Abstracts tagged "osteoarthritis and pain"

Abstract Number: 2131 • 2016 ACR/ARHP Annual Meeting
Transient Receptor Potential Ankyrin 1 (TRPA1) Is Functionally Expressed in Primary Human Osteoarthritic Chondrocytes and Mediates Cartilage Destruction and Joint Pain in the Mia-Model of Osteoarthritis
Elina Nummenmaa¹, Lauri J Moilanen¹, Mari Hämäläinen¹, Erja-Leena Paukkeri¹, Riina Nieminen¹, Teemu Moilanen², Katriina Vuolteenaho¹ and Eeva Moilanen¹, ¹The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, ²Coxa Hospital for Joint Replacement, Tampere, Finland
Background/Purpose: Transient receptor potential ankyrin 1 (TRPA1) is a membrane associated cation channel, which is widely expressed in neuronal cells and known to be involved…
Abstract Number: 2135 • 2016 ACR/ARHP Annual Meeting
Knee Osteoarthritis Pain Is Differentially Associated with Tissue Degradation and Joint Inflammation
Anne C. Bay-Jensen¹, Steven B. Abramson², Jonathan Samuels³, Inger Byrjalsen⁴, Svetlana Krasnokutsky Samuels⁵, Tina Manon-Jensen⁶, Morten Asser Karsdal¹ and Mukundan Attur⁷, ¹Rheumatology, Nordic Bioscience, Herlev, Denmark, ²Rheumatology Research, NYU School of Medicine and NYU Hospital for Joint Diseases, New York, NY, ³Department of Medicine, NYU School of Medicine, NYU Langone Medical Center, New York, NY, ⁴Nordic Bioscience, Clinical Development, Herlev, Denmark, ⁵Svetlana Krasnokutsky, NYU Hospital for Joint Diseases, New York, NY, ⁶Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ⁷Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY
Background/Purpose: Osteoarthritis (OA) is a disease characterized by pain and tissue destruction, in some cases concomitant with inflammation. The link between pain and tissue destruction…
Abstract Number: 2137 • 2016 ACR/ARHP Annual Meeting
Subchondral Bone Structure and Pain Behaviors in Collagenase Induced Noninflammatory Monoarthritis in Mice
Hollis E. Krug^1,2, Christopher W. Dorman³, Sandra Frizelle³, Peter A. Valen^2,4 and Maren L. Mahowald^1,2, ¹Medicine, University of Minnesota Medical School, Minneapolis, MN, ²Medicine, Minneapolis VA Health Care System, Minneapolis, MN, ³Research, Minneapolis VA Health Care System, Minneapolis, MN, ⁴Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN
Background/Purpose: Bone histomorphometry can define OA changes in rodents and in Antigen-Induced arthritis in rats. We previously found that pain from inflammatory monoarthritis in mouse…
Abstract Number: 2180 • 2016 ACR/ARHP Annual Meeting
Association of Anterior Cruciate Ligament/Meniscal Injury with Knee Function, Knee Pain, and Knee Osteoarthritis in Military Officers
Stephen W. Marshall¹, Yvonne M. Golightly², Maryalice Nocera³, Ali Guermazi⁴, L. Stefan Lohmander⁵, John Cantrell³, Darin A. Padua³, Jordan B. Renner⁶, Kenneth L. Cameron⁷, Steven J. Svoboda⁷, Richard F. Loeser⁸, Joanne M. Jordan⁹, Virginia B. Kraus¹⁰ and Anthony I. Beutler¹¹, ¹Epidemiology, University of North Carolina, Chapel Hill, NC, ²Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Injury Prevention Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴Boston University School of Medicine, Boston, MA, ⁵Lund University, Lund, Sweden, ⁶Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁷Orthopedic Research, Keller Army Community Hospital, Highland Falls, NY, ⁸Division of Rheumatology, Allergy and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, ⁹Thurston Arthritis Research Center, University of North CArolina at Chapel Hill, Chapel Hill, NC, ¹⁰Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, ¹¹Family Medicine, Uniformed Services University, Bethesda, MD
Background/Purpose: Traumatic knee injuries, such as injuries to the anterior cruciate ligament (ACL) and menisci, are associated with early onset osteoarthritis (OA). Our understanding of…
Abstract Number: 2181 • 2016 ACR/ARHP Annual Meeting
High Dietary Fiber Intake Is Associated with Lower Likelihood of Severe Knee Pain Trajectory
Zhaoli (Joy) Dai¹, Na Lu², Jingbo Niu², David T. Felson³ and Yuqing Zhang⁴, ¹Clinical epidemiology research and training unit, Boston University School of Medicine, Boston, MA, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ⁴Clinical Epidemiology and Training Unit, Boston University School of Medicine, Boston, MA
High Dietary Fiber Intake is Associated with a Lower Likelihood of Severe Knee Pain Trajectory Background/Purpose: Dietary fiber has been found to reduce systemic inflammation…
Abstract Number: 2198 • 2016 ACR/ARHP Annual Meeting
Is Joint Hypermobility Related to Foot Osteoarthritis and Symptoms?
