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Abstracts tagged "Myopathies"

  • Abstract Number: 0176 • ACR Convergence 2022

    Diagnostic Accuracy and Clinical Relevance of Muscle Biopsy in Patients with Suspected Myositis

    Kastriot Kastrati1, Nasim NAKHOST LOTFI2, Marwa Tawfik3, Ellen Gelpi2, Romana Hoeftberger2, Hans-Peter Kiener2, Daniel Aletaha4, Michael Bonelli5 and Helga Radner5, 1Division of Rheumatology, Vienna, Austria, 2Medical University Vienna, Vienna, Austria, 3Suez Canal University, Ismailia, Egypt, 4Medical University Vienna, Wien, Austria, 5Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

    Background/Purpose: Diagnosis of idiopathic inflammatory myopathies (IIM) represents a clinical challenge and muscle biopsy is regarded as a fundamental procedure for confirming diagnosis. However, the…
  • Abstract Number: 0177 • ACR Convergence 2022

    COVID-19 Vaccination-related Short-term Adverse Events in Patients with Idiopathic Inflammatory Myositis and Autoimmune Multimorbidity: Results from the COVID-19 Vaccination in Autoimmune Diseases Survey

    Mrinalini Dey1, Naveen R2, Elena Nikiphorou3, Parikshit Sen4, James B. Lilleker5, Vishwesh Agarwal6, Sinan Kardes7, Jessica Day8, Marcin Milchert9, Mrudula Joshi10, Tamer A Gheita11, Babur Salim12, Tsvetelina Velikova13, Abraham Edgar Gracia-Ramos14, Ioannis Parodis15, Albert Selva O’Callaghan16, Minchul Kim17, Tulika Chatterjee17, Ai Lyn Tan18, Ashima Makol19, Arvind Nune20, Lorenzo Cavagna21, Miguel Angel Saavedra Salinas22, Samuel Shinjo23, Nelly Ziade24, Johannes Knitza25, Masataka Kuwana26, Oliver Distler27, Hector Chinoy28, John Pauling29, Chris Wincup30, Vikas Agarwal2, Rohit Aggarwal31 and Latika Gupta32, 1Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom, 2Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 3Leiden University Medical Center & King's College London, London, United Kingdom, 4Maulana Azad Medical College, New Delhi, India, 5The University of Manchester, Manchester, United Kingdom, 6Mahatma Gandhi Missions Medical College, Lucknow, India, 7Istanbul University, Istanbul, Turkey, 8Walter and Eliza Hall Institute, Melbourne, Australia, 9Pomeranian Medical University in Szczecin, Szczecin, Poland, 10Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune, India, 11Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt, 12Fauji foundation hospital Rawalpindi, Rawalpindi, Pakistan, 13Sofia University St. Kliment Ohridski, Sofia, Bulgaria, 14Instituto Mexicano del Seguro Social, Ciudad de México, Mexico, 15Karolinska Institutet, Stockholm, Sweden, 16Hospital Universitari Vall d'Hebron, Barcelona, Spain, 17University of Illinois College of Medicine Peoria, Peoria, IL, 18University of Leeds, Leeds, United Kingdom, 19Mayo Clinic, Rochester, MN, Rochester, MN, 20Southport and Ormskirk Hospital NHS Trust, Southport, United Kingdom, 21Università di Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Pavia, Italy, 22IMSS, Ciudad de México, Mexico, 23Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil, 24Saint-Joseph University, Beirut, Lebanon, 25Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany; Deutsches Zentrum Immuntherapie, Friedrich-Alexander-UniversityErlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 26Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 27Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland, 28The University of Manchester, Sale, United Kingdom, 29North Bristol NHS Trust, Bristol, United Kingdom, 30Rayne Institute, University College London, London, United Kingdom, 31Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 32Royal Wolverhampton Trust, Wolverhampton/University of Manchester, United Kingdom

    Background/Purpose: COVID-19 vaccines are safe and effective, though patients with rare rheumatic diseases like idiopathic inflammatory myositis (IIMs), and those with multiple comorbidities continue to…
  • Abstract Number: 0940 • ACR Convergence 2022

    Effect of an 8-week Tailored Physical Therapy Program on Sexual Function in Women with Systemic Sclerosis and Idiopathic Inflammatory Myopathies: A Pilot Controlled Study

