Abstracts tagged "Myositis"

Abstract Number: 0706 • ACR Convergence 2021
Mycophenolate Mofetil and Methotrexate Efficacy in Dermatomyositis
Madison Grinnell¹, Emily Keyes², DeAnna Diaz², Thomas Vazquez³, Rui Feng⁴ and Victoria Werth², ¹Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania and Philadelphia VAMC, OMAHA, NE, ²Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania and Philadelphia VAMC, Philadelphia, PA, ³FIU Wertheim College of Medicine, Virginia Beach, VA, ⁴University of Pennsylvania Department of Biostatistics, Philadelphia, PA
Background/Purpose: Treatment of dermatomyositis (DM) typically follows a stepwise sequence starting with either methotrexate (MTX) or mycophenolate mofetil (MMF) after an inadequate response to antimalarial…
Abstract Number: 0756 • ACR Convergence 2021
Validation of Two Simple Patient-centered Outcome Measures for Virtual Monitoring of Patients with Idiopathic Inflammatory Myositis
R Naveen¹, Darpan R Thakare², Vikas Agarwal², Rohit Aggarwal³ and Latika Gupta¹, ¹Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, ²Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ³University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Changing landscape of patient care from in-person to virtual telemedicine-based consultation in times of a global pandemic has necessitated a wider use of patient-centered…
Abstract Number: 1057 • ACR Convergence 2020
Earlier Cancer Diagnosis After Idiopathic Inflammatory Myopathy Onset Is Associated with Improved Long Term Survival – Results from Four European Cohorts
Alexander Oldroyd¹, Paul New², Janine Lamb¹, William Ollier¹, Robert Cooper², Kuberacka Mariampillai³, Olivier Benveniste³, Jiří Vencovský⁴, Heřman Mann⁵, Zoltan Griger⁶, Melinda Nagy-Vincze⁶, Katalin Dankó⁶ and Hector Chinoy⁷, ¹University of Manchester, Manchester, United Kingdom, ²University of Liverpool, Liverpool, United Kingdom, ³Sorbonne Université, Paris, France, ⁴Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ⁵Institute of Rheumatology, Prague, Czech Republic. Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ⁶University of Debrecen, Debrecen, Hungary, ⁷The University of Manchester, Manchester, United Kingdom
Background/Purpose: The idiopathic inflammatory myopathies (IIMs) are strongly associated with the development of clinically detectable cancer. Cancer screening has therefore been advocated in newly diagnosed…
Abstract Number: 1078 • ACR Convergence 2020
Highly Reactive anti-Jo1 Autoantibodies to Distinct HisRS Variants and Domains Associate with Lung and Joint Involvement in Patients with Myositis
Antonella Notarnicola¹, Charlotta Preger², Susanna L. Lundström², Nuria Renard², Edvard Wigren², Eveline Van Gompel², Angeles S. Galindo-Feria², Helena Persson³, Maryam Fathi⁴, Johan Grunewald², Per-Johan Jakobsson², Susanne Gräslund², Ingrid Lundberg⁵ and Cátia Fernandes-Cerqueira², ¹Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, ²Karolinska Institutet, stockholm, Sweden, ³Science for Life Laboratories, KTH, Stockholm, Sweden, ⁴Karolinska University Hospital, stockholm, Sweden, ⁵Division of Rheumatology, Department of Medicine, Karolinska Institutet,, Stockholm, Sweden
Background/Purpose: To address the reactivity and affinity against histidyl-transfer RNA synthetase (HisRS) autoantigen of anti-Jo1 autoantibodies from serum and bronchoalveolar lavage fluid (BALF) and associations…
Abstract Number: 1457 • ACR Convergence 2020
Two Minute Walking Distance and Other Timed Function Tests Are Superior to MMT-8 in Assessing Outcomes in Polymyositis and Dermatomyositis
Sai kumar Dunga¹, Chengappa G Kavadichanda² and VS Negi², ¹Jawaharlal institute of postgraduate medical education and research, puducherry, India, ²Jawaharlal institute of postgraduate medical education and research, Puducherry, Puducherry, India
Background/Purpose: Inflammatory myositis are heterogenous group of diseases affecting skeletal muscles and multiple different organs. Assessing improvement in disease activity is done by Manual muscle…
Abstract Number: 1059 • ACR Convergence 2020
