Abstracts tagged "osteoarthritis and rheumatoid arthritis (RA)"

Abstract Number: 2076 • 2019 ACR/ARP Annual Meeting
The Opioid Epidemic: The Rheumatology Response to Management of Chronic Pain
Michael Grant¹, Alysia Kwiatkowski ¹ and Najia Shakoor ¹, ¹Rush University Medical Center, Chicago, IL
Background/Purpose: Pain is the hallmark symptom of many rheumatologic conditions and chronic pain management is a major part of clinical practice in rheumatology. Therefore, as…
Abstract Number: 56 • 2018 ACR/ARHP Annual Meeting
Comparison of Metabolic Changes in Osteoarthritis and Rheumatoid Arthritis Mouse Models
Marie-Lisa Hülser¹, Hani Manfred Sauermilch¹, Carina Schreiyäck¹, Yubin Luo², Aline Bozec², Georg Schett³, Ulf Müller-Ladner⁴ and Elena Neumann¹, ¹Dept. of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig-University Gießen, Germany, Bad Nauheim, Germany, ²University of Erlangen-Nürnberg, Department Clinic of Medicine 3 - Immunology and Rheumatology, Erlangen, Germany, Erlangen, Germany, ³Friedrich-Alexander-Universität Erlangen, Nürnberg und Universitätsklinikum Erlangen, Erlangen, Germany, ⁴Dept. of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig-University Giessen, Germany, Bad Nauheim, Germany
Background/Purpose: Adipocytokines are bioactive factors produced mainly by adipose tissue. They not only regulate energy homeostasis, but also influence immune responses. Osteoarthritis (OA) is one…
Abstract Number: 932 • 2018 ACR/ARHP Annual Meeting
Fibroblasts Senescence Is Observed in Rheumatoid and Osteoarthritic Synovial Tissues and Triggers a Pro-Inflammatory Program Ex Vivo
Manuel J Del Rey¹, Alvaro Valin², Alicia Usategui³, Sandra Ergueta³, Vanessa Miranda³, Jesús Fernández-Felipe³, Juan D. Cañete⁴, Francisco J Blanco⁵, Gabriel Criado³ and Jose L. Pablos^6,7, ¹Grupo de Enfermedades Inflamatorias y Autoinmunes, Servicio de Reumatología,, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ²Grupo de Enfermedades Inflamatorias y Autoimmunes, Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ³Grupo de Enfermedades Inflamatorias y Autoinmunes, Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ⁴Rheumatology Department Hospital Clinic and IDIBAPS, Barcelona, Spain, Barcelona, Spain, ⁵Rheumatology Division (INIBIC-CHUAC), Osteoarticular and Aging Research Lab, Proteomics Unit, La Coruna, Spain, ⁶Servicio de Reumatología, Rheumatology Department, Hospital 12 de Octubre, Spain, Madrid, Spain, ⁷Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain
Background/Purpose: Inflammation is an important component of most age-related disorders. Cellular changes associated to aging are tightly connected with pro-inflammatory mechanisms. The purpose of this…
Abstract Number: 1142 • 2018 ACR/ARHP Annual Meeting
Trend of Lymphoma Incidence in US Veterans with Rheumatoid Arthritis Vs Osteoarthritis: 2002-2017
Namrata Singh¹, Yubo Gao², Brice Beck³, Bryant R. England⁴, Grant W. Cannon⁵, Ted R. Mikuls⁶, Jeffrey R. Curtis⁷, Brian Link⁸, Charles Lynch⁹, Elizabeth Field¹⁰ and Mary Vaughan-Sarrazin², ¹Internal Medicine, Iowa City VA Medical Center and University of Iowa, Iowa City, IA, ²University of Iowa Hospitals and Clinics, Iowa City, IA, ³Internal Medicine, Iowa City VA Medical Center, Iowa City, IA, ⁴Rheumatology, VA Nebraska-Western Iowa Health Care System & University of Nebraska Medical Center, Omaha, NE, ⁵Division of Rheumatology, Salt Lake City VA Medical Center and University of Utah, Salt Lake City, UT, ⁶Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁷University of Alabama, Birmingham, AL, ⁸Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, ⁹Epidemiology, University of Iowa, Iowa City, IA, ¹⁰Iowa City VA, Iowa City, IA
Background/Purpose: Past epidemiologic studies have consistently demonstrated a link between Rheumatoid Arthritis (RA) and lymphomas and have posited that high systemic inflammatory activity is a…
Abstract Number: 1015 • 2017 ACR/ARHP Annual Meeting
Key Genes and Pathways between Rheumatoid Arthritis and Osteoarthritis By Integrative Genome-Wide Gene Expression Profiling Analysis
Rongqiang Zhang^1,2, Aimin Yang³, Xiaomei Ren², Jie Zhang³, Xiaoli Yang⁴, Qiling Liu², Na Sun², Puwei Yuan⁵ and Yongmin Xiong⁴, ¹School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of the National Health and Family Planning Commission, Xi'an 710061, China, Xi'an, China, ²Shaanxi University of Chinese Medicine, Xianyang 712046, China, Xianyang, China, ³School of Public Health, Brown University, Providence, RI 02906, US, Providence, RI, ⁴School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of the National Health and Family Planning Commission, Xi'an 710061, China, Xian, China, ⁵Shaanxi University of Chinese Medicine, Xianyang 712046, China, XianYang, China
