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Abstracts tagged "neutrophils"

  • Abstract Number: 1156 • ACR Convergence 2022

    Serum Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) Is Increased in Patients with Active Ankylosing Spondylitis (AS) and Persists Despite Anti-TNF Treatment

    Charalampos Papagoras1, Styliani Tsiami2, Akrivi Chrysanthopoulou1, Ioannis Mitroulis1 and Xenofon Baraliakos3, 1First Department of Internal Medicine and Laboratory of Molecular Hematology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece, 2Rheumazentrum Ruhrgebiet, Herne, Ruhr-University Bochum, Herne, Germany, 3Rheumazentrum Ruhrgebiet Herne, Herne, Germany

    Background/Purpose: There is increasing evidence of the pathogenetic role of monocytes and neutrophils in AS, while the neutrophil-to-lymphocyte ratio correlates with disease activity (1). Granulocyte-Monocyte…
  • Abstract Number: 0049 • ACR Convergence 2022

    IL-18 Receptor-α Signaling Pathway Contributes to Autoantibody-induced Arthritis via Neutrophil Recruitment

    Shinjiro Kaieda and Tomoaki Hoshino, Kurume University School of Medicine, Kurume, Japan

    Background/Purpose: We have previously reported that IL-18 levels in the lungs, serum and bronchoalveolar lavage fluid (BALF) were increased in patients with idiopathic pulmonary lung…
  • Abstract Number: 1321 • ACR Convergence 2022

    Systemic Inflammatory-based Scores and Bone Turnover Ratio as Novel Diagnostic Tools for Chronic Nonbacterial Osteomyelitis (CNO) of the Sternocostoclavicular Region in Adults

    Anne Leerling, Juliette Faber, Natasha Appelman-Dijkstra, Olaf Dekkers and Elizabeth Winter, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands

    Background/Purpose: Chronic non-bacterial osteomyelitis (CNO) in adults exhibits as sterile osteitis and consequent disrupted bone metabolism favoring bone formation of the sternocostoclavicular region (SCCH). Diagnosis…
  • Abstract Number: 0053 • ACR Convergence 2022

    Natural Microbial Exposure Increases Susceptibility of C57BL/6 Mice to Collagen-induced Arthritis

    Sahar Lotfi-Emran1 and David Masopust2, 1University of Minnesota, Minneapolis, MN, 2University of Minnesota, Department of Microbiology and Immunology, Minneapolis, MN

    Background/Purpose: Mice exposed to natural microbes (NME) develop an appropriately mature immune system, one that resembles that of a non-neonatal human.1,2 Collagen induced arthritis is…
  • Abstract Number: 1434 • ACR Convergence 2022

    Retrospective Analysis of Tocilizumab-induced Neutropenia in Patients with Rheumatoid Arthritis

    YoungEun Kim1, Soo Min Ahn1, Ji Seon Oh2, Yong Gil Kim1, Chang Keun Lee1, Bin Yoo1 and Seokchan Hong1, 1Department of Rheumatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea, Seoul, Republic of Korea, 2Department of Information Medicine, Big Data Research Center, Asan Medical Center, Seoul, Republic of Korea

    Background/Purpose: Neutropenia has been reported as one of the most frequent adverse events of tocilizumab. We conducted a retrospective cohort study to determine the risks…
  • Abstract Number: 0047 • ACR Convergence 2021

    A Role for Neutrophils in Disease Onset and Severity of Spondyloarthritis

    Holly Rosenzweig1, Emily Vance2, Rouhin sen3, Liron Caplan4 and Ruth Napier1, 1Oregon Health & Science University, Portland, OR, 2VA Portland Health Care System, Portland, OR, 3Colorado University Anschutz Medical Campus, Denver, CO, 4Rocky Mountain Regional Veterans Affairs Medical Center (VAMC)/University of Colorado School of Medicine, Aurora, CO

    Background/Purpose: Spondyloarthritis (SpA) is a group of inflammatory diseases that includes axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA). AxSpA patients have irregular neutrophil responses, as…
  • Abstract Number: 0356 • ACR Convergence 2021

    The Role of Neutrophils in the Clinical Severity of Lupus Nephritis Patients with Concurrent Skin Disease

    Lais Osmani, Sicong Shan, Zoe Chafouleas, Jason Pettus and Sladjana Skopelja-Gardner, Dartmouth Hitchcock Medical Center, Lebanon, NH

    Background/Purpose: Skin disease affects >80% of lupus patients and has been linked to lupus nephritis (LN) flares. We recently found that skin inflammation caused by…
  • Abstract Number: 0384 • ACR Convergence 2021

    A Tough Cell: The Argument for a Biomarker of Clinical and Imaging Outcomes in Spondyloarthritis: The Neutrophil Lymphocyte Ratio and the Platelet Lymphocyte Ratio

