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Abstracts tagged "neutrophils and systemic lupus erythematosus (SLE)"

  • Abstract Number: 92 • 2018 ACR/ARHP Annual Meeting

    Lupus Nephritis Serum Induces Neutrophil Chemotaxis Towards Glomerular Endothelial Cells in Vitro

    Dayvia Russell1, Margaret Markiewicz2, Xian Zhang2 and Jim C. Oates3, 1Research Service, Ralph H. Johnson VA Medical Center, Charleston, SC, 2Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 3Medical Service, Ralph H. Johnson VA Medical Center, Charleston, SC

    Title: Lupus Nephritis Serum Induces Neutrophil Chemotaxis towards Glomerular Endothelial Cells In Vitro Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease associated with…
  • Abstract Number: 1005 • 2018 ACR/ARHP Annual Meeting

    Regulation of Neutrophil Activation in Systemic Lupus Erythematosus

    Neelakshi R. Jog1, Teresa Aberle1, Eliza Chakravarty1, Cristina Arriens1, Joel M. Guthridge1, Melissa E. Munroe1 and Judith A. James2,3, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease characterized by immune dysfunction and autoantibody production. In addition to the adaptive immune system, neutrophils…
  • Abstract Number: 2116 • 2018 ACR/ARHP Annual Meeting

    Neutrophil Extracellular Trap Formation Is Dependent on Disease Activity in Systemic Lupus Erythematosus: Determination Using a Flow Cytometry-Based Assay

    Sen Hee Tay1, Olga Zharkova2, Hui Yin Lee3, Shubhita Tripathi4, Wei Yee Ong5, Aisha Lateef6, Paul MacAry7, Lina Lim2, John Edward Connolly8 and Anna-Marie Fairhurst3, 1Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Singapore, 2Physiology, National University of Singapore, Singapore, Singapore, 3Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore, 4National University of Singapore, Singapore, Singapore, 5Institute for Molecular and Cellular Biology, Agency for Science, Technology and Research, Singapore, Singapore, 6Medicine, Division of Rheumatology, National University Hospital of Singapore, Singapore, Singapore, 7Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore, 8Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore

    Background/Purpose: Neutrophil extracellular traps (NETs) are composed of decondensed DNA that is released during an active cell death program is known as NETosis.  To date,…
  • Abstract Number: 83 • 2017 ACR/ARHP Annual Meeting

    Whole Blood Stimulations Identify Elevated T Cell Cytokines and Altered Granulocyte/Dendritic Cell Signaling in SLE Patients with Variable Disease Activity

    Samantha Slight-Webb1, Krista M. Bean1, Holden T. Maecker2, Paul J. Utz3, Judith A. James4 and Joel M. Guthridge5, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 3Medicine, Stanford University School of Medicine, Stanford, CA, 4Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 5Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, OKC, OK

    Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by loss of immune tolerance to self-antigens and periods of waxing and waning disease. The clinical aspects of…
  • Abstract Number: 899 • 2017 ACR/ARHP Annual Meeting

    Neutrophil Gene Signature and Low Density Granulocyte Subsets Associate with Coronary Plaque Burden and Vascular Inflammation in Systemic Lupus Erythematosus

    Philip Carlucci1, Monica Purmalek1, Simantini Sakhardande1, Yenealem Temesgen-Oyelakin1, Amit K. Dey2, Aditya A. Joshi2, Joseph B. Lerman3, Alice Fike1, Michael Davis4, Hong-Wei Sun1, Jonathan H. Chung2, Martin P. Playford2, Pragnesh Mistry1, Gustavo Gutierrez-Cruz1, Stefania Dell'Orso1, Faiza Naz1, Heather Teague2, Zerai G. Manna5, Peter C. Grayson1, Mohammad Naqi1, Marcus Chen2, Sarfaraz A. Hasni1, Nehal N. Mehta2 and Mariana J. Kaplan1, 1NIH/NIAMS, Bethesda, MD, 2NIH/NHLBI, Bethesda, MD, 3NIH/CC, Bethesda, MD, 4NIH/NIAMS, Bethesda, IA, 5NIH/NIAMS, Bethesda, MD, Afghanistan

