Abstracts tagged "neutrophils"

Abstract Number: 0777 • ACR Convergence 2020
CLEC12A Expression as a Potential Predictor of Disease Activity in Early Rheumatoid Arthritis
Myriam Vaillancourt¹, Philippe Desaulniers¹, Guillaume Paré¹, Nathalie Pagé¹, Asmaa Lachaab¹, Anthony Kerever¹, Anne-Sophie Julien¹, Nathalie Amiable¹, Martin Pelletier¹, Philippe Tessier¹, Louis Bessette², Paul Fortin³, Laetitia Michou¹ and Maria Fernandes¹, ¹Université Laval, Québec, QC, Canada, ²Laval University, Quebec, Canada, ³CHU de Quebec - Universite Laval, Quebec, Canada
Background/Purpose: Rheumatoid arthritis (RA) develops as a result of the dysregulation of immune activating and inhibitory pathways. Several lines of evidence indicate that inhibitory receptors…
Abstract Number: 0792 • ACR Convergence 2020
LY294002 Improves the Collagen-induced Arthritis by Inducing Neutrophil Apoptosis
Xuechan Huang¹, Tianwang Li¹, Shuyang Chen¹, Zhixiang Huang¹ and Junming Chen¹, ¹Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, Guangdong, China (People's Republic)
Background/Purpose: Neutrophils play a central role in host defense, but they also play important effectors on acute and chronic inflammation. Neutrophil apoptosis is essential for…
Abstract Number: 0845 • ACR Convergence 2020
Hematopoietic Specific Deficiency of Rho Kinase Attenuates Neutrophil NETosis and UVB-induced Skin Inflammation
Minghui Li¹, Xing Lyu¹, Yubin Li², James Liao³, Victoria Werth⁴ and Ming-Lin Liu¹, ¹University of Pennsylvania, philadelphia, ²University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, PA, ³University of Chicago, Chicago, ⁴University of Pennsylvania and Corporal Michael J. Crescenz Veterans Administration Hospital, Philadelphia
Background/Purpose: Neutrophils are the most abundant leukocytes and the first to be recruited to the site of photodamage after ultraviolet B (UVB) exposure. We have…
Abstract Number: 0901 • ACR Convergence 2020
Proinflammatory Neutrophil Function Is Modulated During Secukinumab Therapy in Psoriatic Arthritis Without Compromising Host Defence
Robert Moots¹, Andy Cross², Helen Wright², Steven Edwards², Nicola Goodson³, Jenny Hawkes³, Ayren Mediana¹ and Helen Frankland¹, ¹Liverpool University Hospitals, Liverpool, United Kingdom, ²University of Liverpool, Liverpool, United Kingdom, ³University of Liverpool, Liverpool
Background/Purpose: Secukinumab is a monoclonal antibody that neutralises IL-17A, which plays a key role in the IL-23/17A axis underlying the pathophysiology of psoriatic arthritis (PsA). …
Abstract Number: 0945 • ACR Convergence 2020
Neutrophils Mediate Kidney Inflammation Following Acute Skin Exposure to UV Light
Sladjana Skopelja-Gardner¹, Joyce Tai², Xizhang Sun², Lena Tanaka², James Kuchenbecker², Tomas Mustelin¹ and Keith Elkon², ¹University of Washington, Seattle, WA, ²University of Washington, Seattle
Background/Purpose: Sensitivity to ultraviolet (UV) light affects up to 80% of SLE patients and can exacerbate systemic disease flares, including lupus nephritis (LN). Our findings…
Abstract Number: 2804 • 2019 ACR/ARP Annual Meeting
Neutrophil Passage Through the Megakaryocyte Cytoplasm via Emperipolesis Modulates Neutrophil Migration
Pierre Cunin¹, Alexandra Wactor ², Li Guo ³, Andrew Weyrich ³, Éric Boilard ⁴ and Peter Nigrovic ⁵, ¹Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ²Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, ³Program in Molecular Medicine and Department of Internal Medicine, University of Utah, Salt Lake City, ⁴Axe maladies infectieuses et inflammatoires, Centre de recherche du CHU de Québec – Université Laval, Québec, Qc, Canada, Québec, QC, Canada, ⁵Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA ; Department of Medicine, Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA., Boston