    Barbora Hermankova1, Maja Spiritovic1, Sabina Oreska2, Hana Storkanova2, Karel Pavelka3, Ladislav Šenolt4, Jiří Vencovský4, Radim Becvar2 and Michal Tomcik2, 1Institute of Rheumatology, Department of Physiotherapy, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Czech Republic, 2Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 3Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Praha, Czech Republic, 4Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic

    Background/Purpose: Systemic rheumatic diseases like systemic sclerosis (SSc) and idiopathic inflammatory myopathies (IIM) may affect all aspects of life, including sexual health. However, no non-pharmacological…
  • Abstract Number: 1233 • ACR Convergence 2022

    Ultrasound Is Reliable in the Assessment of Muscle Echogenicity in Patients with Rheumatic Diseases: Results of a Multicenter International Web-based Study

    Andrea Di Matteo1, Erica Moscioni2, Maria Giovanna Lommano1, Edoardo Cipolletta1, Gianluca Smerilli1, Sonia Farah1, Carla Airoldi3, Sibel Aydin4, Becciolini Andrea5, Karina Bonfiglioli6, Marina Carotti7, Greta Carrara8, Tomas Cazenave9, Davide Corradini10, Micaela Ana Cosatti11, Juan Josè de Agustin12, Giulia Maria Destro Castaniti13, Marco Di Carlo1, Eleonora Di Donato5, Luca Di geso14, Ashley Elliott15, Daniela Fodor16, Francesca Francioso1, Alessandra Gabba17, Cristina Hernández-Díaz18, Rudolf Horvath19, Jana Hurnakova19, Diogo Jesus20, Josefina Marin21, Maria Victoria Martire22, Riccardo Mashadi-Mirza23, Marco Massarotti24, Alice Andreea Musca25, Jagdish Nair26, Tadashi Okano27, Ioannis Papalopoulos28, Javier Eduardo Rosa21, Marcos Rosemffet29, João Rovisco30, Davide Rozza8, Fausto Salaffi1, Crescenzio Scioscia31, Carlo Alberto Scirè8, Maria-Magdalena Tamas32, Shun Tanimura33, Lucio Ventura-Rios18, Catalina Villota-Eraso34, Orlando Villota35, Paraksevi V Voulgari36, Florentin Ananu Vreju37, Gentiana Vukatana37, Johana Zacariaz Hereter21, Anna Zanetti8, Walter Grassi1 and Emilio Filippucci1, 1Polytechnic University of Marche, Rheumatology Unit, Department of Clinical and Molecular Sciences, "Carlo Urbani" Hospital, Jesi, Italy, 2Polytechnic University of Marche, Jesi, Italy, 3Hospital Provincial, Rosario, Argentina, 4University of Ottawa, Rheumatology, Ottawa, Canada, Ottawa, ON, Canada, 5Department of Medicine, Internal Medicine and Rheumatology Unit, Azienda Ospedaliero Universitaria di Parma, Parma, Italy, 6Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 7Department of Radiology, Ospedali Riuniti, Università Politecnica delle Marche, Ancona, Italy, 8Epidemiology Unit, Italian Society of Rheumatology, Milano, Italy, 9Rheumatology Unit, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 10Rheumatology Unit, University Clinic AOU Cagliari, Cagliari, Italy, 11CEMIC, Centro de educación médica e investigaciones médicas "Norberto Quirno", Buenos Aires, Argentina, 12Vall D'hebron University Hospital, Barcelona, Spain, 13Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Rheumatology section, University of Palermo, Palermo, Italy, 14Ospedale Madonna del Soccorso, Department of Internal Medicine, San Benedetto del Tronto, Italy, 15Centre for Experimental Medicine, Queen's University, Belfast, Northern Ireland, United Kingdom, 162nd Internal Medicine Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania, 17Local Health Unit (ASL), Oristano, Italy, 18Division de Reumatologia. Instituto Nacional de Rehabilitacion "Luis Guillermo Ibarra Ibarra", Ciudad de México, Mexico, 19Department of Paediatric and Adult Rheumatology, University Hospital Motol, Prague, Czech Republic, 20Rheumatology Department, Centro Hospitalar de Leiria, Leira, Portugal, 21Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 22San Roque Hospital, La Plata, Buenos Aires, Argentina, 23Radiology Department, A.O. Ospedali Riuniti Marche Nord, Pesaro, Italy, 24Department of Rheumatology, University Hospitals Dorset NHS Foundation Trust, Christchurch Hospital, Christchurch, United Kingdom, 25Department of Rheumatology - Colentina Clinical Hospital, Bucharest, Romania, 26Rheumatology, Liverpool University Hospitals Foundation Trust, Liverpool, United Kingdom, 27Department of Orthopedic Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan, 28Department of Rheumatology, Clinical Immunology and Allergy, University Hospital of Heraklion, Heraklion, Greece, 29Rheumatology Unit, Instituto de Rehabilitación Psicofísica, Capital Federal, Argentina, 30Rheumatology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, 31Department of Emergency and Organ Transplantations-Rheumatology Unit, University of Bari "Aldo Moro", Bari, Italy, 32Department of Rheumatology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania, 33Rheumatology Department, Hokkaido Medical Center for Rheumatic Diseases, Sapporo, Japan, 34IPS Servicio integral de reumatología e inmunología Dr Orlando Villota, Pasto, Colombia, 35Division of Rheumatology, Fundación Hospital San Pedro, Pasto, Colombia, 36Department of Rheumatology, School of Health Science, Faculty of Medicine, University of Ioannina, Ioannina, Greece, 37Rheumatology Department, University of Medicine and Pharmacy of Craiova, Craiova, Romania, 37Rheumatology Unit; IRCCS Policlinico S. Orsola Malpighi, Bologna, Italy

