ACR Meeting Abstracts

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Abstracts tagged "New Therapeutics"

  • Abstract Number: 53 • 2018 ACR/ARHP Annual Meeting

    Cyclin-Dependent Kinase 4/6 Inhibitor: A Promising Development Candidate Targeting Synovial Hypertrophy for Rheumatoid Arthritis Treatment

    Shunsuke Tsujimoto, Kyohei Horie, Toshiya Mashiko, Johji Nomura and Tsunefumi Kobayashi, Teijin Institute for Bio-medical Research, TEIJIN PHARMA LIMITED, Tokyo, Japan

    Background/Purpose: The pathogenesis of rheumatoid arthritis (RA) is characterized by the infiltration of immune cells into the synovial tissues and the hypertrophy of synovial fibroblasts,…
  • Abstract Number: 347 • 2018 ACR/ARHP Annual Meeting

    Effectiveness of a Biopsychosocial Exercise Approach in Rheumatic Diseases

    Edibe Ünal1, Gamze Arın2, Nur Banu Karaca3, Fatma Birgül Oflaz2, Aykut Özçadırcı2, Abdulsamet Erden4, Berkan Armağan4, Yavuz Yakut5 and Şule Apraş Bilgen4, 1Department of Physiotherapy and Rehabilitation, Hacettepe University Faculty of Health Sciences, Ankara, Turkey, 2Department of Physical Therapy and Rehabilitation, Hacettepe University Faculty of Health Sciences, Ankara, Turkey, 3Department of Physical Therapy and Rehabilitation, Hacettepe University Faculty of Health Sciences, ankara, Turkey, 4Rheumatology Division, Hacettepe University Faculty of Medicine, Ankara, Turkey, 5Department of Physiotherapy and Rehabilitation, Hasan Kalyoncu University Faculty of Health Sciences, Ankara, Turkey

    Background/Purpose: The trend towards biopsychosocial approaches is increasing today and studies on psychosocial effects of exercise are limited in the literature. There is a need…
  • Abstract Number: 425 • 2018 ACR/ARHP Annual Meeting

    Efficacy, Safety, and Tolerability of ONO-4474, an Orally Available Pan-Tropomyosin Receptor Kinase Inhibitor, in Japanese Patients with Moderate-to-Severe Osteoarthritis of the Knee: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Comparative Study

    Naoki Ishiguro1, Shusuke Oyama2, Ryunosuke Higashi3 and Kunio Yanagida4, 1Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Data Science, Ono Pharmaceutical Co., Ltd., Osaka, Japan, 3Translational Science, Translational Medicine Center, Ono Pharmaceutical Co., Ltd., Osaka, Japan, 4Translational Science, Translational Medicine Center, Ono Pharmaceutical Co., Ltd, Osaka, Japan

    Background/Purpose: ONO-4474 is an orally available, peripheral-specific, pan-tropomyosin receptor kinase (pan-Trk) inhibitor currently under development for treatment of musculoskeletal pain in OA patients. This study…
  • Abstract Number: 934 • 2018 ACR/ARHP Annual Meeting

    HIV Protease Inhibitors Cure Lupus-Prone Mice and Prevent T Helper 17 Cell-Driven Inflammation By Inhibiting CD95-Non-Apoptotic Signaling Pathway

    Manon Charrier1, Amanda Poissonnier2, Daniel Best2, Jean-Philippe Guégan2, Nicolas Levoin3, Raphael Pineau2, Florence Jouan2, Ha Thanh Nguyen2, Lucie Morere2, Sophie Martin2, Melissa Thomas2, Estibaliz Lazaro1, Christophe Richez1, Isabelle Douchet1, Thomas Ducret4, Pierre Van de Weghe2, Patrick Blanco1, Mickael Jean2, Pierre Vacher5 and Patrick Legembre2, 1UMR CNRS 5164 - Immunoconcept, Bordeaux, France, 2Chemistry Oncogenesis Stress Signaling, INSERM UMR 1242 Rennes University, Rennes, France, 3Bioprojet Biotech, Saint-Grégoire, France, 4INSERM U1218, Bordeaux University, Bordeaux, France, 5Actions for onCogenesis understanding and Target Identification in ONcology, INSERM U1218, Bordeaux University, Bordeaux, France

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by loss of tolerance to nuclear components; this results in production of autoantibodies, immune…
  • Abstract Number: 1935 • 2018 ACR/ARHP Annual Meeting

    Multiple Dose Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASP5094, an Anti-Alpha9 Integrin Monoclonal Antibody, in Patients with Rheumatoid Arthritis on Methotrexate

    Jiayin Huang1, Tomasz Wojtkowski1, Paul Blahunka1, Ronald Smulders2 and Christopher Lademacher1, 1Astellas Pharma US, Inc., Northbrook, IL, 2Astellas Pharma Europe BV, Leiden, Netherlands

    Background/Purpose: Joint synovium is the main tissue involved in rheumatoid arthritis (RA) lesions. Alpha9 integrin is expressed by synovial tissue lining cells and has been…
  • Abstract Number: 1794 • 2017 ACR/ARHP Annual Meeting

