Abstracts tagged "osteoarthritis and randomized trials"

Abstract Number: 957 • 2018 ACR/ARHP Annual Meeting
Biomechanical Therapy for Osteoarthritis of the Knee: A Randomized Controlled Trial
Stephan Reichenbach^1,2, Sarah Heldner¹, Armando Lenz³, David T. Felson⁴ and Peter Jüni⁵, ¹Institute for Social and Preventive Medicine, Bern, Bern, Switzerland, ²Department of Rheumatology, Immunology and Allergology, Bern, Bern, Switzerland, ³CTU Bern, University of Bern, Bern, Switzerland, ⁴Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁵Applied Health Research Centre (AHRC), Toronto, Toronto, ON, Canada
Background/Purpose: Biomechanics plays an important role in knee osteoarthritis (OA). A new biomechanical footwear system aims at altering knee loading patterns and retraining neuromuscular control…
Abstract Number: 1196 • 2017 ACR/ARHP Annual Meeting
Safety and Efficacy of ABT-981, an Anti–Interleukin-1α/β Dual Variable Domain (DVD) Immunoglobulin, in Subjects with Knee Osteoarthritis: Results from the Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase 2 Trial
Roy Fleischmann¹, Henning Bliddal², Francisco J Blanco³, Thomas J. Schnitzer⁴, Charles Peterfy⁵, Su Chen⁶, Li Wang⁶, Philip G. Conaghan⁷, Francis Berenbaum⁸, Jean-Pierre Pelletier⁹, Johanne Martel-Pelletier⁹, Ole Vaeterlein¹⁰, Wei Liu⁶, Gwen Levy⁶, Lanju Zhang⁶, Jeroen K. Medema⁶ and Marc C. Levesque⁶, ¹University of Texas Southwestern Medical Center at Dallas, Metroplex Clinical Research Center, Dallas, TX, ²Parker Institute, Bispebjerg-Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark, ³INIBIC-Instituto de Investigaciones Biomédicas de A Coruña-Complexo Hospitalario Universitario de A Coruña, A Coruña, Spain, ⁴Northwestern Medicine, Feinberg School of Medicine, Chicago, IL, ⁵Spire Sciences, Inc., Boca Raton, FL, ⁶AbbVie Inc., North Chicago, IL, ⁷Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁸University Pierre & Marie Curie and Inserm, DHU i2B, APHP, Hospital Saint-Antoine, Paris, France, ⁹Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada, ¹⁰Bioclinica, Hamburg, Germany
Background/Purpose: Animal studies suggested that inhibiting IL-1α/β with ABT-981 may reduce pain and slow structural progression in OA. This study (NCT02087904; ILLUSTRATE-K) assessed the safety…
Abstract Number: 1203 • 2017 ACR/ARHP Annual Meeting
Differences in Serum Protein Biomarkers between Combined Glucosamine and Chondroitin Versus Celecoxib Treatment in a Randomized, Double-Blind Trial in Osteoarthritis Patients
Sandi L Navarro¹, Marta Herrero², Helena Martinez², Jon Ladd¹, Yuzheng Zhang¹, Edward Lo¹, David Shelley¹, Timothy W Randolph¹, Yvonne Schwarz¹, Johanna W Lampe¹ and Paul D Lampe¹, ¹Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, ²Clinical R&D Area, Bioiberica, SAU, Barcelona, Spain
Background/Purpose: Non-steroidal anti-inflammatory drugs, e.g., celecoxib, are commonly used for inflammatory conditions, including osteoarthritis (OA), but are associated with adverse effects. Combined glucosamine hydrochloride plus…
Abstract Number: 1205 • 2017 ACR/ARHP Annual Meeting
Effectiveness of Low-Dose Radiation Therapy on Symptoms in Knee Osteoarthritis: First Results of a Triple Blinded, Randomized Controlled Trial
E.A.M. Mahler¹, M.J.M Minten¹, M.M. Leseman-Hoogenboom², P.M.P. Poortmans², S.S. Boks³, J.W.J. Bijlsma⁴, F.H.J. van den Hoogen^1,5, A.A. Den Broeder^1,5 and C.H.M. van den Ende^1,5, ¹Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ²Radiation Therapy, Radboud university medical centre, Nijmegen, Netherlands, ³Radiology, Sint Maartenskliniek, Nijmegen, Netherlands, ⁴Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, Netherlands, ⁵Rheumatology, Radboud university medical centre, Nijmegen, Netherlands
Background/Purpose: Previous research in animal osteoarthritis (OA) has shown that low-dose radiation therapy (LD-RT) exerts anti-inflammatory effects, but a systematic review concluded that the evidence…
