Abstracts tagged "Osteoarthritis"

Abstract Number: 1186 • ACR Convergence 2023
Presence of Erosions Is Not a Risk Factor for the Development of Knee OA in a Hand OA Population: The Framingham OA Study
Tine Vanhaverbeke¹, Gabriela Rabasa², Ruth Wittoek¹, Ida Kristin Haugen³ and David Felson², ¹Dept. of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium, ²Boston University, Boston, MA, ³Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Osteoarthritis (OA) is a prevalent musculoskeletal disease and can affect multiple joint sites in one patient. Studies have shown an association between hand and…
Abstract Number: 1591 • ACR Convergence 2023
Complement Factor D/Adipsin Knockout Mice Demonstrate Disparate Pain and Structural Damage Phenotypes in Obesity-induced Post Traumatic Osteoarthritis
Kelsey Collins¹, Kristin Lenz², Arin Oestreich², Luke Springer², Antonina Akk², Huimin Yan², Xiaobo Wu², John Atkinson³, Christine Pham⁴ and Farshid Guilak⁴, ¹University of California San Francisco, San Francisco, CA, ²Washington University in St. Louis, St. Louis, MO, ³Washington University School of Medicine, St. Louis, MO, ⁴Washington University, St. Louis, MO
Background/Purpose: Osteoarthritis (OA) is the leading cause of musculoskeletal pain, which is a primary driver of care-seeking behavior. There is lack of mechanistic information detailing…
Abstract Number: 1883 • ACR Convergence 2023
Thalamocortical Mechanisms of a Remote Mind-body Intervention for Knee Osteoarthritis Pain
Jian Kong¹, Valeria Sacca¹ and Chenchen Wang², ¹Massachusetts General Hospital, Boston, MA, ²Center of Integrative Medicine and Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Studies found that individuals with pain exhibit altered thalamocortical rhythm, abnormal function, and structural connectivity within the network. Effective treatment may relieve pain by…
Abstract Number: 1989 • ACR Convergence 2023
Shared Variation Among Cartilage Thickness Change Maps and Baseline Clinical Features at the Initiation of Structural Knee Osteoarthritis
Thomas Keefe¹, Marc Niethammer¹, Boqi Chen¹, Zhengyang Shen¹, Daniel Nissman¹, Mary Catherine Minnig², Yvonne Golightly³, J.S. Marron¹ and Amanda Nelson¹, ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Durham, NC, ³University of Nebraska Medical Center, Omaha, NE
Background/Purpose: To identify features of cartilage thickness change and baseline clinical indicators associated with the transition from normal to mildly reduced joint space as an…
Abstract Number: 2499 • ACR Convergence 2023
Influence of Adiposity on Physical Function, Physical Activity, and Self-Reported Symptom Severity for Individuals with Arthritis Prior to Beginning a Physical Activity Promotion Intervention
Scott Jamieson, Sara Wilcox and Christine Pellegrini, The University of South Carolina, Columbia, SC
Background/Purpose: Engagement in moderate-vigorous physical activity (MVPA) is recommended for individuals with obesity to promote weight loss and mitigate severity of chronic diseases associated with…
Abstract Number: 0319 • ACR Convergence 2023
Knee Flexion Contracture Was Associated with Articular Cartilage Loss in the Central Region but Cartilage Preservation in the Posterior Region of the Tibia: Data from the Osteoarthritis Initiative
Mark Campbell¹, Odette Laneuville² and Guy Trudel³, ¹Elisabeth Bruyere Hospital, Ottawa, ON, Canada, ²University of Ottawa, Ottawa, ON, Canada, ³Ottawa Hospital Research Institute, Ottawa, ON, Canada
Background/Purpose: A knee flexion contracture (FC), present in ~⅓ of patients with knee OA1, is the inability to fully extend the knee2, 3. Having a…
Abstract Number: 0859 • ACR Convergence 2023
Single Injection AAV2-hFGF18 Demonstrates Superior Safety and Efficacy over Repeat rhFGF18 Protein Injections in a Model of Induced Osteoarthritis
Alex Goraltchouk¹, Judith Hollander², Francesco Luppino³, Li Zeng² and Alexey Seregin³, ¹Remedium Bio, Inc, Needham, MA, ²Tufts University, Boston, MA, ³Remedium Bio, Inc., Needham, MA
Background/Purpose: Osteoarthritis (OA) is the largest unmet need in rheumatology, affecting 1 in 7 adults, with no approved disease modifying treatments. A recent placebo-controlled clinical…
Abstract Number: 0877 • ACR Convergence 2023
Loss of Transient Receptor Potential Channel 1 (TRPC1) Links Regulation of Intracellular Calcium to Cellular Senescence and Leads to Development of Osteoarthritis
