Abstracts tagged "osteoarthritis and prognostic factors"

Abstract Number: 431 • 2018 ACR/ARHP Annual Meeting
Early Pre-Radiographic Structural Pathology Precedes the Onset of Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Matthew Harkey¹, Julie Davis², Bing Lu³, Lori Lyn Price^4,5, Robert J. Ward⁶, James MacKay⁷, Charles B. Eaton⁸, Grace H. Lo⁹, Mary Barbe¹⁰, Ming Zhang¹¹, Jincheng Pang¹², Alina Stout¹, Timothy E. McAlindon¹³ and Jeffrey B. Driban¹⁴, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Rheumatology, Tufts Medical Center, BOSTON, MA, ³Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁴Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁵Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ⁶Radiology, Tufts Medical Center, Boston, MA, ⁷Radiology, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, ⁸Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁹Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, ¹⁰Temple University School of Medicine, Philadelphia, PA, ¹¹Tufts Medical Center, Boston, MA, ¹²Electrical Engineering, Tufts University, Medford, MA, ¹³Division of Rheumatology, Tufts Medical Center, Boston, MA, ¹⁴Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Individuals that develop accelerated knee osteoarthritis (AKOA) have more frequent knee pain, decreased physical function, and are more likely to receive a knee replacement…
Abstract Number: 66 • 2017 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Profiling of OA PBMCs Reveals Slowed Epigenetic Aging Among Rapid Radiographic Progressors: Data from the Osteoarthritis Initiative (OAI)
Alexander Rivas¹, Madison Andrews² and Matlock A. Jeffries³, ¹Rheumatology, Immunology, and Allergy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Department of Medicine, Division of Rheumatology, Immunology, and Allergy, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Extensive evidence has correlated epigenetic alterations in articular tissues with both the presence and progression of human osteoarthritis. A recent study demonstrated that accelerated…
Abstract Number: 2856 • 2013 ACR/ARHP Annual Meeting
Influence Of Mechanical Symptoms On Treatment Outcomes For Meniscal Tear In The Setting Of Osteoarthritis
Jeffrey N. Katz¹, John Wright², Lisa A. Mandl³, Brian Cole⁴, Laurel Donnell-Fink⁵, Ali Guermazi⁶, Morgan Jones⁷, Bruce Levy⁸, Scott Martin⁵, Robert Marx⁹, Anthony Miniaci¹⁰, Kurt P. Spindler¹¹, Rick Wright¹² and Elena Losina¹³, ¹Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA, ²Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA, ³Rheumatology, Hospital for Special Surgery, New York, NY, ⁴Rush University, Chicago, IL, ⁵Brigham and Women's Hospital, Boston, MA, ⁶Boston University, Boston, MA, ⁷Orthopedic Surgery, Cleveland Clinic, Cleveland, OH, ⁸Orthopedics, Mayo Clinic, Rochester, MN, ⁹Orthopedic Surgery, Hospital for Special Surgery, New York, NY, ¹⁰Orthopedics, Cleveland Clinic, Cleveland, OH, ¹¹Vanderbilt University, Nashville, TN, ¹²Orthopedics, Washington University, Saint Louis, MO, ¹³Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Clinicians are challenged to identify those patients with knee pain, osteoarthritis (OA) and imaging evidence of a meniscal tear (MT) who are likely to…
Abstract Number: 2756 • 2013 ACR/ARHP Annual Meeting
Serum Periostin Is Associated With Prevalent Knee Osteoarthritis and Predicts Disease Progression In Women: The Ofely Study
Jean-Charles Rousseau¹, Elisabeth Sornay-Rendu¹, Cindy Bertholon¹, Patrick Garnero² and Roland Chapurlat³, ¹INSERM UMR 1033, Lyon, France, ²INSERM, UMR 1033, Lyon and Cisbio Bioassays, Bagnols/Cèze, France, ³Service de Rhumatologie et Pathologie Osseuse, INSERM UMR 1033 and Université de Lyon, Hôpital Edouard Herriot, Lyon, France
Background/Purpose: Periostin (POSTN) is a secreted vitamin K-dependent (Gla-containing) protein produced by osteoblasts and chondrocytes. The aim of this study was to investigate the relationships…
Abstract Number: 912 • 2012 ACR/ARHP Annual Meeting
Clinical Features Associated with Progression of Knee Radiographic Osteoarthritis: Data From the Osteoarthritis Initiative
Michelle S. Yau¹, Laura Yerges-Armstrong¹, Braxton D. Mitchell¹ and Marc C. Hochberg², ¹Departments of Medicine and Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, ²Department of Medicine, University of Maryland, Baltimore, MD
Background/Purpose: A better understanding of the factors associated with structural progression of knee osteoarthritis (OA) may help identify individuals not only at risk for more…

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