ACR Meeting Abstracts

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Abstracts tagged "neutrophils"

  • Abstract Number: 0537 • ACR Convergence 2022

    Neutrophil Extracellular Traps as a Biomarker to Predict Outcomes in Lupus Nephritis

    Laura Patricia Whittall Garcia1, Farnoosh Naderinavi1, Zahi Touma2, Dafna Gladman3, Murray Urowitz4, Anna Konvalinka1 and Joan Wither5, 1University Health Network, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 3Toronto Western Hospital, Schroeder Arthritis Institute, Toronto, ON, Canada, 4University of Toronto, University Health Network, Schroeder Arthritis Institute, Toronto, ON, Canada, 5Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Neutrophil Extracellular Traps (NETs) have been implicated in Lupus Nephritis (LN) pathogenesis. SLE neutrophils release High Mobility Group Box-1 (HMGB1) protein, in turn, HMGB1…
  • Abstract Number: 1684 • ACR Convergence 2022

    A Potent Inhibitor of PAD4 Suppresses Histone Citrullination in Vitro and in Vivo

    Gundula Min-Oo, Victor Lira, Debbie Ruelas, Upasana Mehra, Graham Pimm, Taylor Won, Jean-Philippe Belzile, Kelly Wang, Claire Ellis, Blake Bleier, Paqui Gonzalez Traves, Nikolai Novikov, Adam Schrier and Anita Niedziela-Majka, Gilead Sciences, Foster City, CA

    Background/Purpose: Peptidyl arginine deaminase 4 (PAD4) catalyzes the conversion of arginine residues to citrulline, a post-translational modification that has been implicated in the auto-immune response…
  • Abstract Number: 0567 • ACR Convergence 2022

    Gain-of-Function Mutations in Lyn Kinase Cause a Novel Autoinflammatory Disease with Small Vessel Vasculitis and Liver Fibrosis

    Adriana Almeida de Jesus1, Guibin Chen2, Dan Yang2, Tomas Brdicka3, Natasha Ruth4, David Bennin5, Dita Cebecauerova6, Hana Malcova7, Helen Freeman8, Neil Martin9, Karel Svojgr6, Murray Passo4, Farzana Bhuyan10, Sara Alehashemi11, Andre Rastegar12, Kat Uss12, Lela Kardova12, Iris Duric3, Ebun Omoyinmi13, Petra Peldova6, Chyi-Chia Richard Lee14, David Kleiner14, Colleen Hadigan15, Stephen Hewitt14, Stefania Pittaluga14, Carmelo Carmona-Rivera16, Katherine R. Calvo15, Nirali Shah14, Miroslava Balascakova6, Danielle Fink17, Radana Kotalova6, Zuzana Parackova6, Lucie Peterkova6, Daniela Kuzilkova6, Vit Campr6, Lucie Sramkova6, Stephen Brooks16, Eric Meffre18, Rebecca Harper2, Hyesun Kuehn15, Mariana Kaplan16, Paul Brogan19, Sergio Rosenzweig15, Zuoming Deng16, Anna Huttenlocher5, Susan Moir12, Douglas Kuhns17, Manfred Boehm2, Karolina Skvarova Kramarzova20 and Raphaela Goldbach-Mansky21, 1NIAID, NIH, Silver Spring, MD, 2National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 3Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Academy of Sciences of Czech Republic (ASCR), Prague, Czech Republic, 4Medical University of South Carolina, Charleston, SC, 5Departments of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, 6Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, Czech Republic, 7Second Faculty of Medicine, Charles University/University Hospital Motol, Praha, Czech Republic, 8Raigmore Hospital, Inverness, Scotland, United Kingdom, 9Royal Hospital for Children, Glasgow, Scotland, United Kingdom, 10National Institutes of Health, Bethesda, MD, 11NIH/NIAID/TADS, Clarksville, MD, 12National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 13Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, 14National Cancer Institute, National Institutes of Health, Bethesda, MD, 15Clinical Center, National Institutes of Health, Bethesda, MD, 16National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 17National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, 18Yale University, New Haven, CT, 19UCL Institute of Child Health and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, 20Second Faculty of Medicine, Charles University/University Hospital Motol, Prague, 21NIH/NIAID, Potomac, MD

    Background/Purpose: Lyn kinase is a member of the Src family of tyrosine kinases that regulates innate and adaptive immune responses. Lyn C-terminal tail tyrosine residue,…
  • Abstract Number: 1687 • ACR Convergence 2022

    A Core Inflammation Program Conserved Across Human and Murine Neutrophils

    Nicolaj hackert1, Felix Radtke1, Tarik Exner1, Carsten Müller-Tidow1, Hanns-Martin Lorenz1, Peter Nigrovic2, Guido Wabnitz1 and Ricardo Grieshaber-Bouyer1, 1Heidelberg University Hospital, Heidelberg, Germany, 2Boston Children's Hospital, Boston, MA

