Abstracts tagged "Myositis"

Abstract Number: 2082 • ACR Convergence 2024
Different Clinical Phenotypes of Patients with Anti-synthetase Syndrome: Unsupervised Cluster Analysis in the CLASS Database
Akira Yoshida¹, Iazsmin Bauer Ventura², Eduardo Dourado³, Giovanni Zanframundo⁴, Sara Faghihi Kashani⁵, Aravinthan Loganathan⁶, Daphne Rivero Gallegos⁷, Francisca Bozan⁸, Gianluca sambataro⁹, Sangmee Bae¹⁰, Ernesto Trallero-Araguás¹¹, Andrew Mammen¹², Carlo Scire¹³, Carlomaurizio Montecucco¹⁴, Chester Oddis¹⁵, David Fiorentino¹⁶, Francesco Bonella¹⁷, Frederick Miller¹⁸, Antonella Notarnicola¹⁹, Jens Schmidt²⁰, Jorge Rojas-Serrano²¹, marie Hudson²², Masataka Kuwana²³, Miguel Angel Gonzalez-Gay²⁴, Neil McHugh²⁵, Tamera J Corte²⁶, Tracy J Doyle²⁷, Victoria Werth²⁸, Rohit Aggarwal²⁹ and Lorenzo Cavagna³⁰, and the CLASS project investigators, ¹Nippon Medical School Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan, ²University of Chicago, Chicago, IL, ³Unidade Local de Saúde da Região de Aveiro, Aveiro, Portugal, ⁴Università di Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Milano, Italy, ⁵UCSF, Mountain View, CA, ⁶RUH, Middle Park, Queensland, Australia, ⁷INER, Ciudad de México, Mexico State, Mexico, ⁸Hospital Clinico Universidad de Chile, Santiago, Chile, ⁹University of Catania, Catania, Italy, ¹⁰UCLA, Los Angeles, CA, ¹¹Rheumatology Departament, Vall d'Hebron Hospital, Barcelona, Spain, ¹²NIH, Bethesda, MD, ¹³University of Milano Bicocca, Milan, Italy, ¹⁴IRCCS policlinico S. Matteo foundation, University of Pavia, Pavia, Italy, ¹⁵Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹⁶Stanford University, Menlo Park, CA, ¹⁷Center for Interstitial and Rare Lung Disease Unit, University of Duisburg-Essen, Ruhrlandklinik, Essen, Germany, Essen, Germany, ¹⁸NIH, NIEHS, Chapel Hill, NC, ¹⁹Karolinska University Hospital and Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, ²⁰University Medical Center Goettingen, Göttingen, Germany, ²¹National Institute of Respiratory Diseases, Ismael Cosío Villegas, Mexico City, Mexico, ²²McGill University, Montreal, QC, Canada, ²³Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan, Tokyo, Japan, ²⁴University of Cantabria, Fundación Jimenez Díaz, Madrid, Madrid, Spain, ²⁵University of Bath, Bath, United Kingdom, ²⁶Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia, ²⁷Brigham and Women's Hospital, West Roxbury, MA, ²⁸University of Pennsylvania, Wynnewood, PA, ²⁹Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA, Pittsburgh, PA, ³⁰University of Pavia and Fondazione IRCCS Policlinico San Matteo Hospital of Pavia, Pavia, Pavia, Italy
Background/Purpose: Anti-synthetase syndrome (ASSD) is a rare systemic autoimmune rheumatic disease with significant heterogeneity. The Classification Criteria for Anti-Synthetase Syndrome (CLASS) project is an international…
Abstract Number: 0320 • ACR Convergence 2024
Comparative Transcriptional Profiling Reveals Shared Pathway Activation Between Human Jo-1+ Anti-Synthetase Syndrome and Murine Histidyl-tRNA Synthetase-Induced Myositis
Iago Pinal-Fernandez¹, Daniel Reay², Timothy Oriss², katherine Pak³, Maria Casal-Dominguez⁴, jose milisenda⁵, Albert Selva-O’Callaghan⁶, Werner Stenzel⁷, Andrew Mammen¹ and Dana Ascherman⁸, ¹NIH, Bethesda, MD, ²University of Pittsburgh School of Medicine, Pittsburgh, PA, ³National Institutes of Health, Bethesda, MD, ⁴NIH, Bathesda, MD, ⁵Hospital Clinic de Barcelona, Barcelona, Spain, ⁶Systemic Autoimmune Disease Unit, Vall d’Hebron Institute of Research, Barcelona, Spain, ⁷Charite University, Berlin, Germany, ⁸Division of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA
Background/Purpose: Previous work has shown unique gene expression profiles in muscle tissue corresponding to the anti-synthetase syndrome, with an emphasis on interferon gene signatures (Type…
Abstract Number: 0344 • ACR Convergence 2024
Characteristics of Patients with Antisynthetase Antibodies
Danny Kasto¹, Michael McLucas², Anne-Marie Aubin², Armando Faigl² and Gabor Major¹, ¹Dep of Rheumatology Royal Newcastle Centre / John Hunter Hospital, Rankin Park, New South Wales, Australia, ²Dep of Rheumatology Royal Newcastle Centre / John Hunter Hospital, Rankin Park, Australia
Background/Purpose: Aminoacyl transfer RNA synthetase antibodies (ASAbs) are associated with a range of clinical manifestations, including severe lung and muscle disease and are postulated to…