    Overexpression of Interleuk-22 Induces Expression of the Negative Immune-Regulator SOCS3 and Potently Reduces Collagen-Induced Arthritis in Mice

    Debbie M. Roeleveld1, Monique M. Helsen2, Birgitte Walgreen3, Elly Vitters2, Fons A.J. van de Loo2, Peter L. van Lent2, Wim B. van den Berg2, Peter M. van der Kraan2 and Marije I. Koenders2, 1Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, 2Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 3Experimental, Radboud university medical center, Nijmegen, Netherlands

    Background/Purpose: High interleukin-22 (IL-22) levels are detected in serum and synovial fluid of rheumatoid arthritis (RA) patients and have been shown to positively correlate with…
  • Abstract Number: 258 • 2015 ACR/ARHP Annual Meeting

    Quality of Life Changes with Canakinumab Therapy in Adults with Colchicine Resistant FMF

    Ahmet Gul1, Huri Ozdogan2, Ozgur Kasapcopur3, Burak Erer4, Serdal Ugurlu5, S. Sevgi6 and Soner Turgay7, 1Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 2Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 3Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Professor of Pediatric Rheumatology, Istanbul, Turkey, 4Istanbul Faculty of Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 5Rheumatology, Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 6Novartis Pharma, Istanbul, Turkey, 7Medical, Novartis Pharma, İstanbul, Turkey

    Background/Purpose: Introduction:Familial Mediterranean Fever (FMF), the most common form of the hereditary autoinflammatory disorders, is characterized by recurrent attacks of fever along with serosal or…
  • Abstract Number: 901 • 2015 ACR/ARHP Annual Meeting

    Novel B Cell-Derived Peptide Regulation of Homeostatic T-Cell Trafficking Is Subverted in Rheumatoid Arthritis

    Helen McGettrick1, Myriam Chimen2, Ashley Martin3, Francesca Barone4, Andrew Filer5, Karim Raza6, Christopher Buckley4, Parth Narendran7 and G. Ed Rainger2, 1Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 2Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom, 3School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom, 4University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom, 5University of Birmingham, Birmingham, United Kingdom, 6University of Birmingham, Rheumatology Research Group, Institute of Inflammation and Ageing, United Kingdom, Birmingham, United Kingdom, 7Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom

    Background/Purpose: In rheumatoid arthritis (RA), inappropriate recruitment of T-cells into the joint contributes to disease pathogenesis and joint destruction. We examined the ability of adiponectin…
  • Abstract Number: 1661 • 2015 ACR/ARHP Annual Meeting

    Translational Data and Phase 1 Study Results of a New Monoclonal Antibody Targeting Toll like Receptor 4 (TLR4) Developed for Rheumatoid Arthritis (RA) Treatment with a Potential for Personalized Medicine

    Emmanuel Monnet1, Limin Shang1, Geneviève Lapeyre1, Kathy De Graaf2, Eric Hatterer1, Gaelle Wambiekele1, Walter Ferlin1, Philippe Jacqmin3, Cem Gabay4, Jeremy Sokolove5, Simon Jones6, Ernest H. Choy7, Iain B. McInnes8, Marie Kosco-Vilbois1 and Cristina De Min1, 1NovImmune S.A., Geneva, Switzerland, 2Novimmune S.A., Geneva, Switzerland, 3SGS Exprimo, Mechelen, Belgium, 4Rheumatology, Geneva University Hospital, Geneva, Switzerland, 5Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, 6Cardiff Institute of Infection & Immunity, Cardiff, United Kingdom, 7Cardiff University, Institute of Infection and Immunity, Tenovus Building, University Hospital of Wales, Cardiff, United Kingdom, 8Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: Innate immunity is implicated in RA pathogenesis and is likely mediated via TLR pathways, with anti-citrullinated protein antibodies (ACPA) serving as key triggers. NI-0101…
  • Abstract Number: 2776 • 2015 ACR/ARHP Annual Meeting

    Profiling Compounds in Human Primary Cell-Based Disease Models Guide Indication Selection

    Jason Ptacek, Ellen L. Berg and Alison O'Mahony, BioSeek, a division of DiscoveRx Corp., South San Francisco, CA

    Background/Purpose: In vitro co-cultures of human primary cells, including immune cells, fibroblasts, smooth muscle, keratinocytes, epithelial or endothelial cells were developed to capture the complexity…
  • Abstract Number: 3082 • 2015 ACR/ARHP Annual Meeting

    Nanogel Based Delivery of an Inhibitor of Calcium/ Calmodulin- Dependent Protein Kinase 4 Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice

    Kotaro Otomo1, Tomohiro Koga2, Nobuya Yoshida3, Masayuki Mizui4, Christina Kriegel5, Tarek Fahmy6 and George C. Tsokos3, 1Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, 3Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 4Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan, 5Department of Biomedical Engineering, Yale University, New Heaven, CT, 6Biomedical and Chemical Engineering, Yale University, New Heaven, CT

