ACR Meeting Abstracts

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Abstracts tagged "Natural Killer Cells"

  • Abstract Number: L17 • ACR Convergence 2024

    Allogenic CD19 CAR NK Cells Therapy in Refractory Systemic Lupus Erythematosus: An Open-label, Single Arm, Prospective and Interventional Clinical Trial

    Yiyi Yu1, Ruina Kong1, Xia Xu1, Suxuan Liu1, Qian Chen1, Xiaofang Li2, Ming Sun2, Jianmin Yang1, Dongbao Zhao1 and Jie Gao1, 1Changhai Hospital, Shanghai, China, 2Rui Therapeutics, Nanjing, China

    Background/Purpose: Treatment of systemic lupus erythematosus (SLE) typically necessitates long-term immunosuppression with hormones, immunosuppressants and biologics. CD19-targeting chimeric antigen receptor (CAR) T cells have shown excellent…
  • Abstract Number: 1763 • ACR Convergence 2024

    Circulating NK and CD8+ Cytotoxic T Cells in Treatment Naïve JDM Demonstrate Higher Cytotoxic and Interferon Signature as Compared to Childhood-Onset SLE

    Qinmengge Li1, Celine Berthier1, Christine Goudsmit1, Sophia Matossian1, Rachael Wasikowski2, Johann Gudjonsson1, J. Michelle Kahlenberg1, Lam C. Tsoi2 and Jessica Turnier3, 1University of Michigan, Ann Arbor, MI, 2Michigan, Dept. of Dermatology, Ann Arbor, MI, 3University of Michigan, Saline, MI

    Background/Purpose: Juvenile dermatomyositis (JDM) and childhood-onset systemic lupus erythematosus (cSLE) are pediatric autoimmune diseases that can present with overlapping clinical features yet have unique tropism…
  • Abstract Number: 1782 • ACR Convergence 2024

    DOCK2 Mutations and Hyper-Inflammatory Syndromes

    Randy Cron, Mingce Zhang and Prescott Atkinson, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Cytokine storm syndromes (CSS) are frequently fatal hyper-inflammatory complications of a variety of oncologic, rheumatic, and infectious diseases. Many patients with CSS possess heterozygous…
  • Abstract Number: 1786 • ACR Convergence 2024

    Select Immune Cell Dysregulation Identifies Clinically Quiescent Patients at Risk of Flare Who Stop Mycophenolate Mofetil While Continuing Hydroxychloroquine

    Christian Wright1, Rufei Lu2, Catriona Wagner3, Carla Guthridge4, Susan Macwana1, Eliza Chakravarty4, Tammy Utset5, Diane Kamen6, Gabriel Nicolas Contreras Martin7, William McCune8, Cynthia Aranow9, Kenneth Kalunian10, Elena Massarotti11, Megan Clowse12, Brad Rovin13, S. Sam Lim14, Vikas Majithia15, Richard Looney16, Maria Dall'Era17, Doruk Erkan18, Amit Saxena19, Nancy Olsen20, Kichul Ko21, Ellen Goldmuntz22, William Barry23, Ashley Pinckney24, ALE06 Clinical Study Team4, Judith James4 and Joel Guthridge4, 1Oklahoma Medical Research Foundation, Oklahoma City, 2University of California San Francisco, San Bruno, CA, 3Oklahoma Medical Research Foundation, Santa Cruz, CA, 4Oklahoma Medical Research Foundation, Oklahoma City, OK, 5University of Chicago, Chicago, IL, 6Medical University of South Carolina, Charleston, SC, 7University of Miami, Key Biscayne, FL, 8U Michigan, Ann Arbor, MI, 9Feinstein Institutes for Medical Research, New York, NY, 10University of California San Diego, La Jolla, CA, 11Brigham and Women's Hospital, Boston, MA, 12Duke University, Chapel Hill, NC, 13The Ohio State University, Columbus, OH, 14Emory University, Atlanta, GA, 15Mayo Clinic Florida, Jacksonville, FL, 16University of Rochester, Rochester, NY, 17UCSF, Corte Madera, CA, 18Hospital for Special Surgery, New York, NY, 19NYU School of Medicine, New York, NY, 20Penn State University/Milton S Hershey, Hershey, PA, 21The University of Chicago, Chicago, IL, 22NIAID/ NIH, Washington, DC, 23Rho, Inc, Durham, NC, 24Rho, St Louis Park, NC

