Abstracts tagged "obesity"

Abstract Number: 2984 • 2018 ACR/ARHP Annual Meeting
Lifestyle and MTX Use Are the Strongest Predictors of Not Achieving Remission in the First Year of Rheumatoid Arthritis: Results from the Canadian Early Arthritis Cohort (CATCH)
Susan J. Bartlett^1,2, Orit Schieir³, Marie-France Valois⁴, Carol Hitchon⁵, Louis Bessette⁶, Gilles Boire⁷, Carter Thorne⁸, Janet E. Pope⁹, Vivian P. Bykerk¹⁰, Edward C. Keystone¹¹, Diane Tin¹² and Glen Hazlewood¹³, ¹Department of Medicine, Division of ClinEpi, Rheumatology, Respirology, McGill University, Montreal, QC, Canada, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³McGill University, Montreal, ON, Canada, ⁴McGill University, Montreal, QC, Canada, ⁵University of Manitoba, Winnipeg, MB, Canada, ⁶Division of Rheumatology, Department of Medicine, CHU de Québec-Université Laval, Québec, QC, Canada, ⁷Rheumatology Division, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, ⁸University of Toronto, Newmarket, ON, Canada, ⁹Department of Medicine, University of Western Ontario, London, ON, Canada, ¹⁰Hospital for Special Surgery, New York, NY, ¹¹Mount Sinai Hospital, Toronto, ON, Canada, ¹²The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ¹³Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, AB, Canada
Background/Purpose: Implementation of RA guidelines have improved remission outcomes in RA; nevertheless 45% of early RA participants do not achieve remission in the first year.…
Abstract Number: 56 • 2018 ACR/ARHP Annual Meeting
Comparison of Metabolic Changes in Osteoarthritis and Rheumatoid Arthritis Mouse Models
Marie-Lisa Hülser¹, Hani Manfred Sauermilch¹, Carina Schreiyäck¹, Yubin Luo², Aline Bozec², Georg Schett³, Ulf Müller-Ladner⁴ and Elena Neumann¹, ¹Dept. of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig-University Gießen, Germany, Bad Nauheim, Germany, ²University of Erlangen-Nürnberg, Department Clinic of Medicine 3 - Immunology and Rheumatology, Erlangen, Germany, Erlangen, Germany, ³Friedrich-Alexander-Universität Erlangen, Nürnberg und Universitätsklinikum Erlangen, Erlangen, Germany, ⁴Dept. of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig-University Giessen, Germany, Bad Nauheim, Germany
Background/Purpose: Adipocytokines are bioactive factors produced mainly by adipose tissue. They not only regulate energy homeostasis, but also influence immune responses. Osteoarthritis (OA) is one…
Abstract Number: 434 • 2018 ACR/ARHP Annual Meeting
Trends in Procedure Type, Patient Characteristics, and Outcomes Among Persons with Knee Osteoarthritis Undergoing Bariatric Surgery, 2005-2014
Yusi Gong¹, Faith Selzer², Bhushan Deshpande^1,3 and Elena Losina^1,4,5, ¹Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham & Women's Hospital, Boston, MA, ²Orthopedic Surgery, Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ³Harvard Medical School, Boston, MA, ⁴Orthopaedic Surgery, Harvard Medical School, Boston, MA, ⁵BU School of Public Health, Boston, MA
Background/Purpose: Bariatric surgery, the most effective treatment for losing weight and maintaining weight loss among morbidly obese persons, has been evolving as a treatment for…
Abstract Number: 1898 • 2017 ACR/ARHP Annual Meeting
Overweight/Obesity Affect Histological Features of Synovial Membrane of Rheumatoid Arthritis Patients from Disease Onset to Stable Remission Achievement
Stefano Alivernini¹, Barbara Tolusso¹, Maria Rita Gigante¹, Laura Bui², Clara Di Mario¹, Luca Petricca¹, Gabriele Di Sante¹, Roberta Benvenuto², Anna Laura Fedele¹, Francesco Federico², Gianfranco Ferraccioli³ and Elisa Gremese¹, ¹Institute of Rheumatology, Fondazione Policlinico Universitario A. Gemelli - Catholic University of the Sacred Heart, Rome, Italy, ²Institute of Pathology, Fondazione Policlinico Universitario A. Gemelli - Catholic University of the Sacred Heart, Rome, Italy, ³Institute of Rheumatology, Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy
Background/Purpose: Despite animal models, little is known about synovial tissue (ST) composition of overweight/obese Rheumatoid Arthritis patients. The aim of the study was to investigate…