Anti-mitochondrial Autoantibodies Are Associated with Cardiomyopathy, Dysphagia, and Features of More Severe Disease in Adult-onset Myositis
Sara Sabbagh¹, Iago Pinal-Fernandez², Maria Casal-Dominguez³, Jemima Albayda⁴, Julie Paik⁴, Frederick W. Miller², Lisa G. Rider⁵, Andrew Mammen³ and Lisa Christopher-Stine⁴, ¹Medical College of Wisconsin, Fox Point, WI, ²National Institutes of Health, Bethesda, MD, ³NIH, Bethesda, MD, ⁴Johns Hopkins University, Baltimore, MD, ⁵Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Garrett Park, MD
Background/Purpose: We examined the prevalence of anti-mitochondrial autoantibodies (AMA) in adult- and juvenile-onset myositis longitudinal cohorts and investigated phenotypic differences between myositis patients with or…
Abstract Number: 1079 • ACR Convergence 2020
Sex Differences in Antibody Profile, Phenotype, and Treatment Response in a Racially Diverse Population with Idiopathic Inflammatory Myopathies
Ana Valle¹, Jammie Law², Katherine Mullins³ and Shereen Mahmood⁴, ¹Albert Einstein College of Medicine, New York, NY, ²Montefiore Medical Center, Bronx, NY, ³Montefiore Medical Center, BROOKLYN, NY, ⁴Albert Einstein College of Medicine / Montefiore Medical Center, Wantagh, NY
Background/Purpose: It is established that autoimmune diseases are more common in females than males. Large scale idiopathic inflammatory myopathy (IIM) registries have shown a similar…
Abstract Number: 1556 • ACR Convergence 2020
Assessing Calcinosis in Dermatomyositis with Computed Tomography and Calcium Scoring
Prateek Gowda¹, Briana Cervantes², Lisa G. Rider³, Frederick W. Miller⁴, Marcus Chen⁴ and Adam Schiffenbauer⁴, ¹NIBIB, Baltimore, MD, ²NIEHS, Silver Spring, MD, ³Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Garrett Park, MD, ⁴National Institutes of Health, Bethesda, MD
Background/Purpose: Calcinosis is a condition in which calcium salts are deposited in and around soft tissue and is observed in up to 30% of adult…
Abstract Number: 1060 • ACR Convergence 2020
B-cell-rich Inflammatory Myopathies in Adults: Striking Association with Connective Tissue Diseases
Pat Korathanakhun¹, Océane Landon-Cardinal², Valérie Leclair³, Benjamin Ellezam⁴, Alain Meyer⁵, Josiane Bourré-Tessier², Anne-Marie Mansour⁶, Sandrine Larue⁷, François Grand'Maison⁷, Rami Massie⁸, Matthieu Le Page⁹, Catherine Isabelle⁷, Nathalie Routhier⁶, Flavie Roy¹⁰, Minoru Satoh¹¹, Marvin Fritzler¹², Jean-Luc Senécal², Yves Troyanov¹³, Marie Hudson³, Jason Karamchandani¹⁴ and Erin O'Ferrall⁸, ¹Montreal Neurological Institute and Hospital, Montreal, QC, Canada, ²Division of Rheumatology, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada, ³Division of Rheumatology, Jewish General Hospital, Montréal, QC, Canada, ⁴Division of Pathology, Centre hospitalier universitaire Sainte-Justine, Montréal, QC, Canada, ⁵Service de rhumatologie et Centre de références des maladies autoimmunes rares, Hôpitaux universitaires de Strasbourg, Strasbourg, France, ⁶Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada, ⁷Hôpital Charles-Lemoyne, Longueuil, QC, Canada, ⁸Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, Montreal, QC, Canada, ⁹Centre hospitalier de Lanaudière, Saint-Charles-Borromée, QC, Canada, ¹⁰Uiversité de Montréal, Montreal, QC, Canada, ¹¹Department of Clinical Nursing, University of Occupational and Environmental Health, Kitakyushu, Japan, ¹²Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ¹³Division of Rheumatology, Hôpital du Sacré-Coeur, Montréal, QC, Canada, ¹⁴Department of Pathology, Montreal Neurological Institute and Hospital, Montreal, QC, Canada
Background/Purpose: Myositis with significant B-cell infiltrates on muscle biopsy has scarcely been described in adults. Radke (2018) found B cells in adult dermatomyositis (DM) and…
Abstract Number: 1081 • ACR Convergence 2020
Patient-reported Outcomes in Early Autoimmune Inflammatory Myopathies
