ACR Meeting Abstracts

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Abstracts tagged "Myositis"

  • Abstract Number: 1959 • ACR Convergence 2023

    Quantitative Scoring of High Resolution Chest Computed Tomography (HRCT) Images in Myositis and Antisynthetase Syndrome Related Interstitial Lung Disease in Comparison to Scleroderma Related Interstitial Lung Disease

    Sangmee Bae1, Fereidoun Abtin2, Grace Kim3, Siamak Moghadam-Kia4, Chester V. Oddis5, Lila Pourzand2, Didem Saygin5, Daniel Sullivan6, Koichi Yamaguchi7, Donald Tashkin3, Christina Charles-Schoeman8, Jonathan Goldin3 and Rohit Aggarwal5, 1UCLA Rheumatology, Los Angeles, CA, 2UCLA Radiological Sciences, Los Angeles, CA, 3University of California Los Angeles, Los Angeles, CA, 4University of Pittsburgh Medical Center, Pittsburgh, PA, 5University of Pittsburgh, Pittsburgh, PA, 6UCLA Pulmonology, Pittsburgh, PA, 7University of Pittsburgh Medical Center Rheumatology, Pittsburgh, PA, 8UCLA Medical Center, Santa Monica, CA

    Background/Purpose: High resolution computed tomography (HRCT) of the chest has become an important modality in the evaluation of interstitial lung disease (ILD). A quantitative CT…
  • Abstract Number: 2514 • ACR Convergence 2023

    Myositis Triad Subset Is Associated with High Mortality in Immune Checkpoint Inhibitor- Induced Myositis

    Selene Rubino1, Grant Cannon2, Brian Sauer3, Jorge Rojas Jr4, Greg Stoddard1, Gary Kunkel1, Jessica A Walsh5, Bryant England6, Ted R Mikuls7, Joshua Baker8 and Tawnie Braaten1, 1University of Utah, Salt Lake City, UT, 2University of Utah and Salt Lake City VA, Salt Lake City, UT, 3Salt Lake City VA/University of Utah, Salt Lake City, UT, 4Puget Sound VA and University of Utah, Seattle, WA, 5Salt Lake City Veterans Affairs Health and University of Utah Health, Division of Rheumatology, Salt Lake City, UT, 6University of Nebraska Medical Center, Omaha, NE, 7Division of Rheumatology and Immunology, University of Nebraska Medical Center, Omaha, NE, 8University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Myositis is an infrequent but serious complication associated with immune check point inhibitor (ICI) treatment. Many patients with ICI-induced myositis will develop concurrent myocarditis…
  • Abstract Number: 0150 • ACR Convergence 2023

    Self-reported Levels of Physical Activity and the Association to Pain, Fatigue, Anxiety and Depression Among Patients with Idiopathic Inflammatory Myopathies

    Kristofer Andreasson1, Fabricio Espinosa-Ortega2, Heléne Sandlund3 and Helene Alexanderson4, 1Karolinska Institutet & Karolinska University Hospital, Stockholm, Sweden, 2Division of Rheumatology, Department of Medicine, Karolinska Institutet; Department of Gastroenterology, Dermatotology, Rhematology, Karolinska Universitetssjukhuset, Stockholm, Sweden, 3Karolinska University Hospital, Stockholm, Sweden, 4Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Patients with inflammatory diseases such as rheumatoid arthritis exhibit reduced levels of physical activity (PA) compared to the normative population and suffer from anxiety…
  • Abstract Number: 0303 • ACR Convergence 2023

    Development of a Human Cytotoxic Myoinjury Model with CD8+ T Cells and Muscle Cells Differentiated from Human Induced Pluripotent Stem Cells

