Abstracts tagged "Muscle strength"

Abstract Number: 0694 • ACR Convergence 2021
Glucagon-like Peptide-1 Receptor Agonist Suppresses Muscle Fiber Necroptosis and Muscle Inflammation and Ameliorates Muscle Weakness in Experimental Polymyositis
Mari Kamiya¹, Fumitaka Mizoguchi¹, Hirokazu Sasaki², Natsuka Umezawa¹ and Shinsuke Yasuda³, ¹Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, ²Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, ³Tokyo Medical and Dental University (TMDU), Tokyo, Japan
Background/Purpose: While glucocorticoids (GC) are the cornerstone of the treatment for polymyositis (PM), GC-induced myopathy is inevitable, which deteriorates muscle weakness. Therefore, novel therapeutic strategy…
Abstract Number: 0710 • ACR Convergence 2021
Patients with Recent Onset, Active Polymyositis (PM), Dermatomyositis (DM) and Antisynthetase Syndrome (ASS) Have Reduced Muscle Endurance but Not Reduced Muscle Strength Compared to Patients with Established, Low-active Disease
Kristofer Andreasson¹ and Helene Alexanderson², ¹Karolinska Institute, Stockholm, Sweden, ²Karolinska Institutet, Stockholm, Sweden
Background/Purpose: To analyze for differences in quadriceps maximal isometric voluntary contraction (MVIC), muscle endurance (ME), muscle mass and fat mass (m. vastus lateralis, mid-thigh) in…
Abstract Number: 1664 • ACR Convergence 2021
Changes in Physical Function Were Not Associated with Clinically Important Changes in Muscle Strength or Physical Performance over Time – A Cohort Study
Rafaela Espírito Santo¹, Joshua Baker², Jordana Silva³, Lidiane Filippin⁴, Juliana Portes¹, Claiton Brenol¹, Rafael Chakr⁵ and Ricardo Xavier⁶, ¹Hospital de Clínicas de Porto Alegre, Laboratório de Doenças Autoimunes, Serviço de Reumatologia, Porto Alegre, Brazil; Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Porto Alegre, Brazil, ²University of Pennsylvania, Philadelphia, PA, ³Institute of musculoskeletal medicine, University Hospital Munster, Munster, Germany, ⁴Universidade La Salle, Canoas, Brazil, ⁵Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, ⁶Departamento de Reumatologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
Background/Purpose: The Health Assessment Questionnaire Disability Index (HAQ) is negatively associated with muscle strength by handgrip test and positively associated with physical performance by timed…
Abstract Number: 0221 • ACR Convergence 2021
Trunk Movement Compensation Is Associated with Physical Performance Measures and Fatigue Deficits in Hip Osteoarthritis
Jesse Christensen¹, David Quammen², Justin Rigby², Cory Christiansen³ and Jennifer Stevens-Lapsley³, ¹VA Salt Lake City Health Care System, Salt Lake City, UT, ²University of Utah, Salt Lake City, UT, ³Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO
Background/Purpose: Movement compensation is common in people with hip osteoarthritis (HOA) and a biomarker of physical performance and muscle strength deficits in older adults. Inertial…
Abstract Number: 0563 • ACR Convergence 2020
Relation of Pain Sensitization to Isokinetic Knee Extension Torque: The MOST Study
Patrick Corrigan¹, Tuhina Neogi², Laura Frey Law³, Neil Segal⁴, Michael Nevitt⁵, Beth Lewis⁶ and Joshua Stefanik¹, ¹Northeastern University, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³University of Iowa, Iowa City, IA, ⁴University of Kansas Medical Center, Iowa City, IA, ⁵Department of Epidemiology and Biostatistics, University of California San Francisco, Orinda, CA, ⁶University of Alabama at Birmingham, Birmingham
Background/Purpose: Central and local alterations in nociception are related to heightened pain severity and can be present in people who have knee osteoarthritis (OA). Yet,…
Abstract Number: 1916 • ACR Convergence 2020
KZR-616, a First-in-class Selective Inhibitor of the Immunoproteasome, Ameliorates Polymyositis in a Murine Model
Marta Del Rio Oliva¹, Michael Basler¹, Darrin Bomba², Diana Lam², Jennifer Brandl², Christopher Kirk² and Marcus Groettrup¹, ¹University of Konstanz, Konstanz, Germany, ²Kezar Life Sciences, Inc, San Francisco, CA
Background/Purpose: Polymyositis (PM) is a chronic autoimmune inflammatory myopathy affecting striated muscles and resulting in muscle weakness. PM is a rare disease, and there are…
