Abstracts tagged "OA"

Abstract Number: 23 • 2012 ACR/ARHP Annual Meeting
Differential Effects of Bone Morphogenetic Protein 2 and 9 On Chondroprotective Transforming Growth Factor β Signaling
Arjan P. van Caam¹, Esmeralda N. Blaney Davidson¹, Elly L. Vitters², Laurie de Kroon¹, Ellen W. van Geffen³, Peter ten Dijke⁴, Wim B. van den Berg² and Peter M. van der Kraan², ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁴Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Osteoarthritis (OA) is a multifactorial disease characterized by loss of articular cartilage. TGFβ is considered as a protective factor against cartilage loss in young cartilage…

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