Background/Purpose: Rheumatoid arthritis (RA) and Osteoarthritis (OA) are two most common types of joint diseases with lots of similar symptoms, and their pathological mechanisms remain…
Abstract Number: 1020 • 2017 ACR/ARHP Annual Meeting
The Inflammatory and Proliferative Synovial Lesion in Post-Infectious Lyme Arthritis Results from Impaired Wound Healing
Robert Lochhead^1,2, David Ordonez-Del Valle^1,2, Klemen Strle^2,3, Sheila Arvikar^1,2, John Aversa⁴ and Allen Steere^1,2, ¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, ²Department of Medicine, Harvard Medical School, BOSTON, MA, ³Department of Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, ⁴School of Medicine, Yale University, New Haven, CT
Background/Purpose: Lyme arthritis (LA) is initially triggered by Borrelia burgdorferi infection, but in some patients, the synovitis persists despite 2-3 months of antibiotic therapy and…
Abstract Number: 1L • 2016 ACR/ARHP Annual Meeting
The Cardiovascular Safety of Celecoxib Versus Ibuprofen or Naproxen in 24,081 Patients with Osteoarthritis or Rheumatoid Arthritis
M. Elaine Husni¹, Daniel H. Solomon², Katherine E Wolski³, Lisa M Wisniewski³, Steven E Nissen⁴ and on behalf of the PRECISION Trial Investigators, ¹Rheumatology, Cleveland Clinic, Cleveland, OH, ²Division of Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, ⁴Cardiovascular Medicine, Chair, Cleveland Clinic, Cleveland, OH

*Both authors (Husni, Solomon)　contributed equally and will co present Background/Purpose: The relative cardiovascular (CV) safety of non-selective NSAIDs and selective COX-2 NSAIDs remains unclear. Given…
Abstract Number: 1125 • 2016 ACR/ARHP Annual Meeting
Targeted Lipidomics Reveals Incomplete Activation of Resolution Pathways in Knee Osteoarthritis
Hulda Jonasdottir¹, Hilde Brouwers², Mukundan Attur³, Joanneke Kwekkeboom², Jonathan Samuels³, Eric Strauss⁴, Enrike van der Linden-van der Zwaag⁵, TWJ Huizinga⁶, M. Kloppenburg⁷, REM Toes⁸, Martin Giera⁹, Steven B. Abramson³ and Andreea Ioan-Facsinay², ¹Center for Proteomics and Metabolomics, Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Medicine, NYU School of Medicine, NYU Langone Medical Center, New York, NY, ⁴Department of Orthopedic Surgery, NYU School of Medicine, NYU Langone Medical Center, New York, NY, ⁵Department of Orthopaedics, Leiden University Medical Center, Leiden, Netherlands, ⁶Leiden University Medical Centre, Leiden, Netherlands, ⁷Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ⁸Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁹Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Persistent inflammation is a characteristic of several joint diseases, including OA. It is nowadays appreciated that this could be a result of a failure…
Abstract Number: 23 • 2015 ACR/ARHP Annual Meeting
Microvesicle-Associated Hsa-Mir-223-3p Is Elevated in Rheumatoid Synovial Fluid Compared with Osteoarthritis Synovial Fluid
Nancy D. Kim¹, Robert B. Lochhead¹, Pauline Schmit², Minna J. Kohler³ and Andrew D. Luster⁴, ¹Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Massachusetts General Hospital, Charlestown, MA, ³Rheumatology, Allergy, and Immunology, Massachusetts General Hospital / Harvard Medical School, Boston, MA, ⁴Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Microvesicles (MVs) (100-1000 nm diameter) are subcellular particles that are enriched in nucleic acid, including microRNA (miR), which may be transferred from cell to…
Abstract Number: 119 • 2015 ACR/ARHP Annual Meeting
Triage in Chronic Rheumatic Diseases: Quantitative Physician Estimates for Inflammation (Reversible), Damage (Irreversible), and Distress in Patients with Rheumatoid Arthritis, Osteoarthritis, and Fibromyalgia Seen in Usual Care
Isabel Castrejón¹, Kathryn A. Gibson², Ruchi Jain¹, Annie Huang¹, Joel A. Block³ and Theodore Pincus¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Liverpool Hospital, Liverpool, Australia, ³Rush University Medical Center, Chicago, IL
Background/Purpose: A physician estimate of a patient’s global status (DOCGL) often is most often the most efficient of all 7 rheumatoid arthritis (RA) core data…
Abstract Number: 1256 • 2015 ACR/ARHP Annual Meeting
Gas Chromatography/Time-of-Flight-Mass Spectrometry-Based Metabolomic Profiling in Cultured Fibroblast-like Synoviocytes from Rheumatoid Arthritis
