Abstracts tagged "Nephritis"

Abstract Number: 2678 • 2012 ACR/ARHP Annual Meeting
Novel Nuclear Export Inhibitors Deplete Autoreactive Plasma Cells and Protect Mice with Lupus-Like Disease From Nephritis
Teresa Owen¹, Wensheng Wang¹, Dilara McCauley², Laura Strojny¹, Jennifer Hossler¹, Javier Rangel-Moreno³, Michael Kauffman², Sharon Shacham⁴ and Jennifer H. Anolik⁵, ¹Medicine- Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, ²Karyopharm, Therapeutics Inc., Natick, MA, ³Medicine- Allergy, Immunology, and Rheumatology, University of Rochester, Rochester, NY, ⁴Karyopharm Therapeutics Inc., Natick, MA, ⁵Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Most therapies currently used to treat systemic lupus erythematosus (SLE) and B cell targeted therapies under development do not effectively target plasma cells and…

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Abstracts tagged "Nephritis"

Novel Nuclear Export Inhibitors Deplete Autoreactive Plasma Cells and Protect Mice with Lupus-Like Disease From Nephritis