Abstracts tagged "neutrophils"

Abstract Number: 0384 • ACR Convergence 2020
Serum Neutrophil Count Predicts Progression of Interstitial Lung Disease and Mortality in Patients with Systemic Sclerosis Related Interstitial Lung Disease
Nancy Wareing¹, Ning Li², Elizabeth Volkmann³, Marka Lyons⁴, Michael Roth², Donald Tashkin² and Shervin Assassi¹, ¹University of Texas Houston McGovern Medical School, Division of Rheumatology and Clinical Immunogenetics, Houston, TX, ²University of California, Los Angeles, Los Angeles, ³University of California, Los Angeles, Los Angeles, CA, ⁴University of Texas Houston, McGovern Medical School, Division of Rheumatology and Clinical Immunogenetics, Houston, TX
Background/Purpose: Systemic sclerosis (SSc) patients have a prominent neutrophil gene expression signature. However, investigations into the pathophysiologic role of neutrophils in SSc are lacking. This…
Abstract Number: 0462 • ACR Convergence 2020
Lupus-like Autoimmunity and Increased Interferon Response in Patients with STAT3-deficient Hyper-IgE Syndrome
Brian Dizon¹, Rishi Goel², Shuichiro Nakabo², Amanda Urban², Meryl Waldman², Lilian Howard², Dirk Darnell², Munir Buhaya², Sarfaraz Hasni³, Mariana Kaplan⁴, Alexandra Freeman² and Sarthak Gupta¹, ¹National Institutes of Health, BETHESDA, MD, ²National Institutes of Health, Bethesda, ³Lupus Clinical Trials Unit, NIAMS/NIH, Bethesda, MD, ⁴National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD
Background/Purpose: Autosomal dominant hyper-IgE syndrome (AD-HIES), also known as Job’s syndrome, is a rare primary immunodeficiency caused by dominant-negative loss-of-function (LOF) mutations in signal transducer…
Abstract Number: 0494 • ACR Convergence 2020
Genetic-epigenetic Interaction and the Relationship Between DNA Methylation Patterns and Disease Activity in a Longitudinal Cohort of Lupus Patients
Patrick Coit¹, Lourdes Ortiz-Fernandez², Emily Lewis³, W. Joseph McCune³, Kathleen Maksimowicz-McKinnon⁴ and Amr Sawalha², ¹University of Pittsburgh and University of Michigan, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³University of Michigan, Ann Arbor, MI, ⁴Henry Ford Hospital, Detroit
Background/Purpose: Genetic factors and epigenetic dysregulation are implicated in the pathogenesis of lupus. We performed a longitudinal analysis of DNA methylation in lupus patients for…
Abstract Number: 0740 • ACR Convergence 2020
Card9 Promotes Th17-mediated Arthritis and Spondylitis via Control of Acute Pathogenic Neutrophil Responses in SKG Mice
Holly Rosenzweig¹, Emily Vance¹, Ellen Lee¹ and Ruth Napier¹, ¹Oregon Health & Science University and VA Portland Health Care System, Portland, OR
Background/Purpose: Caspase recruitment domain-containing protein 9 (CARD9) is an intracellular signal transduction molecule that mediates antimicrobial responses following activation of C-type lectin receptors (ie. Dectin-1) by…
Abstract Number: 0752 • ACR Convergence 2020
Serum Proteomics Implicates Neutrophil Degranulation in Rheumatoid Arthritis Disease Activity
Liam O'Neil¹, Vidyanand Anaparti¹, Dana Wiens¹, Irene Smolik¹, Xiaobo Meng¹ and Hani El-Gabalawy¹, ¹University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: Though targeted therapeutics have improved outcomes in Rheumatoid Arthritis (RA) treatment, the understanding of the underlying biological mechanisms that mediate inflammatory arthritis in RA…
Abstract Number: 0777 • ACR Convergence 2020
CLEC12A Expression as a Potential Predictor of Disease Activity in Early Rheumatoid Arthritis
