Abstract Number: L10 • ACR Convergence 2022
Efgartigimod Prevents Necrosis and Allows for Muscle Fiber Regeneration in a Humanized Mouse Model of Immune-mediated Necrotizing Myopathy (IMNM)
Background/Purpose: Immune-mediated necrotizing myopathy (IMNM) is a severe form of myositis characterized by muscle weakness and elevated creatine kinase levels in serum. The most frequent…Abstract Number: 0041 • ACR Convergence 2022
Modeling Juvenile Dermatomyositis with Engineered Human Skeletal Muscle: Effects of Type I Interferonβ and Janus Kinase Inhibitors
Background/Purpose: Upregulation of Type I interferons (IFN I), including IFNβ, is a hallmark of adult and juvenile dermatomyositis (JDM), but its role in pathogenesis is…Abstract Number: 0158 • ACR Convergence 2022
Effect of Type I IFN on Mitochondria and Muscle Weakness in Myositis
Background/Purpose: Muscle weakness is a hallmark of autoimmune myositis. The mechanisms that contribute to muscle weakness are currently unknown. The observed ineffectiveness after immunomodulatory treatment…Abstract Number: 0847 • ACR Convergence 2022
Association of Frontal Plane Trunk Motion During Gait with Abductor Strength, Fatigue, and Physical Activity in Women with Hip Osteoarthritis
Background/Purpose: We have previously reported that fatigue and hip abductor weakness are associated with reduced physical activity (PA) in women with hip osteoarthritis (OA). We…Abstract Number: 1886 • ACR Convergence 2022
Statin-induced Immune-mediated Miopathy: Treatment with Glucocorticoid-free Protocols and Role of Muscle Biopsy in the Follow-up
Background/Purpose: Statin-induced immune mediated necrotizing myopathy (IMNM) is a recently identified autoimmune condition associated with anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibodies, characterized by progressive muscle weakness leading…Abstract Number: 0694 • ACR Convergence 2021
Glucagon-like Peptide-1 Receptor Agonist Suppresses Muscle Fiber Necroptosis and Muscle Inflammation and Ameliorates Muscle Weakness in Experimental Polymyositis
Background/Purpose: While glucocorticoids (GC) are the cornerstone of the treatment for polymyositis (PM), GC-induced myopathy is inevitable, which deteriorates muscle weakness. Therefore, novel therapeutic strategy…Abstract Number: 0710 • ACR Convergence 2021
Patients with Recent Onset, Active Polymyositis (PM), Dermatomyositis (DM) and Antisynthetase Syndrome (ASS) Have Reduced Muscle Endurance but Not Reduced Muscle Strength Compared to Patients with Established, Low-active Disease
Background/Purpose: To analyze for differences in quadriceps maximal isometric voluntary contraction (MVIC), muscle endurance (ME), muscle mass and fat mass (m. vastus lateralis, mid-thigh) in…Abstract Number: 1664 • ACR Convergence 2021
Changes in Physical Function Were Not Associated with Clinically Important Changes in Muscle Strength or Physical Performance over Time – A Cohort Study
Background/Purpose: The Health Assessment Questionnaire Disability Index (HAQ) is negatively associated with muscle strength by handgrip test and positively associated with physical performance by timed…Abstract Number: 0221 • ACR Convergence 2021
Trunk Movement Compensation Is Associated with Physical Performance Measures and Fatigue Deficits in Hip Osteoarthritis
Background/Purpose: Movement compensation is common in people with hip osteoarthritis (HOA) and a biomarker of physical performance and muscle strength deficits in older adults. Inertial…Abstract Number: 0563 • ACR Convergence 2020
Relation of Pain Sensitization to Isokinetic Knee Extension Torque: The MOST Study
Background/Purpose: Central and local alterations in nociception are related to heightened pain severity and can be present in people who have knee osteoarthritis (OA). Yet,…Abstract Number: 1916 • ACR Convergence 2020
KZR-616, a First-in-class Selective Inhibitor of the Immunoproteasome, Ameliorates Polymyositis in a Murine Model
Background/Purpose: Polymyositis (PM) is a chronic autoimmune inflammatory myopathy affecting striated muscles and resulting in muscle weakness. PM is a rare disease, and there are…Abstract Number: 599 • 2019 ACR/ARP Annual Meeting
Muscle Physical Properties in Young Adult Axial Spondyloarthritis Patients, the MyoSpA Study
Background/Purpose: An important mechanism regarding axial spondyloarthritis (axSpA) susceptibility and progression is the biomechanical concept, suspected from axial myofascial hypertonicity and stiffness in ankylosing spondylitis…Abstract Number: 380 • 2018 ACR/ARHP Annual Meeting
A New Tool to Assess Muscle Strength in Polymyositis and Dermatomyositis: Hand-Held Dynamometry
Background/Purpose: Idiopathic inflammatory myopathies (IIM) is a group of systemic autoimmune diseases characterized by proximal muscle weakness, which is often assessed clinically using manual muscle…Abstract Number: 398 • 2018 ACR/ARHP Annual Meeting
Muscle Function and Health-Related Quality of Life in Patients with Polymyositis and Dermatomyositis
Background/Purpose: Poly- and dermatomyositis (PM/DM) are idiopathic inflammatory muscle diseases characterized by reduced muscle function. Oral glucocorticoids and DMARD’s are the usual treatment options and…Abstract Number: 418 • 2018 ACR/ARHP Annual Meeting
Dose-Response Relationship between Neuromuscular Electrical Stimulation and Muscle Function in Patients with Rheumatoid Arthritis
Background/Purpose: Neuromuscular electrical stimulation (NMES) is a viable intervention to improve impaired muscle function of patients with rheumatoid arthritis (RA). However, there is limited evidence…
ACR Meeting Abstracts