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Abstracts tagged "neutrophils"

  • Abstract Number: 1795 • ACR Convergence 2024

    Immune Complexes-Mediated Activation of Neutrophils in Systemic Lupus Erythematosus Is Dependent on RNA Recognition by TLR8

    Ting Wang1, Runa Kuley2, Payton Hermanson2, Gundula Min-oo3, Natasha Crellin4, Ching Shang3 and Christian Lood1, 1University of Washington, Seattle, WA, 2University of Washington, Seattle, 3Gilead Sciences, Foster City, CA, 4Gilead, Foster City, CA

    Background/Purpose: Neutrophil activation has been implicated to contribute to the systemic lupus erythematosus (SLE) pathogenesis. However, factors and mechanisms promoting neutrophil activation in SLE have…
  • Abstract Number: 0103 • ACR Convergence 2024

    CD10highLow-Density Granulocytes Is a Potential Marker of Disease Activity in Antiphospholipid Syndrome

    chun Li, Peking University People's Hospital, Beijing, China

    Background/Purpose: To investigate the relationship between CD10highLow-Density Granulocytes (LDG) and disease activity in antiphospholipid syndrome(APS).Methods: This study included 99 patients with APS who were treated…
  • Abstract Number: 1802 • ACR Convergence 2024

    Heterogeneous Neutrophil Subsets Infiltrate Glomeruli of Lupus Nephritis Patients and Are Elevated in the Kidneys and Urine of Sunlight-induced Nephritis Flares

    Noelle Kosarek1, Joshua Skydel2, Alecia Roy3, Fred Kolling1, Lucas Salas1, Christopher Burns4, Andrea Fava5 and Sladjana Skopelja-Gardner1, 1Geisel School of Medicine at Dartmouth, Lebanon, 2Dartmouth Hitchcock Medical Center, Lebanon, 3Dartmouth College, Lebanon, NH, 4Dartmouth Hitchcock Medical Center, Lebanon, NH, 5Divison of Rheumatology, Johns Hopkins University, Baltimore, MD

    Background/Purpose: Up to ~60% of SLE patients in North America will develop kidney disease, lupus nephritis (LN), one of the main contributors to disease morbidity…
  • Abstract Number: 0507 • ACR Convergence 2024

    Neutrophil Activation Markers Can Predict Rheumatoid Arthritis Treatment Response to the Janus Kinase 1/2 Inhibitor Baricitinib

    Runa Kuley1, Bhargavi Duvvuri1, Sabeeha Hasnain2, Ernst Dow3, Alisa Koch4, Richard Higgs4, Venkatesh Krishnan4 and Christian Lood5, 1University of Washington, Seattle, 2Mahindra University, Hyderabad, India, 3Eli Lilly and Co, Indianapolis, IN, 4Eli Lilly, Indianapolis, IN, 5University of Washington, Seattle, WA

    Background/Purpose: Neutrophils play an important role in regulating immune and inflammatory responses in rheumatoid arthritis (RA). We assessed whether baricitinib, a JAK1/JAK2 inhibitor, could reduce…
  • Abstract Number: 2601 • ACR Convergence 2024

    Platelets Specifically Interact with Remigrating Neutrophils and Promote Immunogenic Cellular Death in Systemic Lupus

    Marie nansion1, Eloi Schmauch2, Pierre Vacher3, Jean Sibilia4, Nathan Broussaudier1, Adeline Bruchon1, Pierre Grenot1, Anne-Sophie Korganow5, Thierry Martin5, Sophie Caillard6, Anna Duval6, Jacques-Eric Gottenberg7, Raphaël Carapito1, Séiamak Bahram1, Patrick Blanco8 and Marc Scherlinger9, 1UMR_INSERM 1109, Strasbourg, France, 2Broad Institute of MIT and Harvard, Cambridge, MA, USA., Boston, MA, 3Inserm U1045, Bordeaux, France, 4Strasbourg University Hospital, National reference center for autoimmune disease, Rheumatology, Strasbourg, France, 5Strasbourg University Hospital, National reference center for autoimmune disease, Clinical Immunology, Strasbourg, France, 6Nephrology department, HUS, Strasbourg, France, 7Rheumatology Department, Strasbourg University Hospital,, Strasbourg, France, 8UMR_CNRS 5164 Immunoconcept, BORDEAUX CEDEX, France, 9Strasbourg University Hospital; INSERM 1109, Strasbourg, France