    Hisanori Hasegawa1, Soki Kashima2, Makoto Otsu3, Hideki Taniguchi4 and Shinsuke Yasuda5, 1Department of Rheumatology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University (TMDU) and Institute of Global Affairs, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 2Laboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University and Department of Urology, Akita University Graduate School of Medicine, Akita, Japan, 3Division of Hematology, Department of Laboratory Sciences, School of Allied Health Sciences, Kitasato University, Sagamihara, Japan, 4Division of Stem Cell Processing/Stem Cell Bank, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, Tokyo, Japan, 5Department of Rheumatology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University (TMDU), Tokyo, Japan

    Background/Purpose: CD8+ cytotoxic lymphocytes (CTLs) play a crucial role in the myoinjury of polymyositis (PM). Nonetheless, conventional treatment for PM depends on high-dose glucocorticoids with…
  • Abstract Number: 1160 • ACR Convergence 2023

    Antibody Predictors of Prognosis in a Large Multi-centre Cohort of Idiopathic Inflammatory Myopathy Associated Interstitial Lung Disease

    Jennifer Hannah1, Alexandra Lawrence2, Jennifer Martinovic2, Marium Naqvi2, Saadia Sasha Ali3, Carmel Stock4, Cara Owens4, Anand Devaraj4, Louise Pollard2, Sangita Agarwal2, Belén Atienza-Mateo5, Amit Patel6, Alex West2, Kate Tinsley2, Hasti Robbie7, Felix Chua4, Boris Lams2, Athol Wells4, Sam Norton7, James Galloway7, Elisabetta Renzoni4 and Patrick Gordon8, 1King's College London, London, United Kingdom, 2Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, 3King's College Hospital, Epsom, United Kingdom, 4Royal Brompton and Harefield Hospitals NHS Trust, London, United Kingdom, 5Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 6King's College Hospital, London, United Kingdom, 7King's College London, London, United Kingdom, 8NHS, London, United Kingdom

    Background/Purpose: IIM-ILD follows a varied clinical course. Serological profile can help predict clinical phenotype, but impact on ILD prognosis is less clear. This multicentre UK…
  • Abstract Number: 1231 • ACR Convergence 2023

    Successful Implementation of a Mental Health Screening Program for Youth with Juvenile Dermatomyositis

    Y. Ingrid Goh1, Kayla Baker1, Audrey Bell-Peter1, Vanessa Carbone1, Brian Feldman1, Luana Flores Pereira1, Jayne MacMahon1, Valerio Maniscalco1, Jo-Anne Marcuz1, Greta Mastrangelo2, Tanya Slater1, Kristi Whitney1 and Andrea Knight1, 1The Hospital for Sick Children, Toronto, ON, Canada, 2Division of Rheumatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada

    Background/Purpose: High levels of emotional distress have been reported in children with juvenile myositis (JM). Inadequate recognition of mental health concerns by healthcare providers (HCPs)…
  • Abstract Number: 1960 • ACR Convergence 2023

    From Clinical Amyopathy to Severe Oropharyngeal Dysphagia in Pure Dermatomyositis: A Greater Extent of Muscle Weakness Is Associated with a Higher Cancer Prevalence

