Abstracts tagged "Myositis"

Abstract Number: 1150 • ACR Convergence 2024
Increased ISG15 Expression in Peripheral Blood from Patients with Positive Dermatomyositis Related Specific Autoantibodies
Sylvia Raftopoulou¹, Nikolaos Michalakeas¹, Maria Gerochristou², Nikolaos Marketos¹, Charalampos Skarlis¹ and Clio Mavragani³, ¹Molecular and Applied Physiology Unit, Department of Physiology, School of Medicine, National and Kapodistrian University of Athens., Athens, Greece, ²Andreas Syggros Hospital, National and Kapodistrian University of Athens, Athens, Greece, ³Department of Physiology and Pathophysiology, School of Medicine, National and Kapodistrian University of Athens., Athens, Greece
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are characterised by muscle inflammation (myositis) and weakness, impacting various organ systems. Clinical subtypes include dermatomyositis (DM), antisynthetase syndrome (ASyS),…
Abstract Number: 1170 • ACR Convergence 2024
Computer Aided Lung Informatics, HRCT and PFT in Patients with Interstitial Lung Disease in Idiopathic Inflammatory Myopathies
Sonali Narain¹, Kourosh Shargani², Ivana Ilic³, Irvind Buttar⁴ and Galina Marder⁵, ¹Northwell Health, Great Neck, NY, ²Northwell, Manhasset, NY, ³Northwell, Brooklyn, NY, ⁴Northwell Health/ Lenox Hill Hospital, Dix Hills, NY, ⁵Donald and Barbara Zucker School of Medicine at Hofstra/ Northwell, Great Neck, NY
Background/Purpose: Evaluation of Interstitial Lung Disease (ILD) progression relies on high resolution computed tomography (HRCT) and pulmonary function test (PFT). As we previously reported in our Idiopathic…
Abstract Number: 2060 • ACR Convergence 2024
Clustering Analysis of Immune Cell Subtypes and Clinical Phenotypes in Idiopathic Inflammatory Myopathy
xiaoyan xing¹, Yuhui Li² and Jing He³, ¹Department of Rheumatology and Immunology and Beijing Key Laboratory for Rheumatism and Immune Diagnosis (BZ0135), Peking University People’s Hospital, Beijing, China, Beijing, China, ²Peking University, BeiJing, China, ³Rheumatology, Beijing, China
Background/Purpose: Immune cell profiling plays a pivotal role in the pathogenesis of idiopathic inflammatory myopathy (IIM). Characterizing immune cell subtypes, such as CD4+ T cells,…
Abstract Number: 2083 • ACR Convergence 2024
A Novel Scoring System to Predict a Cancer Development in Patients with Idiopathic Inflammatory Myopathy
Yun Kyu Kim¹, Ju yeon Kim², Jung Yoon Pyo³, Min Jung Kim⁴, Jin Kyun Park⁵, Eun Young Lee⁶, Yun Jong lee³, eun Bong Lee¹ and Jun Won park², ¹Seoul National University Hospital, Seoul, Republic of Korea, ²Seoul National University Hospital, Seoul, Seoul-t'ukpyolsi, Republic of Korea, ³Seoul National University Bundang Hospital, Seongnam-si, ⁴Seoul Metropolitan Government Boramae Medical center, Dongjak-gu, Seoul, South Korea, ⁵Seoul National University College of Medicine, Jongno-gu, Seoul, Republic of Korea, ⁶3Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
Background/Purpose: Previous studies have demonstrated that idiopathic inflammatory myopathy (IIM) is associated with an elevated cancer risk. However, there is limited evidence on the specific…
Abstract Number: 0321 • ACR Convergence 2024
Diffusion Weighted Imaging in Muscle MRI Can Detect Quantitative Improvements in Muscle Edema: A Post-hoc Analyses of the Study of Tofacitinib in Refractory Dermatomyositis
Julie Paik¹, Patrick Debs², Anshula Nallapati¹, Lisa Christopher-Stine¹, Jemima Albayda³, Eleni Tiniakou⁴ and Laura Fayad², ¹Johns Hopkins University, Baltimore, MD, ²Johns Hopkins Radiology, Baltimore, MD, ³Johns Hopkins School of Medicine, Baltimore, MD, ⁴Johns Hopkins University, Lutherville Timonium, MD