Myriam Vaillancourt¹, Philippe Desaulniers¹, Guillaume Paré¹, Nathalie Pagé¹, Asmaa Lachaab¹, Anthony Kerever¹, Anne-Sophie Julien¹, Nathalie Amiable¹, Martin Pelletier¹, Philippe Tessier¹, Louis Bessette², Paul Fortin³, Laetitia Michou¹ and Maria Fernandes¹, ¹Université Laval, Québec, QC, Canada, ²Laval University, Quebec, Canada, ³CHU de Quebec - Universite Laval, Quebec, Canada
Background/Purpose: Rheumatoid arthritis (RA) develops as a result of the dysregulation of immune activating and inhibitory pathways. Several lines of evidence indicate that inhibitory receptors…
Abstract Number: 118 • 2019 ACR/ARP Annual Meeting
Polymorphonuclear Neutrophils and Regulatory T Lymphocytes (Treg) Cooperate to Sustain Treg Activity but This Interaction Is Altered in Rheumatoid Arthritis Patients
Maxime Batignes ¹, François Santinon ¹, Marie-Christophe Boissier ², Patrice Decker ¹ and Natacha Bessis¹, ¹Inserm UMR 1125, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ²Assistance Publique-Hôpitaux de Paris (AP-HP), Rheumatology Department, Avicenne Hospital, Bobigny, France
Background/Purpose: Regulatory T cells (Treg) are necessary for immune homeostasis but are functionally deficient in inflammatory/autoimmune diseases such as rheumatoid arthritis (RA). On the other…
Abstract Number: 810 • 2019 ACR/ARP Annual Meeting
Small Vessel Vasculitis Syndrome with Autoinflammation Caused by De Novo Mutations in LYN Kinase
Adriana de Jesus¹, Gina Montealegre Sanchez ², Helen Freeman ³, Neil Martin ⁴, Ebun Omoyinmi ⁵, Katherine Calvo ⁶, Richard Chyi-chia Lee ⁷, Murray Passo ⁸, Natasha Ruth ⁸, David Kleiner ⁷, Yan Huang ⁹, Nirali Shah ¹⁰, Paul Brogan ¹¹, SuJin Hwang ¹², HyeSun Kuehn ¹², Sergio Rosenzweig ¹², Zuoming Deng ¹³, Anna Huttenlocher ¹⁴, Susan Moir ¹⁵, Douglas Kuhns ¹⁶ and Raphaela Goldbach-Mansky ¹⁷, ¹Translation Autoinflammatory Diseases Section/NIAID/NIH, Silver Spring, MD, ²Translational Autoinflammatory Disease Section/NIAID/NIH, Bethesda, ³Raigmore Hospital, Inverness, United Kingdom, ⁴Royal Hospital for Children, Glasgow, United Kingdom, ⁵University College London Institute of Child Health, London, United Kingdom, ⁶Hematology Service/Department of Laboratory Medicine/NIH, Bethesda, MD, ⁷Laboratory of Pathology/NCI/NIH, Bethesda, MD, ⁸Medical University of South Carolina, Charleston, SC, ⁹Translational Autoinflammatory Disease Section/NIAID/NIH, Bethesda, MD, ¹⁰Pediatric Oncology Branch/NCI/NIH, Bethesda, MD, ¹¹Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, ¹²Immunology Service/Department of Laboratory Medicine/NIH, Bethesda, MD, ¹³Biomining and Discovery Section/NIAMS/NIH, Bethesda, MD, ¹⁴Department of Pediatrics/University of Wisconsin, Madison, WI, ¹⁵Immunopathogenesis Section/NIAID/NIH, Bethesda, MD, ¹⁶Collaborative Clinical Research Branch/NIAID/NIH, Bethesda, MD, ¹⁷Translational Autoinflammatory Diseases Section/NIAID/NIH, Bethesda, MD
Background/Purpose: Lyn kinase is a member of the Src family of non-receptor tyrosine-protein kinases that modifies signals from various cell surface receptors and regulates innate…
Abstract Number: 1789 • 2019 ACR/ARP Annual Meeting
Defibrotide Inhibits Antiphospholipid Antibody-Mediated NET Release and Endothelial Cell Activation
Ramadan Ali¹, Hui Shi ¹, Srilakshmi Yalavarthi ¹ and Jason Knight ², ¹University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI
Background/Purpose: Defibrotide is a mixture of phosphodiester oligonucleotides derived from porcine intestinal mucosa, currently approved for treatment of hepatic sinusoidal obstruction syndrome. Defibrotide has been…
Abstract Number: 2733 • 2019 ACR/ARP Annual Meeting
Inhibition of Neutrophil Elastase Reduces Autoantibody Levels and Renal Inflammation in Murine Lupus
Gautam Sule¹, Kristen Gilley ¹, Andrew Fernandes ¹, Srilakshmi Yalavarthi ¹ and Jason Knight ², ¹University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI
