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Abstracts tagged "osteoarthritis and synovitis"

  • Abstract Number: 952 • 2018 ACR/ARHP Annual Meeting

    Effusion-Synovitis and Infrapatellar Fat Pad Edema Differentiate Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative

    Julie Davis1, Robert J. Ward2, James MacKay3, Bing Lu4, Lori Lyn Price5,6, Timothy E. McAlindon7, Charles B. Eaton8, Mary Barbe9, Grace H. Lo10, Matthew Harkey1 and Jeffrey B. Driban11, 1Rheumatology, Tufts Medical Center, Boston, MA, 2Radiology, Tufts Medical Center, Boston, MA, 3Radiology, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, 4Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 5Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, 6Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, 7Division of Rheumatology, Tufts Medical Center, Boston, MA, 8Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, 9Temple University School of Medicine, Philadelphia, PA, 10Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, 11Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA

    Background/Purpose: Accelerated knee osteoarthritis (AKOA) is a unique endotype of knee osteoarthritis (KOA) that is characterized by a sudden onset of advance-stage disease and greater…
  • Abstract Number: 51 • 2017 ACR/ARHP Annual Meeting

    Irisin Ameliorates Infrapatellar Adiposity in Knee Osteoarthritis Pathogenesis By Orchestrating Adipokine Signaling

    Feng-Sheng Wang1, Yi-Chih Sun1 and Jih-Yang Ko2, 1Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, 2Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan

    Background/Purpose: Aberrant infrapatellar fat metabolism is a prominent feature that exacerbates inflammation and fibrosis relative to joint deterioration during osteoarthritis (OA). Irisin, a secretory subunit…
  • Abstract Number: 2756 • 2017 ACR/ARHP Annual Meeting

    Effect of Baseline and Change in Effusion-Synovitis on Cartilage Damage over 18 Months in Patients with Osteoarthritis and Meniscal Tear

    Lindsey A. MacFarlane1, Heidi Y. Yang2, Jamie E. Collins3, Mohamed Jarraya4, Ali Guermazi5, Lisa A. Mandl6, Elena Losina3 and Jeffrey N. Katz7, 1Rheumatology, Brigham & Women's Hospital, Boston, MA, 2Orthopaedic and Arthritis Center for Outcomes Research, Brigham & Women's Hospital, Boston, MA, 3Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham & Women's Hospital, Boston, MA, 4Musculoskeletal Radiology, Boston University School of Medicine, Boston, MA, 5Boston University School of Medicine, Boston, MA, 6Department of Rheumatology, Hospital for Special Surgery, New York, NY, 7Rheumatology, Immunology, and Allergy, Brigham & Women's Hospital, Boston, MA

    Background/Purpose: Synovitis is a common feature in meniscal tear (MT) and osteoarthritis (OA). Synovitis has been associated with progression of cartilage damage in persons with…
  • Abstract Number: 2352 • 2016 ACR/ARHP Annual Meeting

    Obesity-Related Systemic Inflammation and Knee Synovitis

    Devyani Misra1, Tuhina Neogi2, Michael C. Nevitt3, James Torner4, Cora E. Lewis5 and David T. Felson6, 1Medicine, Section of, BUSM, Boston, MA, 2Clinical Epidemiology, BUSM, Boston, MA, 3Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, 4University of Iowa, UIowa, Iowa City, IA, 5University of Alabama Birmingham, Birmingham, AL, 6Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA

    Background/Purpose: Obesity, a major risk factor for knee osteoarthritis (OA), is a state of systemic inflammation through elaboration of adipokines (pro and anti-inflammatory cytokines) from…
  • Abstract Number: 2997 • 2016 ACR/ARHP Annual Meeting

    Microrna-29a Curtails Synovitis in the Development of Knee Osteoarthritis By Disrupting VEGF

    Feng-Sheng Wang1, Yi-Chih Sun1, Yu-Shan Chen1 and Jih-Yang Ko2, 1Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, 2Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan

    Background/Purpose:  Intensive synovitis is a prominent feature that progressively aggravated excessive fibrosis reactions relative to joint stiffness in the pathogenesis of osteoarthritis (OA). MicroRNA-29a (miR-29a)…
  • Abstract Number: 1126 • 2016 ACR/ARHP Annual Meeting

    Interleukin-1 Is Not Involved in Synovial Inflammation and Cartilage Destruction in Collagenase-Induced Osteoarthritis