    Hao Cheng Shen1, Victoria Ivensky2, Yves Troyanov3, Josiane Bourre-Tessier1, Farah Zarka2, Sabrina Hoa4, Jessica Nehme2, Jean-Paul Makhzoum5, Anne-Marie Mansour2, Rosalie-Selene Meunier2, Alexandra Mereniuk2, Darosa Lim6, Jean-Pierre Raynauld1, Eric Rich1, Jean-Richard Goulet1, Marianne Landry7, Maude Bouchard-Marmen8, Valerie Leclair9, Hugues Allard-Chamard10, Marie Hudson11, Erin O'Ferrall12, Rami Massie12, Jason Karamchandani13, Benjamin Ellezam14, Ira N. Targoff15, Minoru Satoh16, Marvin Fritzler17, Jean-Luc Senecal1, Alain Meyer18 and Oceane Landon-Cardinal1, 1Centre hospitalier de l'Université de Montréal (CHUM), Université de Montréal, Montréal, QC, Canada, 2Hôpital du Sacré-Coeur de Montréal, Université de Montréal, Montreal, QC, Canada, 3Hôpital du Sacré-Coeur de Montréal, Centre hospitalier de l'Université de Montreal (CHUM), Université de Montréal, Montreal, QC, Canada, 4University of Montreal, Brossard, QC, Canada, 5Vasculitis Clinic, Canadian Network for Research on Vasculitides, Hopital du Sacre-Coeur de Montreal, Montreal, QC, Canada, 6University of Pennsylvania, Philadelphia, PA, 7Hôpital de LaSalle, Montreal, QC, Canada, 8CHU de Québec, Université Laval, Quebec City, QC, Canada, 9Jewish General Hospital, McGill University, Montreal, QC, Canada, 10Université de Sherbrooke, Sherbrooke, QC, Canada, 11McGill University, Montréal, QC, Canada, 12Montreal Neurological Institute, McGill University, Montreal, QC, Canada, 13McGill University Health Center (MUHC), McGill University, Montreal, QC, Canada, 14CHU Sainte-Justine, Université de Montréal, Montreal, QC, Canada, 15Veteran's Affairs Medical Center, University of Oklahoma Health Sciences Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, 16University of Occupational and Environmental Health, Kitakyushu, Japan, 17University of Calgary, Calgary, AB, Canada, 18Hôpitaux Universitaires de Strasbourg, Strasbourg, France

    Background/Purpose: The risk of cancer is increased in patients with pure dermatomyositis (DM), i.e. patients with a DM rash and without an anti-MDA-5 syndrome, a…
  • Abstract Number: 2515 • ACR Convergence 2023

    Machine Learning-Based Stratification of Mixed Connective Tissue Disease Using Immunophenotyping Data from Patients with Related Autoimmune Diseases

    Shinji Izuka1, Toshihiko Komai1, Takahiro Itamiya1, Mineto Ota2, Saeko Yamada1, Yasuo Nagafuchi2, Hirofumi Shoda1, Kosuke Matsuki3, Kazuhiko Yamamoto4, Tomohisa Okamura5 and Keishi Fujio1, 1Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, Department of Functional Genomics and Immunological Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 3Research Division, Chugai Pharmaceutical Co., Ltd., Yokohama City, Japan, 4Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo and Laboratory for Autoimmune Diseases, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, 5Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo and Department of Functional Genomics and Immunological Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

    Background/Purpose: Mixed connective tissue disease (MCTD) is a heterogenous autoimmune disorder with overlapping clinical features of systemic lupus erythematosus (SLE), polymyositis/dermatomyositis, and systemic sclerosis (SSc).…
  • Abstract Number: 0169 • ACR Convergence 2023

    Added Value of Anti-HMGCR and Anti-SRP Antibodies in the Diagnosis of Immune Mediated Necrotizing Myopathy: An Outcome and Cost Comparison from the USA Perspective

    Alejandro Figueroa-Lara1, Mary Ann Aure2 and Carmen Andalucia1, 1Werfen, San Diego, CA, 2Werfen, Chula Vista, CA

    Background/Purpose: Immune-mediated necrotizing myopathies (IMNM) is a subgroup of immune-mediated myopathies (IMM). The diagnosis of IMNM relied on the presence of proximal muscle weakness, high…
  • Abstract Number: 0304 • ACR Convergence 2023

    Incidence of Disease Flares Following COVID-19 Vaccination in a Diverse Idiopathic Inflammatory Myopathy Cohort

    Hillary Weisleder1, Ana Valle1, Xianhong Xie2 and Shereen Mahmood3, 1Montefiore Medical Center, Bronx, NY, 2Albert Einstein College of Medicine, Bronx, NY, 3Albert Einstein College of Medicine / Montefiore Medical Center, New York, NY

