Abstracts tagged "Myositis"

Abstract Number: 2137 • 2017 ACR/ARHP Annual Meeting
Clinical Factors Associated with Long-Term Damage and Calcinosis in an Adult-Age Referral Population of Juvenile Myositis Patients
Vladislav Tsaltskan¹, Annette Aldous², Sam Serafi¹, Heidi Sami¹, Gulnara Mamyrova¹, Frederick W Miller³, Sam Simmens², Rodolfo Curiel¹, Olcay Y. Jones⁴ and Lisa G Rider³, ¹Department of Rheumatology, George Washington University, Washington, DC, ²Department of Epidemiology and Biostatistics, George Washington University Milken Institute School of Public Health, Washington, DC, ³Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, ⁴Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD
Background/Purpose: Juvenile idiopathic inflammatory myopathies (JIIM) are rare, autoimmune chronic muscle diseases of childhood with significant potential long-term morbidity. In this study we investigate associations…
Abstract Number: 2145 • 2017 ACR/ARHP Annual Meeting
Anti-CXCR3 Antibody Suppresses Inflammation in C Protein-Induced Myositis Model
Ji Yong Choi¹, Joo Youn Lee², Ji Soo Park³, Sehui Shon³, Kathleen Phillips⁴, Eun Young Lee¹, Eun Bong Lee¹ and Yeong Wook Song^3,5, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, Korea, Republic of (South), ²Department of Molecular medicine and biopharmaceutical science, Seoul National University, seoul, Korea, Republic of (South), ³Department of Molecular medicine and biopharmaceutical science, Seoul National University, Seoul, Korea, Republic of (South), ⁴Pfizer Inc. Cambridge, MA. USA, Cambridge, MA, ⁵Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South)
Background/Purpose: CXCR3 is a chemokine receptor that plays an important role in T cell chemotaxis in human autoimmune diseases. CXCR3, which is activated by ligand…
Abstract Number: 2166 • 2017 ACR/ARHP Annual Meeting
Intravenous Immunoglobulins in Idiopathic Inflammatory Myopathies: Efficacy and Predictive Factors for Clinical Response
Simone Barsotti^1,2, Ilaria Cavazzana³, Rossella Neri⁴, Francesco Locatelli⁵, Mara Taraborelli^3,6, Elisa Cioffi⁷, Ilaria Chiapparoli⁵, Angela Tincani⁸, Franco Franceschini³ and Marta Mosca¹, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²Department of Medical Biotechnologies, University of Siena, Siena, Italy, ³Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Brescia, Italy, ⁴Rheumatology Unit, University of Pisa, PISA, Italy, ⁵Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foudation, Pavia, Italy, ⁶Internal Medicine; Ospedale Mellini, Chiari (Brescia), Italy, ⁷Rheumatology Unit, Rheumatology Unit, University of Pisa, Pisa, Italy, ⁸Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy
Background/Purpose: Despite the absence of specific guidelines or trials on intravenous immunoglobulins (IvIg) in patients with idiopathic inflammatory myopathies (IIM), the treatment is considered effective…
Abstract Number: 2309 • 2016 ACR/ARHP Annual Meeting
Focal Myositis: New Insights on Diagnosis and Pathology
Laure Gallay¹, Philippe Petiot², Arnaud Hot³, Francoise Thivolet-Bejui⁴ and Nathalie Streichenberger⁴, ¹Department of Internal Medicine, Edouard Heriot University Hospital, Hoscpices Civils de Lyon, Lyon cedex 03, France, ²Department of Neurology, Croix-Rousse Hospital, Hospices Civils de Lyon, Lyon, France, ³Department of Internal Medicine, Edouard Herriot University Hospital, Hospices Civils de Lyon, Lyon cedex 03, France, ⁴Department of Pathology, Neurology and Neurosurgery Pierre Wertheimer University Hospital, Hospices Civils de Lyon, Bron, France