    Background/Purpose: In SLE, platelet activation (express P-selectin+) follows the disease activity, which plays a role in thrombosis as well as in inflammation (1). Neutrophils express high levels of PSGL-1,…
  • Abstract Number: 0515 • ACR Convergence 2024

    Scavenging Isolevuglandins with 2-HOBA Decreases In Vitro Neutrophil Extracellular Traps in Cells from Patients with Rheumatoid Arthritis

    Olivia Posey, Anastasiia Phothisane, Phicharmon Kulapatana and Michelle Ormseth, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Neutrophils contribute to the innate immune response of killing pathogens through the formation of neutrophil extracellular traps (NETs), which is also called NETosis. NETosis…
  • Abstract Number: 2690 • ACR Convergence 2024

    ANCA IgG Promotion of Neutrophil Recruitment, Migration and Vascular Damage in ANCA Associated Vasculitis May Be Enhanced by Hypoxia

    Noelle Pisacano, Amrita Dhutia, Stephen Rothery, Charles Pusey, Edwin Chilvers, Andrew Cowburn, Katharine Lodge and Maria Prendecki, Imperial College London, London, United Kingdom

    Background/Purpose: Neutrophils are main mediators of disease in ANCA associated vasculitis (AAV). Pathogenic ANCA IgG on neutrophils promotes neutrophil adhesion and migration at the endothelium.…
  • Abstract Number: 0766 • ACR Convergence 2024

    Neutrophil Transcriptomics in VEXAS Syndrome

    Chloe Palmer1, Gustaf Wigerblad1, Tom Hill2, Bhavisha Patel3, Emma Groarke4, Neal Young4, Stefania Dell'Orso5 and Peter Grayson6, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, 3National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Beltsville, MD, 4National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, 5National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, Bethesda, MD, 6National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Chevy Chase, MD

    Background/Purpose: Vacuoles, E1 ubiquitin-activating enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is caused by somatic mutations of the ubiquitin-like modifier activating enzyme 1 (UBA1) gene and…
  • Abstract Number: 0773 • ACR Convergence 2024

    Anti-Citrullinated Histone Antibody CIT-013 Targets NETs in Inflamed Joints and Halts NET-mediated Joint Deterioration

    Leonie Middelink1, Annemarie Kip2, Maarten van der Linden3, Sangeeta Kumari2, Stephanie van Dalen2, Josephine Stein4, Tirza Bruurmijn2, Martyn Foster5, Peter van Zandvoort2, Patrick Round2, Eric Meldrum2, Helmuth van Es2 and Renato Chirivi2, 1Citryll, Oss, Noord-Brabant, Netherlands, 2Citryll BV, Oss, Noord-Brabant, Netherlands, 3Citryll BV, Oss, Netherlands, 4Citryll BV, Oss, Noord-Holland, Netherlands, 5Experimental Pathology Consultancy, Benfleet, United Kingdom

    Background/Purpose: Neutrophil extracellular traps (NETs) contribute to the pathophysiology of many immune-mediated inflammatory diseases (IMIDs). Though NETosis-targeting therapeutics have shown potential as effective treatments, currently…
  • Abstract Number: 0801 • ACR Convergence 2024

    Neutrophil Activation as a Novel Marker of Lung Disease in Rheumatoid Arthritis

    Jia Shi1, Yang Wu1, Ting Wang2, Chen Yu3, qian wang4, Xinping Tian5, Mengtao Li4, Kristen Demoruelle6, Joshua Solomon7 and Christian Lood2, 1University of Washington, Seattle, 2University of Washington, Seattle, WA, 3Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Dong Cheng Qu, China (People's Republic), 4Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China 2National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China, 5Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 6University of Colorado Anschutz Medical Campus, Golden, CO, 7National Jewish Health, Denver, CO

    Background/Purpose: Neutrophil activation is seen in rheumatoid arthritis (RA), but its involvement in RA interstitial lung disease (RA-ILD) is not clear. Levels of N-formyl methionine…
  • Abstract Number: 0901 • ACR Convergence 2023