    Background/Purpose: Systemic lupus erythematosus (SLE) increases a young woman’s risk of myocardial infarction by up to 50-fold. This marked increase in cardiovascular disease (CVD) risk…
  • Abstract Number: 2641 • 2017 ACR/ARHP Annual Meeting

    Immune Complex-Driven Neutrophil Activation in Systemic Lupus Erythematosus – Novel Biomarkers of Disease Activity and Severity

    Hsin-Hsuan Juo1, Edward Chiou2, Keith B. Elkon3 and Christian Lood4, 1Rheumatology, University of Washington, Seattle, WA, 2University of Washington, Seattle, WA, 3Department of Medicine & Immunology, University of Washington, Seattle, WA, 4Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: Neutrophil activation is linked to inflammation and autoimmune diseases, including systemic lupus erythematosus (SLE) where nucleic acid-containing immune complexes (ICs) drive inflammation through engagement…
  • Abstract Number: 2828 • 2017 ACR/ARHP Annual Meeting

    A Graph-Theoretic-Approach Applied to Modular-Repertoire-Analysis Identifies Shared Gradual Whole Blood Interferon Signatures in Systemic Lupus Erythematosus and Primary Sjögren’s Syndrome Patients and Reveals New Interferon-Related Modules in Disease Progression

    Ilya Korsunski1, Noémie Jourde-Chiche2, Peter Gregersen3, Damien Chaussabel4, Laurent Chiche5 and Naomi I. Maria6, 1Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 2Nephrology, AP-HM, Department of Nephrology, CHU Conception, Marseille, France, 3Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institute for Med Res, Manhasset, NY, 4Translational Medicine, Sidra Medical and Research Center, Doha, Qatar, 5Internal medicine, Hopital europeen, Marseille, France, 6Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose: There is significant clinical and molecular heterogeneity among patients suffering from systemic autoimmune diseases, such as systemic lupus erythematosus (SLE) and primary Sjögren’s Syndrome…
  • Abstract Number: 1825 • 2016 ACR/ARHP Annual Meeting

    the Non-Coding Genome and the Genetics of Systemic Lupus

    Joyce Hui-Yuen1, Lisha Zhu2, Lai Ping Wong3, Kaiyu Jiang4, Yanmin Chen4, Tao Liu5 and James Jarvis6, 1North Shore-Long Island Jewish Health System, Lake Success, NY, 2Biochemistry, University at Buffalo, Buffalo, NY, 3Pediatrics, University at Buffalo, Buffalo, NY, 4Pediatrics, The University at Buffalo, Buffalo, NY, 5Department of Biochemistry, University at Buffalo, Buffalo, NY, 6Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY

    Background/Purpose:  Systemic lupus erythematosus (SLE) is a multi-system, complex disease believed to be triggered by gene-environment interactions. While we have made considerable progress in investigation…
  • Abstract Number: 1831 • 2016 ACR/ARHP Annual Meeting

    A Novel Graph Theoretic Approach Applied to Modular Repertoire Analysis Identifies a Dual Molecular Progression in Adult SLE Patients, with Distinct Interferon and Neutrophil Transcription Patterns

    Ilya Korsunski1, Noémie Jourde-Chiche2,3, Peter K. Gregersen1, Damien Chaussabel4, Laurent Chiche5 and Naomi I Maria6, 1Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, 2Vascular Research Center of Marseille, Aix-Marseille Univ., Vascular Research Center of Marseille, Marseille, France, 3Nephrology, AP-HM, Department of Nephrology, CHU Conception, Marseille, France, 4Translational Medicine, Sidra Medical and Research Center, Doha, Qatar, 5internal medicine, Hopital Europeen, Marseille, France, 6Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose:  Gene expression studies support a pivotal role for type I interferon (IFN) in SLE. Previous work using a modular repertoire analysis based on co-clustered…
  • Abstract Number: 2853 • 2016 ACR/ARHP Annual Meeting

    Neutrophilia in Systemic Lupus Erythematosus As a Potential Indicator of Disease Activity

    Emily E. Lewis1, W Joseph McCune2 and Jason S Knight3, 1University of Michigan, Ann Arbor, MI, 2Int Med/ Rheum, University of Michigan, Ann Arbor, MI, 3Division of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose:  Neutrophilia and elevated neutrophil-to-lymphocyte ratio are being increasingly recognized as reliable markers of inflammation (and usually negative prognostic outcome) in scenarios as diverse as…
  • Abstract Number: 2073 • 2015 ACR/ARHP Annual Meeting

    Mitochondrial ROS Is a Novel Regulator of Sting-Mediated Type I IFN Production By Governing Extrusion of Oxidized Mitochondrial DNA upon Neutrophil Extracellular Trap Formation.