Meike Sambale¹, starlee lively², Osvaldo Espin-Garcia², Pratibha Potla², Chiara Pastrello³, Alexandra Schaefer¹, Jessica Bertrand⁴, Mohit Kapoor⁵, Thomas Pap¹ and Joanna Sherwood¹, ¹University Hospital Münster, Münster, Germany, ²University Health Network, Toronto, ON, Canada, ³Osteoarthritis Research Program, Division of Orthopaedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic diseases, Krembil Research Institute, Toronto, ON, Canada, ⁴Department of Orthopaedic Surgery, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany, ⁵Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, and Krembil Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: Transient receptor potential channel 1 (TRPC1) is a widely expressed mechanosensitive ion channel located within the endoplasmic reticulum membrane. It is crucial for the…
Abstract Number: 1187 • ACR Convergence 2023
Post-hoc Analysis of Individual Questions from the Australian/Canadian Osteoarthritis Hand Index from a Randomized, Double-blind, Placebo-controlled Trial of Patients with Hand OA
Karin Nicholson¹, Edwin Sanchez¹, Wendy Wright², Joel Block³ and Richard Petruschke¹, ¹Haleon, Warren, NJ, ²Wright & Associates Family Healthcare, Amherst, NH, ³Rush University Medical Center, Chicago, IL
Background/Purpose: Hand osteoarthritis (OA) is a frequently occurring form of OA characterized by symptoms including joint pain, stiffness, and swelling which affect performance of activities…
Abstract Number: 1592 • ACR Convergence 2023
Memantine Attenuates the Development of Osteoarthritis by Blocking NMDA Receptor Mediated Calcium Overload and Chondrocyte Senescence
Ning Wang¹, Qingmei Cheng¹, Xiaoxiao Li², ke he¹, Junyu Zhu¹, Hui Li³ and Jie Wei⁴, ¹中南大学湘雅医院, Changsha, China, ²Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China, ³Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China, ⁴Health Management Center, Xiangya Hospital Central South University, Changsha, China
Background/Purpose: Memantine is an FDA proved drug utilized for the treatment of dementia and exerts its function by blocking the NMDA (N-methyl-D-aspartate) receptor, a calcium…
Abstract Number: 1894 • ACR Convergence 2023
3-Dimensional Regional Variation in Inter-rater Reliability of Bone Marrow Lesion Scoring in the Knee
Stephanie Wichuk¹, Walter P. Maksymowych¹, Joel Paschke², Abhilash Hareendranathan³ and Jacob Jaremko¹, ¹University of Alberta, Edmonton, AB, Canada, ²CARE Arthritis, Edmonton, AB, Canada, ³Radiology and Diagnostic Imaging, Edmonton, AB, Canada
Background/Purpose: Bone marrow lesions (BML) are an important scoring feature on magnetic resonance imaging (MRI) of knee osteoarthritis (OA), and their presence in certain anatomical…
Abstract Number: 1990 • ACR Convergence 2023
Effects of Exercise on Movement-Evoked Pain in People with Knee Osteoarthritis
Ehyun Kim¹, Tuhina Neogi², Benjamin Senderling¹, Mary Gheller¹, Lee Marinko¹, Michael LaValley³, Lukas Adamowicz⁴, Pirinka Georgiev⁴, Charmaine Demanuele⁴, Paul Wacnik⁴ and Deepak Kumar¹, ¹Boston University, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³Boston University School of Public Health, Arlington, MA, ⁴Pfizer Inc., Cambridge, MA
Background/Purpose: Movement-evoked pain (MEP), i.e., pain that appears with or is made worse by movement, is a common complaint in people with knee osteoarthritis (OA).…
Abstract Number: 2503 • ACR Convergence 2023
Cytokines Regulate the Fibrotic Response of Growth Factors in Joint Fibroblast-like Synoviocytes
Sofie Falkenløve Madsen¹, Mikkel Rathsach Andersen², Alexander Scheller Madrid², Signe Holm Nielsen³, Morten Karsdal³, Christian Thudium³ and Anne-Christine Bay-Jensen³, ¹University of Copenhagen, Herlev, Denmark, ²Herlev-Gentofte Hospital, Gentofte, Denmark, ³Nordic Bioscience, Herlev, Denmark
Background/Purpose: Rheumatoid arthritis (RA) and osteoarthritis (OA) are characterized by inflammation, joint swelling, stiffness, and pain. A fibroid phenotype has been identified in RA, where…
Abstract Number: 0320 • ACR Convergence 2023
Feasibility and Acceptability of Geniculate Artery Embolization for the Treatment of Painful Knee Osteoarthritis
Amaya Smole¹, Benjamin Swett¹, Alison Zhao¹, Yvonne Shea¹, Sarah Gottesman¹, Dongmei Sun¹, Geoffrey Westrich¹, Michael Alexiades¹, Alejandro Gonzalez Della Valle¹, Sirish Kishore² and Lisa Mandl³, ¹Hospital for Special Surgery, New York, NY, ²Stanford Medicine, Stanford, CA, ³Hospital for Special Surgery, Weill Cornell Medicine, New York, NY
Background/Purpose: There are limited non-surgical options for patients with severe pain due to knee osteoarthritis (KOA).Using geniculate artery embolization (GAE) to infarct hypervascular synovium, a…
Abstract Number: 0861 • ACR Convergence 2023
The Analgesic Effect of RC-0165, a TRPV1 Antagonist, for Osteoarthritis Pain
Donghui kim, Juil park, Minjung kim and Yongho kim, RudaCure, Seoul, South Korea
Background/Purpose: Osteoarthritis (OA), the most common form of arthritis, arises from the deterioration of cartilage within joint bones, resulting in pain and functional disability with…

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