Abstracts tagged "osteoarthritis and synovitis"

Abstract Number: 952 • 2018 ACR/ARHP Annual Meeting
Effusion-Synovitis and Infrapatellar Fat Pad Edema Differentiate Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Julie Davis¹, Robert J. Ward², James MacKay³, Bing Lu⁴, Lori Lyn Price^5,6, Timothy E. McAlindon⁷, Charles B. Eaton⁸, Mary Barbe⁹, Grace H. Lo¹⁰, Matthew Harkey¹ and Jeffrey B. Driban¹¹, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Radiology, Tufts Medical Center, Boston, MA, ³Radiology, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, ⁴Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁵Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ⁶Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁷Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁸Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁹Temple University School of Medicine, Philadelphia, PA, ¹⁰Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, ¹¹Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Accelerated knee osteoarthritis (AKOA) is a unique endotype of knee osteoarthritis (KOA) that is characterized by a sudden onset of advance-stage disease and greater…
Abstract Number: 51 • 2017 ACR/ARHP Annual Meeting
Irisin Ameliorates Infrapatellar Adiposity in Knee Osteoarthritis Pathogenesis By Orchestrating Adipokine Signaling
Feng-Sheng Wang¹, Yi-Chih Sun¹ and Jih-Yang Ko², ¹Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, ²Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan
Background/Purpose: Aberrant infrapatellar fat metabolism is a prominent feature that exacerbates inflammation and fibrosis relative to joint deterioration during osteoarthritis (OA). Irisin, a secretory subunit…
Abstract Number: 2756 • 2017 ACR/ARHP Annual Meeting
Effect of Baseline and Change in Effusion-Synovitis on Cartilage Damage over 18 Months in Patients with Osteoarthritis and Meniscal Tear
Lindsey A. MacFarlane¹, Heidi Y. Yang², Jamie E. Collins³, Mohamed Jarraya⁴, Ali Guermazi⁵, Lisa A. Mandl⁶, Elena Losina³ and Jeffrey N. Katz⁷, ¹Rheumatology, Brigham & Women's Hospital, Boston, MA, ²Orthopaedic and Arthritis Center for Outcomes Research, Brigham & Women's Hospital, Boston, MA, ³Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham & Women's Hospital, Boston, MA, ⁴Musculoskeletal Radiology, Boston University School of Medicine, Boston, MA, ⁵Boston University School of Medicine, Boston, MA, ⁶Department of Rheumatology, Hospital for Special Surgery, New York, NY, ⁷Rheumatology, Immunology, and Allergy, Brigham & Women's Hospital, Boston, MA
Background/Purpose: Synovitis is a common feature in meniscal tear (MT) and osteoarthritis (OA). Synovitis has been associated with progression of cartilage damage in persons with…
Abstract Number: 1126 • 2016 ACR/ARHP Annual Meeting
Interleukin-1 Is Not Involved in Synovial Inflammation and Cartilage Destruction in Collagenase-Induced Osteoarthritis
Stephanie van Dalen¹, Arjen Blom¹, Annet Sloetjes¹, Monique M. Helsen¹, Johannes Roth², Thomas Vogl², Wim B. van den Berg¹, Martijn van den Bosch¹ and Peter L. E. M. van Lent¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Institute of Immunology, University of Münster, Münster, Germany
Background/Purpose: Osteoarthritis (OA) is characterized by severe cartilage destruction, with a putative role for synovial macrophages. Up to 50% of the patients also show low…
Abstract Number: 2352 • 2016 ACR/ARHP Annual Meeting
Obesity-Related Systemic Inflammation and Knee Synovitis
Devyani Misra¹, Tuhina Neogi², Michael C. Nevitt³, James Torner⁴, Cora E. Lewis⁵ and David T. Felson⁶, ¹Medicine, Section of, BUSM, Boston, MA, ²Clinical Epidemiology, BUSM, Boston, MA, ³Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁴University of Iowa, UIowa, Iowa City, IA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Obesity, a major risk factor for knee osteoarthritis (OA), is a state of systemic inflammation through elaboration of adipokines (pro and anti-inflammatory cytokines) from…
Abstract Number: 2997 • 2016 ACR/ARHP Annual Meeting