    Christian Lood1, Luz P. Blanco2, Monica Purmalek3, Carolyne K. Smith3, Carmelo Carmona-Rivera3, Jeffrey Ledbetter4, Mariana J. Kaplan2 and Keith B. Elkon5, 1Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 2Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 3Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 4University of Washington, Seattle, WA, 5Division of Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: Neutrophil extracellular trap generation (NETosis) is a reactive oxygen species (ROS)-dependent cell death pathway implicated in autoimmune disorders such as systemic lupus erythematosus (SLE).…
  • Abstract Number: 1619 • 2014 ACR/ARHP Annual Meeting

    Interferon Dysregulation in an Academic SLE Cohort Is Associated with Distinct Signaling Differences in Blood Neutrophils Versus PBMCs

    David Drubin1, Xiang Guo2, Linglin Yang3, Rong Zeng3, Yuling Wu3, Mustimbo EliPollard Roberts3, Reynald Lescarbeau1, Aaron Van Hooser1, Michael Macoritto1, Michelle Petri4 and Wendy White5, 1Selventa, Cambridge, MA, 2Translational Sciences, MedImmune LLC, Gaithersburg, MD, 3MedImmune LLC, Gaithersburg, MD, 4Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 5Translational Sciences, MedImmune, Gaithersburg, MD

    Background/Purpose Interferons (IFNs) have long been implicated in the pathogenesis of systemic lupus erythematosus (SLE). However, the specific consequences of the IFN activity have not…
  • Abstract Number: 1877 • 2013 ACR/ARHP Annual Meeting

    A Neutrophil Signature Comprised Of Low Density Granulocyte (LDG)-Enriched Genes Is Associated With Organ-Specific Disease Activity In Systemic Lupus Erythematosus

    Michelle Petri1, Hong Fang1, Jadwiga Bienkowska2, Andrea Dearth3, Norm Allaire4 and Ann Ranger3, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Translational Medicine, Biogen Idec Inc., Cambridge, MA, 3Biogen Idec Inc, Cambridge, MA, 4Biogen Idec Inc., Cambridge, MA

    Background/Purpose: The neutrophil gene signature (NGS) has recently gained interest due to new understanding of the role of neutrophils and NETosis in SLE pathogenesis. We…
  • Abstract Number: 1626 • 2013 ACR/ARHP Annual Meeting

    Genetic Alterations In Abnormal Neutrophils Isolated From Human Systemic Lupus Erythematosus Patients

    Namrata Singh1, Kayla Martin2, Mariana J. Kaplan3, Philip L. Cohen4 and Michael F. Denny5, 1Internal Medicine, Temple University, Philadelphia, PA, 2Microbiology and Immunology, Temple University, Philadelphia, PA, 3Systemic Autoimmunity Branch, National Institutes of Health/NIAMS, Bethesda, MD, 4Rheumatology, Temple University School of Medicine, Philadelphia, PA, 5Rheumatology, Temple University, Philadelphia, PA

    Background/Purpose: Human SLE patients have an abnormal population of neutrophils called low density granulocytes (LDGs). LDGs express the surface markers of mature neutrophils, yet their…
  • Abstract Number: 882 • 2013 ACR/ARHP Annual Meeting

    Association Of a Neutrophil Gene Signature Comprised Of Low Density Granulocyte (LDG)-Enriched Genes With Both Future Systemic Lupus Erythematosus Disease Activity and Poor Longterm Outcomes

    Michelle Petri1, Laurence S. Magder2, Hong Fang1, Jadwiga Bienkowska3, Andrea Dearth4, Norm Allaire5 and Ann Ranger4, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, 3Translational Medicine, Biogen Idec Inc., Cambridge, MA, 4Biogen Idec Inc, Cambridge, MA, 5Biogen Idec Inc., Cambridge, MA

    Background/Purpose: Neutrophils and neutrophil death (NETosis) have a role in the pathogenesis of SLE. A neutrophil gene signature (NGS) exists in SLE, although its association…
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