoarthritis Patients Demonstrates Baseline Alterations in Monocyte Populations in OA, Dendritic Cell Subpopulations Among Radiographic Progressors, and Th17 Cells Among Pain Progressors
Gabby Dyson¹, Montana Barrett² and Matlock Jeffries¹, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma State University, Guthrie, OK
Background/Purpose: Previous studies have suggested low-level chronic inflammation plays a key role in knee osteoarthritis (OA) development and progression. In the present study, we set…
Abstract Number: 2471 • ACR Convergence 2023
Higher Pain and Functional Impairment in Erosive Hand Osteoarthritis Than in Treated Rheumatoid Arthritis: A Comparative Study Between DIGICOD and ESPOIR Cohorts
Sabryne Berkani¹, Ainhoa Aparicio Monforte², Sophie tuffet², alexandra rousseau², nathalie rincheval³, emmanuel maheu⁴, bernard combe³, Alain SARAUX⁵, Bruno Fautrel⁶, Laure Gossec⁷, Francis Berenbaum⁴, Jeremie SELLAM⁶ and alice courties⁴, ¹Sorbonne Université, Rheumatology department, (AP-HP) Saint-Antoine Hospital, Paris, France, ²Department of Clinical Pharmacology and Clinical Research Platform Paris-East (URCEST-CRC-CRB), APHP, Hôpital St Antoine, Paris, France, ³Department of Rheumatology, University of Montpellier, Montpellier, France, ⁴Sorbonne Université Assistance Publique – Hôpitaux de Paris (AP-HP), Saint-Antoine Hospital, Department of Rheumatology, Paris, France, ⁵CHU Brest, Brest, France, ⁶Sorbonne Université APHP, Paris, France, ⁷Sorbonne Université and Pitié Salpêtrière Hospital, Paris, France
Background/Purpose: Hand osteoarthritis (HOA) is considered as a less severe disease with a better functional prognosis and a lower global burden than rheumatoid arthritis (RA).…
Abstract Number: 0316 • ACR Convergence 2023
Relationship of Sensitization to Pain Severity in Patients with Knee Osteoarthritis
Lindsey MacFarlane¹, Hanna Mass¹, Catherine Yang¹, Jose Acosta Julbe¹, Antonia Chen¹, Jeffrey Lange¹, Morgan Jones¹, Faith Selzer¹, Jamie Collins¹, Elena Losina² and Jeffrey Katz¹, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA
Background/Purpose: Pain in knee osteoarthritis (OA) is multifactorial and influenced by factors including pain sensitization. Most literature on sensitization and OA has contrasted persons with…
Abstract Number: 0821 • ACR Convergence 2023
Effects of Sprifermin on a Novel Outcome of Osteoarthritis Symptom Progression: Post Hoc Analysis of the FORWARD Study
Philip Conaghan¹, Nathaniel Katz², david Hunter³, Marc Hochberg⁴, Ali Guermazi⁵, Kenneth Somberg⁶, Julia Clive⁶, Mary Johnson⁶ and Niti Goel⁷, ¹University of Leeds, Leeds, United Kingdom, ²Tufts University and Ein Sof Innovation, Boston, MA, ³Sydney Musculoskeletal Health, University of Sydney, St. Leonards, Australia, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Boston University, Boston, MA, ⁶TrialSpark, New York, NY, ⁷TrialSpark, Duke University, Durham, NC
Background/Purpose: People with knee OA (KOA) desire therapies which delay or reverse disease progression supporting the need for disease-modifying OA drugs (DMOADs). Sprifermin, truncated recombinant…
Abstract Number: 0874 • ACR Convergence 2023
RNA-Binding Proteins That Are Highly Expressed and Enriched in Healthy Cartilage but Suppressed in Osteoarthritis
Hannah Swahn, Merissa Olmer and Martin K Lotz, Scripps Research Institute, La Jolla, CA
Background/Purpose: RNA-binding proteins (RBPs) have diverse and essential biological functions, but their role in cartilage health and disease is largely unknown. The objectives of this…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].