    Stephanie van Dalen1, Arjen Blom1, Annet Sloetjes1, Monique M. Helsen1, Johannes Roth2, Thomas Vogl2, Wim B. van den Berg1, Martijn van den Bosch1 and Peter L. E. M. van Lent1, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Institute of Immunology, University of Münster, Münster, Germany

    Background/Purpose: Osteoarthritis (OA) is characterized by severe cartilage destruction, with a putative role for synovial macrophages. Up to 50% of the patients also show low…
  • Abstract Number: 1133 • 2015 ACR/ARHP Annual Meeting

    Microrna-128 Interference Mitigates the Progression of Keen Osteoarthritis By Regulating Sirtuin-1

    Feng-Sheng Wang1, Yi-Chih Sun1, Yu-Shan Chen1 and Jih-Yang Ko2, 1Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, 2Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan

    Background/Purpose:  MicroRNAs, non-coding small RNAs, reportedly regulate development, remodeling and pathogenesis activities in various tissues through silencing mRNA targets and protein translation. This study is…
  • Abstract Number: 1300 • 2015 ACR/ARHP Annual Meeting

    Comparison Between Semiquantitative and Quantitative Methods for the Assessment of Knee Synovitis Using Non-Enhanced and Gadolinium-Enhanced MRI

    Michel D. Crema1, Frank Roemer2, Ling Li3, Laura B. Rosen4, Amanda Dudley5, Robert Alexander6 and Ali Guermazi7, 1Department of Radiology, Boston University School of Medicine, Boston, MA, 2Radiology, Boston University School of Medicine, Boston, MA, 3Dana-Farber Cancer Institute, Boston, MA, 4AstraZeneca Neuroscience Innovative Medicines, Cambridge, MA, 5AstraZeneca Neuroscience Innovative Medicines, Cambridge, United Kingdom, 6Pfizer Neuroscience, Cambridge, MA, 7Boston University School of Medicine, Boston, MA

    Background/Purpose:   There is evidence that the presence of synovitis in knee osteoarthritis (OA) is clinically relevant since it is associated with pain and structural…
  • Abstract Number: 2952 • 2014 ACR/ARHP Annual Meeting

    S100A9 Inhibitor Paquinimod (ABR-215757) reduces Joint Destruction in Experimental Osteoarthritis and Blocks Activating Effects of S100A9 in OA Synovium

    Peter L. van Lent1, Rik Schelbergen2, Arjen B. Blom1, Tomas Leanderson3, Helena Eriksson4 and Wim B. van den Berg5, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Radboud university medical center, Nijmegen, Netherlands, 3Immunology Group, Lund University, Lund, Sweden, 4BioScience, Active Biotech AB, Lund, Sweden, 5Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose Synovial activation is present in more than 50% of osteoarthritis (OA) patients and it is thought to be involved in the development of OA…
  • Abstract Number: 1292 • 2014 ACR/ARHP Annual Meeting

    Synovitis Characteristics and Associated Intra-Articular Pathology in a Cohort of Patients Undergoing Meniscectomy for Meniscal Tear

    Marta Favero1, Giovanni Trisolino2, Antonello Lazzaro3, Mary B. Goldring4, Steven R. Goldring5, Elisa Assirelli6, Claudio Iacobellis7, Augusto Cigolotti8, Assunta Pozzuoli3, Ambrogio Fassina8, Ermanno Martucci2, Leonardo Punzi9, Andrea Facchini6 and Eleonora Olivotto6, 1University Hospital of Padova, Italy, Rheumatology Unit, Padova, Italy, 2Rizzoli Orthopaedic Institute, Reconstructive Hip and Knee Joint Surgery, Bologna, Italy, 3University of Padova, Orthopaedic Clinic, Padova, Italy, 4Tissue Engineering Repair and Regeneration Program, Hospital for Special Surgery and Weill Cornell Medical College, New York, NY, 5Hospital for Special Surgery, New York, NY, 6Rizzoli Orthopaedic Institute, Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES, Bologna, Italy, 7Hospital of Padova, UOC of Orthopaedic and Traumatology, Padova, Italy, 8University of Padova, Surgical Pathology and Cytopathology Unit, Department of Medicine, University of Padova, Italy, Padova, Italy, 9Department of Medicine - DIMED, University of Padova, Padova, Italy