    Background/Purpose: Studies have showed that an increased ultrasound (US) muscle echogenicity indicating fatty replacement/fibrosis of muscle tissue may represent an early indicator of muscle involvement associated…
  • Abstract Number: 1283 • ACR Convergence 2022

    Frequency of Checking Creatine Kinase in Patients on Statins with Elevated Transaminase for Early Detection of Statin Induced Myopathy

    ANJALI NIDHAAN, Andrei Hastings, david gonzalez, rajshri joshi, nathan gilbert and carolyn o'connor, Cleveland Clinic Akron General, Akron, OH

    Background/Purpose: Some of the most commonly reported side effects of statins (widely used lipid lowering agents) are muscle injury (incidence ranging from 0.1-20% based on…
  • Abstract Number: 0701 • ACR Convergence 2021

    Use and Yield of Computed Tomography as a Cancer Surveillance Method in Idiopathic Inflammatory Myositis

    Christopher Mecoli1, Brant Chee2, XingYao Wang3, Mengkun Chen4, William Kelly3, Elizabeth Platz4, Livia Casciola-Rosen5, Lisa Christopher-Stine3 and Ami Shah6, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Applied Physics Laboratory, Baltimore, MD, 3Johns Hopkins University, Baltimore, MD, 4Johns Hopkins School of Public Health, Baltimore, MD, 5Johns Hopkins, Baltimore, MD, 6Johns Hopkins Rheumatology, Baltimore, MD

    Background/Purpose: To inform guidance for cancer surveillance in patients with idiopathic inflammatory myositis (IIM), we conducted a retrospective cohort study in a single tertiary referral…
  • Abstract Number: 0704 • ACR Convergence 2021

    Anti-SSa/SSb and Ro52 and Interstitial Lung Disease in Idiopathic Inflammatory Myopathies

    Sonali Narain1, Ana Valle2, Maria-Louise Barilla-Labarca1 and Galina Marder3, 1Northwell Health, Great Neck, NY, 2Montefiore Medical Center/Albert Einstein College of Medicine, New York, NY, 3Division of Rheumatology, Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY

    Background/Purpose: In idiopathic inflammatory myopathies (IIM), SSa/SSb and Ro52 antibodies are frequently reported, especially in association with interstitial lung disease (ILD). However, limited literature exists…
  • Abstract Number: 0706 • ACR Convergence 2021

    Mycophenolate Mofetil and Methotrexate Efficacy in Dermatomyositis

    Madison Grinnell1, Emily Keyes2, DeAnna Diaz2, Thomas Vazquez3, Rui Feng4 and Victoria Werth2, 1Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania and Philadelphia VAMC, OMAHA, NE, 2Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania and Philadelphia VAMC, Philadelphia, PA, 3FIU Wertheim College of Medicine, Virginia Beach, VA, 4University of Pennsylvania Department of Biostatistics, Philadelphia, PA

    Background/Purpose: Treatment of dermatomyositis (DM) typically follows a stepwise sequence starting with either methotrexate (MTX) or mycophenolate mofetil (MMF) after an inadequate response to antimalarial…
  • Abstract Number: 0707 • ACR Convergence 2021