    Background/Purpose: Mycophenolate mofetil (MMF) is commonly used to treat major SLE manifestations; however, it is associated with significant toxicities. Thus, MMF withdrawal is desirable in…
  • Abstract Number: 2422 • ACR Convergence 2024

    Development of a Multiplexed-engineered, Off-the-shelf CAR NK Cell with Unique Multi-Pathogenic Cell Targeting Capacity for the Treatment of Autoimmune Diseases in the Absence of Conditioning Chemotherapy

    Anil Bagri1, Alec Witty1, Amanda Sims1, Allan Williams1, Rina Mbofung1, Daniel Morales-Mantilla1, Yang Wang1, Stacey Moreno1, Allison Aguilar1, Cara Bickers1, Yijia Pan1, Amber Chang1, Christine Chen1, Karina Palomares1, Lauren Fong1, Nicholas Brookhouser1, Berhan Mandefro1, Sajid Mahmood1, Ramesh Janani1, Ramzey Abujarour1, Tom Lee1, Raedun Clarke1, Rebecca Elstrom1, Frank Cichocki2, Lilly Wong1, Betsy Rezner1, Jode Goodridge1, Jeffrey Miller2 and Bahram Valamehr1, 1Fate Therapeutics Inc., San Diego, CA, 2Department of Medicine, University of Minnesota, Minneapolis, MN

    Background/Purpose: Unprecedented clinical data have recently shown that patients with certain highly refractory autoimmune diseases (AI Dz) treated with conditioning chemotherapy (CCT) and autologous anti-CD19…
  • Abstract Number: 0004 • ACR Convergence 2024

    Beyond Antibodies and CAR-T: Topologically Engineered, Superdimeric Antibody NK Engagers and T Cell Engagers for B Cell Depletion Demonstrating Cooperative Binding to Target and Effector Cells

    Daniel Capon, Larisa Troitskaya, Marina Fomin, Brendon Frank, Ursula Edman, Benjamin Capon, Brian Law, Steven Chapin, Gavin Lewis, Malcolm Gefter, Juha Punnonen and Nelson Chan, Hinge Bio, Inc., Burlingame, CA

    Background/Purpose: The dramatic demonstration of CD19 CAR-T efficacy in systemic lupus erythematosus (SLE), idiopathic inflammatory myositis, and systemic sclerosis by Georg Schett and colleagues (F.…
  • Abstract Number: 0060 • ACR Convergence 2024

    Spectral Cytometry Shows Increased CD56hi NK Cells and New HLA-DR+CD56+ Phenotypes in RA

    Estelle Khairallah1, Haani Qudsi2, Jihad Ben Gabr1, Andras Perl3 and Christian Geier1, 1SUNY Upstate Medical University, Syracuse, NY, 2Norton College of Medicine, Syracuse, NY, 3SUNY, Syracuse, NY

    Background/Purpose: Previous studies of RA patients have shown changes in NK cell populations (as defined by CD56 expression). The nature of these cellular changes remains…
  • Abstract Number: 0952 • ACR Convergence 2024

    Single Cell RNA-seq of Scleroderma-associated Interstitial Lung Disease Lung Explants Reveals an Active, Cytotoxic Natural Killer Cell Population