    Rouhin Sen1, Emmeline Kim2, Elizabeth Cheng3, Kavya Ganuthula4, Meika Fang5, Gail Kerr6, Jessica Walsh7, Elizabeth Chang8, Siba Raychaudhuri9, Andreas Reimold10 and Liron Caplan11, 1University of Colorado School of Medicine/Rocky Mountain Regional Veterans Affairs Medical Center (VAMC), Denver, CO, 2University of Colorado School of Medicine, Aurora, CO, 3Rocky Mountain Regional VAMC, Aurora, CO, 4Rocky Mountain Regional VAMC/University of Colorado School of Medicine, Aurora, CO, 5David Geffen School of Medicine at UCLA/West Los Angeles Veterans Affairs Medical Center (VAMC), Los Angeles, CA, 6Washington D.C., Veterans Affairs Medical Center (VAMC)/Georgetown and Howard Universities, Washington, DC, 7Salt Lake City Veteran Affairs Medical Center (VAMC)/University of Utah Hospital, Salt Lake City, UT, 8Phoenix Veterans Affairs Medical Center (VAMC), Phoenix, AZ, 9Sacramento Veterans Affairs Medical Center (VAMC)/University of California-Davis Health, Davis, CA, 10University of Texas – Southwestern Medical Center/Dallas Veterans Affairs Medical Center (VAMC), Dallas, TX, 11Rocky Mountain Regional Veterans Affairs Medical Center (VAMC)/University of Colorado School of Medicine, Aurora, CO

    Background/Purpose: Biomarkers of disease activity/severity and imaging outcomes in axial spondyloarthritis (axSpA) remain a challenge. The most common relevant biomarker is the C-Reactive Protein (CRP),…
  • Abstract Number: 0520 • ACR Convergence 2021

    Leukocyte Immunoglobulin-like Receptor A3 Facilitates Neutrophil Extracellular Trap Formation in TLR7-induced Lupus Mice

    Hongjiang Liu1, Yundi Tang1, Chen Chen2 and Jianping Guo2, 1Peking University People's Hospital, Beijing, China (People's Republic), 2Peking University People’s Hospital, Beijing, China (People's Republic)

    Background/Purpose: Leukocyte immunoglobulin-like receptor A3 (LILRA3) is a secreted protein belongs to LILR family. Our research group previously reported that the functional LILRA3 is a…
  • Abstract Number: 0535 • ACR Convergence 2021

    Therapeutic Efficacy of a Biomimetic ALXR Agonist in Murine Systemic Lupus Erythematosus (SLE)

    Priyal Dave1, Tiange Dong1, Andrew Mead1, Isaac Asante1, Brandon Ebright1, Eugene Zhou1, RIta Li1, Nicos Petasis1, William Stohl2 and Stan Louie1, 1University of Southern California, Los Angeles, CA, 2University of Southern California Keck School of Medicine, Los Angeles, CA

    Background/Purpose: Neutrophils are key initiators and promoters of autoimmunity, including SLE, via the elaboration of neutrophil extracellular traps (NETs). We tested the efficacy of the…
  • Abstract Number: 0541 • ACR Convergence 2021

    N-formyl Methionine Peptide-mediated Neutrophil Activation in Systemic Sclerosis

    Runa Kuley1, Ryan Stultz2, Bhargavi Duvvuri2, Roger Hesselstrand3, J Lee Nelson4 and Christian Lood2, 1Division of Rheumatology, University of Washington, Seattle, WA, 2University of Washington, Seattle, WA, 3Lund University, Lund, Sweden, 4Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA

    Background/Purpose: Systemic sclerosis (SSc) is a complex systemic autoimmune disease, and its etiology is unknown. Exaggerated neutrophil activation and formation of neutrophil extracellular traps (NETs)…
  • Abstract Number: 0948 • ACR Convergence 2021

    Immunometabolism of Neutrophils in Antiphospholipid Syndrome (APS)

    Ajay Tambralli1, Alyssa Harbaugh2, Shanea Estes2, Srilakshmi Yalavarthi2, Claire Hoy2, Gautam Sule2 and Jason Knight2, 1University of Michigan, Ypsilanti, MI, 2University of Michigan, Ann Arbor, MI

    Background/Purpose: Neutrophil hyperactivity and neutrophil extracellular trap (NET) release (NETosis) appear to play roles in APS pathophysiology. Until recently, it was thought that neutrophils relied…
  • Abstract Number: 0994 • ACR Convergence 2021

    Role of SLE Associated Cytokines in Generation of Mature Neutrophils

    Neelakshi R. Jog, Julia Nguyen and Judith James, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by autoantibody production and periods of elevated disease activity. Recent studies indicate that along…
  • Abstract Number: 0998 • ACR Convergence 2021

    Increasing Age Impairs the Metabolic Adaptation of Human Neutrophils to Glucose Deprivation

    Moritz Pfeiffenberger1, Pierre-Louis Krau2, Yuling Chen3, Thomas Buttgereit4, Alexandra Damerau1, Timo Gaber1 and Frank Buttgereit4, 1Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 2Charit Universittsmedizin Berlin, corporate member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany, 3Charité University Medicine Berlin, Berlin, Germany, 4Charité – Universitätsmedizin Berlin, Berlin, Germany

    Background/Purpose: Age-related impairment of characteristic neutrophil functions is well described (Fortin, McDonald et al. 2008). However, experimental evidence for age-related alterations of neutrophil metabolic adaptation…
  • Abstract Number: 1430 • ACR Convergence 2021

    Autoantibodies Stabilize Neutrophil Extracellular Traps in COVID-19

    Yu Zuo1, Srilakshmi Yalavarthi1, Sherwin Navaz1, Claire Hoy1, Alyssa Harbaugh1, Kelsey Gockman1, Melanie Zuo1, Jacqueline Madison1, Hui Shi1, Yogendra Kanthi2 and Jason Knight1, 1University of Michigan, Ann Arbor, MI, 2NHLBI, NIH, Bethesda, MD

    Background/Purpose: The release of neutrophil extracellular traps (NETs) by hyperactive neutrophils is recognized to play an important role in the thromboinflammatory milieu inherent to severe…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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