Background/Purpose: Due to the rarity of the entity, the literature on focal myositis (FM) fails to address important questions on its nosology, associated disorders, clinical…
Abstract Number: 2315 • 2016 ACR/ARHP Annual Meeting
The Effectiveness of Social Media in Recruiting for Rare Rheumatic Diseases
Adam Schiffenbauer¹, Lisa G. Rider², Sara Faghihi-Kashani³, Komal Patel⁴ and Frederick W. Miller⁵, ¹Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ²Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, ³Environmental Autoimmunity Group, National Institute of Environmental Health, Bethesda, MD, ⁴Social and Scientific Systems, Inc., Bethesda, MD, ⁵Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH, Bethesda, MD
Background/Purpose: Clinical research is dependent on being able to recruit and enroll appropriate patients in sufficient numbers to make robust conclusions. For many diseases it…
Abstract Number: 2326 • 2016 ACR/ARHP Annual Meeting
Intravenous Cyclophosphamide Followed By Oral Immunosuppressive Treatment Versus Rituximab in Inflammatory Myopathy-Related Interstitial Lung Disease
Vincent Langlois¹, Kuberaka Mariampillai², Nicolas Champtiaux³, Marie-Laure Chabi⁴, Yurdagul Uzunhan⁵, Eric Hachulla⁶, Olivier Benveniste⁷ and Baptiste Hervier³, ¹Internal Medicine, University Hospital, Rouen, France, ²Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Department of Internal Medicine and Clinical Immunology, Hospital University Department: inflammation, immunopathology and biotherapy (DHU i2B), Paris, France, Paris, France, ³Internal Medicine, Pitié-Salpêtrière University Hospital, Paris, France, ⁴Radiology department, APHP, Hôpital Pitié Salpêtrière, Paris, France, ⁵Pulmonary diseases department, Avicenne Hospital (AP-HP), Bobigny, France, ⁶Internal Medicine, Lille University Hospital, Lille, France, ⁷Pitié-Salpêtrière University Hospital, Paris, France
Background/Purpose: Interstitial lung disease (ILD) associated with inflammatory myopathy (IM) has a poor prognosis and requires specific treatments. Intravenous Cyclophosphamide (CYC) is one of the…
Abstract Number: 288 • 2015 ACR/ARHP Annual Meeting
Myositis Associated Interstitial Lung Disease: Clinical Predictors of Failure to Conventional Treatment and Their Response to Tacrolimus
Niharika Sharma¹, Anisha Dua¹, Michael Putman², Rekha Vij³ and Mary Strek³, ¹Rheumatology, The University of Chicago, Chicago, IL, ²Internal Medicine, The University of Chicago, Chicago, IL, ³Pulmonology, The University of Chicago, Chicago, IL
Background/Purpose: Interstitial lung disease (ILD) frequently complicates Polymyositis (PM) and Dermatomyositis (DM) and accounts for significant morbidity and mortality in affected patients. Patients with Myositis…
Abstract Number: 302 • 2015 ACR/ARHP Annual Meeting
Resource Utilization in a US Sample of Patients with Sporadic Inclusion Body Myositis
Victoria Barghout¹, Carla DeMuro², Bob Goldberg³, Mark A Price², Linda Lowes⁴, Gorana capkun-Niggli⁵, Valerie Williams⁶ and Brian Tseng⁷, ¹VEB HealthCare LLC, Morristown, NJ, ²RTI Health Solutions, North Carolina, NC, ³The Myositis Association, Alexandria, VA, ⁴Nationwide Children’s Hospital, Columbus, OH, ⁵Novartis Pharmaceuticals Corporation, Basel, Switzerland, ⁶Psychometrics, RTI Health Solutions, North Carolina, NC, ⁷Novartis Pharmaceuticals Corporation, East Hanover, NJ
Background/Purpose: Sporadic Inclusion Body Myositis (sIBM) is a progressive, idiopathic inflammatory myopathy characterized by dysphagia, weakness of proximal and distal muscles and atrophy. This cross-sectional…
Abstract Number: 2361 • 2015 ACR/ARHP Annual Meeting
Abatacept in the Treatment of Adult Dermatomyositis and Polymyositis: a Randomized, Treatment Delayed-Start Trial
