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Abstracts tagged "osteoarthritis and proteomics"

  • Abstract Number: 1190 • 2017 ACR/ARHP Annual Meeting

    Orosomucoid 2 Serves As Predictor of Therapeutic Response in Osteoarthritis Patients Treated with Chondroitin Sulfate/Glucosamine Hydrochloride

    Valentina Calamia1, M Camacho1, Ignacio Rego-Pérez1, L González1, P Fernández-Puente1, F Picchi1, Marta Herrero2, Helena Martinez2, C Ruiz-Romero1 and Francisco J Blanco3,4, 1Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain, 2Clinical R&D Area, Bioiberica, SAU, Barcelona, Spain, 3RIER-RED de Inflamación y Enfermedades Reumáticas, INIBIC-CHUAC, A Coruña, Spain, A Coruña, Spain, 4Rheumatology Division, ProteoRed/ISCIII, Proteomics Group, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain

    Orosomucoid 2 Serves as Predictor of Therapeutic Response in Osteoarthritis Patients Treated with Chondroitin Sulfate/Glucosamine HydrochlorideV. Calamia, M. Camacho, I. Rego-PŽrez, L. Gonz‡lez, P. Fern‡ndez-Puente,…
  • Abstract Number: 1151 • 2015 ACR/ARHP Annual Meeting

    The Proteomic Profile of Histological Samples Derived from a Surgical Mouse Model of Osteoarthritis Reveals an Unexpected Mode of Action for the Anti-Aggrecanase-2 Monoclonal Antibody CRB0017

    Gianfranco Caselli1, Riccardo Chiusaroli2, Michela Visintin3, Tiziana Piepoli2, Ornella Letari2, Adriana Grotti2, Marco Lanza2, Antonella De Palma4, Dario di Silvestre4, Pierluigi Mauri4 and Lucio Claudio Rovati2, 1Pharmacology & Toxicology, Rottapharm Biotech Srl, Monza, Italy, 2Rottapharm Biotech Srl, Monza, Italy, 3Rottapharm Biotech Srl, Trieste, Italy, 4Institute for Biomedical Technologies - CNR, Segrate, Italy

    Background/Purpose : CRB0017 is a novel therapeutic monoclonal antibody that recognizes the spacer domain of aggrecanase-2, a key enzyme in the degradation of extracellular matrix…
  • Abstract Number: 1259 • 2015 ACR/ARHP Annual Meeting

    Verification of Haptoglobin and Von Willebrand Factor As Potential Biomarkers of Knee Osteoarthritis Using a Targeted Proteomics Approach in Serum

    Patricia Fernandez-Puente1, Valentina Calamia1, Jesús Mateos1, Lucia Lourido1, Beatriz Rocha2, Cristina Ruiz-Romero1 and Francisco J. Blanco1, 1Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, 2Rheumatology Division, Proteomics Group-ProteoRed/ISCIII, INIBIC-CHUAC, A Coruña, Spain

    Background/Purpose:   The current diagnosis of osteoarthritis (OA) relies on the description of pain symptoms, affected joint stiffness, and radiography used as the reference technique…
  • Abstract Number: 1003 • 2014 ACR/ARHP Annual Meeting

    Proteomic Analysis of Connexin 43 Reveals Novel Interactors Related to Osteoarthritis

    Raquel Gago-Fuentes1, Patricia Fernández-Puente2,3, Paula Carpintero-Fernández1, Jesus Mateos2,3, Maria Dolores Mayan1 and Francisco Javier Blanco2,3, 1Cartilage Biology Research Group, Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 2Rheumatology Division, ProteoRed/ISCIII, Proteomics Group, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 3Rheumatology Division, CIBER-BBN/ISCIII, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain

    Background/Purpose: We have previously reported that articular chondrocytes in tissue contain long cytoplasmic arms that physically connect two distant cells. Cell-to-cell communication occurs through connexin…
  • Abstract Number: 1878 • 2013 ACR/ARHP Annual Meeting

    Proteomics Analysis Of Cartilage Secretome: A Powerful Tool For The Discovery Of OA Biomarkers

    Lucía Lourido1, Valentina Calamia1, Patricia Fernández-Puente1, Jesus Mateos1, Beatriz Rocha2, Carolina Fernández-Costa2, Francisco J. Blanco1 and Cristina Ruiz-Romero3, 1Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain, 2Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, 3Grupo de Proteomica-PBR2-ProteoRed/ISCIII Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006 A Coruña, Spain, A Coruña, Spain