Valérie Leclair¹, Brett Thombs², Mianbo Wang³, Evelyne Vinet⁴, Alexandra Albert⁵ and Marie Hudson⁶, ¹Division of Rheumatology, Jewish General Hospital, Montreal, QC, Canada, ²Department of Psychology, McGill University, Montreal, QC, Canada, ³Lady Davis institute for Medical Research, Montreal, QC, Canada, ⁴McGill University Health Center, Montreal, QC, Canada, ⁵Division of Rheumatology, Centre Hospitalier de l’Université Laval, Québec, QC, Canada; Department of Medicine, Université Laval, Québec, QC, Canada., Neuville, Canada, ⁶Division of Rheumatology, Jewish General Hospital, Montréal, QC, Canada
Background/Purpose: Patient-reported outcomes (PROs) are increasingly used in rheumatology. Such outcomes are under-reported in autoimmune inflammatory myopathies (AIM) especially in incident cohorts. The objective of…
Abstract Number: 1559 • ACR Convergence 2020
Fully Automatic Assessment of Nail Fold Capillaroscopy Software – Early Results
Olga Brzezińska¹, Krzysztof Rychlicki-Kicior² and Joanna Makowska¹, ¹Department of Rheumatology, Medical University of Lodz, Poland, Lodz, Lodzkie, Poland, ²University of Economics and Human Sciences in Warsaw, Poland, Lodz, Poland
Background/Purpose: Changes in capillaroscopy nailfold image are a valuable element in the diagnostic procedure and monitoring of systemic sclerosis as well as other systemic diseases.…
Abstract Number: 1061 • ACR Convergence 2020
Daily Myositis Symptom Changes Collected via a Smartphone-Based App Are Associated with Flare Occurrence – Providing Evidence of Potential Digital Biomarkers
Alexander Oldroyd¹, Belay Yimer², Max Little³, William Dixon² and Hector Chinoy⁴, ¹University of Manchester, Manchester, United Kingdom, ²Centre for Epidemiology Versus Arthritis, University of Manchester, Manchester, United Kingdom, ³University of Birmingham, Birmingham, United Kingdom, ⁴The University of Manchester, Manchester, United Kingdom
Background/Purpose: The concept of idiopathic inflammatory myopathy (IIM) flare is widely used, although no consensus definition exists. Studies have demonstrated the feasibility and utility of…
Abstract Number: 1082 • ACR Convergence 2020
The Presence of Anti-Jo1, anti-PL7, And/or anti-MDA5 Antibodies in Idiopathic Inflammatory Myopathy Confers an Increased Risk of a Significant Restrictive Pulmonary Defect
Dmitriy Cherny¹ and Carrie Richardson¹, ¹Rush University Medical Center, Chicago, IL
Background/Purpose: A subset of patients with idiopathic inflammatory myopathy develop significant restrictive lung disease, although risk factors for this are poorly defined. Autoantibodies may be…
Abstract Number: 1574 • ACR Convergence 2020
Over Half of Patients with Immune Checkpoint Inhibitor-related Myositis, Myasthenia Gravis and/or Myocarditis Have Autoantibodies: Results from a Systematic Literature Review
Nilasha Ghosh¹, Karmela Kim Chan², Bridget Jivanelli³ and Anne Bass¹, ¹Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ²Hospital For Special Surgery, New York, NY, ³Hospital for Special Surgery, New York
Background/Purpose: Although immune checkpoint inhibitor (ICI) cancer treatments are known to activate cytotoxic T-cells, autoantibodies may also contribute to the development of immune-related adverse events…
Abstract Number: 1062 • ACR Convergence 2020
Dermatomyositis: A Dermatology-Rheumatology Clinic Retrospective Analysis
Burak Elkiran¹, Mahroo Tajalli², Terrence M. Vance³, Abrar A. Qureshi⁴ and Anthony M. Reginato⁵, ¹Department of Medicine, Division of Rheumatology; Warren Alpert Medical School of Brown University, BOSTON, ²Department of Dermatology, Warren Alpert Medical School of Brown University, PROVIDENCE, ³Department of Epidemiology, Warren Alpert Medical School of Brown University, PROVIDENCE, ⁴Department of Dermatology, Warren Alpert Medical School of Brown University, BOSTON, ⁵Department of Medicine, Division of Rheumatology, Warren Alpert Medical School of Brown University, Boston, MA
Background/Purpose: Dermatomyositis (DM) can be categorized into two major subtypes: clinically amyopathic dermatomyositis (CADM) and classic dermatomyositis (CDM). In this study, we aimed to identify characteristics…

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