Ingrid E. Lundberg¹, Anna Tjärnlund², Quan Tang³, Cecilia Wick², Maryam Dastmalchi⁴, Herman F Mann⁵, Jana Tomasová Studýnková⁵, Radka Chura⁶, Nicola J. Gullick⁷, Rosaria Salerno⁷, Eva Lindroos^3,8, Patrick Gordon⁶ and Jiri Vencovsky⁵, ¹Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, ³Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Medicine, Solna, Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁵Institute of Rheumatology, Prague, Czech Republic, ⁶Department of Rheumatology, King`s College Hospital NHS Foundation Trust, London, United Kingdom, ⁷Rheumatology, Department of Rheumatology, King`s College Hospital NHS Foundation Trust, London, United Kingdom, ⁸Department of Medicine, Rheumatology Unit, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden., Stockholm, Sweden
Background/Purpose: The aim of the study was to assess the effects of abatacept, a T cell blocking agent, on disease activity and on muscle biopsy…
Abstract Number: 2375 • 2015 ACR/ARHP Annual Meeting
Interstitial Lung Disease in Patients with Anti-PM-Scl Antibody
Hiromichi Tamaki¹, Ruchi Yadav², James Bena³ and Soumya Chatterjee⁴, ¹Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, Cleveland, OH, ²Diagnostic Radiology, Cleveland Clinic, Cleveland, OH, ³Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH, ⁴Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Patients with anti-PM-Scl antibody (PM-Scl) can present with several different phenotypes: polymyositis (PM), dermtomyositis (DM), systemic sclerosis (SSc), scleromyositis, or sclero-dermatomyositis. Interstitial Lung Disease…
Abstract Number: 2456 • 2015 ACR/ARHP Annual Meeting
Anti SRP+Ve Myositis in Childhood. Presentation and Physiotherapy Treatment of This Rare Childhood Myositis
Susan Maillard and Clarissa Pilkington, Paediatric Rheumatology, Great Ormond Street Hospital NHS Foundation Trust for Children, London, United Kingdom
Background/Purpose: Previously it was understood that all Myositis in childhood was Juvenile Dermatomyositis. More recently Myositis specific antibodies have been discovered and these appear to…
Abstract Number: 1327 • 2014 ACR/ARHP Annual Meeting
Decreased CD3-CD16CD56+ Natural Killer Cell Counts Are Associated with Disease Activity in Children with Orbital Myositis
Melissa R. Bussey¹, Gabrielle A. Morgan², Maria C. Amoruso², Bahram Rahmani³ and Lauren M. Pachman⁴, ¹Rheumatology, Division of Rheumatology, Loyola University Medical Center, Maywood, IL, ²Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Cure JM Myositis Center, Chicago, IL, ³Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Division of Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Orbital myositis (OM), an inflammatory disease affecting the extra-ocular muscles, typically presents in the third decade. It more commonly affects females and is extremely…
Abstract Number: 1263 • 2014 ACR/ARHP Annual Meeting
Evidence for the Involvement of NK Cells in Antisynthetase Syndrome
Baptiste Hervier¹, Yves Allenbach², Mikael Perez³, Hervé Devilliers⁴, Fleur Cohen-Aubart⁵, Zahir Amoura⁶, Werner Stenzel⁷, Isabelle Cremer⁸, Olivier Benveniste² and Vincent Vieillard¹, ¹INSERM UMR-S 1135, UPMC, Paris, France, ²UMR 974, Sorbonne Universités, University Pierre et Marie-Curie-Paris 6, INSERM, Paris, France, ³UMR-S 1138, INSERM & UPMC, Paris, France, ⁴CHU de Dijon, Dijon, France, ⁵Internal Medicine Dpt 2, Pitié-Salpêtrière Hospital, APHP, Paris, France, ⁶Internal medicine 2, French National Reference Center for Systemic Lupus and Antiphospholipid Syndrome, Pitié-Salpêtrière Hospital (AP-HP), Paris, France, ⁷Department of Neuropathology, Charite Hospital, Berlin, Germany, ⁸INSERM UMR-S 1138, INSERM & UPMC, Paris, France