Abstract Number: 1947 • 2017 ACR/ARHP Annual Meeting
Thy1 Is a Positive Regulator of Osteoblast Differentiation and Modulates Bone Homeostasis in Obese Mice
Ananta Paine¹, Collynn Woeller², Nelson Huertas¹, Maria de la Luz Garcia-Hernandez³, Richard Phipps² and Christopher T. Ritchlin⁴, ¹Department of Medicine, Division of Allergy, Immunology and Rheumatology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY, ²Department of Environmental Medicine, School of Medicine and Dentistry,, Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY, ³Department of Medicine,, Division of Allergy, Immunology and Rheumatology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY, ⁴Division of Allergy, Immunology and Rheumatology, School of Medicine and Dentistry, Division of Allergy, Immunology and Rheumatology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA, Rochester, NY
Background/Purpose: Thy1 (CD90) is a glycosylated, glycophosphatidylinositol (GPI)-anchored membrane protein originally identified as a marker for mouse T cells but subsequent reports noted expression on…
Abstract Number: 2263 • 2017 ACR/ARHP Annual Meeting
Obesity Independently Associates with Worse Patient Reported Outcomes in Women with Systemic Lupus Erythematosus
Sarah L. Patterson¹, Gabriela Schmajuk², Kashif Jafri³, Katherine D. Wysham³ and Patricia P. Katz⁴, ¹Division of Rheumatology, University of California, San Francisco, San Francisco, CA, ²San Francisco VA Medical Center, University of California San Francisco, San Francisco, CA, ³University of California, San Francisco, San Francisco, CA, ⁴Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA
Background/Purpose: Obesity has been shown to exacerbate systemic inflammation in the general population and contributes to worse disease-related outcomes in rheumatoid arthritis. The impact of…
Abstract Number: 2308 • 2017 ACR/ARHP Annual Meeting
The Prevalence of Comorbidities in Pediatric Psoriasis and Juvenile Psoriatic Arthritis
Cuoghi Edens¹, Angela Byun Robinson² and Maria Antonelli³, ¹Division of Pediatric Infectious Diseases and Rheumatology and Division of Rheumatology, Rainbow Babies and Children's Hospital and University Hospitals Cleveland Medical Center, Cleveland, OH, ²Division of Pediatric Infectious Diseases and Rheumatology, Case Western Reserve University School of Medicine, Rainbow Babies and Children’s Hospital, Cleveland, OH, ³Department of Medicine/Division of Rheumatology, Case Western Reserve University School of Medicine, MetroHealth Medical Center, Cleveland, OH
Background/Purpose: Adult-onset psoriasis (PsO) and psoriatic arthritis (PsA) have been associated with increased rates of diabetes, obesity, and hypertension. We sought to evaluate the prevalence…
Abstract Number: 2524 • 2017 ACR/ARHP Annual Meeting
Weight Change before and after Diagnosis in Patients with Psoriatic Arthritis, Rheumatoid Arthritis, and Ankylosing Spondylitis
Alexis Ogdie¹, Michael D. George², Joel Gelfand³, Maureen Dubreuil⁴, Thorvardur Love⁵ and Joshua Baker⁶, ¹Medicine/Rheumatology and Epidemiology, University of Pennsylvania, Philadelphia, PA, ²Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ³University of Pennsylvania Health System , Philadelphia, PA, ⁴Clinical Epidemiology, Boston University School of Medicine, Boston, MA, ⁵Landspitali University Hospital, Reykjavik, Iceland, ⁶Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Rheumatoid arthritis (RA) has been associated with weight loss around the time of diagnosis; little is known about weight change around diagnosis in…
Abstract Number: 2770 • 2017 ACR/ARHP Annual Meeting
Using Fitbits. Fitabase®, and Remote Coaching to Increase Physical Activity in Employees with Knee Osteoarthritis Symptoms
Pamela Semanik¹, Julia (Jungwha) Lee², Christine Pellegrini³, Jing Song⁴ and Rowland W. Chang⁵, ¹College of Nursing, Rush University, Chicago, IL, ²Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Knee osteoarthritis (OA) affects approximately 6% of adults and is a leading cause of disability among U.S. adults. Physical activity (PA) is known to…