Background/Purpose: Emperipolesis (EP) is a little-understood phenomenon referring to the presence neutrophils within megakaryocytes (MKs). We developed methods to study EP in vitro and in…
Abstract Number: 28 • 2019 ACR/ARP Annual Meeting
Novel Ex Vivo Model of Septic Arthritis Identifies Role of Neutrophils in Joint Destruction
Kathryn McCall¹, Caroline Atherton ², Neal Millar ², Carl Goodyear ³, Tom Evans ⁴ and Iain McInnes ², ¹Institute of Infection, Immunity & Inflammation, University of Glasgow, Galsgow, United Kingdom, ²Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, ³University of Glasgow, Glasgow, United Kingdom, ⁴Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow
Background/Purpose: Septic arthritis (SA) caused by bacterial species, such as Staphylococcus aureus, has high morbidity and mortality1. Currently diagnosis is often prolonged and unreliable, with…
Abstract Number: 73 • 2019 ACR/ARP Annual Meeting
Potent Anti-neutrophil Properties of the Natural Compound 6-Gingerol in Models of Lupus and Antiphospholipid Syndrome
Ramadan Ali¹, Julia Weiner ¹, Alex Gandhi ¹, Shanea Estes ¹ and Jason Knight ², ¹University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI
Background/Purpose: 6-gingerol, the major bioactive compound of ginger root, is known to have anti-inflammatory and anti-oxidative effects. Indeed, ginger has been employed for millennia as…
Abstract Number: 81 • 2019 ACR/ARP Annual Meeting
UV Light Stimulates a Systemic Neutrophil Response Associated with Transient Kidney Injury
Sladjana Skopelja-Gardner¹, Joyce Tai ², Xizhang Sun ², Lena Tanaka ², Payton Hermanson ² and Keith Elkon ², ¹University of Washington, Seattle, WA, ²University of Washington, Seattle
Background/Purpose: Sensitivity to ultraviolet B (UVB) light affects ~70% of SLE patients and exacerbates both skin disease and systemic flares, including lupus nephritis (LN). Our…
Abstract Number: 118 • 2019 ACR/ARP Annual Meeting
Polymorphonuclear Neutrophils and Regulatory T Lymphocytes (Treg) Cooperate to Sustain Treg Activity but This Interaction Is Altered in Rheumatoid Arthritis Patients
Maxime Batignes ¹, François Santinon ¹, Marie-Christophe Boissier ², Patrice Decker ¹ and Natacha Bessis¹, ¹Inserm UMR 1125, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ²Assistance Publique-Hôpitaux de Paris (AP-HP), Rheumatology Department, Avicenne Hospital, Bobigny, France
Background/Purpose: Regulatory T cells (Treg) are necessary for immune homeostasis but are functionally deficient in inflammatory/autoimmune diseases such as rheumatoid arthritis (RA). On the other…
Abstract Number: 810 • 2019 ACR/ARP Annual Meeting
Small Vessel Vasculitis Syndrome with Autoinflammation Caused by De Novo Mutations in LYN Kinase
Adriana de Jesus¹, Gina Montealegre Sanchez ², Helen Freeman ³, Neil Martin ⁴, Ebun Omoyinmi ⁵, Katherine Calvo ⁶, Richard Chyi-chia Lee ⁷, Murray Passo ⁸, Natasha Ruth ⁸, David Kleiner ⁷, Yan Huang ⁹, Nirali Shah ¹⁰, Paul Brogan ¹¹, SuJin Hwang ¹², HyeSun Kuehn ¹², Sergio Rosenzweig ¹², Zuoming Deng ¹³, Anna Huttenlocher ¹⁴, Susan Moir ¹⁵, Douglas Kuhns ¹⁶ and Raphaela Goldbach-Mansky ¹⁷, ¹Translation Autoinflammatory Diseases Section/NIAID/NIH, Silver Spring, MD, ²Translational Autoinflammatory Disease Section/NIAID/NIH, Bethesda, ³Raigmore Hospital, Inverness, United Kingdom, ⁴Royal Hospital for Children, Glasgow, United Kingdom, ⁵University College London Institute of Child