Yvonne M. Golightly¹, Marian T. Hannan², Amanda Nelson³, Rebecca J. Cleveland⁴, Virginia Kraus⁵, Todd A. Schwartz⁶, Howard J. Hillstrom⁷, Adam P. Goode⁸, Jordan B. Renner⁹ and Joanne M. Jordan¹⁰, ¹Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Institute for Aging Research, Hebrew SL & Harvard Med School, Boston, MA, ³Division of Rheumatology, Allergy, and Immunology and Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, ⁶Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁷Rehabilitation, Hospital Special Surgery (HSS), New York, NY, ⁸O, Duke University, Durham, NC, ⁹Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ¹⁰Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Reports of associations of hypermobility and osteoarthritis (OA) vary widely. One possible cause for this lack of agreement may be different impacts of hypermobility…
Abstract Number: 2343 • 2016 ACR/ARHP Annual Meeting
A Phase 2, Multi-Center, Randomized, Double-Blind, Active-Controlled, Parallel Group Study to Evaluate the Safety and Dose Effectiveness of Intradermal Injections of Purified Apis Mellifera Toxin to Improve Pain and Physical Function in Patients with Osteoarthritis of the Knee
Douglas R. Schumacher¹, Anna Jakubowska² and Christopher M.H. Kim³, ¹Radiant Research, Columbus, OH, ²Apimeds, Inc., Jungwongu, Seongnam, Gyeonggido, Korea, The Republic of, ³CHA University, Bundanggu, Seongnam, Gyeongghido, Korea, The Republic of
Background/Purpose: This Phase 2a/b trial evaluated the safety and dose effectiveness of honeybee toxin (purified Apis melliferatoxin) injections to improve pain and physical function in…
Abstract Number: 2367 • 2016 ACR/ARHP Annual Meeting
Association Between MRI-Detected Osteophytes and Changes in Knee Pain and Structures in Older Adults: A Population Based Cohort Study
Zhaohua Zhu¹, Laura Laslett², Xingzhong Jin³, Weiyu Han¹, Benny Samuel Eathakkattu Antony⁴, Xia Wang⁵, Flavia M Cicuttini⁶, Graeme Jones^7,8 and Changhai Ding⁷, ¹Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ²Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia, ³Menzies institute for Medical Research, University of Tasmania, Hobart, Australia, ⁴Musculoskeletal, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia, ⁵Menzies institute for medical research, University of Tasmania, Hobart, Australia, ⁶Monash University, Department of Epidemiology and Preventive Medicine, Melbourne, Australia, ⁷Musculoskeletal Unit, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ⁸Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia
Background/Purpose: Osteophyte (OP) formation is one of the clinical features of osteoarthritis (OA), so early detection of OP formation can be of diagnostic value. OP…
Abstract Number: 3131 • 2016 ACR/ARHP Annual Meeting
Pregabalin Is More Effective in Treating Hand Osteoarthritis Pain Than Duloxetine or Placebo: A Double-Blind Randomized Controlled Trial
Nidhi Sofat¹, Abiola Harrison², Salma Ayis³, Patrick Kiely⁴, Thomas Richard Barrick⁵ and Franklyn Howe⁶, ¹Basic Medical Sciences, St. George's, University of London, London, United Kingdom, ²Rheumatology, Mailpoint J1A, St George's, University of London, London, United Kingdom, ³Department if Statistics, Division of Health & Social Care Research, Guy's Campus, King's College London, London, United Kingdom, ⁴Rheumatology Dept, St Georges Hospital, London, Great Britain, ⁵Clinical Sciences, St George's, University of London, London, United Kingdom, ⁶Cardiovascular and Cell Sciences, St George's, University of London, London, United Kingdom
Background/Purpose: A prospective, randomized, double-blind, placebo-controlled trial from 42 primary care and rheumatology clinics in the UK. We recruited 85 participants: 65 with hand OA…
Abstract Number: 367 • 2016 ACR/ARHP Annual Meeting
Microarray Analyses of Dorsal Root Ganglia for the Study of Pathways Contributing to Pain in Experimental Osteoarthritis
Rachel E. Miller¹, Shingo Ishihara², Delfien Syx³, Richard J. Miller⁴, Ana M. Valdes⁵ and Anne-Marie Malfait⁶, ¹Biochemistry, Rush University Medical Center, Chicago, IL, ²Internal Medicine, Rush University Medical Center, Chicago, IL, ³Ghent University, Ghent, Belgium, ⁴Pharmacology/Medical Humanities and Bioethics, Northwestern University, Chicago, IL, ⁵Arthritis Research UK Centre for Sports, Exercise and Osteoarthritis, Nottingham, United Kingdom, ⁶Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Destabilization of the medial meniscus (DMM) in the mouse knee results in slowly progressive joint damage, accompanied by pain-related behaviors. Secondary mechanical allodynia develops…