Background/Purpose: Diffusion weighted imaging (DWI) in muscle magnetic resonance imaging is an underutilized, quantitative assessment tool in idiopathic inflammatory myopathies (IIM). It is not uncommon…
Abstract Number: 0346 • ACR Convergence 2024
Clonally Expanded and Total B Cells in Patients with Idiopathic Inflammatory Myopathies Show Skewed B Cell Subset Distribution and Reduced Somatic Hypermutation Relative to Healthy Controls
Amelia Sawyers¹, Leslie Crofford², Erin Wilfong³ and Rachel Bonami³, ¹Vanderbilt University School of Medicine, Nashville, TN, ²Vanderbilt University Medical Center, Melbourne, AR, ³Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are a collection of rare, systemic rheumatic diseases. A role for B cells in IIM is indicated by the success…
Abstract Number: 1151 • ACR Convergence 2024
Clinical Characterization and Recurrence Prediction Model for Immune-Mediated Necrotizing Myopathy
Beibei Cui¹, Hongjiang Liu², Geng Yin³ and Qibing Xie⁴, ¹Rheumatology and Immunology, Chengdu, China (People's Republic), ²West China Hospital, Sichuan University, Chengdu, China (People's Republic), ³Department of Rheumatology and Immunology, chengdu, China (People's Republic), ⁴Department of Rheumatology and Immunology, Chengdu, Sichuan, China
Background/Purpose: The primary objective of this study was to comprehensively analyze the clinical characteristics of immune-mediated necrotizing myopathy (IMNM) and develop a reliable recurrence prediction…
Abstract Number: 1233 • ACR Convergence 2024
Narrative Medicine Intervention for Mental Wellbeing in Juvenile Myositis and Juvenile Idiopathic Arthritis
Aviya Lanis¹, Emily Steelquist², Christian Lood³ and Susan Shenoi⁴, ¹Seattle Children's Hospital, Seattle, WA, ²OHSU, Portland, OR, ³Division of Rheumatology, University of Washington, Seattle, WA, Seattle, WA, ⁴Seattle Children's Hospital and Research Center, Mercer Island, WA, WA
Background/Purpose: Children with juvenile dermatomyositis (JDM) and juvenile idiopathic arthritis (JIA) have impaired quality of life and increased rates of anxiety and depression (15-65%), even…
Abstract Number: 2063 • ACR Convergence 2024
Serum Glutamate Dehydrogenase in Idiopathic Inflammatory Myopathy Patients
Nantakarn Pongtarakulpanit¹, Tanya Chandra¹, shiri keret², Vladimir Liarski¹, Dana Ascherman³, Siamak Mogahadam¹, Chester Oddis¹ and Rohit Aggarwal⁴, ¹Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²Rheumatology unit, Bnai-Zion medical center and the faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel., Atlit, Israel, ³Division of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁴Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA, Pittsburgh, PA
Background/Purpose: Diagnosing hepatocellular injury in idiopathic inflammatory myopathy (IIM) patients with active myositis is challenging due to the lack of liver specificity of the transaminase…
Abstract Number: 2084 • ACR Convergence 2024
Efficacy and Safety of a Step-down Regimen of Low Dosage of Glucocorticoids Combined with Early Administration of Synthetic or Biologic Immunosuppressants in Anti-synthetase Syndrome: A Pilot Study
Edoardo Conticini¹, Paolo Cameli¹, Silvia Grazzini¹, Miriana d'Alessandro¹, Laura Bergantini¹, Brunetta Porcelli¹, Maria Antonietta Mazzei¹, Luca Cantarini¹, Elena Bargagli¹ and Bruno Frediani², ¹Università di Siena, Siena, Italy, ²Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy
Background/Purpose: Anti-synthetase syndrome (ASS) is a rare autoimmune disease characterized by the presence of anti-aminoacyl-transfer-RNA synthetase antibodies (ARS) and the involvement of muscles, skin, joints,…
Abstract Number: 0322 • ACR Convergence 2024
Enhanced Detection of Myocarditis in Idiopathic Inflammatory Myopathies Utilizing Multiparametric Cardiac Magnetic Resonance Imaging