Health, London, United Kingdom, ⁶Hematology Service/Department of Laboratory Medicine/NIH, Bethesda, MD, ⁷Laboratory of Pathology/NCI/NIH, Bethesda, MD, ⁸Medical University of South Carolina, Charleston, SC, ⁹Translational Autoinflammatory Disease Section/NIAID/NIH, Bethesda, MD, ¹⁰Pediatric Oncology Branch/NCI/NIH, Bethesda, MD, ¹¹Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, ¹²Immunology Service/Department of Laboratory Medicine/NIH, Bethesda, MD, ¹³Biomining and Discovery Section/NIAMS/NIH, Bethesda, MD, ¹⁴Department of Pediatrics/University of Wisconsin, Madison, WI, ¹⁵Immunopathogenesis Section/NIAID/NIH, Bethesda, MD, ¹⁶Collaborative Clinical Research Branch/NIAID/NIH, Bethesda, MD, ¹⁷Translational Autoinflammatory Diseases Section/NIAID/NIH, Bethesda, MD
Background/Purpose: Lyn kinase is a member of the Src family of non-receptor tyrosine-protein kinases that modifies signals from various cell surface receptors and regulates innate…
Abstract Number: 1789 • 2019 ACR/ARP Annual Meeting
Defibrotide Inhibits Antiphospholipid Antibody-Mediated NET Release and Endothelial Cell Activation
Ramadan Ali¹, Hui Shi ¹, Srilakshmi Yalavarthi ¹ and Jason Knight ², ¹University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI
Background/Purpose: Defibrotide is a mixture of phosphodiester oligonucleotides derived from porcine intestinal mucosa, currently approved for treatment of hepatic sinusoidal obstruction syndrome. Defibrotide has been…
Abstract Number: 2733 • 2019 ACR/ARP Annual Meeting
Inhibition of Neutrophil Elastase Reduces Autoantibody Levels and Renal Inflammation in Murine Lupus
Gautam Sule¹, Kristen Gilley ¹, Andrew Fernandes ¹, Srilakshmi Yalavarthi ¹ and Jason Knight ², ¹University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI
Background/Purpose: Dysregulated neutrophil extracellular trap (NET) release has been proposed as a source of autoantigens in lupus. Furthermore, it has recently been shown that the…
Abstract Number: 152 • 2018 ACR/ARHP Annual Meeting
Polymorphonuclear Neutrophils and Regulatory T Lymphocytes (Treg) Cooperate to Sustain Treg Activity in Normal and Arthritic Contexts
Maxime Batignes¹, François Santinon¹, Marie-Christophe Boissier^2,3, Patrice Decker⁴ and Natacha Bessis¹, ¹INSERM UMR 1125 University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ²University of Paris 13,Sorbonne Paris Cité, Bobigny, France, ³Rheumatology Department, Assistance Publique – Hôpitaux de Paris (AP-HP), Avicenne Hospital, Bobigny, France, ⁴Inserm UMR 1125, Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France
Background/Purpose: Polymorphonuclear neutrophils (PMN) are abundant and activated in rheumatoid arthritis (RA) joints. In addition to their pro-inflammatory role, PMN exert immunoregulatory functions and may…
Abstract Number: 1456 • 2018 ACR/ARHP Annual Meeting
Neutrophil Activation Is Associated with Disease Activity and Predicts Development of Erosive Disease and Extra Articular Manifestations in Rheumatoid Arthritis
Mary Bach^1,2, Tiffany Pan³, J. Lee Nelson^3,4 and Christian Lood⁵, ¹VA Puget Sound Health Care System, Seattle, WA, ²Division of Rheumatology, University of Washington, Seattle, WA, ³Fred Hutchinson Cancer Research Center, Seattle, WA, ⁴Division of Rheumatology, University of Washington, SEATTLE, WA, ⁵Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Neutrophil activation is associated with inflammation and autoimmunity, including rheumatoid arthritis (RA), where neutrophil infiltration into joints participates in tissue destruction and development of…

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