ACR Meeting Abstracts

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Abstracts tagged "neutrophils and rheumatoid arthritis (RA)"

  • Abstract Number: 2044 • 2018 ACR/ARHP Annual Meeting

    Impaired microRNA Processing in Neutrophils from Rheumatoid Arthritis Patients Confers Their Pathogenic Profile. Modulation By Biological Therapies

    Ivan Arias de la Rosa1, Patricia Ruiz-Limon1, Carlos Perez-Sanchez2, Maria Carmen Abalos-Aguilera1, Yolanda Jiménez-Gómez2, Irene Cecchi3, Rafaela Ortega-Castro2, Miguel Angel Caracuel-Ruiz4, Jerusalem Calvo-Gutierrez2, Alejandro Escudero-Contreras1, Eduardo Collantes-Estévez2, Chary Lopez-Pedrera4 and Nuria Barbarroja2, 1Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, 4IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain

    Background/Purpose: Neutrophils are the most abundant cells in synovial fluid, having all the features of activated cells in rheumatoid arthritis (RA), including prolonged cell survival,…
  • Abstract Number: 485 • 2017 ACR/ARHP Annual Meeting

    Different Citrullination Profiles in Spontaneous Versus Leukemia-Associated Rheumatoid Arthritis

    Tal Gazitt1, Son Hong Nguyen2, Ari Salinger2, Christian Lood3, Xizhang Sun1, Lena M. Tanaka1, David Feith4, Jeffrey Ledbetter5, Gordon Starkebaum6, Thomas Loughran Jr.7, Paul R. Thompson2 and Keith B. Elkon8, 1Division of Rheumatology, University of Washington, Seattle, WA, 2Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, 3Division of Rheumatology, Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, 4Hematology and Oncology, University of Virginia, Charlottesville, VA, 5University of Washington, Seattle, WA, 6Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 7Hematology Oncology, University of Virginia, Charlottesville, VA, 8Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA

    Background/Purpose: Protein citrullination, the post-translational conversion of arginine to citrulline, mediated by peptidylarginine deiminase (PAD) enzymes, is considered a likely mechanism for the stimulation of…
  • Abstract Number: 2917 • 2017 ACR/ARHP Annual Meeting

    Neutrophil Activation in Rheumatoid Arthritis – Potential Biomarkers of Disease Activity and Severity

    Mary Bach1, Daniel Moon2, Marcel Bach2, Marcus Bach2 and Christian Lood3, 1VA Puget Sound Health Care System, Seattle, WA, 2University of Washington, Seattle, WA, 3Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: Neutrophil activation is associated with inflammation and autoimmunity, including rheumatoid arthritis (RA), where neutrophil infiltration to joints participates in tissue destruction and development of…
  • Abstract Number: 2709 • 2015 ACR/ARHP Annual Meeting

    Immediate  Release of Peripheral Neutrophil Myeloperoxidase and Elastase and Formation of Extracellular Traps to Cigarette Smoking in Rheumatoid Arthritis

    Juliane Franz1, Stavros Giaglis1,2, Guenther Schaefer3, Erik Deman1, Andreas Thueler4, Sinuhe Hahn2 and Paul Hasler1, 1Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, 2Biomedicine, Laboratory of Prenatal Medicine, University Hospital Basel, Basel, Switzerland, 3Dept. of Biomedicine, Laboratory of Prenatal Medicine, University Hospital Basel, Basel, Switzerland, 4Rheumatology, Kantonsspital Baden, Baden, Switzerland

    Background/Purpose: Smoking represents an independent risk factor for rheumatoid arthritis (RA) (1). In response to infectious agents, neutrophil granulocytes can extrude their nuclear contents as…
  • Abstract Number: 1467 • 2014 ACR/ARHP Annual Meeting

    Do G-CSF and Neutrophils Contribute to the Pathophysiology of Rheumatoid Arthritis?

    Gabrielle Goldberg1, Simon Chatfield2,3, Jane Murphy1, Ee Shan Pang1, Yunshun Chen4, Gordon Smyth4, Milica Ng5, Michael Wilson5, Clare O'Neill3, Samantha Busfield5, Arna Andrews5 and Ian P. Wicks3,6,7, 1Inflammation Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, 2Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, 3Rheumatology, The Royal Melbourne Hospital, Melbourne, Australia, 4Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, 5Research, CSL Limited, Melbourne, Australia, 6Inflammation, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, 7Medical Biology, The University of Melbourne, Melbourne, Australia

    Background/Purpose Rheumatoid arthritis (RA) is characterised by a persistent, but poorly understood interplay between innate and adaptive immunity. Neutrophils are the predominant cell type in…
  • Abstract Number: 1061 • 2012 ACR/ARHP Annual Meeting

    Generation of Myeloid-Derived Suppressor Cells in Vitro From Murine Bone Marrow Precursors

    Julia Kurko1, Beata Tryniszewska1, Tibor A. Rauch1, Colt Egelston2, Tibor T. Glant1 and Katalin Mikecz1, 1Orthopedic Surgery, Rush University Medical Center, Chicago, IL, 2Immunology, Rush University Medical Center, Chicago, IL

    Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are innate immune cells that expand under pathological conditions (such as cancer and autoimmune diseases) in response to local growth…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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