Abstract Number: 372 • 2016 ACR/ARHP Annual Meeting
Effect of Chronicity on Pain Behaviors in Collagenase Induced Non-Inflammatory Monoarthritis in Mice
Hollis E. Krug^1,2, Christopher W. Dorman³, Sandra Frizelle³, Peter A. Valen^2,4 and Maren L. Mahowald^1,2, ¹Medicine, University of Minnesota Medical School, Minneapolis, MN, ²Medicine, Minneapolis VA Health Care System, Minneapolis, MN, ³Research, Minneapolis VA Health Care System, Minneapolis, MN, ⁴Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN
Background/Purpose: Background/Purpose: Osteoarthritis pain remains a significant health problem due to a growing elderly population and the need for newer effective medical therapies. Osteoarthritis…
Abstract Number: 1959 • 2016 ACR/ARHP Annual Meeting
How Do Bone Marrow Lesions Cause Osteoarthritis Pain? a Structural and Functional Tissue-Based Study
Nidhi Sofat¹, Lena Assi², Anasuya Kuttapitiya³, Alan Boyde⁴, Vivian Ejindu⁵ and Christine Heron⁵, ¹Basic Medical Sciences, St. George's, University of London, London, United Kingdom, ²St George's University of London, Institute for Infection & Immunity, London, United Kingdom, ³St George's, University of London, Institute for Infection & Immunity, London, United Kingdom, ⁴Queen Mary University of London, London, United Kingdom, ⁵Department of Radiology, St George's Hospital, London, United Kingdom
Background/Purpose: Bone marrow lesions (BML) are well described in osteoarthritis (OA) and associate with pain, but little is known about histological and functional features of…
Abstract Number: 1980 • 2016 ACR/ARHP Annual Meeting
Relation of Pain Sensitization to the Evolution from Intermittent to Chronic, Persistent Pain in Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Jia Liu¹, Laura Frey-Law², Gillian Hawker³, Carrie Brown⁴, Cora E. Lewis⁵, Michael C. Nevitt⁶ and Tuhina Neogi⁷, ¹Boston Medical Center, Boston, MA, ²UIowa, Iowa City, IA, ³University of Toronto, Toronto, ON, Canada, ⁴Boston University School of Public Health, Boston, MA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁷Clinical Epidemiology, Boston University School of Medicine, Boston, MA
Background/Purpose: Patients with knee osteoarthritis (OA) often start with acute intermittent, activity-related pain, which evolves to additionally experiencing chronic, persistent pain; why this transition happens…
Abstract Number: 324 • 2015 ACR/ARHP Annual Meeting
Activity Limitations in Persons with Low, Medium, and High Levels of Pain Prior to Total Knee Replacement: Implications for Appropriateness and Efficacy
Ilana M. Usiskin¹, Heidi Y. Yang¹, Bhushan R. Deshpande¹, Jamie E. Collins², Griffin L. Michl¹, Savannah R. Smith³, Kristina M. Klara¹, Jeffrey N. Katz² and Elena Losina⁴, ¹Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ²Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ⁴Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopaedic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Historically, persons with knee OA considered for total knee replacement (TKR) have had severe pain, as reflected in high WOMAC scores, in addition to…
Abstract Number: 329 • 2015 ACR/ARHP Annual Meeting
Serum Leptin and Risk of Knee Pain and Osteoarthritis: Multicenter Osteoarthritis Study
Devyani Misra¹, Jingbo Niu², David T. Felson², Michael C. Nevitt³, James Torner⁴, Cora E. Lewis⁵, Anyu Hu⁶, Sadao Jinno⁷ and Tuhina Neogi⁸, ¹Medicine, Section of, BUSM, Boston, MA, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³Epidemiology and Biostatistics, UCSF, San Francisco, CA, ⁴University of Iowa, UIowa, Iowa City, IA, ⁵Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁶Clinical Epidemiology Research Unit, Boston University School of Medicine, Boston, MA, ⁷BUSM, Boston, MA, ⁸Clinical Epidemiology, BUSM, Boston, MA
Serum Leptin and Risk of Knee Pain and Osteoarthritis: Multicenter Osteoarthritis StudyD. Misra, J. Niu, D.T. Felson, M. Nevitt, J. Torner, C.E. Lewis, A. Hu,…

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