ACR Meeting Abstracts

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Abstracts tagged "Natural Killer Cells"

  • Abstract Number: 0692 • ACR Convergence 2021

    Immunophenotyping of Inclusion Body Myositis Blood T Cells: Pathogenic and Biomarker Implications

    Namita Goyal1, Jonathan Cauchi1, Tyler Irani1, Nadia Araujo1, Leo Wang2, Marie Wencel1, Vivian Li3, Steven Greenberg4 and Tahseen Mozaffar1, 1University of California Irvine, Irvine, CA, 2University of Washington, Seattle, WA, 3University of California, Irvine, CA, 4Brigham and Women's Hospital Department of Neurology, Boston, MA

    Background/Purpose: The recent discovery of highly differentiated, killer cell lectin-like receptor subfamily G member 1 (KLRG1)+ T cells in the muscle of inclusion body myositis…
  • Abstract Number: 0992 • ACR Convergence 2021

    Inflammatory Arthritis in HIV-Infected Humanized Mice

    Can Sungur1, Ayse Ozanturk1, Hongbo Gao1, Li-ping Yang1, Liang Shan1 and Wayne Yokoyama2, 1Washington University, St Louis, MO, 2Washington University School of Medicine, St. Louis, MO

    Background/Purpose: Human immunodeficiency virus (HIV) remains a significant life-threatening agent and burden on public health. Lesser studied and understood aspects of HIV include HIV-associated inflammatory…
  • Abstract Number: 0993 • ACR Convergence 2021

    The Mechanistic Basis of anti-CD6 as a Novel Form for the Treatment of Autoimmune Diseases and Cancer

    Mikel Gurrea-Rubio1, Jeffrey Ruth1, Qi Wu1, Eliza Pei-Suen Tsou1, Phillip Campbell1, Peggy Randon1, M.Asif Amin1, Nora Singer2, Feng Lin3 and David Fox1, 1University of Michigan, Ann Arbor, MI, 2The MetroHealth System, Cleveland, OH, 3Cleveland Clinic, Cleveland, OH

    Background/Purpose: The use of Immune Checkpoint Inhibitors (ICIs) is limited by the induction of immune-related adverse events. CD6 is expressed by most T lymphocytes and…
  • Abstract Number: 1438 • ACR Convergence 2021

    Development of a Computationally Designed, Hyperstable Dual Inhibitor of the IL-2 and IL-15 Receptors: A Novel Therapeutic Candidate for Inflammatory Conditions

    Renan Vergara1, Alex Chen1, Jerry Chen1, Marianne Riley1, Luis Blancas-Mejia1, Christie Mortales1, Tania Berrocal1, Tanu Priya1, Marsha Mason1, Kevin Yu1, Olga Sharapova1, Jorgen Nelson1, Alfredo Quijano-Rubio1, Thomas Linsky1, Ryan Swanson1 and Daniel-Adriano Silva2, 1Neoleukin Therapeutics, Inc., Seattle, WA, 2Formerly of Neoleukin Therapeutics, Inc., Seattle, WA

    Background/Purpose: T cell mediated pathology is central to many forms of autoimmunity, and cytokines perform critical inflammatory functions during this process. IL-2 and IL-15 are…
  • Abstract Number: 1480 • ACR Convergence 2021

    LncRNA XIST Alters the Balance of Peripheral Blood Immune Cells in Systemic Lupus Erythematosus by Regulating the miR-17-92/OFLM4 and CEACAM8 Axis

    Qi Cheng, Mo Chen, xin Chen, peiyu zhang, huaxiang wu and yan du, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (People's Republic)

    Background/Purpose: X-inactive-specific transcript (XIST) has been shown to silence linked genes on the X chromosome that may be related to the pathogenesis of systemic lupus…
  • Abstract Number: 1488 • ACR Convergence 2021

    Metabolic Alterations of Systemic Lupus Erythematosus NK Cells Determine Response to Anti-CD38 and Anti-SLAMF7 Monoclonal Antibodies

    Morgane Humbel, Natalia Fluder, Florence Bellanger, Alice Horisberger, Craig Fenwick, Camillo Ribi and Denis Comte, CHUV, Lausanne, Switzerland

    Background/Purpose: Systemic lupus erythematosus (SLE) is a multisystem inflammatory condition of unknown pathogenesis. We have previously shown that SLE Natural killer (NK) cells are decreased…
  • Abstract Number: 1928 • ACR Convergence 2021

    In Vitro and In Vivo Evidence for DOCK8 as a Risk Allele for Cytokine Storm Syndrome, Including COVID-19 and MIS-C