    Association of Pneumomediastinum with Poor Prognosis in Patients with Myositis-Associated Interstitial Lung Disease

    Kazuki Hirano1, Azusa Kojima1, Akira Ishii1, Mai Sugiyama1, Yuto Izumi1, Noriko Sasaki2, Yuji Hosono1, Chiho Yamada1 and Shinji Sato3, 1Tokai University School of Medicine, Isehara, Japan, 2tokai university, sagamihara-city, Japan, 3Tokai University, Isehara, Japan

    Background/Purpose: Pneumomediastinum is an important complication in patients with myositis-associated interstitial lung disease (ILD). Patients with myositis and ILD who had pneumomediastinum during the disease…
  • Abstract Number: 0712 • ACR Convergence 2021

    Immune Checkpoint Inhibitor-related Myotoxicity : Musculoskeletal and/or Neuromuscular Junction Disorder ?

    Hortense Chassepot1, Lotta Plomp2, Dimitri Psimaras3, Thierry Maisonobe3, Sarah Leonard Louis4, Isabelle Plu4, Mehdi Touat3, Celine Anquetil5, Nadege Wesner5, Nicolas Champtiaux5, Aude Rigolet5, Sophie Demeret3, Nicolas Weiss3, Baptiste Abbar6, Marie-Claire Bretagne7, Bruno Pinna7, Capucine Morelot8, Martin Dres8, Thomas Similowski8, Stephane Ederhy9, Joe-Elie Salem7, Olivier Benveniste5 and Yves Allenbach5, 1Universite de Picardie Jules Verne UPJV - Amiens Picardie Hospital, Department of Clinical Immunology and Internal Medicine, Fourqueux, France, 2Amsterdam University Medical Center (AUMC), Amsterdam, Netherlands, 3Sorbonne University - AP-HP, Pitié-Salpêtrière Hospital, Department of Neurology, Paris, France, 4Sorbonne University - AP-HP, Pitié-Salpêtrière Hospital, Department of Neuropathology, Paris, France, 5Sorbonne University - AP-HP, Pitié-Salpêtrière Hospital, Department of Clinical Immunology and Internal Medicine, Paris, France, 6Sorbonne University - AP-HP, Pitié-Salpêtrière Hospital, Department of Oncology, Paris, France, 7Sorbonne University - AP-HP, Pitié-Salpêtrière Hospital, Department of Pharmacology, Paris, France, 8Sorbonne University - AP-HP, Pitié-Salpêtrière Hospital, Department of Pneumology - R3S, Paris, France, 9Sorbonne University - AP-HP, Pitié-Salpêtrière Hospital, Department of Cardiology, Paris, France

    Background/Purpose: Immune checkpoint inhibitor (ICI)-related adverse events (irAE) recently emerged as new diseases in the field of auto-immunity. Among them, ICI-related myotoxicity has the highest…
  • Abstract Number: 0718 • ACR Convergence 2021

    Pain Severity and Interference in Adult Autoimmune Inflammatory Myopathies

    Harmony Tsui1, Mianbo Wang2, Mathieu Piché3, Alexandra Ladouceur4, Evelyne Vinet5, Alexandra Albert6, Maggie Larche7, Annaliese Tisseverasinghe8, Marie Hudson1 and Valerie Leclair9, 1McGill University, Montréal, QC, Canada, 2Lady Davis institute for Medical Research, Montréal, QC, Canada, 3Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada, 4McGill University Health Center, Montréal, QC, Canada, 5McGill University Health Centre, Mont Royal, QC, Canada, 6CHU de Quebec, Québec City, QC, Canada, 7McMaster University, Hamilton, ON, Canada, 8University of Manitoba, Winnipeg, MB, Canada, 9McGill University, Karolinska Insitutet, Montréal, QC, Canada

    Background/Purpose: Although pain is one of the most common and highest priority symptoms reported by people with autoimmune inflammatory myopathies (AIM), large descriptive studies on…
  • Abstract Number: 0441 • ACR Convergence 2021

    A Randomized, Double-blind, Placebo-controlled Study of Arimoclomol in Patients with Inclusion Body Myositis