    Cristina Padilla, Eleanor Valenzi, Tracy Tabib, Banafsheh Nazari, Patrizia Fuschiotti and Robert Lafyatis, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Scleroderma-associated interstitial lung disease (SSc-ILD) is the leading cause of death among SSc patients. Loss of alveolar epithelial cells (AEC) and bronchial cell hyperplasia,…
  • Abstract Number: 0954 • ACR Convergence 2024

    Increased Proliferating Natural Killer Cells Exhibit an Aberrant Pro-Inflammatory Gene Signature in Systemic Sclerosis Patients

    Pietro Bearzi1, Elena Pachera2, Sophie Wagner3, Astrid Hofman4, Lumeng Li4, Laura Much4, Mike Becker5, Kristina Bürki4, Luca Navarini6, Anna-Maria Hoffmann-Vold7, Roberto Giacomelli8 and Oliver Distler9, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Schlieren, Switzerland, 2University Hospital Zurich, Zurich, Switzerland, 3University of Zurich, Schlieren, Switzerland, 4Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 5Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland, 6Rheumatology, Immunology and Clinical Medicine Unit, Department of Medicine, University of Rome "Campus Bio-Medico", Rome, Italy, 7Oslo University Hospital, Oslo, Norway, 8Rheumatology, Immunology and Clinical Medicine Unit, Department of Medicine, University of Rome "Campus Bio-Medico", Roma, Italy, 9Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Zurich, Switzerland

    Background/Purpose: Recent transcriptomic data suggest a prominent involvement of innate immune cells in the pathogenesis of SSc. In this regard, contrasting data on NK cells…
  • Abstract Number: 1702 • ACR Convergence 2024

    Placental Developmental Defects in a Humanized-TLR8 Mouse Model of Spontaneous Anti-Phospholipid Antibody Induced Pregnancy Loss

    Yunwei Xia1, Naomi I. Maria2, Zhengzi Yi3, Chirag Raparia4, Gayathri Konanur Gopikrishna1, Weijia Zhang3 and Anne Davidson2, 1Feinstein Institutes for Medical Research, Manhasset, 2Feinstein Institutes for Medical Research, Manhasset, NY, 3Mt. Sinai School of Medicine, New York, NY, 4Donald and Barbara Zucker School of Medicine At Hofstra/Northwell, Shoreham, NY

    Background/Purpose: Antiphospholipid antibodies (aPL) confer a high risk for adverse pregnancy outcomes, especially in women with SLE. aPLs can induce pro-inflammatory signaling via TLR8 receptors,…
  • Abstract Number: 1705 • ACR Convergence 2024

    Deep Phenotyping Characterization of Peripheral Natural Killer Cells Reveals Impaired Cytotoxicity and Exhaustion During VEXAS Syndrome

    Paul Breillat1, Carbone Francesco2, Possémé Céline3, Marie Templé4, Aurélien Corneau5, Marine Luka2, Camille Gobeaux6, Rodéreau Outh7, Estibaliz Lazaro8, Guillaume Le Guenno9, François Lifermann10, Marie Berleur11, Melchior Le Mene4, Chloé Friedrich4, Cédric Lenormand12, Thierry Weitten13, Vivien Guillotin14, Barbara Burroni6, Jeremy Boussier15, Lise Willems6, Léa Dionet16, Tharaux Pierre-Louis16, Darragh duffy17, Mickael Ménager18, Olivier Kosmider4 and Benjamin Terrier19, 1Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes et Autoinflammatoires Rares d'Ile de France de l’Est et de l’Ouest, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), INSERM U970, Université de Paris, PARIS, France, 2Institut Imagine, Paris, France,, Paris, France, 3Institut Pasteur, Paris, France, Paris, France, 4Hematology Laboratory, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris Cité, Cochin Hospital, Paris, France, Paris, France, 5Sorbonne Université, Paris, France, 6Cochin Hospital, Paris, France, Paris, France, 7CH, Perpignan, France,, Perpignan, France, 8Bordeaux University Hospital, Pessac, France, 9CHU, Clermont-Ferrand, France,, Clermont-Ferrand, France, 10Dax Hospital, Dax, France, Dax, France, 11CHU Bichat, Paris France, Paris, France, 12CHRU, Strasbourg, France, Strasbourg, France, 13CHIGAS, Gap, France, Gap, France, 14CHU Bordeaux, Bordeaux, France, Bordeaux, France, 15Sorbonne University, Paris, France, 16Paris Cardiovascular Research Center, INSERM U970, Paris, France, 17Translational Immunology Unit, Institut Pasteur, Université Paris-Cité, Paris, France, Paris, France, 18Institut Imagine, Paris, France, Paris, France, 19Service de Médecine interne, Hôpital Cochin, AP-HP, Paris, Ile-de-France, France