Background/Purpose: Dysregulated neutrophil extracellular trap (NET) release has been proposed as a source of autoantigens in lupus. Furthermore, it has recently been shown that the…
Abstract Number: 2804 • 2019 ACR/ARP Annual Meeting
Neutrophil Passage Through the Megakaryocyte Cytoplasm via Emperipolesis Modulates Neutrophil Migration
Pierre Cunin¹, Alexandra Wactor ², Li Guo ³, Andrew Weyrich ³, Éric Boilard ⁴ and Peter Nigrovic ⁵, ¹Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ²Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, ³Program in Molecular Medicine and Department of Internal Medicine, University of Utah, Salt Lake City, ⁴Axe maladies infectieuses et inflammatoires, Centre de recherche du CHU de Québec – Université Laval, Québec, Qc, Canada, Québec, QC, Canada, ⁵Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA ; Department of Medicine, Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA., Boston
Background/Purpose: Emperipolesis (EP) is a little-understood phenomenon referring to the presence neutrophils within megakaryocytes (MKs). We developed methods to study EP in vitro and in…
Abstract Number: 28 • 2019 ACR/ARP Annual Meeting
Novel Ex Vivo Model of Septic Arthritis Identifies Role of Neutrophils in Joint Destruction
Kathryn McCall¹, Caroline Atherton ², Neal Millar ², Carl Goodyear ³, Tom Evans ⁴ and Iain McInnes ², ¹Institute of Infection, Immunity & Inflammation, University of Glasgow, Galsgow, United Kingdom, ²Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, ³University of Glasgow, Glasgow, United Kingdom, ⁴Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow
Background/Purpose: Septic arthritis (SA) caused by bacterial species, such as Staphylococcus aureus, has high morbidity and mortality1. Currently diagnosis is often prolonged and unreliable, with…
Abstract Number: 73 • 2019 ACR/ARP Annual Meeting
Potent Anti-neutrophil Properties of the Natural Compound 6-Gingerol in Models of Lupus and Antiphospholipid Syndrome
Ramadan Ali¹, Julia Weiner ¹, Alex Gandhi ¹, Shanea Estes ¹ and Jason Knight ², ¹University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI
Background/Purpose: 6-gingerol, the major bioactive compound of ginger root, is known to have anti-inflammatory and anti-oxidative effects. Indeed, ginger has been employed for millennia as…
Abstract Number: 81 • 2019 ACR/ARP Annual Meeting
UV Light Stimulates a Systemic Neutrophil Response Associated with Transient Kidney Injury
Sladjana Skopelja-Gardner¹, Joyce Tai ², Xizhang Sun ², Lena Tanaka ², Payton Hermanson ² and Keith Elkon ², ¹University of Washington, Seattle, WA, ²University of Washington, Seattle
Background/Purpose: Sensitivity to ultraviolet B (UVB) light affects ~70% of SLE patients and exacerbates both skin disease and systemic flares, including lupus nephritis (LN). Our…
Abstract Number: 152 • 2018 ACR/ARHP Annual Meeting
Polymorphonuclear Neutrophils and Regulatory T Lymphocytes (Treg) Cooperate to Sustain Treg Activity in Normal and Arthritic Contexts
Maxime Batignes¹, François Santinon¹, Marie-Christophe Boissier^2,3, Patrice Decker⁴ and Natacha Bessis¹, ¹INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ²University of Paris 13,Sorbonne Paris Cité, Bobigny, France, ³Rheumatology Department, Assistance Publique – Hôpitaux de Paris (AP-HP), Avicenne Hospital, Bobigny, France, ⁴Inserm UMR 1125, Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France
Background/Purpose: Polymorphonuclear neutrophils (PMN) are abundant and activated in rheumatoid arthritis (RA) joints. In addition to their pro-inflammatory role, PMN exert immunoregulatory functions and may…

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