    Background/Purpose: Neutrophils mediate a range of homeostatic and inflammatory processes and display substantial phenotypic and functional heterogeneity. While animal models enable important mechanistic discoveries, differences…
  • Abstract Number: 0593 • ACR Convergence 2022

    A New Cytokine Interleukin 40 Is Elevated in the Serum of Patients with Early Rheumatoid Arthritis and Associates with Autoantibodies and Neutrophil Activation

    Adéla Navrátilová1, Viktor Bečvář1, Hana Hulejová1, Michal Tomcik2, Heřman Mann2, Olga Růžičková1, Olga Šléglová3, Jakub Závada1, Karel Pavelka4, Jiří Vencovský5, Ladislav Šenolt5 and Lucie Andrés Cerezo1, 1Institute of Rheumatology, Prague, Czech Republic, 2Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 3Institute of Rheumatology, Prague, 4Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Praha, Czech Republic, 5Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic

    Background/Purpose: IL-40 is a newly described cytokine related to malignant transformation and immune system function. In our previous study, we showed that IL-40 is elevated…
  • Abstract Number: 1688 • ACR Convergence 2022

    Biomechanical Phenotype of Circulating Neutrophils Is Altered in ANCA Associated Vasculitis

    Noelle Pisacano1, Stephen P. McAdoo1, Jochen Guck2, Charles D. Pusey1, Edwin R. Chilvers1, Andrew S. Cowburn1, Katharine M. Lodge1 and Maria F. Prendecki1, 1Imperial College London, London, United Kingdom, 2Max Planck Institute, Erlangen, Germany

    Background/Purpose: Real Time-Deformability Cytometry (RT-DC) is a novel technique able to identify morpho-rheological characteristics of individual cells such as size, deformability, and elasticity using only…
  • Abstract Number: 0596 • ACR Convergence 2022

    Neutrophil Extracellular Traps (NET) Trigger an Enhanced Pro-inflammatory Response in Macrophage Subpopulations in Rheumatoid Arthritis Patients via the Aryl Hydrocarbon Receptor (AhR) Pathway

    Dyhia Melbouci1, Sarra Seninet1, Marie-Christophe Boissier2, Elodie Segura3 and Patrice Decker1, 1University Sorbonne Paris Nord, Inserm UMR 1125, Li2P, Bobigny, France, 2INSERM UMR 1125, Sorbonne Paris Nord University,Rheumatology Dpt, APHP, GHUPSSD, Avicenne Hosp, Bobigny, France, 3U932 Inserm, Curie Institute, Paris, France

    Background/Purpose: Activated neutrophils (PMN) form neutrophil extracellular traps (NET), fibers of DNA and associated proteins expelled in the extracellular space. Increased NET formation has been…
  • Abstract Number: 1689 • ACR Convergence 2022

    Oral Ginger Supplementation Counteracts NETosis in Autoimmune Mouse Models and in Healthy Humans

    Ramadan Ali1, Miela Zahavi2, Christine Rysenga1, Cyrus Sarosh3, Claire Hoy1, Kristen Demoruelle4 and Jason S Knight5, 1University of Michigan, Ann Arbor, MI, 2Universtiy of Michigan, Ann Arbor, MI, 3University of Michigan, Temperance, MI, 4University of Colorado Anschutz Medical Campus, Aurora, CO, 5University of Michigan, Division of Rheumatology, Ann Arbor, MI

    Background/Purpose: It has previously been reported that 6-gingerol, the most abundant phytochemical in ginger root, inhibits neutrophil phosphodiesterase activity and thereby counteracts neutrophil hyperactivity in…
  • Abstract Number: 0611 • ACR Convergence 2022

    Proteomics Reveals Dysregulated Molecular Mechanisms of Cell Death in Neutrophils in Rheumatoid Arthritis

    Jennifer Amsler1, Constance Beaudouin2, Morgane LeGall3, Géraldine Falgarone4, François Rannou5, Léa Tourneur3 and Véronique Witko-Sarsat3, 1Institute Cochin, Schoenenwerd, Switzerland, 2Hôpital Privé de Provence, Aix-en-Provence, France, 3Institute Cochin, Paris, France, 4Hôpital Avicenne, Paris, France, 5Hôpital Cochin, Paris, France

    Background/Purpose: Favoring apoptosis of neutrophils infiltrating the joints of patients suffering from rheumatoid arthritis (RA) and perpetuating inflammation has recently been discussed as an alternative…
  • Abstract Number: 1694 • ACR Convergence 2022

