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Abstracts tagged "neuropsychiatric disorders and systemic lupus erythematosus (SLE)"

  • Abstract Number: 709 • 2018 ACR/ARHP Annual Meeting

    Differential Characteristics of Lupus Psychosis and Steroid Psychosis

    Shunsei Hirohata1,2,3, Yoshinori Kanai4, Akiko Mitsuo5, Yoshiaki Tokano4 and Hiroshi Hashimoto4, 1Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 2Nobuhira Hospital, Tatsuno, Japan, 3Kitasato University School of Medicine, Sagamihara, Japan, 4Juntendo University School of Medicine, Tokyo, Japan, 5Rheumatology, National Hospital Organization Disaster Medical Center, Tokyo, Japan

    Background/Purpose: Psychiatric manifestations are relatively common in patients with systemic lupus erythematosus (SLE).  Since there are a number of factors causing psychiatric manifestations other than…
  • Abstract Number: 731 • 2018 ACR/ARHP Annual Meeting

    Clinical Characteristics and Neurophysiological Patterns of Peripheral Neuropathies in Patients with Systemic Lupus Erythematosus: A Single Center Experience

    Francisco Treviño-Tello1, Erwin Chiquete2, Christopher Cabib2, Ariadna Díaz-Mora1, Mariana Lopez-Lopez1, Ivonne Sandoval-Flores1, Juan José Gómez-Piña2 and Hilda Fragoso-Loyo1, 1Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 2Neurology and Neuropsychiatry, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico

    Background/Purpose: The prevalence of peripheral neurological manifestations in Systemic Lupus Erythematosus (SLE) ranges between 5% and 27% and are a major cause of morbidity. The…
  • Abstract Number: 900 • 2017 ACR/ARHP Annual Meeting

    Choroid Plexus Tertiary Lymphoid Structures in Lupus: A Novel Neuro-Immune Interface

    Ariel Stock1, Evan Der2, Sivan Gelb3, Ayal Ben-Zvi3 and Chaim Putterman4, 1Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, 2Albert Einstein College of Medicine, Bronx, NY, 3Hebrew University, Jerusalem, Israel, 4Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY

    Background/Purpose: The central nervous system (CNS) manifestations of SLE remain poorly understood. Although potentially neuropathic autoantibodies have been identified in the serum, lupus patients show…
  • Abstract Number: 2649 • 2017 ACR/ARHP Annual Meeting

    Anti-Suprabasin Antibody; A Novel Autoantibody May Contribute to the Pathogenesis of Neuropsychiatric Systemic Lupus Erythematosus

    Kunihiro Ichinose1, Kaname Ohyama2, Kaori Furukawa1, Osamu Higuchi3, Shunya Nakane4, Masataka Umeda1, Tomohiro Koga1, Takashi Igawa1 and Atsushi Kawakami1, 1Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 2Course of Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 3Department of Clinical Research, Nagasaki Kawatana Medical Center, Nagasaki, Japan, 4Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

    Background/Purpose: Systemic lupus erythematosus (SLE), an autoimmune disorder characterized by the production of pathogenic autoantibodies and inflammatory mediators, involves multiple organ systems. Neuropsychiatric systemic lupus…
  • Abstract Number: 691 • 2017 ACR/ARHP Annual Meeting

    Serum Anti-NR2 Has a Better Specificity Than Sensitivity in Diagnosing Neuropsychiatric Systemic Lupus Erythematosus (NPSLE)

    Seyed-Foad Ahmadi1, Golara Zahmatkesh2, Masoud Majed3 and Sheetal Desai4, 1Department of Medicine, University of California Irvine, Orange, CA, 2Department of Psychiatry, Charles Drew University of Medicine and Science/UCLA, Los Angeles, CA, 3Division of Neuroimmunology, Mayo Clinic, Rochester, MN, 4Medicine/Rheumatology, Unviersity of California, Irvine, Orange, CA