Microrna-29a Curtails Synovitis in the Development of Knee Osteoarthritis By Disrupting VEGF
Feng-Sheng Wang¹, Yi-Chih Sun¹, Yu-Shan Chen¹ and Jih-Yang Ko², ¹Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, ²Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan
Background/Purpose: Intensive synovitis is a prominent feature that progressively aggravated excessive fibrosis reactions relative to joint stiffness in the pathogenesis of osteoarthritis (OA). MicroRNA-29a (miR-29a)…
Abstract Number: 1133 • 2015 ACR/ARHP Annual Meeting
Microrna-128 Interference Mitigates the Progression of Keen Osteoarthritis By Regulating Sirtuin-1
Feng-Sheng Wang¹, Yi-Chih Sun¹, Yu-Shan Chen¹ and Jih-Yang Ko², ¹Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, ²Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan
Background/Purpose: MicroRNAs, non-coding small RNAs, reportedly regulate development, remodeling and pathogenesis activities in various tissues through silencing mRNA targets and protein translation. This study is…
Abstract Number: 1300 • 2015 ACR/ARHP Annual Meeting
Comparison Between Semiquantitative and Quantitative Methods for the Assessment of Knee Synovitis Using Non-Enhanced and Gadolinium-Enhanced MRI
Michel D. Crema¹, Frank Roemer², Ling Li³, Laura B. Rosen⁴, Amanda Dudley⁵, Robert Alexander⁶ and Ali Guermazi⁷, ¹Department of Radiology, Boston University School of Medicine, Boston, MA, ²Radiology, Boston University School of Medicine, Boston, MA, ³Dana-Farber Cancer Institute, Boston, MA, ⁴AstraZeneca Neuroscience Innovative Medicines, Cambridge, MA, ⁵AstraZeneca Neuroscience Innovative Medicines, Cambridge, United Kingdom, ⁶Pfizer Neuroscience, Cambridge, MA, ⁷Boston University School of Medicine, Boston, MA
Background/Purpose: There is evidence that the presence of synovitis in knee osteoarthritis (OA) is clinically relevant since it is associated with pain and structural…
Abstract Number: 1199 • 2014 ACR/ARHP Annual Meeting
Alarmins S100A8/S100A9 Aggravate Osteophyte Formation in Experimental Osteoarthritis and Predict Osteophyte Progression in EARLY Human Osteoarthritis in the Dutch Check Cohort
Rik Schelbergen¹, Wouter de Munter², Martijn van den Bosch³, Floris Lafeber⁴, Annet Sloetjes³, Thomas Vogl⁵, Johannes Roth⁵, Peter M. van der Kraan⁶, Arjen B. Blom³, Wim B van den Berg³ and Peter L. van Lent³, ¹Radboud university medical center, Nijmegen, Netherlands, ²Experimental rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁴Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Immunology, Institute of Immunology University of Muenster, Muenster, Germany, ⁶Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands
Background/Purpose The main pathological feature of osteoarthritis (OA) is degradation of the articular cartilage. Other important hallmarks include subclinical inflammation of the synovium and ectopic…
Abstract Number: 2952 • 2014 ACR/ARHP Annual Meeting
S100A9 Inhibitor Paquinimod (ABR-215757) reduces Joint Destruction in Experimental Osteoarthritis and Blocks Activating Effects of S100A9 in OA Synovium
Peter L. van Lent¹, Rik Schelbergen², Arjen B. Blom¹, Tomas Leanderson³, Helena Eriksson⁴ and Wim B. van den Berg⁵, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Radboud university medical center, Nijmegen, Netherlands, ³Immunology Group, Lund University, Lund, Sweden, ⁴BioScience, Active Biotech AB, Lund, Sweden, ⁵Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands
Background/Purpose Synovial activation is present in more than 50% of osteoarthritis (OA) patients and it is thought to be involved in the development of OA…
Abstract Number: 1292 • 2014 ACR/ARHP Annual Meeting
Synovitis Characteristics and Associated Intra-Articular Pathology in a Cohort of Patients Undergoing Meniscectomy for Meniscal Tear