Abstract Number: 1150 • ACR Convergence 2024
Increased ISG15 Expression in Peripheral Blood from Patients with Positive Dermatomyositis Related Specific Autoantibodies
Sylvia Raftopoulou¹, Nikolaos Michalakeas¹, Maria Gerochristou², Nikolaos Marketos¹, Charalampos Skarlis¹ and Clio Mavragani³, ¹Molecular and Applied Physiology Unit, Department of Physiology, School of Medicine, National and Kapodistrian University of Athens., Athens, Greece, ²Andreas Syggros Hospital, National and Kapodistrian University of Athens, Athens, Greece, ³Department of Physiology and Pathophysiology, School of Medicine, National and Kapodistrian University of Athens., Athens, Greece
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are characterised by muscle inflammation (myositis) and weakness, impacting various organ systems. Clinical subtypes include dermatomyositis (DM), antisynthetase syndrome (ASyS),…
Abstract Number: 1170 • ACR Convergence 2024
Computer Aided Lung Informatics, HRCT and PFT in Patients with Interstitial Lung Disease in Idiopathic Inflammatory Myopathies
Sonali Narain¹, Kourosh Shargani², Ivana Ilic³, Irvind Buttar⁴ and Galina Marder⁵, ¹Northwell Health, Great Neck, NY, ²Northwell, Manhasset, NY, ³Northwell, Brooklyn, NY, ⁴Northwell Health/ Lenox Hill Hospital, Dix Hills, NY, ⁵Donald and Barbara Zucker School of Medicine at Hofstra/ Northwell, Great Neck, NY
Background/Purpose: Evaluation of Interstitial Lung Disease (ILD) progression relies on high resolution computed tomography (HRCT) and pulmonary function test (PFT). As we previously reported in our Idiopathic…
Abstract Number: 2060 • ACR Convergence 2024
Clustering Analysis of Immune Cell Subtypes and Clinical Phenotypes in Idiopathic Inflammatory Myopathy
xiaoyan xing¹, Yuhui Li² and Jing He³, ¹Department of Rheumatology and Immunology and Beijing Key Laboratory for Rheumatism and Immune Diagnosis (BZ0135), Peking University People’s Hospital, Beijing, China, Beijing, China, ²Peking University, BeiJing, China, ³Rheumatology, Beijing, China
Background/Purpose: Immune cell profiling plays a pivotal role in the pathogenesis of idiopathic inflammatory myopathy (IIM). Characterizing immune cell subtypes, such as CD4+ T cells,…
Abstract Number: 2083 • ACR Convergence 2024
A Novel Scoring System to Predict a Cancer Development in Patients with Idiopathic Inflammatory Myopathy
Yun Kyu Kim¹, Ju yeon Kim², Jung Yoon Pyo³, Min Jung Kim⁴, Jin Kyun Park⁵, Eun Young Lee⁶, Yun Jong lee³, eun Bong Lee¹ and Jun Won park², ¹Seoul National University Hospital, Seoul, Republic of Korea, ²Seoul National University Hospital, Seoul, Seoul-t'ukpyolsi, Republic of Korea, ³Seoul National University Bundang Hospital, Seongnam-si, ⁴Seoul Metropolitan Government Boramae Medical center, Dongjak-gu, Seoul, South Korea, ⁵Seoul National University College of Medicine, Jongno-gu, Seoul, Republic of Korea, ⁶3Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
Background/Purpose: Previous studies have demonstrated that idiopathic inflammatory myopathy (IIM) is associated with an elevated cancer risk. However, there is limited evidence on the specific…
Abstract Number: 0321 • ACR Convergence 2024
Diffusion Weighted Imaging in Muscle MRI Can Detect Quantitative Improvements in Muscle Edema: A Post-hoc Analyses of the Study of Tofacitinib in Refractory Dermatomyositis
Julie Paik¹, Patrick Debs², Anshula Nallapati¹, Lisa Christopher-Stine¹, Jemima Albayda³, Eleni Tiniakou⁴ and Laura Fayad², ¹Johns Hopkins University, Baltimore, MD, ²Johns Hopkins Radiology, Baltimore, MD, ³Johns Hopkins School of Medicine, Baltimore, MD, ⁴Johns Hopkins University, Lutherville Timonium, MD
Background/Purpose: Diffusion weighted imaging (DWI) in muscle magnetic resonance imaging is an underutilized, quantitative assessment tool in idiopathic inflammatory myopathies (IIM). It is not uncommon…
Abstract Number: 0346 • ACR Convergence 2024
Clonally Expanded and Total B Cells in Patients with Idiopathic Inflammatory Myopathies Show Skewed B Cell Subset Distribution and Reduced Somatic Hypermutation Relative to Healthy Controls
Amelia Sawyers¹, Leslie Crofford², Erin Wilfong³ and Rachel Bonami³, ¹Vanderbilt University School of Medicine, Nashville, TN, ²Vanderbilt University Medical Center, Melbourne, AR, ³Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a collection of rare, systemic rheumatic diseases. A role for B cells in IIM is indicated by the success…