Abstract Number: 2851 • 2017 ACR/ARHP Annual Meeting
General and Abdominal Obesity As Risk Factors for Late-Life Mobility Limitation Among Women with Total Knee or Hip Replacement for Osteoarthritis
Aladdin Shadyab¹, Wenjun Li², Charles Eaton³ and Andrea LaCroix⁴, ¹Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, ²Medicine, University of Massachusetts Medical School, Worcester, MA, ³Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI, ⁴Family Medicine and Public Health, University of California, San Diego School of Medicine, La Jolla, CA
Background/Purpose: The population is rapidly aging, and by 2060, more than 12 million women will be ages 85 years and older in the United States.…
Abstract Number: 36 • 2017 Pediatric Rheumatology Symposium
The Association of Obesity with Pediatric Psoriatic Arthritis
Cynthia Manos¹, Rui Xiao², Timothy G. Brandon¹, Alexis Ogdie-Beatty³ and Pamela Weiss⁴, ¹Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, ³Rheumatology, Hospital of the University of Pennsylvania, Philadelphia, PA, ⁴Division of Rheumatology, Center for Pediatric Clincial Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Obesity is associated with a significantly increased risk of inflammatory arthritis in adult patients with psoriasis. Obese adults with psoriatic arthritis (PsA) also…
Abstract Number: 2352 • 2016 ACR/ARHP Annual Meeting
Obesity-Related Systemic Inflammation and Knee Synovitis
Devyani Misra¹, Tuhina Neogi², Michael C. Nevitt³, James Torner⁴, Cora E. Lewis⁵ and David T. Felson⁶, ¹Medicine, Section of, BUSM, Boston, MA, ²Clinical Epidemiology, BUSM, Boston, MA, ³Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁴University of Iowa, UIowa, Iowa City, IA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Obesity, a major risk factor for knee osteoarthritis (OA), is a state of systemic inflammation through elaboration of adipokines (pro and anti-inflammatory cytokines) from…
Abstract Number: 2369 • 2016 ACR/ARHP Annual Meeting
Obesity and Severity of Joint Space Narrowing Are Associated with Viscosupplementation Failure in Patients with Knee Osteoarthritis. Post-Hoc Analysis of a Double-Blind, Controlled, Multicentre, Randomized Trial
Florent Eymard¹, Xavier Chevalier² and Thierry Conrozier³, ¹Department of Rheumatology, APHP Henri Mondor Hospital, Paris, France, ²Rheumatology, Hopital Henri Mondor, Créteil, France, ³Department of Rheumatology,, Nord Franche-Comté Hospital, Belfort, France
Background/Purpose: Viscosupplementation (VS) is still controversial. One of the key points is the lack of well-identified factors of response. We aimed to identify clinical…
Abstract Number: 2996 • 2016 ACR/ARHP Annual Meeting
High Fat Diet-Induced Osteoarthritis Progression Is Dependent on Toll-like Receptor 4
Mary Beth Humphrey¹, Evangelia Kalaitzoglou², Camille Herron², Yanqing HU², Yao Fu³, Erika Barboza Prado Lopes³, Elise Donovan³, Joanna Hudson³ and Timothy Griffin³, ¹Medicine/Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Aging and Metabolism, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Obesity is considered the primary preventable risk factor for OA, increasing the risk of developing OA in weight-bearing joints, especially the knee, as…
Abstract Number: 3069 • 2016 ACR/ARHP Annual Meeting
Weight Loss in the Early Rheumatoid Arthritis Period Is Associated with Subsequent Increased Mortality in RA Patients and Matched Comparators: Evidence Against an RA-Specific Obesity Paradox
Jeffrey A. Sparks¹, Shun-Chiao Chang², Uyen Sa D.T. Nguyen^3,4, Medha Barbhaiya², Sara K. Tedeschi², Bing Lu², Karen H. Costenbader², Yuqing Zhang⁵, Hyon K. Choi⁶ and Elizabeth W. Karlson², ¹Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ⁴Boston University School of Medicine, Boston, MA, ⁵Clinical Epidemiology and Training Unit, Boston University School of Medicine, Boston, MA, ⁶Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA
Background/Purpose : Weight loss may explain the obesity paradox for mortality, since those who unintentionally lose weight to reach normal BMI may have higher mortality…

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