    Background/Purpose: Previous epidemiologic studies have established that there is a strong relationship between meniscal tear and the risk for subsequent development of osteoarthritis (OA). Though…
  • Abstract Number: 1199 • 2014 ACR/ARHP Annual Meeting

    Alarmins S100A8/S100A9 Aggravate Osteophyte Formation in Experimental Osteoarthritis and Predict Osteophyte Progression in EARLY Human Osteoarthritis in the Dutch Check Cohort

    Rik Schelbergen1, Wouter de Munter2, Martijn van den Bosch3, Floris Lafeber4, Annet Sloetjes3, Thomas Vogl5, Johannes Roth5, Peter M. van der Kraan6, Arjen B. Blom3, Wim B van den Berg3 and Peter L. van Lent3, 1Radboud university medical center, Nijmegen, Netherlands, 2Experimental rheumatology, Radboud university medical center, Nijmegen, Netherlands, 3Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 4Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 5Immunology, Institute of Immunology University of Muenster, Muenster, Germany, 6Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose The main pathological feature of osteoarthritis (OA) is degradation of the articular cartilage. Other important hallmarks include subclinical inflammation of the synovium and ectopic…
  • Abstract Number: 169 • 2013 ACR/ARHP Annual Meeting

    Effects Of Chondroitin Sulfate On The Gene Expression Profile In Interleukin-1β Stimulated Synovial Fibroblast Cells Cultures

    Cécile Lambert1, Jean-Emile Dubuc2, Eulalia Montell3, Josep Verges3 and Yves Henrotin1, 1University of Liège, Bone and Cartilage Research Unit, Liège, Belgium, 2Clinical University Saint Luc, Orthopaedic Department, Bruxelles, Belgium, 3Pre-Clinical R&D Area, Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain

    Background/Purpose: Chondroitin sulfate (CS) is one the most used molecules in the management of OA. Its mechanism of action remains to be detailed. In this…
  • Abstract Number: 171 • 2013 ACR/ARHP Annual Meeting

    Effects Of Chondroitin Sulfate On The Gene Expression Profile In The Inflamed Synovial Membrane

    Cécile Lambert1, Jean-Emile Dubuc2, Eulalia Montell3, Josep Verges3 and Yves Henrotin1, 1University of Liège, Bone and Cartilage Research Unit, Liège, Belgium, 2Clinical University Saint Luc, Orthopaedic Department, Bruxelles, Belgium, 3Pre-Clinical R&D Area, Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain

    Background/Purpose: Chondroitin sulfate (CS) is one the most used molecules in the management of OA. Its mechanism of action remains to be detailed. The aim…
  • Abstract Number: 148 • 2013 ACR/ARHP Annual Meeting

    Microarray Analysis Of  Synovial Specimen of Early Human (CHECK) and Experimental Osteoarthritis to Identify Pathways and Processes Associated with Pathology

    Arjen B. Blom1, Peter L. van Lent2, Martijn H. van den Bosch1, Hans Cats3, Frank H.J. van den Hoogen4, Peter M. van der Kraan5 and Wim B. van den Berg6, 1Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 3Rheumatology, Rheumatology Centre Sint Maartenskliniek, Nijmegen, Netherlands, 4Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, 5Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 6Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

    Background/Purpose: The majority of osteoarthritis (OA) patients show synovial inflammation, even relatively early during the disease. We used microarray analysis of synovial tissue of early…
  • Abstract Number: 2729 • 2013 ACR/ARHP Annual Meeting

    Identification Of Osteoarthritis Patients With Chronic Inflammation Driven Disease Progression

    Anne Sofie Siebuhr1, Kristian Kjaer Petersen2, Lars Arendt-Nielsen3, Line Egsgaard2, Thomas Navndrup Eskehave4, Ole Simonsen5, Claus Christiansen4,6, Hans Christian Hoeck4, Morten Asser Karsdal7 and Anne C. Bay-Jensen8, 1Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 2Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark, Center for Sensory-Motor Interaction, Aalborg, Denmark, 3Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Center for Sensory-Motor Interaction, Aalborg, Denmark, 4Center for Clinical and Basic Research and C4Pain, Aalborg, Denmark, 5Frederikshavn Hospital, Frederikshavn, Denmark, 6Nordic Bioscience, Herlev, Denmark, 7Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, 8Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark

    Background/Purpose: In osteoarthritis (OA) it is evident that a subset of patients experiences chronic tissue inflammation and may benefit from anti-inflammatory treatment. The systemic inflammation…
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