Abstracts tagged "Nephritis and systemic lupus erythematosus (SLE)"

Abstract Number: 641 • 2014 ACR/ARHP Annual Meeting
Peptidylarginine Deiminase Inhibition Mitigates NET Formation and Protects Against Kidney, Skin, and Vascular Disease in Lupus-Prone MRL/Lpr Mice
Jason S. Knight¹, Venkataraman Subramanian², Alexander A. O'Dell¹, Srilakshmi Yalavarthi¹, Wenpu Zhao³, Carolyne K. Smith³, Jeffrey B. Hodgin⁴, Paul Thompson² and Mariana J. Kaplan³, ¹Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²The Scripps Research Institute, Jupiter, FL, ³Systemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴Department of Pathology, University of Michigan, Ann Arbor, MI
Background/Purpose: An imbalance between neutrophil extracellular trap (NET) production and NET degradation has been observed in systemic lupus erythematosus (SLE), potentially contributing to autoantigen externalization,…
Abstract Number: 2898 • 2013 ACR/ARHP Annual Meeting
Atherosclerosis In Systemic Lupus Erythematosus (SLE) and Controls, -An Analysis Of SLE Subgroups
Johanna Gustafsson¹, Kerstin Jensen-Urstad², Marie Herlitz-Lindberg², Sonia Möller¹, Susanne Pettersson¹, Iva Gunnarsson¹, Anders Larsson³ and Elisabet Svenungsson⁴, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ²Department of Clinical Physiology, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden, ³Department of Clinical Chemistry and Pharmacology, Akademiska Hospital, Uppsala, Sweden, ⁴Department of Medicine, Unit of Rheumatology, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Atherosclerosis is often assumed to be the main underlying cause of premature vascular events (VE) among patients with systemic lupus erythematosus (SLE) and accelerated…
Abstract Number: 602 • 2013 ACR/ARHP Annual Meeting
Repeat Biopsy In Lupus Nephritis: A Single-Center Experience
Josefina Marin¹, Marina Scolnik², Eliana Lancioni³, Gustavo Greloni⁴, Cristian Quiroz⁵, Johana Zacariaz³, Carla Saucedo⁶, Luis J. Catoggio² and Enrique R. Soriano², ¹Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ²Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ³Rheumatology Unit, Internal Medicine Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁴Nephrology Service. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁵Internal Medicine, Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁶Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Background/Purpose: Renal involvement in systemic lupus erythematosus (SLE) is an important cause of morbidity and even mortality. Lupus nephritis has diverse morphologic manifestations with varying clinical…
Abstract Number: 608 • 2012 ACR/ARHP Annual Meeting
Association of Discoid Lupus with Other Clinical Manifestations Among Patients with Systemic Lupus Erythematosus
Joseph F. Merola¹, Christina Iversen², Jose A. Gomez-Puerta², Tabatha Norton², Hsun Tsao², Peter H. Schur², Elena M. Massarotti², Bonnie L. Bermas³ and Karen H. Costenbader², ¹Rheumatology, Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Prior studies suggest that cutaneous discoid lupus (DLE) is a marker for less severe disease with a low frequency of nephritis and end-stage renal…
Abstract Number: 1454 • 2012 ACR/ARHP Annual Meeting
Characterization of Renal Mononuclear Phagocyte Populations in Murine SLE Nephritis
Ranjit Sahu¹, Ramalingam Bethunaickan² and Anne Davidson¹, ¹Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ²Autoimmunity, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Macrophages and dendritic cells contribute to renal damage in chronic renal diseases including lupus nephritis. However owing to their multiple phenotypic and functional variations,…
Abstract Number: 1445 • 2012 ACR/ARHP Annual Meeting
Shared and Unique Molecular Features of Nephritis in 3 Models of Murine SLE
Ramalingam Bethunaickan¹, Celine C. Berthier², Matthias Kretzler³ and Anne Davidson⁴, ¹Autoimmunity, Feinstein Institute for Medical Research, Manhasset, NY, ²Nephrology, University of Michigan, Ann Arbor, MI, ³Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI, ⁴Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: Mouse models are useful for studying the pathogenesis of SLE nephritis but it is not clear which model is the most appropriate for understanding…
Abstract Number: 2239 • 2012 ACR/ARHP Annual Meeting
Characterization of Pure Membranous Lupus Nephritis: A Cohort of 150 Patients
Lucía Silva¹, Teresa Oton¹, Anca Askanase², Patricia Carreira³, Francisco Javier López-Longo⁴, Anne Riveros⁵, Íñigo Rúa-Figueroa⁶, Javier Narvaez⁷, Esther Ruiz-Lucea⁸, Mariano Andres⁹, Enrique Calvo¹⁰, Francisco Toyos¹¹, Juan J. Alegre¹², Eva Tomero¹³, Carlos Montilla¹⁴, Antonio Zea¹⁵, Esther Uriarte-Isacelaya¹⁶, Jaime Calvo-Alen¹⁷, Carlos Marras¹⁸, Víctor M. Martínez-Taboada¹⁹, María Ángeles Belmonte²⁰, Jose Rosas²¹, Enrique Raya²², Gema Bonilla²³ and Mercedes Freire²⁴, ¹Rheumatology, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda (Madrid), Spain, ²NYU School of Medicine, New York, NY, ³Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ⁴Hospital General Universitario Gregorio Marañón, Department of Rheumatology, Madrid, Spain, ⁵Rheumatology, Hospital Universitario Germans Trias i Pujol, Badalona, Spain, ⁶Rheumatology, Hospital Universitario Dr Negrín. Las Palmas, Las Palmas de Gran Canaria, Spain, ⁷Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁸Rheumatology, Hospital de Basurto, Bilbao, Spain, ⁹Seccion Reumatologia, Hospital General Universitario de Alicante, Alicante, Spain, ¹⁰Rheumatology, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Spain, ¹¹Rheumatology, Hospital Universitario Virgen Macarena, Sevilla, Spain, ¹²Rheumatology, Hospital Universitario Dr Peset, Valencia, Spain, ¹³Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ¹⁴Unit Rheumatology, Hospital Universitario de Salamanca, Salamanca, Spain, ¹⁵Rheumatology, Hospital Universitario Ramon y Cajal, Madrid, Spain, ¹⁶Rheumatology, Hospital Universitario de Donostia, Donosti, Spain, ¹⁷Rheumatology, Hospital Sierrallana. Torrelavega, Torrelavega, Spain, ¹⁸Rheumatology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain, ¹⁹Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ²⁰Rheumatology, Hospital Universitario Carlos Haya, Málaga, Spain, ²¹Rheumatology, Hospital Marina Baixa. Villajoyosa, Villajoyosa, Spain, ²²Rheumatology, University Hospital San Cecilio, Granada, Spain, ²³Rheumatology, Hospital La Paz, Madrid, Spain, ²⁴Rheumatology, Hospital Universitario Juan Canalejo, La Coruña, Spain
Background/Purpose : Over 50% of patients with SLE develop renal involvement but only 20% of these are found to have pure membranous lupus neprhitis (MLN)…