    Background/Purpose: Anti-NR2, a subclass of anti-NMDA receptor antibodies, is reportedly associated with NPSLE syndromes. However, its diagnostic accuracy is inconsistent across prior studies. Hence, we…
  • Abstract Number: 717 • 2017 ACR/ARHP Annual Meeting

    Risk Factors for Neuropsychiatric Systemic Lupus Erythematosus and Its Recurrence

    Ryusuke Anan, Yuko Kaneko, Jun Kikuchi and Tsutomu Takeuchi, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: Neuropsychiatric involvement in systemic lupus erythematosus (NPSLE) is the leading cause of morbidity and mortality in patients with SLE but not well understood. The…
  • Abstract Number: 1773 • 2016 ACR/ARHP Annual Meeting

    Risk Factors for Cerebrovascular Events in Systemic Lupus Erythematosus: Results from an International, Inception Cohort Study

    John G Hanly1, Qiuju Li2, Li Su3, Murray Urowitz4, Juanita Romero-Diaz5, Caroline Gordon6, Sang-Cheol Bae7, Sasha Bernatsky8, Ann E. Clarke9, Daniel J Wallace10, Joan T. Merrill11, David A. Isenberg12, Anisur Rahman13, Ellen M. Ginzler14, Paul R. Fortin15, D Gladman16, Jorge Sanchez-Guerrero17, Michelle Petri18, Ian N. Bruce19, Mary Anne Dooley20, Rosalind Ramsey-Goldman21, Cynthia Aranow22, Graciela S. Alarcon23, Kristján Steinsson24, Gunnar K. Sturfelt25, Ola Nived26, Susan Manzi27, M Khamashta28, Ronald F. van Vollenhoven29, Asad Zoma30, Guillermo Ruiz-Irastorza31, S. Sam Lim32, Murat Inanc33, Kenneth C. Kalunian34, Diane L. Kamen35, Christine A. Peschken36, Søren Jacobsen37, Anca Askanase38, Chris Theriault39, Vernon Farewell40 and Manuel Ramos-Casals41, 1Division of Rheumatology, Department of Medicine and Department of Pathology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada, 2MRC Biostatistics Unit, Cambridge, United Kingdom, 3Nova Scotia Rehab Site, Division of Rheumatology, Capital Health and Dalhousie University, Halifax, NS, Canada, 4Medicine, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, 5Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, 6NIHR/Wellcome Trust Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, 7Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of, 8Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, 9Division of Rheumatology, University of Calgary, Calgary, AB, Canada, 10Cedars-Sinai Medical Center, West Hollywood, CA, 11Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 12Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom, 13Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, 14Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY, 15Rheumatology, University of Laval, Quebec, QC, Canada, 16University of Toronto, Toronto, ON, Canada, 17Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, 18Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD, 19NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, 20Dooley Rheumatology, Chapel Hill Doctors, Chapel Hill, NC, 21FSM, Northwestern University, Chicago, IL, 22Molecular Medicine and Medicine, Hofstra Northwell School of Medicine, Hempstead, NY, 23Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 24Rheumatology, Univ. Hospital, Reykjavik, Iceland, 25Department of Rheumatology, Univ Hospital Lund, Lund, Sweden, 26Department of Rheumatology, University Hospital, Lund, Sweden, 27Lupus Center of Excellence, West Penn Allegheny Health System, Pittsburgh, PA, 28Lupus Research Unit, Lupus Research Unit, The Rayne Institute, King's College London School of Medicine, St Thomas' Hospital, London, United Kingdom, 29Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, 30Rheumatology, Hairmyres Hospital, East Kilbride, Great Britain, 31Universidad del Pais Vasco, Servicio de Medicina Interna, Hospital de Cruces, Bizkaia, Spain, 32Medicine, Emory University School of Medicine, Atlanta, GA, 33Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 34Division of Rheumatology, Allergy & Immunology, UCSD School of Medicine Center for Innovative Therapy, La Jolla, CA, 35Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, 36RR 149G, Univ of Manitoba, Winnipeg, MB, Canada, 37Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, 38Rheumatology, Columbia University Medical Center, New York, NY, 39Medicine, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada, 40Medicine, Division of Rheumatology, Capital Health and Dalhousie University, Halifax, NS, Canada, 41Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Spain, Barcelona, Spain