    Skin Exposure to UV Light Triggers Podocyte and Distal Tubular Injury, in the Presence of CD177+ Neutrophil Cell Cluster

    Angelique Cortez1, Lindsay Mendyka1, Fred Kolling2 and Sladjana Skopelja-Gardner1, 1Dartmouth Hitchcock Medical Center, Lebanon, NH, 2Geisel School of Medicine at Dartmouth, Lebanon, NH

    Background/Purpose: Sensitivity to ultraviolet (UV) light affects ~ 80% of systemic lupus erythematosus (SLE) patients. UV light exposure of lupus skin leads to local and…
  • Abstract Number: 0687 • ACR Convergence 2022

    DNA- and NET-Binding Beta-2 Glycoprotein I in a Large Cohort of Antiphospholipid Antibody-Positive Patients

    Katarina Kmetova1, Srilakshmi Yalavarthi2, Claire Hoy2, Cyrus Sarosh3, Noah Peters2, Tristin Smith2, Sherwin Navaz2, Yu Zuo2 and Jason S Knight4, 1Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2University of Michigan, Ann Arbor, MI, 3University of Michigan, Temperance, MI, 4University of Michigan, Division of Rheumatology, Ann Arbor, MI

    Background/Purpose: Beta-2 glycoprotein I (β2GPI) is an abundant plasma protein and a critically important autoantigen in APS. While β2GPI has been reported to have antioxidant,…
  • Abstract Number: 1714 • ACR Convergence 2022

    The Circadian Clock Gene Bmal1 Negatively Regulates Autoantibody Production in SLE

    Shuichiro Nakabo1, Donavon Sandoval-Heglund1, Victoria Hoffmann2, Mingzeng Zhang1, Norio Hanata1, Zerai Manna1, Elaine Poncio1, Sarfaraz Hasni3 and Mariana Kaplan4, 1NIAMS/NIH, Bethesda, MD, 2ORS/ORF/NIH, Bethesda, MD, 3National Institutes of Health, Bethesda, MD, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD

    Background/Purpose: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects multiple organs including kidney and skin. While its etiology and pathogenesis are still…
  • Abstract Number: 0688 • ACR Convergence 2022

    Antibodies of the IgA Isotype Target Neutrophil Extracellular Traps in APS

    Sherwin Navaz1, Lyndsay Kluge1, Katarina Kmetova2, Bruna Jacintho3, Srilakshmi Yalavarthi1, Claire Hoy1, Cyrus Sarosh4, Noah Peters1, Tristin Smith1, Gabriel Figueroa Parra5, Jacqueline Madison1, Kristen Demoruelle6, Ali Duarte-Garcia5, Jason S Knight7 and Yu (Ray) Zuo1, 1University of Michigan, Ann Arbor, MI, 2Division of Rheumatology, University of Michigan, Ann Arbor, MI, 3University of Michigan, São Paulo, Brazil, 4University of Michigan, Temperance, MI, 5Mayo Clinic, Rochester, MN, 6University of Colorado Anschutz Medical Campus, Aurora, CO, 7University of Michigan, Division of Rheumatology, Ann Arbor, MI

    Background/Purpose: Neutrophil extracellular traps (NETs) are prothrombotic and proinflammatory webs of nuclear DNA, histones, and microbicidal proteins extruded by neutrophils into the extracellular space in…
  • Abstract Number: 1721 • ACR Convergence 2022

    Protective Effects of the Natural Antioxidant Taxifolin in Models of Lupus and Antiphospholipid Syndrome

    Christine Rysenga1, Linda May-Zhang2, Miela Zahavi3, Jason S Knight4 and Ramadan Ali1, 1University of Michigan, Ann Arbor, MI, 2Blue California, Rancho Santa Margarita, CA, 3Universtiy of Michigan, Ann Arbor, MI, 4University of Michigan, Division of Rheumatology, Ann Arbor, MI

    Background/Purpose: Taxifolin, also known as dihydroquercetin, is a bioactive flavonoid commonly found in apples, onions, French maritime bark, and milk thistle. Given its potent anti-inflammatory…
  • Abstract Number: 1430 • ACR Convergence 2021

    Autoantibodies Stabilize Neutrophil Extracellular Traps in COVID-19

    Yu Zuo1, Srilakshmi Yalavarthi1, Sherwin Navaz1, Claire Hoy1, Alyssa Harbaugh1, Kelsey Gockman1, Melanie Zuo1, Jacqueline Madison1, Hui Shi1, Yogendra Kanthi2 and Jason Knight1, 1University of Michigan, Ann Arbor, MI, 2NHLBI, NIH, Bethesda, MD

    Background/Purpose: The release of neutrophil extracellular traps (NETs) by hyperactive neutrophils is recognized to play an important role in the thromboinflammatory milieu inherent to severe…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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