Abstract Number: 599 • 2019 ACR/ARP Annual Meeting
Muscle Physical Properties in Young Adult Axial Spondyloarthritis Patients, the MyoSpA Study
Fernando Pimentel-Santos¹, Agna Neto ², Lúcia Domingues ³, Atlas Sardoo ³, Santiago Rodrigues-Manica ¹, Rita Pinheiro Torres ⁴, Carolina Crespo ⁵, Alexandre Sepriano ⁶, Sofia Ramiro ⁷, Kalyani Nair ⁸, Júlia Costa ⁹, Patrícia Gomes-Alves ¹⁰, Alfonse Masi ¹¹ and Jaime Branco ¹, ¹CEDOC, NOVA-Medical School | Hospital Egas Moniz, CHLO, Lisbon, Lisbon, Portugal, ²Rheumatology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental; CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisbon; Hospital Central do Funchal, Madeira., Lisbon, Portugal, ³CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisbon, Lisbon, Portugal, ⁴Rheumatology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental; CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisbon., Lisbon, Portugal, ⁵CEDOC, NOVA Medical School, Universidade Nova de Lisboa, Lisboa, Portugal, Lisbon, Portugal, ⁶Leiden University Medical Center, Leiden, Netherlands, ⁷Leiden University Medical Center and Zuyderland Medical Centre, Leiden, Netherlands, ⁸Bradley University and University of Illinois College of Medicine at Peoria, Illinois, USA, Peoria, IL, ⁹Instituto de Tecnologia Química e BiológicaAntónio Xavier, Universidade NOVA de Lisboa, Av. República, 2780-157 Oeiras, Portugal, Oeiras, Portugal, ¹⁰Instituto de Tecnologia Química e Biológica António Xavier, Universidade NOVA de Lisboa, Oeiras, Portugal, Oeiras, Portugal, ¹¹University of Illinois College of Medicine at Peoria and Bradley University, Peoria Illinois, USA, Peoria, IL
Background/Purpose: An important mechanism regarding axial spondyloarthritis (axSpA) susceptibility and progression is the biomechanical concept, suspected from axial myofascial hypertonicity and stiffness in ankylosing spondylitis…
Abstract Number: 380 • 2018 ACR/ARHP Annual Meeting
A New Tool to Assess Muscle Strength in Polymyositis and Dermatomyositis: Hand-Held Dynamometry
Didem Saygin¹, Chester V. Oddis², Siamak Moghadam-Kia³, Diane Koontz⁴, Nicole Marie Neiman³ and Rohit Aggarwal⁵, ¹Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, ²Division of Rheumatology and Clinical Immunology, Department of Medicine, Unviersity of Pittsburgh/University of Pittsburgh Medical Center, Pittsburgh, PA, ³Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Internal Medicine Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁵Medicine / Rheumatology, University of Pittsburgh/University of Pittsburgh Medical Center, Pittsburgh, PA
Background/Purpose: Idiopathic inflammatory myopathies (IIM) is a group of systemic autoimmune diseases characterized by proximal muscle weakness, which is often assessed clinically using manual muscle…
Abstract Number: 398 • 2018 ACR/ARHP Annual Meeting
Muscle Function and Health-Related Quality of Life in Patients with Polymyositis and Dermatomyositis
Kristofer Andreasson¹, Li Alemo Munters^1,2 and Helene Alexanderson^3,4, ¹Karolinska University Hospital, Function Area Occupational therapy and Physical therapy, Stockholm, Sweden, ²Swedish Rheumatism Association, Stockholm, Sweden, ³Department of NVS, Division of Physical Therapy, Karolinska Institutet, Huddinge, Sweden, ⁴Function Area Occupational therapy & Physiotherapy, Allied Health Professionals Function, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Poly- and dermatomyositis (PM/DM) are idiopathic inflammatory muscle diseases characterized by reduced muscle function. Oral glucocorticoids and DMARD’s are the usual treatment options and…
Abstract Number: 418 • 2018 ACR/ARHP Annual Meeting
Dose-Response Relationship between Neuromuscular Electrical Stimulation and Muscle Function in Patients with Rheumatoid Arthritis
Gustavo J. Almeida¹, Samannaaz S. Khoja² and Sara R. Piva¹, ¹Physical Therapy, University of Pittsburgh, Pittsburgh, PA, ²Department of Physical Therapy, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Neuromuscular electrical stimulation (NMES) is a viable intervention to improve impaired muscle function of patients with rheumatoid arthritis (RA). However, there is limited evidence…