    Background/Purpose: Autoimmune activation in the setting of vaccination against coronavirus disease 2019 (COVID-19) is a well-documented phenomenon in the medical literature. For patients with idiopathic…
  • Abstract Number: 1161 • ACR Convergence 2023

    Proteasome Inhibitor Repurposed for Dermatomyositis: Results of a Drug Repurposing Analysis Based on the Transcriptomic Signature of Patients’ Perifascicular Fibers Validated in Pre-clinical Models

    Léa Debrut1, Margherita Giannini2, Céline Keime1, Daniela Rovito1, Béatrice Lannes3, Anne-Laure Charles4, Daniel Metzger1, Bernard Geny5, Gilles Laverny1 and Alain Meyer6, 1Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France, 2Nouvel Hopital Civil, Strasbourg, Strasbourg, France, 3Hôpital de Hautepierre - Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 4UR3072, Centre de Recherche en Biomédecine de Strasbourg (CRBS), Strasbourg, France, 5Nouvel Hôpital Civil, Strasbourg, France, 6Hôpitaux Universitaires de Strasbourg, Strasbourg, France

    Background/Purpose: Dermatomyositis (DM) is an autoimmune myopathy responsible for muscle weakness associated with decreased quality of life and increased mortality. DM muscular histology is characterized…
  • Abstract Number: 1246 • ACR Convergence 2023

    Assessment and Outcomes of 63 Cases of Juvenile Dermatomyositis-Associated Calcinosis

    Belina Yi1, Dawn Wahezi2, Lauren Covert3, Kaveh Ardalan4, Joyce Hui-Yuen5, Natalia Vasquez Canizares6, Doaa Mosad Mosa7, Madison Jones8, Colleen Correll9, Alexis Begezda10, Susan Shenoi11, Eveline Wu12, Leonard Kovalick13, William Lapin14, Stacey Tarvin15, Melissa Oliver16, Martha Rodriguez17, Itay Marmor18, Kevin Baszis19, Alysha Taxter20, Andrew Hanson21, Cynthia Crowson22 and Amir Orandi22, 1Children's Hospital Los Angeles, Los Angeles, CA, 2Children's Hospital at Montefiore, New Rochelle, NY, 3Duke University, Durham, NC, 4Duke University School of Medicine, Durham, NC, 5North Shore LIJ Health System, Great Neck, NY, 6Children's Hospital at Montefiore, New York, NY, 7Mansoura University Hospitals, Mansoura University Faculty of Medicine, Mansoura city, Egypt, 8Keck School of Medicine of University of Southern California, Los Angeles, CA, 9University of Minnesota, Minneapolis, MN, 10Penn State, Hummelstown, PA, 11Seattle Childrens Hospital, Mercer Island, WA, 12University of North Carolina School of Medicine, Chapel Hill, NC, 13UNC Health Care, Durham, NC, 14Connecticut Children's, Hartford, CT, 15Riley Hospital for Children at Indiana University Health, Indianapolis, IN, 16Indiana University, Indianapolis, IN, 17Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN, 18Dana-Dwek Children's Hospital, Hod Hasharon, Israel, 19Washington Univ in St. Louis School of Medicine, St. Louis, MO, 20Nationwide Children's, Columbus, OH, 21Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, 22Mayo Clinic, Rochester, MN

    Background/Purpose: Calcinosis is a poorly understood and morbid complication of juvenile dermatomyositis (JDM). As there is no consensus treatment approach for calcinosis, and limited knowledge…
  • Abstract Number: 1961 • ACR Convergence 2023

    Anti-PM/Scl Autoantibodies in Juvenile Myositis Are Associated with a Distinct Phenotype Resembling Anti-synthetase Syndrome