    Background/Purpose: Neuropsychiatric (NP) disease in patients with SLE includes cerebrovascular events (CerVE). We determined the frequency, attribution and risk factors for CerVE in a large,…
  • Abstract Number: 1781 • 2016 ACR/ARHP Annual Meeting

    Analysis of Influences of Various Factors on the Prognosis of Acute Confusional State of Diffuse Psychiatric/Neuropsychological Syndromes in Systemic Lupus Erythematosus

    Gakuro Abe1, Yoshiyuki Arinuma1, Hirotoshi Kikuchi2 and Shunsei Hirohata1, 1Kitasato University School of Medicine, Sagamihara, Japan, 2Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan

    Background/Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE), especially diffuse psychiatric/neuropsychological syndromes (diffuse NPSLE), is one of the most difficult complications of the disease. For the evaluation…
  • Abstract Number: 2808 • 2016 ACR/ARHP Annual Meeting

    Role of Serum Autoantibodies in Blood Brain Barrier Damages in Neuropsychiatric Systemic Lupus Erythematosus

    Shunsei Hirohata1, Yuko Sakuma2, Tamiko Yanagida3 and Taku Yoshio4, 1Kitasato University School of Medicine, Sagamihara, Japan, 2Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, 3Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 4Jichi Medical University, Tochigi, Japan

    Background/Purpose: Neuropsychiatric manifestation in systemic lupus erythematosus (NPSLE) is one of the most serious complications of the disease. We have recently demonstrated that the breakdown…
  • Abstract Number: 2819 • 2016 ACR/ARHP Annual Meeting

    Clinical Utility of Anti-Aquaporin 4 Antibody Measurement in Patients with Neuropsychiatric Systemic Lupus Erythematosus with Neuromyelitis Optica Spectrum Disorder Manifestations

    Simone Mader1, Yoshiyuki Arinuma1, Venkatesh Jeganathan1, Yuichiro Fujieda2, Irena Dujmovi3, Jelen Drulovic3, Yuko Sakuma4, Shinsuke Yasuda5, Joel Stern6, Cynthia Aranow6, Meggan Mackay7, Tatsuya Atsumi5, Shunsei Hirohata8 and Betty Diamond9, 1Center of Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Manhasset, NY, 2Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 3Clinical Centre of Serbia University School of Medicine, Belgrade, Serbia, 4Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, 5Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 6The Feinstein Institute for Medical Research, Manhasset, NY, 7Autoimmune & Musculoskeletal Disorders, The Feinstein Institute for Medical Research, Manhasset, NY, 8Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, 9Autoimmune & Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose:  Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by the presence of autoantibodies. Among the complications of SLE, neuropsychiatric manifestations (NPSLE) can…
  • Abstract Number: 2826 • 2016 ACR/ARHP Annual Meeting

    Clinical Utility of Circulating Anti-N-Methyl-D-Aspartate Receptor Subunits NR2A/B Antibody for the Diagnosis of Neuropsychiatric Syndromes in Systemic Lupus Erythematosus and Sjogren’s Syndrome: An Updated Meta-Analysis

    Sen Hee Tay1, Anna-Marie Fairhurst2 and Anselm Mak1, 1Division of Rheumatology, Department of Medicine, National University Hospital, National University Health System, Singapore, Singapore, Singapore, 2Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore

    Background/Purpose: Neuropsychiatric (NP) events are found in patients with rheumatic diseases, commonly in systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). The standard nomenclature and…
  • Abstract Number: 2856 • 2016 ACR/ARHP Annual Meeting