Abstract Number: 913 • 2018 ACR/ARHP Annual Meeting
Risk Factors for Knee Pain Exacerbation on Walking: A within-Person Knee-Matched Study
Qiang Liu^1,2, David J. Hunter³, Manuela Ferreira⁴, Barton L Wise⁵, Ke Tao¹, Yuqing Zhang⁶ and Jianhao Lin¹, ¹Arthritis Clinic and Research Center, Peking University People's Hospital, Beijing, China, ²Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁴Institute of Bone and Joint Research | The Kolling Institute, Sydney Medical School, Sydney, Australia, ⁵Orthopaedics, Internal Medicine, University of California, Davis School of Medicine, Sacramento, CA, ⁶Department of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA
Background/Purpose: Pain exacerbation on walking is common among patients with knee osteoarthritis and often lead to activity avoidance. To date, few risk factors for pain…
Abstract Number: 2332 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Effect´s on Bone Mass and Muscle
María Lorena Brance¹, Bernardo A Pons-Estel², Javier Quagliatto³, Marisa Jorfen⁴, Noel Cortese⁴, Guillermo Berbotto⁵, Juan Carlos Raggio⁶, Juan Soldano³, Mariano Palatnik¹, Ignacio Chavero¹, Carolina Dieguez¹, Silvana Di Gregorio⁷ and Lucas Ricardo Brun⁸, ¹Centro de Reumatología, Rosario, Argentina, ²Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Rosario, Argentina, ³Hospital Provincial, Rosario, Argentina, ⁴Municipalidad de Rosario, Rosario, Argentina, ⁵Hospital Escuela Eva Perón, Granadero Baigorria, Argentina, Granadero Baigorria, Argentina, ⁶Hospital Eva Perón, Granadero Baigorria, Argentina, ⁷Centre Medic Cetir, Barcelona, Spain, ⁸School of Medicine. Rosario National University, Bone Biology Laboratory, Rosario, Argentina
Background/Purpose: Rheumatoid arthritis (RA) is a progressive auto-immune disease characterized by chronic inflammation which leads to joint deformity and disability. However, the bone and muscle…
Abstract Number: 1541 • 2016 ACR/ARHP Annual Meeting
Frailty Is Associated with Decreased Physical Function in Adults with Rheumatoid Arthritis
James Andrews¹, Ken Covinsky², Catherine Hough¹, Laura Trupin³, Edward H. Yelin³ and Patricia P. Katz³, ¹Medicine, University of Washington, Seattle, WA, ²Medicine, University of California San Francisco, San Francisco, CA, ³Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA
Background/Purpose: Reduced physical function and health-related quality of life remain common in Rheumatoid Arthritis (RA), and further studies are needed that examine potential, novel determinates…
Abstract Number: 217 • 2014 ACR/ARHP Annual Meeting
The Relationship of Quadriceps and Hamstrings Intramuscular Fat and Lean Muscle with Power in Women with Knee Osteoarthritis
Michael J. Davison¹, Monica R. Maly², Karen A. Beattie³, Peter J. Keir⁴ and Jonathan D. Adachi⁵, ¹Medical Sciences, McMaster University, Hamilton, ON, Canada, ²School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada, ³Medicine, McMaster University, Hamilton, ON, Canada, ⁴Kinesiology, McMaster University, Hamilton, ON, Canada, ⁵Division of Rheumatology, McMaster University, Hamilton, ON, Canada
Background/PurposeReduced quadriceps and hamstrings strength is a risk factor for knee osteoarthritis (OA). This strength loss is partly due to the loss of lean muscle…
Abstract Number: 2096 • 2013 ACR/ARHP Annual Meeting
Impaired Shoulder-Arm Mobility and Muscle Function In Patients With Systemic Sclerosis
Helene Alexanderson¹, Fia Bringby², Annica Nordin³, Lena Björnådal⁴, Elisabet Svenungsson⁵ and Carina Boström⁶, ¹Department of Neurobiology, Care Science and Society, Division of Physiotherapy, Division of Physiotherapy, Karolinska Institutet, Huddinge, Stockholm, Sweden, ²Capio Arthro Clinic, Stockholm, Sweden, ³Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁴Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ⁵Department of Medicine, Unit of Rheumatology, Karolinska Institutet, Stockholm, Sweden, ⁶Department of Neurobiology, Care Sciences and Society,, Division of Physiotherapy, Karolinska Institutet Huddinge, Stockholm, Sweden
Background/Purpose: Patients with systemic sclerosis (SSc) have reduced hand function and self-reported limitations in daily activities. Few studies have explored limitations in shoulder-arm mobility and…