ACR Meeting Abstracts

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Abstracts tagged "Nephritis"

  • Abstract Number: 0988 • ACR Convergence 2020

    Two-Year Results from a Randomized, Controlled Study of Obinutuzumab for Proliferative Lupus Nephritis

    Richard Furie1, Gustavo Aroca2, Analia Alvarez3, Hilda Fragoso-Loyo4, Elizabeth Zuta Santillan5, Brad Rovin6, Paul Brunetta7, Thomas Schindler8, Imran Hassan9, Matthew Cascino10, Jay Garg10 and Ana Malvar11, 1Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, 2Simon Bolivar University y Clinica de la Costa, Barranquilla, Colombia, 3CEMIC, Buenos Aires, Argentina, 4Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 5Instituto de Ginecología y Reproducción, Lima, Peru, 6The Ohio State University, Columbus, 7Genentech, Inc., South San Francisco, 8F. Hoffmann-La Roche Ltd., Basel, Switzerland, 9Hoffmann-La Roche Ltd, Mississauga, Canada, 10Genentech, Inc., South San Francisco, CA, 11Organizacion Medica de Investigacion, Buenos Aires, Argentina

    Background/Purpose: NOBILITY demonstrated improved renal responses and complete B-cell depletion with the humanized type II anti-CD20 monoclonal antibody obinutuzumab (OBI) compared with placebo (PBO) through…
  • Abstract Number: 1673 • ACR Convergence 2020

    Principles of Pediatric Lupus Nephritis in a Contemporary Multi-Center Cohort

    Kathleen Vazzana1, Ankana Daga2, Beatrice Goilav3, Ekemini Ogbu4, Daryl Okamura5, Catherine Park6, Rebecca Sadun7, Emily Smitherman8, Brian Stotter9, Scott Wenderfer10 and Laura Lewandowski11, 1National Institute of Health/Children's National Hospital, Washington, DC, 2Harvard, Boston, MA, 3The Children’s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, 4Johns Hopkins University, Baltimore, MD, 5Seattle's Children's, Seattle, WA, 6Emory University, Atlanta, GA, 7Duke University, Durham, NC, 8University of Alabama at Birmingham, Birmingham, AL, 9Washington University School of Medicine, St. Louis, MO, 10Renal Section, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, 11NIAMS, NIH, Rockville, MD

    Background/Purpose: Lupus nephritis (LN) is a well-established and life-threatening manifestation of systemic lupus erythematosus (SLE) that is more common in children than adults. The demographics…
  • Abstract Number: 1807 • ACR Convergence 2020

    The Extent of Tubulointerstitial Inflammation in Lupus Nephritis Identifies Two Distinctive Subgroups: Impact on Inflammation Characteristics and Prognosis in Patients with Lupus Nephritis

    Sang Jin Lee1, Eon Jeong Nam1, Man-Hoon Han2 and Yong Jin Kim2, 1Department of Internal Medicine, Kyungpook National University Hospital,, Daegu, Republic of Korea, 2Department of Pathology, Kyungpook National University Hospital,, Daegu, Republic of Korea

    Background/Purpose: Lupus nephritis is common clinical manifestation and contributes significantly to mortality in systemic lupus erythematosus (SLE). Recently several studies has been reported that severity of…
  • Abstract Number: 1836 • ACR Convergence 2020

    Alternative Renal Response Definitions in a Randomized, Controlled Trial of Obinutuzumab for Proliferative Lupus Nephritis

    Zahir Amoura1, Philippe Remy2, Luis Fernando Quintana Porras3, Laurent Chiche4, Dominique Chauveau5, Dario Roccatello6, Richard Furie7, Thomas Schindler8, Jay Garg9, Matthew Cascino9, Brad Rovin10 and Andrea Doria11, 1Hôpital Pitié-Salpêtrière, Paris, 2APHP Groupe Hospitalier Henri-Mondor, Creteil, France, 3Hospital Clinic de Barcelona, Barcelona, Catalonia, Spain, 4Hôpital Européen, Marseille, France, 5Hôpital Rangueil, Centre Hospitalier Univ de Toulouse, Toulouse, France, 6S Giovanni Hospital, Univ of Turin, Turin, Italy, 7Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, 8F. Hoffmann-La Roche Ltd., Basel, Switzerland, 9Genentech, Inc., South San Francisco, CA, 10The Ohio State University, Columbus, 11University of Padua, Padua, Italy