    Background/Purpose: VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a severe auto-inflammatory disorder associated with acquired mutations in the UBA1 gene that occur in hematopoietic stem cells…
  • Abstract Number: 0059 • ACR Convergence 2023

    GM-CSF by Natural Killer Cells Drives Inflammatory Arthritis in HIV-Infected Humanized Mice

    Can Sungur1, Li-ping Yang2, Liang Shan1 and wayne Yokoyama3, 1Washington University, St. Louis, MO, 2Washington University in St. Louis, St. Louis, MO, 3Washington University School of Medicine, St. Louis, MO

    Background/Purpose: Human immunodeficiency virus (HIV) remains a significant life-threatening agent and burden on public health. Lesser studied and understood aspects of HIV include HIV-associated inflammatory…
  • Abstract Number: 1783 • ACR Convergence 2023

    Integrative Functional Genomics Points to Natural Killer Cells as Key Drivers in the Pathogenesis of Ankylosing Spondylitis

    Marcos Chiñas1, Daniela Fernandez-Salinas1, Vitor Aguiar1, Victor Caballero-Nieto2, Micah Lefton3, Joerg Ermann4 and Maria Gutierrez-Arcelus1, 1Boston Children's Hospital, Boston, MA, 2Boston Children's Hospital, Montpellier, France, 3Brigham and Women's Hospital, Boston, MA, 4Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Multiple lines of evidence indicate that ankylosing spondylitis (AS) is a lymphocyte-driven disease. However, which lymphocyte populations are critical in AS pathogenesis is not…
  • Abstract Number: 0163 • ACR Convergence 2022

    Changes in Juvenile Dermatomyositis After the COVID-19 Pandemic

    Christopher Costin1, Gabrielle Morgan2, Amer Khojah3 and Lauren Pachman4, 1Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 2Ann & Robert H. Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, 3Umm Al-Qura University, Makkah, Saudi Arabia, 4Northwestern's Feinberg School of Medicine. Ann and Robert H. Lurie Children's Hospital of Chicago; Stanley Manne Children's Research Institute of Chicago, Lake Forest, IL

    Background/Purpose: Prior research has shown that viruses may trigger JDM, although the degree to which COVID-19 may serve as a trigger for JDM remains unknown.…
  • Abstract Number: 0288 • ACR Convergence 2022

    Comparison of the Effect of Different Janus Kinase Inhibitors on Activation, Function and Property of NK Cells to Control Cancer Cell Lines Proliferation: An Ex Vivo and in Vitro Study

    Loïc Meudec1, Pauline Richebé1, Juliette Pascaud2, Xavier Mariette3 and Gaetane Nocturne4, 1Université Paris-Saclay, AP-HP-Hôpital Bicêtre, Le Kremlin Bicêtre, France, 2Université Paris-Saclay, INSERM U1184, Le Kremlin Bicêtre, France, 3Paris-Saclay University, Rueil Malmaison, Ile-de-France, France, 4APHP, Le Kremlin Bicêtre, France

    Background/Purpose: Janus kinase inhibitors (JAKi) are effective treatments licensed in rheumatoid arthritis (RA). Concerns about a risk of cancer may arise with JAKi as in…
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