Abstract Number: 1211 • 2017 ACR/ARHP Annual Meeting
Biomarkers Predictive of Pain Improvement in Knee Osteoarthritis Subjects Treated with the Anti-IL-1α/β Dual Variable Domain Immunoglobulin ABT-981
Sheng Feng¹, Su Chen¹, Li Wang¹, Charles Peterfy², Virginia B. Kraus³, Rajesh Kamath¹, Lanju Zhang¹, Yanping Luo¹, Lu Cui¹, Jeroen K. Medema¹ and Marc C. Levesque¹, ¹AbbVie Inc., North Chicago, IL, ²Spire Sciences, Inc., Boca Raton, FL, ³Duke University School of Medicine, Durham, NC
Background/Purpose: Development of disease-modifying drugs for OA has been challenging, partly due to lack of predictive biomarkers. Our primary objective was to identify baseline (BL)…
Abstract Number: 2230 • 2014 ACR/ARHP Annual Meeting
Treatment of Symptomatic Knee Osteoarthritis with Oral Salmon Calcitonin: Results from Two Phase 3 Randomized Clinical Trials
Morten Asser Karsdal¹, Anne C. Bay-Jensen², Asger Bihlet³, Peter Alexandersen⁴, Inger Byrjalsen³, Jeppe Andersen³, Bente J. Riis³ and Claus Christiansen³, ¹Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ²Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ³Nordic Bioscience, Herlev, Denmark, ⁴Center for Clinical and Basic Research, Vejle, Denmark
Background/Purpose: To evaluate the structure-modifying and symptom efficacy, as well as safety and tolerability of oral salmon calcitonin (sCT) formulated with a 5-CNAC carrier (a…
Abstract Number: 2095 • 2013 ACR/ARHP Annual Meeting
Hand Exercises Significantly Improved Activity Performance, Grip Strength and Pain In Women With Hand Osteoarthritis – Results From a Randomised Controlled Trial
Toril Hennig¹, Liv Haehre¹, Vivian Tryving Hornburg¹, Petter Mowinckel², Ellen Sauar Norli³ and Ingvild Kjeken⁴, ¹Department of Rheumatology, Martina Hansens Hospital, Gjettum, Norway, ²National Resource Center for Rehabilitation in Rheumatology, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Dept. of Rheumatology, Martina Hansens Hospital, Sandvika, Norway, ⁴Norwegian Resource Center for Rehailitation in Rheumatology, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Even if hand exercises is regarded as a core treatment for individuals with hand osteoarthritis (HOA), the evidence for the effect is limited. The…
Abstract Number: 266 • 2012 ACR/ARHP Annual Meeting
Knee Joint Stabilization Therapy in Patients with Osteoarthritis of the Knee: A Randomized, Controlled Trial
Jesper Knoop¹, Joost Dekker², Marike van der Leeden³, Martin van der Esch¹, Carina A. Thorstensson⁴, Martijn Gerritsen⁵, Ramon E. Voorneman⁵, Wilfred FH Peter¹, Mariette de Rooij¹, Suzanne Romviel¹, Willem F. Lems⁶, Leo D. Roorda⁷ and Martijn P.M. Steultjens⁸, ¹Amsterdam Rehabilitation Research Center, Reade, centre for rehabilitation and rheumatology, Amsterdam, Netherlands, ²VU University Medical Centre, Department of Rehabilitation Medicine, EMGO Institute and Department of Psychiatry, Amsterdam, Netherlands, ³Amsterdam Rehabilitation Research Center, Reade, Amsterdam, Netherlands, ⁴Department of Clinical Neurosciences and Rehabilitation, University of Gothenburg, Institute of Neuroscience and Physiology, Gothenburg, Sweden, ⁵Jan van Breemen Research Institute, Reade, centre for rehabilitation and rheumatology, Amsterdam, Netherlands, ⁶Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ⁷Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands, Amsterdam, Netherlands, ⁸Institute for Applied Health Research and School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, Scotland
Background/Purpose: Patients with knee osteoarthritis (OA) and instability of the knee joint may not benefit optimally from regular strengthening training. Therefore, we evaluated the effectiveness of a newly…

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