    Pedro Machado1, Richard Barohn2, Michael McDermott3, Thomas Blaetter4, Tom Lloyd5, Aziz Shaibani6, Miriam Freimer7, Anthony Amato8, Emma Ciafaloni3, Sarah Jones9, Tahseen Mozaffar10, Summer Gibson11, Matthew Wicklund12, Todd Levine13, Claus Sundgreen4, Tim Carstensen4, Karen Bonefeld4, Anders Jørgensen4, Karina Phonekeo4, Andrew Heim14, Laura Herbelin14, Michael Hanna15 and Mazen Dimachkie14, 1Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, United Kingdom, 2University of Missouri - Columbia, Columbia, MO, 3University of Rochester, Rochester, NY, 4Orphazyme A/S, Copenhagen, Denmark, 5Johns Hopkins University, Baltimore, MD, 6Nerve and Musle Center, Houston, TX, 7Ohio State University, Columbus, OH, 8Brigham and Women's Hospital, Boston, MA, 9University of Virginia, Charlottesville, VA, 10University of California Irvine, Irvine, CA, 11University of Utah, Salt Lake City, UT, 12University of Colorado, Denver, CO, 13Phoenix Neurological Associates, Phoenix, AZ, 14University of Kansas Medical Center, Kansas City, KS, 15University College London, London, United Kingdom

    Background/Purpose: Inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy occurring in patients over the age of 45 years. Since immune suppression has…
  • Abstract Number: 0443 • ACR Convergence 2021

    Safety and Efficacy of Belimumab in the Treatment of Adult Idiopathic Inflammatory Myositis (Polymyositis and Dermatomyositis)

    Priyal Chadha1, Sonali Narain2, Preeya Nandkumar3, Cristine Sison4, Elena Schiopu5, Todd Levine6, James Tsang7 and Galina Marder8, 1SUNY Upstate Medical University, Syracuse, NY, 2Northwell Health, Great Neck, NY, 3Division of Rheumatology, Department of Medicine, Northwell, Great Neck, NY, 4Biostatistics Unit , Department of Molecular Medicine, Feinstein Institutes for Medical Research at Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, 5University of Michigan, Ann Arbor, MI, 6Phoenix Neurological Associates, Phoenix, AZ, 7Center for Research Informatics & Innovation (CRII), Feinstein Institute for Medical Research at Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, 8Division of Rheumatology, Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY

    Background/Purpose: Treatment of Idiopathic Inflammatory Myositis (IIM) includes steroids and immunosuppressive agents. Targeting IL6, IL1, TNF for treatment of IIM has not been successful, and…
  • Abstract Number: 0697 • ACR Convergence 2021

    Detection of Autoantibodies Against Muscle-Specific Four-and-a-Half-LIM Domain 1 (FHL1) in Inflammatory Myopathies: Results from a Single-Center Cohort

    Angeles Shunashy Galindo-Feria1, Begum Horuluoglu1, Jessica Day2, Catia Cerqueira3, Edvard Wigren4, Susanne Gräslund4, Susanna Proudman5, Ingrid E Lundberg4 and Vidya Limaye6, 1Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 2Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia and Discipline of Medicine, University of Adelaide, Adelaide, Australia, 34Dcell, Montreuil, France, 4Karolinska Institutet, Karolinska University Hospital, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden, Stockholm, Sweden, 5University of Adelaide, Medindie, Australia, 6Royal Adelaide Hospital, Adelaide, Australia

    Background/Purpose: Autoantibodies targeting a muscle-specific autoantigen, four-and-a-half-LIM-domain 1 (FHL1), have been previously identified in patients with idiopathic inflammatory myopathies (IIM) (1). The aim of this…
  • Abstract Number: 1062 • ACR Convergence 2020

    Dermatomyositis: A Dermatology-Rheumatology Clinic Retrospective Analysis

    Burak Elkiran1, Mahroo Tajalli2, Terrence M. Vance3, Abrar A. Qureshi4 and Anthony M. Reginato5, 1Department of Medicine, Division of Rheumatology; Warren Alpert Medical School of Brown University, BOSTON, 2Department of Dermatology, Warren Alpert Medical School of Brown University, PROVIDENCE, 3Department of Epidemiology, Warren Alpert Medical School of Brown University, PROVIDENCE, 4Department of Dermatology, Warren Alpert Medical School of Brown University, BOSTON, 5Department of Medicine, Division of Rheumatology, Warren Alpert Medical School of Brown University, Boston, MA

    Background/Purpose: Dermatomyositis (DM) can be categorized into two major subtypes: clinically amyopathic dermatomyositis (CADM) and classic dermatomyositis (CDM). In this study, we aimed to identify characteristics…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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