Julie Paik¹, Shadi Ayoumi², Ghazal Zandieh², Cody Calhoun², Caoilfhionn Connolly², Lisa Christopher-Stine¹, Christopher Mecoli¹, Myma Albayda², Eleni Tiniakou³, Nisha Gilotra², Stefan Zimmerman² and Bharath Venkatesh², ¹Johns Hopkins University, Baltimore, MD, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Johns Hopkins University, Lutherville Timonium, MD
Background/Purpose: Myocarditis in idiopathic inflammatory myopathies (IIM) is poorly understood despite its association with poor outcomes such as heart failure and sudden cardiac death. It…
Abstract Number: 0347 • ACR Convergence 2024
Dermato-polymyositis Mortality in U.S. Population: Declining Cancer and Cardiovascular Diseases Among the Leading Underlying Causes of Death over Two Decades
Elizabeth Matz¹ and Ram Singh², ¹UCLA David Geffen School of Medicine, Los Angeles, ²UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Dermatomyositis and polymyositis (DM/PM) are chronic inflammatory muscle diseases that may cause premature death due to progressive muscle weakness, lung disease, and disease and…
Abstract Number: 1152 • ACR Convergence 2024
Nailfold Videocapillaroscopy Abnormalities in Different Autoimmune Inflammatory Myopathy Subsets
Thaisa Cotton¹, Valérie Leclair², Claudie Berger³, Yves Troyanov⁴, marie Hudson² and Geneviève Gyger², and Canadian Inflammatory Myopathy Study (CIMS), ¹Université de Montréal, Montreal, QC, Canada, ²McGill University, Montreal, QC, Canada, ³Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁴Centre hospitalier de l'Université de Montréal, Montreal, QC, Canada
Background/Purpose: Nailfold videocapillaroscopy (NVC) alterations have mostly been described in autoimmune inflammatory myopathies (AIM) classified using Bohan and Peter criteria. The aim of this study…
Abstract Number: 1261 • ACR Convergence 2024
Association of Muscle Biopsies and Functional Recovery Trajectories in Children with Juvenile Dermatomyositis
Shannon O'Connor¹, Ilaria Maccora², Megan Quinlan-Waters¹, hermine brunner³, sheila Angeles-Han⁴, grant schulert¹ and leah kottyan¹, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²?PhD student, in the Area of Drugs and Innovative Treatments, NeuroFARBA Department, University of Florence. Meyer Children's Hospital, Florence Italy, Firenze, Florence, Italy, ³Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, ⁴Cincinnati Children's Hospital, Cincinnati, OH
Background/Purpose: Juvenile dermatomyositis (JDM) is an idiopathic inflammatory myopathy characterized by proximal muscle weakness, a distinct rash, and an increased risk of calcinosis, with long-term…
Abstract Number: 2066 • ACR Convergence 2024
Comparative Diagnostic Efficacy of Quantitative Measurement of Echo Intensity and Texture versus Qualitative Analysis of Ultrasound Images in Myositis
Takeshi Yoshida¹, Hiroki Yamazaki², Naoko Takamatsu², Yoshinori Taniguchi³, Taiki Nozaki⁴, masataka inoue⁵, Yoshitaka Kumon⁶, yuki matsumoto², Yuki Kanazawa², Masafumi Harada², Ichizo Nishino⁷, Jemima Albayda⁸ and Yuishin Izumi², ¹Chikamori Hospital, Kochi, Kochi, Japan, ²Tokushima University School of Medicine, Tokushima, Japan, ³Kochi University School of Medicine, kochi, Japan, ⁴keio University School of Medicine, Tokyo, Japan, ⁵Hyogo Medical University, Nishinomiya, Japan, ⁶Chikamori Hospital, Kochi, Japan, ⁷National Center of Neurology and Psychiatry, Tokyo, Japan, ⁸Johns Hopkins School of Medicine, Baltimore, MD
Background/Purpose: Recently, the role of imaging tests such as magnetic resonance imaging and ultrasound (US) in the diagnosis and classification of myositis has become increasingly…

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