    Scavenging of Isolevuglandins Attenuates Neutrophil Expansion and Aortic NETosis in Systemic Lupus Erythematosus

    Jaya Krishnan1, Néstor de la Visitación1, Jonathan Williams1, Leslie Crofford2 and David Patrick3, 1Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University Medical Center, Melbourne, AR, 3Department of Veterans Affairs, Nashville, TN

    Background/Purpose: Atherosclerosis and vascular inflammation are a cause of morbidity and mortality in systemic lupus erythematosus (SLE). Vascular NETosis is a driver of atherosclerosis and…
  • Abstract Number: 2442 • ACR Convergence 2023

    Neutrophils Induce Contact-Dependent Expansion of Arthritogenic Th17 Cells and Are Necessary for Disease in Experimental Ankylosing Spondylitis

    Hillary Struthers1, Emily Vance1, Kofi Asare-Konadu1, Holly Rosenzweig2 and Ruth Napier1, 1Oregon Health & Science University, Portland, OR, 2VA Portland Healthcare System, Portland, OR

    Background/Purpose: Ankylosing spondylitis (AS) patients have irregular neutrophil responses, as indicated clinically by neutrophilia and increased neutrophil to lymphocyte ratios that positively associate with disease…
  • Abstract Number: 0905 • ACR Convergence 2023

    Low-Density Granulocytes and Neutrophil Extracellular Traps in Incomplete Systemic Lupus Erythematosus

    Svenja Henning1, Tobias Reimers2, Berber Doornbos-van der Meer2, Barbara Horvath3, Hendrika Bootsma4, Karina de Leeuw2 and Johanna Westra2, 1University Medical Center Groningen, Department of Rheumatology and Clinical Immunology, Groningen, Netherlands, 2University Medical Center Groningen, Groningen, Netherlands, 3University Medical Center Groningen / Department of Dermatology, Groningen, Netherlands, 4Department of Rheumatology, University Medical Centre Groningen, Groningen, Netherlands

    Background/Purpose: Incomplete SLE (iSLE) defines a group of patients with symptoms typical of SLE but not meeting sufficient criteria required for the classification of SLE.…
  • Abstract Number: 2462 • ACR Convergence 2023

    Mitochondrial-Mediated Neutrophil Activation in Dermatomyositis (DM) and Inclusion Body Myositis (IBM): Insights into Pathogenesis and Therapeutic Implications

    Jorge Armando Gonzalez-Chapa1, Jemima Albayda2, Begum Horuluoglu3, Despina Michailidou1, Marina Barguil Macedo1, Lisa Christopher-Stine2, Ingrid Lundberg4 and Christian Lood1, 1University of Washington, Seattle, WA, 2Johns Hopkins University, Baltimore, MD, 3Karolinska Institutet, Stockholm, Sweden, 4Division of Rheumatology, Department of Medicine, Karolinska Institutet; Department of Gastroenterology, Dermatotology, Rhematology, Karolinska Universitetssjukhuset, Stockholm, Sweden

    Background/Purpose: Dermatomyositis (DM) and inclusion body myositis (IBM) are characterized by muscle weakness and inflammation, with emerging evidence of mitochondrial and neutrophil involvement. Prior work…
  • Abstract Number: 0911 • ACR Convergence 2023

    Spatial Transcriptomics Reveals Normal-density and Low-density Neutrophils Are More Prevalent Than Macrophages in Lupus Nephritis Glomeruli, and Urine DNA Methylation Analyses Capture Both Myeloid Populations

    Sladjana Skopelja-Gardner1, Joshua Skydel2, Alecia Roy3, Brenna Kerin3, James Whitley3, Fred Kolling4, Noelle Kosarek4, Michelle Petri5, Andrea Fava6, Lucas Salas7 and Christopher Burns3, 1Department of Medicine, Dartmouth Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, 2Dartmouth-Hitchcock Medical Center, Lebanon, NH, 3Dartmouth Hitchcock Medical Center, Lebanon, NH, 4Geisel School of Medicine at Dartmouth, Hanover, NH, 5Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, 6Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 7Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH

    Background/Purpose: Despite compelling evidence that normal-density (NDN) and low-density neutrophils (LDN) are activated in the blood of lupus patients, their role in lupus nephritis (LN)…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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