Joong Kyong Ahn¹, Sooah Kim², Jiwon Hwang¹, Jungyeon Kim², Young Hee Eun³, Hyemin Jeong⁴, Ji-Min Oh⁵, Hyungjin Kim³, Jaejoon Lee³, Eun-Mi Koh³, Kyoung Heon Kim² and Hoon-Suk Cha⁶, ¹Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Department of Biotechnology, Korea University Graduate School, Seoul, South Korea, ³Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁴Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁵Anyang SAM Hospital, Anyang, South Korea, ⁶Division of Rheumatology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Background/Purpose: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial inflammation and hyperplasia. Fibroblast-like synoviocytes (FLS) in RA exhibit a tumor cell-like…
Abstract Number: 2206 • 2015 ACR/ARHP Annual Meeting
Dopamine Pathway and Bone Metabolism in Arthritis
Silvia Capellino¹, Klaus W. Frommer¹, Markus Rickert², Jürgen Steinmeyer³, Stefan Rehart⁴, Ulf Müller-Ladner¹ and Elena Neumann¹, ¹Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Dept of Orthopedics and Orthopedic Surgery, University Hospital of Giessen and Marburg, Gießen, Germany, ³Dept Orthopedics and Experimental Orthopedics, University Hospital of Giessen and Marburg, Giessen, Germany, ⁴Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany
Background/Purpose: A body of studies demonstrates the influence of the nervous system on the immune response. We recently described that dopamine, a neurotransmitter of the…
Abstract Number: 2653 • 2015 ACR/ARHP Annual Meeting
Diagnostic Value of the Prednisolone Test in Patients with Possible Rheumatoid Arthritis
Uta Kiltz¹, Christine von Zabern¹, Xenofon Baraliakos¹, Frank Heldmann¹, Bernhard Mintrop¹, Michael Sarholz¹, Martin van Werde¹, Claudia Klink², Dietmar Krause², Friedrich Dybowski³, Ludwig Kalthoff³, Liane Hein³ and Juergen Braun¹, ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Private rheumatology office, Gladbeck, Germany, ³Private rheumatology office, Herne, Germany
Background/Purpose: In patients with tender and swollen finger joints, the differential diagnosis between rheumatoid arthritis (RA) and osteoarthritis (OA) of the hands can be initially…
Abstract Number: 1933 • 2014 ACR/ARHP Annual Meeting
Getting a Grip on Arthritis Online: Web-Based Continuing Education Supports the Dissemination of Arthritis Clinical Practice Guidelines Among Rural/Remote Primary Care Providers
Sydney Lineker¹, Mary Bell², Lisa Fleet³, Elizabeth M. Badley⁴, Vernon Curran⁵, Marlene Del Pino⁶, Fran Kirby³, Anne Lyddiatt⁷, Lynn Moore⁸, Karla Simmons³, Raquel Sweezie¹, Peter Tugwell⁹ and Ed Ziesmann¹, ¹Arthritis Rehabilitation and Education Program, The Arthritis Society, Toronto, ON, Canada, ²Rheum Div/Univ of Toronto, Sunnybrook Health Sciences Ctr, Toronto, ON, Canada, ³Professional Development and Conferencing Services, Memorial University, St. John's, NF, Canada, ⁴Division of Health Care and Outcomes Research, Toronto Western Research Institute; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ⁵Centre for Collaborative Health Professional Education, Memorial University, St. John's, NF, Canada, ⁶First Nations and Inuit Health Branch, Health Canada, Regina, SK, Canada, ⁷Patient Partners in Arthritis, Toronto, ON, Canada, ⁸Programs and Services, The Arthritis Society, Toronto, ON, Canada, ⁹Center For Global Health, Institute of Population Hlth, Ottawa, ON, Canada
Background/Purpose Primary care providers (physiotherapists, occupational therapists, nurses, family physicians) are often challenged with accessing relevant up-to-date arthritis information to enable delivery of optimal care.…
Abstract Number: 1470 • 2014 ACR/ARHP Annual Meeting
Malondialdehyde-Acetaldehyde Adducts (MAA) and Anti-Malondialdehyde-Acetaldehyde Antibody in Rheumatoid Arthritis
Geoffrey Thiele¹, Michael J. Duryee², Daniel Anderson³, Lynell W. Klassen⁴, Stephen Mohring⁵, Kathleen Young⁶, Dathe Benissan-Messan⁷, Harlan Sayles³, Jeremy Sokolove⁸, William H. Robinson⁹, James O' Dell³, Anthony Nicholas¹⁰ and Ted R. Mikuls³, ¹Int Med/Sec of Rheum/Immun, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁴Dept of Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁵Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁶Int Med/Sec of Rheum/Immun, University of Nebraska Medical Center, Omaha, NE, ⁷University of Nebraska Medical Center, Omaha, NE, ⁸VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ⁹VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ¹⁰Neurology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Products of oxidative stress, MAA adducts are highly immunogenic and have been associated with tolerance loss. To examine their potential role in disease-related…

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