    Serum C5a Is Elevated in Lupus Nephritis and in Neuropsychiatric Systemic Lupus Erythematosus through Different Mechanisms

    Yuko Sakuma1, Tatsuo Nagai2, Taku Yoshio3 and Shunsei Hirohata4, 1Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, 2Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan, 3Jichi Medical University, Tochigi, Japan, 4Kitasato University School of Medicine, Sagamihara, Japan

    Background/Purpose: Neuropsychiatric manifestation in systemic lupus erythematosus (NPSLE) is one of the most serious complications of the disease. We have recently demonstrated that the breakdown…
  • Abstract Number: 387 • 2015 ACR/ARHP Annual Meeting

    Features of 847 Childhood-Onset Systemic Lupus Erythematousus Patients in Three Age-Related Groups at Diagnosis: A Brazilian Multicenter Study

    Clovis A Silva1, Roberta C. Gomes Sr.2, Marco F. Silva3, Katia T. Kozu4, Eloisa Bonfá5, Rosa M R Pereira6, Maria Teresa Terreri7, Claudia S. Magalhães Sr.8, Silvana B. Sacchetti Sr.9, Roberto Marini Sr.10, Melissa Fraga11, Luciana M. Carvalho Sr.12, Cássia M. Barbosa13 and Magda Carneiro-Sampaio Sr.14, 1Pediatric Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, 2Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 3Pediatric Rheumatology Unit-Children’s Institute,, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, 4Pediatrics, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, 5Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 6Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 7Pediatrics, Universidade Federal de Sao Paulo, São Paulo, Brazil, 8Pediatric Rheumatology Unit, São Paulo State University – Faculdade de Medicina de Botucatu, São Paulo, Brazil, 9Pediatric Rheumatology Unit, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil, 10Pediatric Rheumatology Unit, State University of Campinas, São Paulo, Brazil, 11Pediatrics, Universidade Federal de São Paulo / UNIFESP, São Paulo, Brazil, 12Pediatric Rheumatology Unit, Ribeirão Preto Medical School – University of São Paulo, São Paulo, Brazil, 13Pediatric Rheumatology Unit, Hospital Infantil Darcy Vargas, São Paulo, Brazil, 14Pediatric Allergology and Immunology Unit, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: Previous retrospective evaluations suggested that age at diagnosis may influence disease expression in terms of initial clinical presentation, pattern of organ involvement and serological…
  • Abstract Number: 761 • 2015 ACR/ARHP Annual Meeting

    Neurometabolic Alterations in Korean Lupus Patients with Chronic Daily Headache

    Ji-Min Kim1, Tae-Han Lee1, Chang-Nam Son1, Sung Soo Kim2, Hyuk Won Chang3 and Sang-Hyon Kim1, 1Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Ulsan University School of Medicine, GangNeung Asan Hospital, Gangneung, South Korea, 3Department of Radiology, Keimyung University School of Medicine, Daegu, South Korea

    Background/Purpose: Neuropsychiatric systemic lupus erythematosus (SLE) includes a broad spectrum of neurologic and psychiatric manifestations. One of the most commonly observed neuopsychiatric symptoms is headache.…
  • Abstract Number: 2951 • 2015 ACR/ARHP Annual Meeting

    Anti-NR2 Antibody and Blood-Brain Barrier Disruption in Systemic Lupus Erythematosus Patients with Cognitive Dysfunction

    Gaurav Gulati1, Philip Iffland2, Damir Janigro2, Bin Zhang3 and Michael Luggen4, 1Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, OH, 2Cleveland Clinic Lerner College of Medicine, Cleveland, OH, 3Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, 4Division of Immunology, University of Cincinnati Medical Center, Cincinnati, OH

    Background/Purpose: Cognitive Dysfunction (CD) is one of the most common manifestations of neuropsychiatric SLE (NPSLE) and one of the most devastating. The pathogenesis of CD…
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