    Background/Purpose: Treatment of autoimmune diseases is still based on the use of general immunosuppressive drugs which invariably cause severe side effects. This fact has compelled…
  • Abstract Number: 3191 • 2015 ACR/ARHP Annual Meeting

    Siglec9 Suppresses Arthritis in Collagen-Induced Mice Model and Inhibits M1 Activation of RAW264.7 Macrophages

    Takuya Matsumoto1, Nobunori Takahashi1, Toshihisa Kojima1 and Naoki Ishiguro2, 1Department of Orthopedic Surgery, Nagoya University Hospital, Nagoya, Japan, 2Department of Orthopedic Suregery, Nagoya University Hospital, Nagoya, Japan

    Background/Purpose: Siglecs (Sialic acid-binding immunoglobulin-type lectins) are type1 transmembrane proteins and expressed on cell surface of various immunocytes. Siglec9 is a member of CD33 related…
  • Abstract Number: 3219 • 2015 ACR/ARHP Annual Meeting

    Efficacy and Safety of 4 Weeks Administration of Arsenic Trioxide in Moderate Active Systemic Lupus Erythematosus. a Phase I/II Proof-of-Concept Sequential Dose Escalation Multicenter Study

    Mohamed Hamidou1, Benjamin Gaborit2, Eric Hachulla3, Zahir Amoura4, Mikael Ebbo5, Emmanuel Chatelus6, Jean Sibilia7, Jean-Francois Viallard8,9, Julie Graveleau1, Melanie Saint Jean10, Sandrine Gardes11, Yohann Foucher11, Christelle Volteau12, Joel Poupon13, Antoine Neel14 and François Rieger15, 1Internal Medicine Department, Nantes University Hospital, Nantes, France, 2Internal Medicine, Department of Internal Medicine, Nantes University Hospital, Nantes, France, 3Department of Internal Medicine, University Lille Nord-de-France, Lille, France, 4Internal Medecine - Centre de Référence National pour les Lupus et et le Syndrome des Antiphospholipides, Pitié-Salpêtrière hospital, Paris, France, 5Internal Medicine, Aix-Marseille Université, AP-HM, Marseille, France, 6Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 7Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 8Internal Medecine, Haut Lévèque Hospital, Bordeaux, France, 9Hôpital Haut-Lévêque, Bordeaux, CHU Bordeaux, France, 10Department of Dermatology, Nantes University Hospital, Nantes, France, 11Nantes Universitary Hospital, Nantes, France, 12Clinical Research Department, Nantes University Hospital, Nantes, France, 13Paris University, Paris, France, 14Department of Internal Medicine, Nantes University Hospital, Nantes, France, 15MEDSENIC, Hôpital Cochin, Paris Descartes University, Paris, France

    Background/Purpose: Arsenic Trioxide (ATO) is approved for the treatment of acute promyelocytic leukemia, increasing oxidative stress with selective apoptosis of leukemia cells. In MLR/lpr model…
  • Abstract Number: 1484 • 2014 ACR/ARHP Annual Meeting

    Discovery of ARN-4079 – a Potent, Orally Available Dual Target Inhibitor of Janus Kinase 3 (JAK3) and Interleukin-2 Inducible T-Cell Kinase (ITK) for Rheumatoid Arthritis

    Hariprasad Vankayalapati1, Venkatakrishnareddy Yerramreddy1, Philip Bendele2, Alison Bendele3, Rueban Jacob Anicattu Issac4, Ram Sudheer Adluri5, Philip LoGrasso6 and Joel M. Kremer7, 1Early Discovery and Medicinal Chemistry, Arrien Pharmaceuticals, Salt Lake City, UT, 2Principal Investigator CIA models, Bolder BioPATH, Inc., Boulder, CO, 3Pathologist, Bolder BioPATH Inc., Boulder, CO, 4Biology, GVK Biosciences Private Limited., Hyderabad, India, 5GVK Biosciences Private Limited., Hyderabad, India, 6Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL, 7Medicine, Albany Medical College and the Center for Rheumatology, Albany, NY

    Background/Purpose: The Non-receptor tyrosine kinases, JAK3 and ITK are key regulators of cytokine pathways and are important clinically validated targets, which offer the potential for…
  • Abstract Number: 1498 • 2014 ACR/ARHP Annual Meeting

    ALX-0061, an Anti-IL-6R Nanobody® for use in Rheumatoid Arthritis, Demonstrates a Different in Vitro Profile As Compared to Tocilizumab

    Maarten Van Roy1, Ariella Van De Sompel2, Kristi De Smet2, Jasper Jacobs2, Tinneke Denayer2 and Hans Ulrichts3, 1Department of Pharmacology, Ablynx N.V., Zwijnaarde, Belgium, 2Ablynx N.V., Zwijnaarde, Belgium, 3Pharmacology, Ablynx N.V., Zwijnaarde, Belgium

    Background/Purpose Interleukin-6 (IL-6) is a pleiotropic cytokine inducing a wide range of biological activities via its receptor, which can either be soluble (sIL-6R) or membrane-bound…
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