    Background/Purpose: Obinutuzumab, a type II anti-CD20 mAb, resulted in rapid and complete B-cell depletion and improved renal responses in proliferative lupus nephritis (LN) in the…
  • Abstract Number: 0035 • ACR Convergence 2020

    Distinct Biological Pathways in Both Blood and Kidney Further Define Molecular Profiles Across Diverse Nephritides

    Loqmane Seridi1, Matteo Cesaroni1, Qingxuan Song2, Ashley Orillion1, Frédéric Baribaud1, Tatiana Ort1, Sheng Gao2, Tomas Parker3, James Chevalier3, Dan Levine3, Alan Perlman3 and Jarrat Jordan1, 1Janssen Research & Development, LLC, Spring House, PA, 2Janssen Research & Development, LLC, Spring House, PA, USA, Spring House, PA, 3The Rogosin Institute, New York Presbyterian Hospital-Weill Medical College of Cornell University New York, NY, USA., New York, NY

    Background/Purpose: Approximately 40% of SLE patients will develop Lupus Nephritis (LN), of which 10-30 % will progress to end-stage renal disease. To further understand LN…
  • Abstract Number: 0257 • ACR Convergence 2020

    Application of Text Mining Methods to Identify Lupus Nephritis from Electronic Health Records

    Milena Gianfrancesco1, Suzanne Tamang2, Gabriela Schmajuk3 and Jinoos Yazdany4, 1University of California, San Francisco, San Francisco, CA, 2Stanford Center for Population Health Sciences, Redwood City, CA, 3University of California, San Francisco, Atherton, CA, 4UCSF, San Francisco, CA

    Background/Purpose: Lupus nephritis (LN) is a frequent complication of SLE and associated with higher morbidity and mortality. Accurate estimates of the prevalence of LN in…
  • Abstract Number: 0261 • ACR Convergence 2020

    Predictors of Future Repeat Renal Biopsies in Patients with Lupus Nephritis and Influence of Repeat Biopsy in Flare Management: A Retrospective Study

    Rosalba Santana-Flores1, Anitha Ramu1, Hana Rajevac2 and Belinda Jim3, 1Jacobi Medical Center at Albert Einstein College of Medicine, BRONX, NY, 2James J Peters Medical Center, NEW YORK, NY, 3Jacobi Medical Center at Albert Einstein College of Medicine, New Hyde Park, NY

    Background/Purpose: Repeat renal biopsies are considered in patients with Lupus Nephritis (LN) flares or with failure of response to treatment. The influence of repeat renal…
  • Abstract Number: 0303 • ACR Convergence 2020

    SLE Patients Stratify into Distinct Clusters Based on Their Peripheral Blood Immunologic Phenotype During Acute Flare

    Kieran Manion1, Carolina Munoz-Grajales2, Michael Kim3, Kirubel Goliad4, Dennisse Bonilla5, Dafna Gladman1, Murray Urowitz6, Zahi Touma7 and Joan Wither5, 1Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 2University of Toronto-UHN, Toronto, ON, Canada, 3Krembil Research Insitute, Toronto, ON, Canada, 4University of Toronto-UHN, Toronto, Canada, 5University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, 6University Health Network, University of Toronto, Toronto, ON, Canada, 7University of Toronto, Toronto, ON, Canada

    Background/Purpose: SLE is a chronic autoimmune disease in which periods of quiescence are interspersed with acute flares of disease activity that produce much of the…
  • Abstract Number: 0497 • ACR Convergence 2020

    Interleukin-23 Acts Directly on Podocytes and Contributes to the Development of Glomerulonephritis

    Shui Lian Yu1, Hao Li1, Abhigyan Satyam1, Shawn Rose2, Jarrat Jordan3 and George Tsokos4, 1Division of Rheumatology & Clinical Immunology/Beth Israel Deaconess Medical Center/Harvard Medical School, boston, 2Rheumatology & Autoimmunity Translational Medicine at Janssen Pharmaceuticals, boston, 3Janssen Research & Development, LLC, Spring House, PA, 4Division of Rheumatology & Clinical Immunology/Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA

