ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Natural Killer Cells"

  • Abstract Number: 0035 • ACR Convergence 2020

    Distinct Biological Pathways in Both Blood and Kidney Further Define Molecular Profiles Across Diverse Nephritides

    Loqmane Seridi1, Matteo Cesaroni1, Qingxuan Song2, Ashley Orillion1, Frédéric Baribaud1, Tatiana Ort1, Sheng Gao2, Tomas Parker3, James Chevalier3, Dan Levine3, Alan Perlman3 and Jarrat Jordan1, 1Janssen Research & Development, LLC, Spring House, PA, 2Janssen Research & Development, LLC, Spring House, PA, USA, Spring House, PA, 3The Rogosin Institute, New York Presbyterian Hospital-Weill Medical College of Cornell University New York, NY, USA., New York, NY

    Background/Purpose: Approximately 40% of SLE patients will develop Lupus Nephritis (LN), of which 10-30 % will progress to end-stage renal disease. To further understand LN…
  • Abstract Number: 0291 • ACR Convergence 2020

    SLAMF7 and CD38 on NK Cells Represent Potential New Therapeutic Targets for Systemic Lupus Erythematosus

    Morgane Humbel1, Florence Bellanger2, Craig Fenwick2, Alice Horisberger2, Camillo Ribi2 and Denis Comte2, 1CHUV, Lausanne, Vaud, Switzerland, 2CHUV, Lausanne, Switzerland

    Background/Purpose: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by the production of autoantibodies. For this reason, anti-B cell therapy seems to be…
  • Abstract Number: 0473 • ACR Convergence 2020

    Characterization of DOCK8 as a Novel Gene Associated with Cytokine Storm Syndrome

    Mingce Zhang1, Remy Cron2, Devin Absher3, Prescott Atkinson1, Winn Chatham1 and Randy Cron1, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, 3HudsonAlpha Institute for Biotechnology, Huntsville, AL

    Background/Purpose: Cytokine storm syndrome (CSS), also known as macrophage activation syndrome (MAS) or secondary hemophagocytic lymphohistiocytosis (HLH), is a life threatening condition that commonly presents…
  • Abstract Number: 1575 • ACR Convergence 2020

    CD6 Is a Target for Cancer Immunotherapy

    Jeffrey Ruth1, Mikel Gurrea Rubio2, Kalana Athukorala3, Stephanie Rasmussen1, Weber Daniel1, Peggy Randon1, M Asif Amin1, Phillip Campbell1, Pei-suen Tsou1, Yang Mao-Draayer1, Qi Wu4, Matthew Lind1, Rosemary Gedert1, Thomas Lanigan1, Venkateshwar Keshamouni1, Nora Singer5, Feng Lin6 and David Fox7, 1University of Michigan, Ann Arbor, MI, 2Division of Rheumatology, University of Michigan, Canton, MI, 3University of Michigan, Ann Arbor, MN, 4University of Michigan, Ann Arbor, 5The MetroHealth System, Case Western Reserve University School of Medicine, Cleveland, OH, 6Cleveland Clinic Foundation, Cleveland, OH, 7Division of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: Limitations of checkpoint inhibitor immunotherapy include induction of autoimmune syndromes and resistance of many cancers. Definition of additional molecular targets is required. CD6, expressed…
  • Abstract Number: 1857 • ACR Convergence 2020

    KIR3DL2 Is Not Overexpressed on CD4+ T Cells and NK Cells in Patients with Axial Spondyloarthritis csDMARD and bDMARD Naive

    Guillaume Larid1, Sophie Trijau1, Clothilde Barral1, Pierre Lafforgue1 and Thao Pham2, 1Aix Marseille Univ, APHM, Rheumatology department, Marseille, France, 2Aix Marseille Univ, APHM, department of rheumatology, Marseille, France

    Background/Purpose: Overexpression of KIR3DL2 on CD4+ T-cells and NK-cells has been reported in patients with ankylosing spondylitis (AS) HLAB27+. We aimed to 1) analyse KIR3DL2…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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