Abstract Number: 1151 • ACR Convergence 2024
Clinical Characterization and Recurrence Prediction Model for Immune-Mediated Necrotizing Myopathy
Beibei Cui¹, Hongjiang Liu², Geng Yin³ and Qibing Xie⁴, ¹Rheumatology and Immunology, Chengdu, China (People's Republic), ²West China Hospital, Sichuan University, Chengdu, China (People's Republic), ³Department of Rheumatology and Immunology, chengdu, China (People's Republic), ⁴Department of Rheumatology and Immunology, Chengdu, Sichuan, China
Background/Purpose: The primary objective of this study was to comprehensively analyze the clinical characteristics of immune-mediated necrotizing myopathy (IMNM) and develop a reliable recurrence prediction…
Abstract Number: 1233 • ACR Convergence 2024
Narrative Medicine Intervention for Mental Wellbeing in Juvenile Myositis and Juvenile Idiopathic Arthritis
Aviya Lanis¹, Emily Steelquist², Christian Lood³ and Susan Shenoi⁴, ¹Seattle Children's Hospital, Seattle, WA, ²OHSU, Portland, OR, ³Division of Rheumatology, University of Washington, Seattle, WA, Seattle, WA, ⁴Seattle Children's Hospital and Research Center, Mercer Island, WA, WA
Background/Purpose: Children with juvenile dermatomyositis (JDM) and juvenile idiopathic arthritis (JIA) have impaired quality of life and increased rates of anxiety and depression (15-65%), even…
Abstract Number: 2063 • ACR Convergence 2024
Serum Glutamate Dehydrogenase in Idiopathic Inflammatory Myopathy Patients
Nantakarn Pongtarakulpanit¹, Tanya Chandra¹, shiri keret², Vladimir Liarski¹, Dana Ascherman³, Siamak Mogahadam¹, Chester Oddis¹ and Rohit Aggarwal⁴, ¹Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²Rheumatology unit, Bnai-Zion medical center and the faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel., Atlit, Israel, ³Division of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁴Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA, Pittsburgh, PA
Background/Purpose: Diagnosing hepatocellular injury in idiopathic inflammatory myopathy (IIM) patients with active myositis is challenging due to the lack of liver specificity of the transaminase…
Abstract Number: 2084 • ACR Convergence 2024
Efficacy and Safety of a Step-down Regimen of Low Dosage of Glucocorticoids Combined with Early Administration of Synthetic or Biologic Immunosuppressants in Anti-synthetase Syndrome: A Pilot Study
Edoardo Conticini¹, Paolo Cameli¹, Silvia Grazzini¹, Miriana d'Alessandro¹, Laura Bergantini¹, Brunetta Porcelli¹, Maria Antonietta Mazzei¹, Luca Cantarini¹, Elena Bargagli¹ and Bruno Frediani², ¹Università di Siena, Siena, Italy, ²Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy
Background/Purpose: Anti-synthetase syndrome (ASS) is a rare autoimmune disease characterized by the presence of anti-aminoacyl-transfer-RNA synthetase antibodies (ARS) and the involvement of muscles, skin, joints,…
Abstract Number: 0322 • ACR Convergence 2024
Enhanced Detection of Myocarditis in Idiopathic Inflammatory Myopathies Utilizing Multiparametric Cardiac Magnetic Resonance Imaging
Julie Paik¹, Shadi Ayoumi², Ghazal Zandieh², Cody Calhoun², Caoilfhionn Connolly², Lisa Christopher-Stine¹, Christopher Mecoli¹, Myma Albayda², Eleni Tiniakou³, Nisha Gilotra², Stefan Zimmerman² and Bharath Venkatesh², ¹Johns Hopkins University, Baltimore, MD, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Johns Hopkins University, Lutherville Timonium, MD
Background/Purpose: Myocarditis in idiopathic inflammatory myopathies (IIM) is poorly understood despite its association with poor outcomes such as heart failure and sudden cardiac death. It…
Abstract Number: 0347 • ACR Convergence 2024
Dermato-polymyositis Mortality in U.S. Population: Declining Cancer and Cardiovascular Diseases Among the Leading Underlying Causes of Death over Two Decades
Elizabeth Matz¹ and Ram Singh², ¹UCLA David Geffen School of Medicine, Los Angeles, ²UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Dermatomyositis and polymyositis (DM/PM) are chronic inflammatory muscle diseases that may cause premature death due to progressive muscle weakness, lung disease, and disease and…

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