    Background/Purpose: Interleukin (IL)-23 is central in the advancement of an inflammatory response and has been shown to be involved in the pathogenesis of autoimmune diseases.…
  • Abstract Number: 0837 • ACR Convergence 2020

    Deletion of miR-223 Exacerbates Lupus Nephritis by Targeting S1pr1 in Faslpr/lpr Mice

    Sumie Hiramatsu Asano1, Tomoyuki Mukai2, Yoshitaka Morita3 and Jun Wada4, 1Kawasaki Medical School/Department of Rheumatology, Kurashiki city, Japan, 2Kawasaki Medical School, Kurashiki-shi, Okayama, Japan, 3Kawasaki Medical School/Department of Rheumatology, Kurashiki, Okayama, Japan, 4Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences., Okayama city, Japan

    Background/Purpose: To identify new candidate genes regulated by micro RNAs (miRNAs) and involved in the pathogenesis of systemic lupus erythematosus (SLE), we integrated miRNA and…
  • Abstract Number: 0846 • ACR Convergence 2020

    MHC Class I Epitopes Derived from Autoantibody Variable Regions, Conjugated to Synthetic Oligodeoxynuleotides, Induce Cytotoxic T Cells That Deplete Autoreactive B Cells and Ameliorate Murine Lupus

    Ram Singh1, 1UCLA David Geffen School of Medicine, Los Angeles, CA

    Background/Purpose: B cell depletion or modulation is emerging as a major treatment modality for autoimmune diseases. However, the current treatments to accomplish this non-specifically target…
  • Abstract Number: 0868 • ACR Convergence 2020

    Impact of Proteinuria on the Clearance of Monoclonal Antibodies: Potential Clinical Implications

    Justin Penzenstadler1, Jianmeng Chen2, Aaron Park2, Rosemarie Neuner2, Aliza Thompson2, Lei He2, Ping Ji2, Nikolay Nikolov2 and Chandrahas Sahajwalla2, 1FDA, F, 2FDA, Silver spring

    Background/Purpose: In general, renal elimination is minimal for therapeutic proteins with a molecular weight more than 69 KDa. However, in patients with proteinuria, there is…
  • Abstract Number: 077 • 2020 Pediatric Rheumatology Symposium

    Tubulointerstitial Nephritis and Uveitis (TINU): A Pediatric Case Series with Longitudinal Followup

    Deborah Stein 1, Elizabeth Benoit 1 and Mindy Lo1, 1Boston Children's Hospital, Boston

    Background/Purpose: Tubulointerstitial nephritis and uveitis (TINU) syndrome is an uncommon condition that is likely under-recognized. The ideal treatment of both renal and ophthalmologic disease activity…
  • Abstract Number: 1899 • 2019 ACR/ARP Annual Meeting

    sFlt-1, PlGF and VEGF in the Differential Diagnosis Between Active SLE Nephritis During Pregnancy and Preeclampsia

    Guilherme De Jesus1, Marcela Lacerda 1, Bruna Rodrigues 1, Flavia dos Santos 1, Adriana Nascimento 1, Luis Cristóvão Porto 1, Nilson Ramires de Jesús 1, Roger Levy 2 and Evandro Klumb 1, 1Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, 2GlaxoSmithKline, Upper Providence, PA

    Background/Purpose: Pregnancy in patients with SLE is associated with significant morbidity and mortality. SLE activity during pregnancy, specifically nephritis, makes the differential diagnosis with preeclampsia…
  • Abstract Number: 459 • 2018 ACR/ARHP Annual Meeting

    Readmission Rate within 30 Days of Hospitalization Due to New Onset Lupus Nephritis and Associated Risk Factors: The Importance of Intravenous Pulse Methylprednisolone Therapy

    Angel Alberto Herrera Guerra1, Sampath Prahalad1, Kelly A. Rouster-Stevens1, Rouba Garro2, Leah Bryan3 and Yin Hong4, 1Pediatric Rheumatology, Emory University School of Medicine, Atlanta, GA, 2Pediatric Nephrology, Emory University School of Medicine, Atlanta, GA, 3Pediatrics, Emory University School of Medicine, Atlanta, GA, 4Pathology, Children's Health Care of Atlanta, Atlanta, GA

    Background/Purpose: There is a paucity of data regarding the early hospital readmission rates in newly diagnosed childhood lupus nephritis (cLN). We conducted a retrospective study…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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