    Matthew Sherman1, Payam Noroozi Farhad2, Edward Trieu3, Katherine Pak4, Iago Pinal-Fernandez4, Kakali Sarkar2, Megan Neely5, Ira Targoff6, Frederick Miller7, Andrew Mammen8 and Lisa Rider9, 1NIAMS/NIH, Washington, DC, 2Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, 3Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4National Institutes of Health, Bethesda, MD, 5Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, 6Veterans Affairs Medical Center, University of Oklahoma Health Sciences Center, and Oklahoma Medical Research Foundation, Oklahoma City, OK, 7NIH, NIEHS, Chapel Hill, NC, 8NIH, Bethesda, MD, 9NIEHS, NIH, Bethesda, MD

    Background/Purpose: Anti-PM/Scl autoantibodies (Abs) are an uncommon myositis-associated autoantibody (MAA) in juvenile myositis. The clinical features and outcomes associated with anti-PM/Scl Abs in juvenile myositis…
  • Abstract Number: 2575 • ACR Convergence 2023

    Accurate Stratification of Cancer Risk in a Real-World Cohort Using the International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening

    Alexander Oldroyd1, Francisca Bozan1, Xia Lyu2, Patrick Gordon3, David Isenberg4, Neil McHugh5, Harsha Gunawardena6, Patrick Kiely7, Janine Lamb1, Pedro Machado8, James Miller9, Sarah Tansley5 and Hector Chinoy10, 1University of Manchester, Manchester, United Kingdom, 2Department of Rheumatology, Shanghai Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China, 3NHS, London, United Kingdom, 4University College London, London, United Kingdom, 5University of Bath, Bath, United Kingdom, 6North Bristol NHS Trust, Bristol, United Kingdom, 7St George’s University Hospitals NHS Foundation Trust, London, United Kingdom, 8Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, UK. Department of Rheumatology, Northwick Park Hospital, London North West University Healthcare NHS trust, London, UK., London, United Kingdom, 9Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, United Kingdom, 10The University of Manchester, Sale, United Kingdom

    Background/Purpose: Adult-onset idiopathic inflammatory myopathy (IIM) is associated with an increased cancer risk within three years prior to or following IIM onset. The International Guideline…
  • Abstract Number: 0283 • ACR Convergence 2023

    Transcriptomic Profiles in Muscle Biopsies from Systemic Sclerosis Patients with Different Autoantibodies

    Maria Casal-Dominguez1, Jose Cesar Milisenda2, Iago Pinal-Fernandez1, Katherine Pak3, Sandra Muñoz-Braceras1, Jose Jiram Torres-Ruiz1, Stefania Dell´Orso4, Faiza Naz4, Gustavo Gutierrez-Cruz4, Shamima Islam1, Yaiza Duque-Jaimez2, Ana Matas-Garcia2, Francesc J Garcia-Garcia2, Mariona Guitart-Manpel2, Gloria Garrabou2, Ernesto Trallero-Araguas5, Brian Wallit6, Lisa Christopher-Stine7, Tom Lloyd8, Alfredo Guillen-Del-Castillo9, Carmen Pilar Simeon-Aznar10, Josep Maria Grau2, Albert Selva-O’Callaghan5 and Andrew Mammen11, 1Muscle Disease Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2Muscle Research Unit, Internal Medicine Service, Hospital Clinic, Barcelona, Spain, 3National Institutes of Health, Bethesda, MD, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 5Systemic Autoimmune Disease Unit, Vall d’Hebron Institute of Research, Barcelona, Spain, 6National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD, 7Johns Hopkins University, Baltimore, MD, 8Johns Hopkins University School of Medicine, Baltimore, MD, 9Unit of Autoimmune Diseases, Department of Internal Medicine, Hospital Universitario Vall d'Hebron, Barcelona, Spain, 10Department of Internal Medicine, Systemic Autoimmune Diseases Unit, Hospital Universitario Vall d'Hebronh, Barcelona, Spain, 11NIH, Bethesda, MD

    Background/Purpose: The inflammatory myopathies (IM) include dermatomyositis (DM), antisynthetase syndrome (AS), immune-mediated necrotizing myopathy (IMNM), inclusion body myositis (IBM), and overlap myositis (OM), in which…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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