    Randy Cron1, Mingce Zhang1, Niansheng Chu2, Devin Absher3, John Bridges1, Amanda Schnell1, Anshul Vagrecha4, Shannon Lozinsky4, Suchitra Acharya4, Carolyn Levy4, Winn Chatham1 and Edward Behrens2, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Pennsylvania, Philadelphia, PA, 3HudsonAlpha Institute for Biotechnology, Huntsville, AL, 4Hofstra/Northwell School of Medicine, Hempstead, NY

    Background/Purpose: Cytokine storm syndromes (CSS) are frequently fatal complications of a variety of oncologic, rheumatic, and infectious diseases. Many patients with CSS possess heterozygous missense…
  • Abstract Number: 0035 • ACR Convergence 2020

    Distinct Biological Pathways in Both Blood and Kidney Further Define Molecular Profiles Across Diverse Nephritides

    Loqmane Seridi1, Matteo Cesaroni1, Qingxuan Song2, Ashley Orillion1, Frédéric Baribaud1, Tatiana Ort1, Sheng Gao2, Tomas Parker3, James Chevalier3, Dan Levine3, Alan Perlman3 and Jarrat Jordan1, 1Janssen Research & Development, LLC, Spring House, PA, 2Janssen Research & Development, LLC, Spring House, PA, USA, Spring House, PA, 3The Rogosin Institute, New York Presbyterian Hospital-Weill Medical College of Cornell University New York, NY, USA., New York, NY

    Background/Purpose: Approximately 40% of SLE patients will develop Lupus Nephritis (LN), of which 10-30 % will progress to end-stage renal disease. To further understand LN…
  • Abstract Number: 0291 • ACR Convergence 2020

    SLAMF7 and CD38 on NK Cells Represent Potential New Therapeutic Targets for Systemic Lupus Erythematosus

    Morgane Humbel1, Florence Bellanger2, Craig Fenwick2, Alice Horisberger2, Camillo Ribi2 and Denis Comte2, 1CHUV, Lausanne, Vaud, Switzerland, 2CHUV, Lausanne, Switzerland

    Background/Purpose: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by the production of autoantibodies. For this reason, anti-B cell therapy seems to be…
  • Abstract Number: 0473 • ACR Convergence 2020

    Characterization of DOCK8 as a Novel Gene Associated with Cytokine Storm Syndrome

    Mingce Zhang1, Remy Cron2, Devin Absher3, Prescott Atkinson1, Winn Chatham1 and Randy Cron1, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, 3HudsonAlpha Institute for Biotechnology, Huntsville, AL

    Background/Purpose: Cytokine storm syndrome (CSS), also known as macrophage activation syndrome (MAS) or secondary hemophagocytic lymphohistiocytosis (HLH), is a life threatening condition that commonly presents…
  • Abstract Number: 1575 • ACR Convergence 2020

    CD6 Is a Target for Cancer Immunotherapy

    Jeffrey Ruth1, Mikel Gurrea Rubio2, Kalana Athukorala3, Stephanie Rasmussen1, Weber Daniel1, Peggy Randon1, M Asif Amin1, Phillip Campbell1, Pei-suen Tsou1, Yang Mao-Draayer1, Qi Wu4, Matthew Lind1, Rosemary Gedert1, Thomas Lanigan1, Venkateshwar Keshamouni1, Nora Singer5, Feng Lin6 and David Fox7, 1University of Michigan, Ann Arbor, MI, 2Division of Rheumatology, University of Michigan, Canton, MI, 3University of Michigan, Ann Arbor, MN, 4University of Michigan, Ann Arbor, 5The MetroHealth System, Case Western Reserve University School of Medicine, Cleveland, OH, 6Cleveland Clinic Foundation, Cleveland, OH, 7Division of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: Limitations of checkpoint inhibitor immunotherapy include induction of autoimmune syndromes and resistance of many cancers. Definition of additional molecular targets is required. CD6, expressed…
  • Abstract Number: 1857 • ACR Convergence 2020

    KIR3DL2 Is Not Overexpressed on CD4+ T Cells and NK Cells in Patients with Axial Spondyloarthritis csDMARD and bDMARD Naive

    Guillaume Larid1, Sophie Trijau1, Clothilde Barral1, Pierre Lafforgue1 and Thao Pham2, 1Aix Marseille Univ, APHM, Rheumatology department, Marseille, France, 2Aix Marseille Univ, APHM, department of rheumatology, Marseille, France

    Background/Purpose: Overexpression of KIR3DL2 on CD4+ T-cells and NK-cells has been reported in patients with ankylosing spondylitis (AS) HLAB27+. We aimed to 1) analyse KIR3DL2…
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