    Background/Purpose: Osteoarthritis (OA) is characterized by the progressive loss of cartilage structural extracellular matrix (ECM) components, mainly collagenous and non-collagenous proteins. The release of these…
  • Abstract Number: 1849 • 2013 ACR/ARHP Annual Meeting

    Proteomic Analysis Of Connexin 43 Reveals Association With Proteins Dysfunctional Related With Osteoarthrosis

    Patricia Fernández-Puente1,2, Raquel Gago-Fuentes1,2, Paula Carpintero-Fernández1, Jesús Mateos1, Maria Dolores Mayan1,3 and Francisco J. Blanco4,5, 1Osteoarticular and Aging Research Group. Rheumatology Division, Biomedical Research Center (INIBIC). Hospital Universitario A Coruña, Xubias de Arriba 84, 15006, A Coruña, Spain, 2These authors contribute equally to this work, A Coruña, Spain, 3Correspondence to: [email protected] and [email protected], A Coruña, Spain, 4Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain, 5Proteo-Red/ISCIII, Madrid, Spain

    Background/Purpose: Human adult articular cartilage is composed of a dense extracellular matrix and specialized cells called chondrocytes. The chondrocytes are found to their own lacuna…
  • Abstract Number: 164 • 2013 ACR/ARHP Annual Meeting

    Haptoglobin Chains As Potential Biomarkers In Serum Of Osteoarthritis Disease

    Carolina Fernandez-Costa1, Valentina Calamia1, Patricia Fernandez-Puente1, Jesus Mateos1, Beatriz Rocha2, Lucia Lourido1, Jose Luis Capelo3, Cristina Ruiz-Romero1,4 and Francisco J. Blanco1, 1Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain, 2Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, 3BIOSCOPE Group, REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, FCT, Universidade Nova de Lisboa,, Caparica, Portugal, 4CIBER-BBN, INIBIC-CHUAC, A Coruña, Spain

     Background/Purpose: The aim of this study is to search for osteoarthritis (OA) biomarkers in human serum using an easy and fast approach and the validation…
  • Abstract Number: 156 • 2013 ACR/ARHP Annual Meeting

    Cartilage Peptide Profiling: Identifying Novel OA Biomarkers For Early Disease Detection

    Valentina Calamia1, Lucía Lourido1, Diego López1, Jesus Mateos1, Patricia Fernández-Puente1, Carolina Fernández-Costa2, Beatriz Rocha2, Cristina Ruiz-Romero3 and Francisco J. Blanco1, 1Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain, 2Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, 3Grupo de Proteomica-PBR2-ProteoRed/ISCIII Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006 A Coruña, Spain, A Coruña, Spain

    Background/Purpose: Cartilage secretome contains a complex matrix of proteolytically derived peptides that may provide useful information of the biological events occurring in the articular joint…
  • Abstract Number: 988 • 2012 ACR/ARHP Annual Meeting

    Zone-Specific Protein Profiles in Human Cartilage Unraveled by a Quantitative Proteomic Approach

    Patricia Fernandez-Puente1, Lucia Lourido2, Valentina Calamia2, Jesus Mateos3, Cristina Ruiz-Romero4, Martin K. Lotz5 and Francisco J. Blanco6, 1Osteoarticular and Aging Research Group. Rheumatology Division, Biomedical Research Center (INIBIC). Hospital Universitario A Coruña, As Xubias de Arriba 84, 15006, A Coruña, Spain, 2Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, 3Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain, 4Grupo de Proteomica-PBR2-ProteoRed/ISCIII Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006 A Coruña, Spain, A Coruña, Spain, 5Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 6Rheumatology Division, Proteomics Group/ProteoRed-ISCIII, INIBIC-C. Hospitalario, A Coruña, Spain

    Background/Purpose: Articular cartilage consists of a single type of cells called chondrocytes, which comprise 2-5% of total tissue mass and an extracellular matrix (ECM) mainly…
  • Abstract Number: 990 • 2012 ACR/ARHP Annual Meeting

    Proteomic Shotgun Analysis of Mesenchymal Stem Cells Reveals an Alterated Regulation of Proteosomal Proteins in Osteoarthritis Patients

    Jose Ramon Lamas, Rheumatology, Hospital Clinico San Carlos, Madrid, Spain

    Background/Purpose:   To describe proteins with a potential role in OA pathogenesis, in this study we have followed a proteomic approach based on a shotgun…
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