Marta Favero¹, Giovanni Trisolino², Antonello Lazzaro³, Mary B. Goldring⁴, Steven R. Goldring⁵, Elisa Assirelli⁶, Claudio Iacobellis⁷, Augusto Cigolotti⁸, Assunta Pozzuoli³, Ambrogio Fassina⁸, Ermanno Martucci², Leonardo Punzi⁹, Andrea Facchini⁶ and Eleonora Olivotto⁶, ¹University Hospital of Padova, Italy, Rheumatology Unit, Padova, Italy, ²Rizzoli Orthopaedic Institute, Reconstructive Hip and Knee Joint Surgery, Bologna, Italy, ³University of Padova, Orthopaedic Clinic, Padova, Italy, ⁴Tissue Engineering Repair and Regeneration Program, Hospital for Special Surgery and Weill Cornell Medical College, New York, NY, ⁵Hospital for Special Surgery, New York, NY, ⁶Rizzoli Orthopaedic Institute, Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES, Bologna, Italy, ⁷Hospital of Padova, UOC of Orthopaedic and Traumatology, Padova, Italy, ⁸University of Padova, Surgical Pathology and Cytopathology Unit, Department of Medicine, University of Padova, Italy, Padova, Italy, ⁹Department of Medicine - DIMED, University of Padova, Padova, Italy
Background/Purpose: Previous epidemiologic studies have established that there is a strong relationship between meniscal tear and the risk for subsequent development of osteoarthritis (OA). Though…
Abstract Number: 169 • 2013 ACR/ARHP Annual Meeting
Effects Of Chondroitin Sulfate On The Gene Expression Profile In Interleukin-1β Stimulated Synovial Fibroblast Cells Cultures
Cécile Lambert¹, Jean-Emile Dubuc², Eulalia Montell³, Josep Verges³ and Yves Henrotin¹, ¹University of Liège, Bone and Cartilage Research Unit, Liège, Belgium, ²Clinical University Saint Luc, Orthopaedic Department, Bruxelles, Belgium, ³Pre-Clinical R&D Area, Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain
Background/Purpose: Chondroitin sulfate (CS) is one the most used molecules in the management of OA. Its mechanism of action remains to be detailed. In this…
Abstract Number: 171 • 2013 ACR/ARHP Annual Meeting
Effects Of Chondroitin Sulfate On The Gene Expression Profile In The Inflamed Synovial Membrane
Cécile Lambert¹, Jean-Emile Dubuc², Eulalia Montell³, Josep Verges³ and Yves Henrotin¹, ¹University of Liège, Bone and Cartilage Research Unit, Liège, Belgium, ²Clinical University Saint Luc, Orthopaedic Department, Bruxelles, Belgium, ³Pre-Clinical R&D Area, Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain
Background/Purpose: Chondroitin sulfate (CS) is one the most used molecules in the management of OA. Its mechanism of action remains to be detailed. The aim…
Abstract Number: 148 • 2013 ACR/ARHP Annual Meeting
Microarray Analysis Of Synovial Specimen of Early Human (CHECK) and Experimental Osteoarthritis to Identify Pathways and Processes Associated with Pathology
Arjen B. Blom¹, Peter L. van Lent², Martijn H. van den Bosch¹, Hans Cats³, Frank H.J. van den Hoogen⁴, Peter M. van der Kraan⁵ and Wim B. van den Berg⁶, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology, Rheumatology Centre Sint Maartenskliniek, Nijmegen, Netherlands, ⁴Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, ⁵Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁶Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: The majority of osteoarthritis (OA) patients show synovial inflammation, even relatively early during the disease. We used microarray analysis of synovial tissue of early…
Abstract Number: 2729 • 2013 ACR/ARHP Annual Meeting
Identification Of Osteoarthritis Patients With Chronic Inflammation Driven Disease Progression
Anne Sofie Siebuhr¹, Kristian Kjaer Petersen², Lars Arendt-Nielsen³, Line Egsgaard², Thomas Navndrup Eskehave⁴, Ole Simonsen⁵, Claus Christiansen^4,6, Hans Christian Hoeck⁴, Morten Asser Karsdal⁷ and Anne C. Bay-Jensen⁸, ¹Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark, Center for Sensory-Motor Interaction, Aalborg, Denmark, ³Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Center for Sensory-Motor Interaction, Aalborg, Denmark, ⁴Center for Clinical and Basic Research and C4Pain, Aalborg, Denmark, ⁵Frederikshavn Hospital, Frederikshavn, Denmark, ⁶Nordic Bioscience, Herlev, Denmark, ⁷Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ⁸Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark
Background/Purpose: In osteoarthritis (OA) it is evident that a subset of patients experiences chronic tissue inflammation and may benefit from anti-inflammatory treatment. The systemic inflammation…

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