Background/Purpose Antisynthetase syndrome (aSS) is characterized by the association of interstitial lung disease and myositis with anti-tRNA-synthetase autoantibodies. Its pathogenesis remains unknown, especially regarding the…
Abstract Number: 1262 • 2014 ACR/ARHP Annual Meeting
Mechanisms of Muscular Necrosis in Auto-Immune Myopathies Associated with Anti-Signal Recognition Particle and Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme a Reductase Antibodies: Pathogenic Role of Auto-Antibodies
Yves Allenbach^1,2,3, Aude Rigolet³, Bruno Eymard⁴, Tanya Stojkovic⁴, Anthony. Behin⁴, Pascal Laforet⁴, Peter Hufnagl⁵, Norman Zerbe⁶, Thierry Maisonobe⁷, Kuberaka Mariampillai⁸, Serge Herson⁸, Olivier Benveniste^2,3 and Werner Stenzel⁹, ¹Neuropathology, Charite Hospital, Berlin, Germany, ²UMR 974, Sorbonne Universités, University Pierre et Marie-Curie-Paris 6, INSERM, Paris, France, ³Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France, ⁴Department of Neurology, Myology Institute, Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University, Paris, France, ⁵Pathology departmen, Charite Hospital, Berlin, Germany, ⁶Department of Pathology, Charite Hospital, Berlin, Germany, ⁷Neuropathology, Pitie-Salpetriere Hospital, Paris, France, ⁸Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University, Paris, France, ⁹Department of Neuropathology, Charite Hospital, Berlin, Germany
Background/Purpose: Necrotizing auto-immune myopathies (NAM) are a group of acquired idiopathic inflammatory myopathies characterized by severe muscle weakness and no or mild extra-muscular involvement. Definition of…
Abstract Number: 1269 • 2014 ACR/ARHP Annual Meeting
Epidemiology and Characteristics of Antisynthetase Syndrome in the African Descent Population of Martinique
Christophe Deligny¹, Maryvonne Dueymes², Serge Arfi¹, José Zécler³, Maia Forgues⁴, Véronique Dehlinger⁵, Michel DeBandt⁶, Lauren Brunier-Agot⁶, Remi Bellance⁷, Isabelle Lamaury⁸, Nadege Cordel⁸, Nicolas Baillet⁹, Gilbert. Cadelis¹⁰, Georges Jean Baptiste¹¹ and Katlyne Polomat¹², ¹Rhumatologie Et Médecine Interne, Centre hospitalier Universitaire de Fort de France, Fort de France, Martinique, ²Immunology, Centre Hospitalier Universitaire de Fort de France, Fort de France, Martinique, ³Respiratory, Centre Hospitalier Universitaire de Fort de France, Fort de France, Martinique, ⁴Internal medicine, Centre Hospitalier Andre Rosemon, Cayenne, French Guiana, ⁵Rheumatology, Centre Hospitalier universitaire de Fort de France, Fort De France - Martinique, Martinique, ⁶Rheumatology, Centre Hospitalier universitaire de Fort de France, Fort de France, Martinique, ⁷National center for rare neuromuscular disorders, Centre Hospitalier universitaire de Fort de France, Fort de France, Martinique, ⁸Infectious diseases, dermatology and internal medicine, Centre Hospitalier universitaire de Guadeloupe, Pointe à Pitre, Guadeloupe, ⁹internal medicine, Centre Hospitalier de la Basse Terre, Basse Terre, Guadeloupe, ¹⁰Respiratory, Cnetre Hospitalier Universitaire de Guadeloupe, Pointe à Pitre, Guadeloupe, ¹¹Rheumatology, Centre Hospitalier Universitaire de Fort de France, Fort de France, Guadeloupe, ¹²Centre Hospitalier universitaire de Fort de France, Fort de France, Martinique
Background/Purpose : There is no population based epidemiologic studies of antisynthetase syndrome (ASS). We described characteristics and epidemiology of this disease in Martinique, populated by…

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